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Office of Neuroscience Research > Neuroscience Calendar > Annual Hope Center Retreat: Leonard Petrucelli (Mayo Clinic Florida), Brian Kaspar (AveXis, Inc.)

Annual Hope Center Retreat: Leonard Petrucelli (Mayo Clinic Florida), Brian Kaspar (AveXis, Inc.)

Leonard Petrucelli: “Mechanistic and Therapeutic Insights into c9FTD/ALS”
Brian Kaspar: "Gene Delivery Translation in Spinal Muscular Atrophy”


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When: Tuesday, April 10, 2018 at 8:30 AM to 6:00 PM
Where: Danforth Plant Science Center (975 North Warson Road)

We received notice that Brian Kaspar (AveXis) is unable to attend the Hope Center Retreat.  We apologize for any inconvenience.

The Eighth Annual Hope Center Retreat will be held at the Danforth Plant Science Center.

2018 Retreat program

8:00a    Shuttle departs from the Farrell LTC (66o S. Euclid)

8:30a    Continental Breakfast

9:00a    Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

9:05a    Hope Center Lecture – Leonard Petrucelli, PhD (Mayo Clinic Florida) 

“Mechanistic and Therapeutic Insights into c9FTD/ALS”

10:05a    Session 1: Neurodegeneration Group (Chair: Timothy Miller, MD PhD (Neurology))

  • Kiersten Ruff, PhD (Pappu Lab, Biomedical Engineering) "Polyglutamine length dependent structural properties and phase behavior of huntingtin exon 1"
  • Tien-Phat Huynh (Holtzman Lab, Neurology) "Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis"

10:35a    Break

11:00a    Session 2: Lysosome Processing & Transport and NeuroRestorative Therapy Groups (Chairs: Bruno Benitez, MD and Albert Kim, MD & Fumihiko Urano, MD PhD (Medicine))

  • Devi Annamalai, PhD (Kim Lab, Neurosurgery) "Epigenomic reprogramming as a therapeutic strategy for malignant gliomas"
  • Sidhartha Mahali, PhD (Karch Lab, Psychiatry) "Lysosomal dysfunction and altered tau metabolism in stem cell models of autosomal dominant Alzheimer’s disease"

11:30a    Session 2: Neurovascular Injury & Repair Group (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Charise Garber (Klein Lab, Medicine) “T-cells promote microglial activation and prevent cognitive recovery from viral encephalitis via interferon gamma”
  • Deepti Diwan, PhD (Zipfel Lab, Neurosurgery) “Sirt1 mediates hypoxic conditioning-induced delayed cerebral ischemia protection in subarachnoid hemorrhage”

12:00p    Lunch

1:15p    Hope Center Lecture – Brian Kaspar, PhD (AveXis, Inc.)

“Gene Delivery Translation in Spinal Muscular Atrophy”

2:15p    Session 4: Neurogenetics & Transcriptomics Group (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Umber Dube (Cruchaga Lab, Psychiatry) “Circular RNAs in Alzheimers disease brain tissues”
  • Denis Avey, PhD (Milbrant Lab, Genetics) “Single cell RNA-seq facilitates characterization of glial and neuronal responses to morphine”

2:45p    Session 5: Axon Injury & Repair Group (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Scott Karney-Grobe (DiAntonio Lab, Developmental Biology) “HSP90 is a chaperone for DLK and is required for axon injury signaling”
  • Deng Pan (MacKinnon Lab, Developmental Biology) “Reduced T cell accumulation in long gap nerve injuries inhibit peripheral nerve regeneration”

3:15p    Poster set-up

3:30p    Poster session

5:45p    Shuttle departs

Click here for more information.

For more information, please contact Jan Konrad



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