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Office of Neuroscience Research > Neuroscience Calendar > MIR/NIAC Seminar: Yen-Yu Ian Shih (University of North Carolina, Chapel Hill)

MIR/NIAC Seminar: Yen-Yu Ian Shih (University of North Carolina, Chapel Hill)

"Dissecting the source of negative fMRI response using optogenetics" 


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When: Tuesday, June 20, 2017 at 1:00 PM to 2:00 PM
Where: NIL Large Conference Room 2311 (Medical Campus, 4525 Scott Ave.)

Background:  Dr. Yen-Yu Ian Shih, Ph.D., is an Assistant Professor in the Department of Neurology, and the Director of Small Animal MRI at the Biomedical Research Imaging Center, at the University of North Carolina at Chapel Hill.  The Experimental Neuroimaging Laboratory’s research focuses on functional dissection of therapeutic deep brain stimulation circuitry using optogenetic fMRI.  This project addresses three critical, yet elusive questions: 1) which neural circuits represent on and off-target STN-DBS effects, 2) whether selective optogenetic stimulation of STN neurons ameliorate parkinsonian motor deficits, and 3) which neural circuits are necessary for therapeutic STN-DBS.  In another project they are dissecting the source of fMRI signals using DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to find out how neurons and astrocytes, the two major cell populations in the brain, orchestrate to generate BOLD fMRI signal.  The team has developed multi-modal MRI techniques to measure cerebral blood oxygenation, blood flow, blood volume, and oxygen metabolism changes in animal models.  They have also developed and applied multi-modal MRI techniques to investigate eye function and ocular circulation.  The Lab is developing simultaneous fMRI/electrophysiology at high spatial resolution (ranged from 30 to 100 microns) to elucidate the neurophysiological origins of fMRI signals and the pathophysiological mechanisms of neurovascular diseases.

 

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