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Office of Neuroscience Research > Neuroscience Calendar > Division of Biostatistics Seminar: Yun Ju Sung (WashU Biostatistics)

Division of Biostatistics Seminar: Yun Ju Sung (WashU Biostatistics)

"A Large International Multi-ancestry Consortium Investigating Gene-Lifestyle Interactions in Cardiovascular Traits: Gene-Smoking Interactions in Blood Pressure "


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When: Friday, November 17, 2017 at 12:30 PM to 1:30 PM
Where: Becker Library 502 (Medical Campus, 5th floor)

Abstract: Genome-wide association analysis has advanced understanding of blood pressure (BP), a major public health priority with implications for vascular conditions such as coronary heart disease and stroke. Incorporating gene-environment interactions in genome-wide analysis represents an additional route for discovery of BP loci and extending our knowledge of its genetic architecture. Within the CHARGE Gene-Lifestyle Interactions Working Group, we performed genome-wide meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in up to 610,091 individuals from five ancestries. Stage 1 meta-analyses examined ~18.8 million SNPs and small insertion/deletion (indel) variants among 129,913 individuals from four ancestries (European, African, Asian, and Hispanic). Stage 2 analyses examined the top variants selected from Stage 1 (with P < 10-6) among 480,178 additional individuals from five ancestries. I will present major findings and challenges we encountered with this first large-scale multi-ancestry investigation of gene-smoking interactions.

Coffee, water and cookies will be provided.

Visit the calendar for the full list of Division of Biostatistics seminars.

For inquiries contact Chengjie Xiong.  



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