Below is a listing of facilities, services, programs, and expertise available to Neuroscience investigators. Access may vary depending on the facility or program. For additional information, please follow links and contact information for each entry. If you would like to add an entry, please contact the Office of Neuroscience Research.
Confocal and multiphoton microscopy; digital whole-slide scanning; atomic force microscopy
AMP (Anatomic and Molecular Pathology) Lab
Immunohistochemistry, histology, molecular pathology, tissue microarrays, digital imaging
Phenotyping of small animal behavior including assessment of motor/sensorimotor functions (e.g., rotarod, gait analysis), learning and memory capabilities (e.g., Morris water maze), altered emotionality, social behaviors, and visual thresholds
Models for stroke, traumatic brain injury
Confocal and multiphoton microscopes for live or fixed tissue imaging; low light imaging system; FRET/FRAP; upright or inverted microscope capability; post acquisition work station (Metamorph, Image J, Adobe Photoshop)
Dennis Oakley, Paul Taghert
Biology - Low Light Imaging
Low Light Imaging for bioluminescence
Confocal and deconvolution microscopy
Design of experiments and clinical trials, protocol development, database management, assistance with grant preparation, statistical analysis of data
Brain, Behavior and Performance Unit (ICTS)
Testing and other support for neurologic, psychiatric and psychometric parameters, muscle strength and function, quantified measures of movement, performance-based measures of daily living activities and quality-of-life measures; infrastructure for common database collection, retrieval and transfer of all research information, and technical personnel
Center for Administrative Data Research (CADR)
The Center for Administrative Data Research (CADR) serves to provide leadership and training in the use of health services administrative data in clinical epidemiologic, health services and outcomes research.
Center for Advanced Cellular & Genetic Technology
The Center for Advanced Cellular & Genetic Technology consists of the Tissue Culture Support Center, the Induced Pluripotent Stemcell Center and the Genome Engineering Center. We offer basic tissue culture services, generate, maintain and induce stem cell differentiation, and provide custome genome editing services. We also serve as a centralized general store offering more than 1500 commonly used lab consumables.
Center for Applied Research Sciences (CARS)
The Center for Applied Research Sciences (CARS) has been established within the Institute of Clinical and Translational Sciences (ICTS) to increase access to specialized clinical research units where investigators can have access to state-of-the-art resources for conducting efficient, safe, and ethical studies in research volunteers.
Center for Biomedical Informatics (CBMI)
Software tools to facilitate biomedical research. These tools allow investigators to store, integrate, query, analyze, and visualize complex clinical and molecular data sets. The CBMI provides comprehensive training resources and facilitates collaborative studies for the identification of diagnostic and prognostic biomarkers and the subsequent development of personalized therapies.
Center for Clinical Research Ethics (ICTS)
Education, consultation and research on topics of clinical research ethics
Center for Community-Engaged Research (CCER)
A transformative initiative that fosters collaborative research partnerships between and among the community at large, community organizations, ICTS academic institutions, community-based health providers, and community researchers. Dynamic and productive, the CCER is a platform to establish partnerships between academic and community researchers.
Center for Economic Evaluation in Medicine (CEEM)
Helps people are who making decisions weigh the cost of and benefit of their alternatives.
Central Neuroimaging Data Archive
Storage and analysis of MRI, PET, and CT imaging data
Clinical Research Training Center (ICTS)
Infrastructure to foster clinical research training and career development for predoctoral students, house-staff, postdoctoral fellows and faculty by integrating diverse training programs into a single location and administrative umbrella
Clinical Research Unit (ICTS)
Facilities, equipment and staffing for in-patient and out-patient clinical research
Clinical Trials Unit (ICTS)
Research space, equipment, and nursing support for a wide range of clinical studies
Community-Based Recruitment and Retention (ICTS)
Recruitment to link populations that have been underrepresented in research to health information, physician referrals and clinical trials
Confocal Microscopy (Dept of Cell Biology & Physiology)
Zeiss LSM-510 META confocal microscope, Stallion Fluorescence Imaging microscope
Deep-Etch Electron Microscope (DEEM) (Dept of Cell Biology & Physiology)
Quick-freezing of biological samples, subsequent preparation of quick-frozen samples for electron microscopy
John Heuser, Robyn Roth
Dissemination & Implementation Research Core (DIRC)
Provides methodological expertise to advance translational (T2) research to inform and move efficacious health practices from clinical knowledge into routine, real-world use.
Electron Microscopy (Dept of Cell Biology & Physiology)
Tissue processing for morphology and/or immunolabeling, technical support for embedding, sectioning, immunoprocessing, scoping and darkroom services
Excitability Imaging Core
Genome Center: DNA and RNA Analysis
Genotyping and expression, all commercial microarray formats, custom array design and manufacture, RNA/DNA QC analysis, microarray processing and data analysis
Seth Crosby, Mike Heinz
Genome Center: Investigatory Sequencing
Mapping, whole genome sequencing, clone sequencing, sequence refinement, EST and cDNA sequencing
Genome Technology Access Center (ICTS)
Cutting-edge and cost effective sequencing and analysis technologies to local colleagues and external investigators. The GTAC offers fee-for-service sample preparation, data generation, bioinformatics analysis, and intellectual support for microarray, PCR, and high-throughput sequencing studies.
Histology and Microscopy (Dept of Developmental Biology)
Full service histology, Zeiss Apotome structured resolution microscope, stereoscope, brightfield/fluorescence microscopes, transmission EM, scanning EM
Bill Coleman, Marlene Scott
Human & Mouse Linked Evaluation of Tumors (HAMLET) Core
The mission is to promote understanding of the biology and genetics of Human Breast Cancer, and to provide better preclinical models for the validation of new treatment and imaging approaches.
Human Imaging Unit (ICTS)
Advanced imaging technology, equipment and expertise to support basic and translational inpatient and outpatient clinical research
In Vitro Physiology
In vitro brain slice preparations, whole-cell recording (cultured neurons or transfected cells), data analysis
In Vivo Physiology
EEG, EMG, evoked synaptic responses from dentate granule cell layer, assessment of tetanus-induce long-term synaptic potentiation
Lifestyle Intervention Research Core (ICTS)
Specialized nutrition services, behavioral assessment and therapy, training in sensory evaluation techniques and lifestyle behavior-change therapy, image processing and analysis services
Cathy Anderson Spearie
Microbiological Media Services
The Microbiology Media Services Core Facility is fully staffed and equipped to provide complete services in hand poured, made-to-order microbiological media. The Media Services mission is to provide speedy and accurate products that enhance user confidence.
Molecular Imaging Center
Provides assistance to investigators who have limited experience or resources by advice or direct help with experimental design and execution. The Core can clone and screen reporters and generate cell lines and transgenic or knock-in animals. Furthermore, MIRC can characterize reporter gene expression and molecular function using either radio-labeled or fluorescently tagged probes (together with the Chemistry Core) or through bioluminescence assays in vitro. Furthermore, the MIRC assists in planning and executing xenograft and transgenic studies in vivo.
Production and maintenance of transgenic or chimeric mice, pcr genotyping, speed congenics, reproductive services including cryopreservation, in vitro fertilization, rederivations
Multiple Sclerosis Research Interest Group
Multiple Sclerosis animal models - EAE
Our Community, Our Health (ICTS)
Disseminate relevant and culturally appropriate health information and actively engage the St. Louis community in partnerships to help address local health disparities
Consuelo Hopkins Wilkins
Behavioral tests of baseline pain sensitivity (mechanical,heat, cold, chemical, visceral); models of persistent pain (inflammatory and neuropathic); studies of analgesia in response to systemically- or intrathecally-administered drugs
Pediatric Clinical Research Unit (ICTS)
Space, nursing and bionutritional support for clinical research projects conducted with children at Washington University in St. Louis
Protein and Nucleic Acid Chemistry Laboratories (PNACL)
Automated DNA sequencing, synthetic oligonucleotides, Edman degradation protein sequencing
Erin Ramshur, Misty Veschak, Greg Grant
Proteomics & Mass Spectrometry Program (PMSP)
Offers next generation mass spectrometry and data analysis tools for global and targeted protein quantification in biological fluids and tissues.
Recruitment Enhancement Core (REC)
A unique service that helps ICTS investigators meet and exceed study recruitment targets. The REC takes responsibility for enhancing recruitment; university wide, by passing a steady stream of qualified participants to the PIs and study coordinators.
Regulatory Support Center (ICTS)
Regulatory Core, Participant Advocacy and Ombudsman Core, and Recruitment Enhancement Core to assist in overcoming organizational barriers, navigating through regulatory requirements for human research, and recruiting adequate numbers of appropriate research participants for studies
Research Design & Biostatistics Group (RDBG)
Guides clinical study design, data collection and data analysis. Assistance is available from protocol/proposal preparation to manuscript development.
J. Philip Miller
Viral vector-based RNAi technology to alter gene function in primary cultures
Standard noninvasive functional assays of inner ear/auditory brainstem function, and retina/central visual pathways
Tissue Procurement Core (ICTS)
Facilitate collection, processing, storage, and molecular analysis of biospecimens from participants enrolled on clinical and translational research studies, assist in design and execution of studies focused on genomic and molecular analyses of study participant biospecimens
Design and construction of mouse transgenes and gene targeting vectors using recombineering technology; mouse ES cell screening (pcr and southern blot)
Translational Cardiovascular Biobank & Repository (TCBR)
TCBR was founded for the acquisition (using standardized, validated procedures), utilization and storage of integrated human cardiovascular tissues and clinical data for detailed phenotypic (electrophysiological, structural, molecular and biochemical) and genotypic (genomic, epigenetic and somatic) analyses.
Translational Research Methods & Analysis Center (TRAC)
(TRAC) will make the analytic tools of translational research more easily accessible to Institute of Clinical & Translational Sciences (ICTS) investigators and trainees by supporting the spectrum of translational research that continues to evolve with the support of the ICTS. The mission of TRAC is to increase the efficiency and organization of clinical and translational research at WU and its regional partners by providing a centralized platform of state-of-the-art design, methodological support, and analytic services.
Assist in design/preparation of lentiviral vectors and adeno-associated viral vectors; some shared molecular biology equipment available
Mingjie Li, Joy Snider
Washington University Pediatric & Adolescent Ambulatory Research Consortium (WU PAARC)
WU PAARC has developed a formal infrastructure to actively engage community practitioners in clinical and translational research. WU PAARC initiates and conducts research studies and collaborates with other investigators to design and implement studies in the community setting.