WashU weekly Neuroscience publications: February 18, 2022

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
(2022) JAMA Neurology, . Cited 1 time.

Jansen, W.J.^a b , Janssen, O.^a , Tijms, B.M.^c , Vos, S.J.B.^a , Ossenkoppele, R.^c d , Visser, P.J.^a c e , Aarsland, D.^f g , Alcolea, D.^h i , Altomare, D.^j k , Von Arnim, C.^l m , Baiardi, S.ⁿ , Baldeiras, I.^o p q , Barthel, H.^r , Bateman, R.J.^s , Van Berckel, B.^t , Binette, A.P.^u v , Blennow, K.^w , Boada, M.^x y , Boecker, H.^z , Bottlaender, M.^aa , Den Braber, A.^ab , Brooks, D.J.^ac ad ae , Van Buchem, M.A.^af , Camus, V.^ag , Carill, J.M.^ah , Cerman, J.^ai , Chen, K.^aj , Chételat, G.^ak , Chipi, E.^al , Cohen, A.D.^am , Daniels, A.^an , Delarue, M.^ak , Didic, M.^ao ap , Drzezga, A.^z aq , Dubois, B.^ar , Eckerström, M.^as , Ekblad, L.L.^at , Engelborghs, S.^au av , Epelbaum, S.^ar , Fagan, A.M.^aw , Fan, Y.^ax , Fladby, T.^ay , Fleisher, A.S.^az , Van Der Flier, W.M.^ab , Förster, S.^ba bb , Fortea, J.^h i , Frederiksen, K.S.^bc , Freund-Levi, Y.^bd be bf , Frings, L.^bg , Frisoni, G.B.^bh , Fröhlich, L.^bi , Gabryelewicz, T.^bj , Gertz, H.-J.^bk , Gill, K.D.^bl , Gkatzima, O.^bm , Gómez-Tortosa, E.^bn , Grimmer, T.^bo , Guedj, E.^bp , Habeck, C.G.^bq , Hampel, H.^br , Handels, R.^bs , Hansson, O.^bt , Hausner, L.^bu , Hellwig, S.^bv , Heneka, M.T.^bw bx , Herukka, S.-K.^by bz , Hildebrandt, H.^ca , Hodges, J.^cb , Hort, J.^ai , Huang, C.-C.^cc , Iriondo, A.J.^cd , Itoh, Y.^ce , Ivanoiu, A.^cf , Jagust, W.J.^cg ch , Jessen, F.^ci cj ck , Johannsen, P.^cl , Johnson, K.A.^cm , Kandimalla, R.^{bl cn co cp} , Kapaki, E.N.^cq , Kern, S.^cr , Kilander, L.^cs , Klimkowicz-Mrowiec, A.^ct , Klunk, W.E.^cu cv , Koglin, N.^cw , Kornhuber, J.^cx , Kramberger, M.G.^cy , Kuo, H.-C.^cz , Van Laere, K.^da db , Landau, S.M.^dc , Landeau, B.^ak , Lee, D.Y.^dd , De Leon, M.^de , Leyton, C.E.^df , Lin, K.-J.^dg dh , Lleó, A.^h i , Löwenmark, M.^di , Madsen, K.^dj , Maier, W.^dk , Marcusson, J.^dl , Marquié, M.^x y , Martinez-Lage, P.^dm , Maserejian, N.^dn , Mattsson, N.^bt , De Mendonça, A.^do , Meyer, P.T.^bg , Miller, B.L.^dp , Minatani, S.^ce , Mintun, M.A.^dq , Mok, V.C.T.^dr ds dt , Molinuevo, J.L.^du , Morbelli, S.D.^dv dw , Morris, J.C.^aw , Mroczko, B.^dx dy , Na, D.L.^dz ea , Newberg, A.^eb , Nobili, F.^ec ed , Nordberg, A.^a , Olde Rikkert, M.G.M.^ee , De Oliveira, C.R.^o , Olivieri, P.^ef fd , Orellana, A.^x y , Paraskevas, G.^eg , Parchi, P.^eh ei , Pardini, M.^ej , Parnetti, L.^al , Peters, O.^ek , Poirier, J.^el , Popp, J.^em en , Prabhakar, S.^eo , Rabinovici, G.D.^ep , Ramakers, I.H.^bs , Rami, L.^eq , Reiman, E.M.^aj , Rinne, J.O.^er , Rodrigue, K.M.^es , Rodríguez-Rodriguez, E.^et , Roe, C.M.^aw , Rosa-Neto, P.^el , Rosen, H.J.^eu , Rot, U.^ev , Rowe, C.C.^ew ex , Rüther, E.^ey , Ruiz, A.^x y , Sabri, O.^r , Sakhardande, J.^ez , Sánchez-Juan, P.^fa , Sando, S.B.^fb fc , Santana, I.^o p q , Sarazin, M.^ef fd , Scheltens, P.^ab , Schröder, J.^fe , Selnes, P.^ay , Seo, S.W.^ff , Silva, D.^fg , Skoog, I.^cr , Snyder, P.J.^fh , Soininen, H.^fi fj , Sollberger, M.^fk fl , Sperling, R.A.^fm fn , Spiru, L.^fo fp , Stern, Y.^ez , Stomrud, E.^bt , Takeda, A.^ce , Teichmann, M.^ar fq , Teunissen, C.E.^ab , Thompson, L.I.^fr , Tomassen, J.^ab , Tsolaki, M.^fs , Vandenberghe, R.^ft fu , Verbeek, M.M.^fv , Verhey, F.R.J.^bs , Villemagne, V.^ew fw , Villeneuve, S.^u v fx , Vogelgsang, J.^fy , Waldemar, G.^bc fz , Wallin, A.^cr , Wallin, Å.K.^bt , Wiltfang, J.^ga gb , Wolk, D.A.^gc , Yen, T.-C.^gd ge , Zboch, M.^gf , Zetterberg, H.^{cr gg gh gi gj}

^a Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, Maastricht, 6200 MD, Netherlands
^b Banner Alzheimer’s Institute, Phoenix, AZ, United States
^c Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, Netherlands
^d Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden
^e Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
^f Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden
^g Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway
^h Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Madrid, Spain
ⁱ Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
^j Laboratory Alzheimer’s Neuroimaging and Epidemiology, Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS) Fatebenefratelli, Brescia, Italy
^k Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
^l Division of Geriatrics, University of Goettingen Medical School, Goettingen, Germany
^m Clinic for Neurogeriatrics and Neurological Rehabilitation, University and Rehabilitation Hospital Ulm, Ulm, Germany
ⁿ Department of Experimental Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Spain
^o Center for Neuroscience and Cell Biology (CIBB), University of Coimbra, Coimbra, Portugal
^p Neurology Department and Laboratory of Neurochemistry, Centro Hospitalar e Universitário de Coimbra, Praceta Professor Mota Pinto, Coimbra, Portugal
^q Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra, Portugal
^r Department of Nuclear Medicine, University Hospital of Leipzig, Leipzig, Germany
^s Department of Neurology and the Alzheimer’s Disease Research Center, Washington University, School of Medicine in St Louis, St Louis, MO, United States
^t Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
^u Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada
^v Douglas Mental Health University Institute, Montreal, QC, Canada
^w Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren’s University Hospital, Mölndal, Sweden
^x Research Center and Memory Clinic of Fundació, Alzheimer Centre Educacional, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
^y CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
^z Deutsches Zentrum für Neurodegenerative Erkrankungen E.V. (DZNE), Bonn, Germany
^aa Université Paris-Saclay, Service Hospitalier Frédéric Joliot (CEA), French National Centre for Scientific Research (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), BioMaps, Service Hospitalier Frederic Joliot, Orsay, France
^ab Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
^ac Translational and Clinical Research Institute, University of Newcastle Upon Tyne, United Kingdom
^ad Department of Nuclear Medicine, Positron Emission Tomography Centre, Aarhus University, Aarhus, Denmark
^ae Department of Brain Sciences, Imperial College London, London, United Kingdom
^af Department of Neurology, University Hospital Leiden, Leiden, Netherlands
^ag Unite Mixte de Recherche, INSERM U930, French National Centre for Scientific Research (CNRS), ERL, Tours, France
^ah Nuclear Medicine Department, University Hospital Marqués de Valdecilla, Molecular Imaging, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), University of Cantabria, Santander, Spain
^ai Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic
^aj Banner Alzheimer’s Institute, Phoenix, AZ, United States
^ak Normandie University, University of Caen Normandie (UNICAEN), INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France
^al Centro Disturbi della Memoria, Laboratorio di Neurochimica Clinica, Clinica Neurologica, Università di Perugia, Perugia, Italy
^am Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States
^an Department of Neurology, Washington University, School of Medicine in St Louis, St Louis, MO, United States
^ao Assistance Publique Hôpitaux de Marseille (AP-HM), Timone, Service de Neurologie et Neuropsychologie, Hôpital Timone Adultes, Marseille, France
^ap Aix Marseille Univ, INSERM, Institut de Neurosciences des Systèmes (INS), Marseille, France
^aq Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany
^ar Department of Neurology, Institut de la Mémoire et de la Maladie d’Alzheimer, Centre de Reference Demences Rares, Hopital de la Pitie-Salpetriere, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
^as Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
^at Turku PET Centre, University of Turku, Turku, Finland
^au Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
^av Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium
^aw Department of Neurology, The Alzheimer’s Disease Research Center, Washington University, School of Medicine in St Louis, St Louis, MO, United States
^ax Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
^ay Department of Neurology, Akershus University Hospital, Lorenskog, Norway
^az Eli Lilly and Company, Indianapolis, IN, United States
^ba Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
^bb Department of Nuclear Medicine, Klinikum Bayreuth, Bayreuth, Germany
^bc Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
^bd School of Medical Sciences, Örebro University, Örebro, Sweden
^be Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden
^bf Department of Old Age Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
^bg Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
^bh Memory Clinic, University Hospitals, University of Geneva, Geneva, Switzerland
^bi Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
^bj Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
^bk Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Leipzig, Leipzig, Germany
^bl Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
^bm Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece
^bn Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain
^bo Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany
^bp Aix Marseille University, AP-HM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, Centre Européen de Recherche en Imagerie Médicale (CERIMED), Nuclear Medicine Department, Marseille, France
^bq Department of Neurology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, Irving Medical Center, New York, NY, United States
^br Sorbonne University, Clinical Research Group No. 21, Alzheimer Precision Medicine, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
^bs Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands
^bt Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden
^bu Universität Heidelberg, Abteilung Gerontopsychiatrie, Zentralinstitut für Seelische Gesundheit Mannheim, Mannheim, Germany
^bv Department of Psychiatry, Psychotherapy Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
^bw Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany
^bx Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States
^by Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland
^bz Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
^ca Klinikum Bremen-Ost, University of Oldenburg, Institute of Psychology, Oldenburg, Germany
^cb Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
^cc Chang Gung Memorial Foundation-Linkou, Taoyuan, Taiwan
^cd Center for Research and Advanced Therapies, Centro de Investigación y Ciencias Avanzadas-Alzheimer Foundation, Donostia-San Sebastian, Spain
^ce Department of Neurology, Osaka City University, Graduate School of Medicine, Osaka, Japan
^cf Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
^cg Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United States
^ch Division of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, United States
^ci Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany
^cj Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
^ck DZNE, Bonn, Germany
^cl Memory Disorder Unit, Copenhagen University Hospital, Copenhagen, Denmark
^cm Department of Radiology, Massachusetts General Hospital, Boston, United States
^cn Department of Radiation Oncology, Emory University, Atlanta, GA, United States
^co Applied Biology, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Telangana State, Hyderabad, India
^cp Department of Biochemistry, Kakatiya Medical College, Mahatma Gandhi Memorial Hospital, Telangana State, Warangal, India
^cq National and Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece
^cr Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, The University of Gothenburg, Gothenburg, Sweden
^cs Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
^ct Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
^cu Department of Psychiatry, Massachusetts General Hospital, Boston, United States
^cv Department of Neurology, University of Pittsburgh, Pittsburgh, PA, United States
^cw Life Molecular Imaging GmbH, Berlin, Germany
^cx Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
^cy Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
^cz Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, College of Medicine, Taoyuan, Taiwan
^da Division of Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Leuven, Belgium
^db Department of Imaging and Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
^dc Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United States
^dd Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea
^de Brain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, United States
^df School of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW, Australia
^dg Healthy Aging Research Center, Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
^dh Department of Nuclear Medicine, Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan
^di Memory Clinic, Department of Geriatrics, Uppsala University Hospital, Uppsala, Sweden
^dj Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
^dk Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
^dl Acute Internal Medicine and Geriatrics, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
^dm Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Donostia-San Sebastian, Spain
^dn Biogen, Cambridge, MA, United States
^do Faculty of Medicine, University of Lisboa, Lisboa, Portugal
^dp Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, United States
^dq Avid Radiopharmaceuticals, Philadelphia, PA, United States
^dr Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong
^ds Margaret K.L. Cheung Research Centre for Management of Parkinsonism, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong
^dt BrainNow Research Institute, Guangdong Province, Shenzhen, China
^du Alzheimer’s Disease and Other Cognitive Disorders Unit, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Clinic University Hospital, Barcelona, Spain
^dv Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy
^dw Ospedale Policlinico San Martino, IRCCS, Genoa, Italy
^dx Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland
^dy Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland
^dz Department of Neurology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea
^ea Neuroscience Center, Samsung Medical Center, Seoul, South Korea
^eb Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia, PA, United States
^ec Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, University of Genoa, Genoa, Italy
^ed Ospedale Policlinico San Martino, IRCCS, Genoa, Italy
^ee Radboudumc Alzheimer Centre, Radboud University Medical Center, Nijmegen, Netherlands
^ef Department of Neurology of Memory and Language, Groupe Hospitalier Universitaire Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, F-75014, France
^eg National and Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece
^eh Istituto Delle Scienze Neurologiche di Bologna, IRCCS, Bologna, Italy
^ei DIMES, University of Bologna, Bologna, Italy
^ej DINOGMI, University of Genoa, Genoa, Italy
^ek Klinik für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin-CBF, Berlin, Germany
^el Studies on Prevention of Alzheimer’s Disease (StOP-AD) Centre, Montreal, QC, Canada
^em Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, University of Zürich, Zürich, Switzerland
^en Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland
^eo Department of Neurology, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh, India
^ep Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, United States
^eq Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, IDIBAPS, Barcelona, Spain
^er Turku PET Centre, Turku, Finland
^es Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States
^et Neurology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
^eu Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, United States
^ev Department of Neurology, Medical Center, Zaloska 7, Ljubljana, Slovenia
^ew Department of Molecular Imaging, Austin Health, Melbourne, VIC, Australia
^ex Florey Department of Neuroscience, University of Melbourne, Melbourne, VIC, Australia
^ey Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany, Germany
^ez Cognitive Neuroscience Division, Department of Neurology, The Taub Institute, Columbia University, New York, NY, United States
^fa Service of Neurology, University Hospital Marqués de Valdecilla-IDIVAL, CIBERNED, Santander, Spain
^fb Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
^fc Department of Neurology, University Hospital of Trondheim, Trondheim, Norway
^fd Université de Paris, Paris, Université Paris-Saclay, BioMaps, CEA, CNRS, INSERM, Orsay, France
^fe Section for Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany
^ff Department of Neurology, Sungkyunkwan University, School of Medicine, Samsung Medical Center, Seoul, South Korea
^fg Faculty of Medicine, University of Lisboa, Lisboa, Portugal
^fh Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, United States
^fi Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland, Finland
^fj Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
^fk Memory Clinic, University Department of Geriatric Medicine, Felix Platter-Hospital, Basel, Switzerland
^fl Department of Neurology, University Hospital Basel, Basel, Switzerland
^fm Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
^fn Harvard Aging Brain Study, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States
^fo Geriatrics, Gerontology and Old Age Psychiatry Clinical Department, Carol Davila University of Medicine and Pharmacy-Elias, Emergency Clinical Hospital, Bucharest, Romania
^fp Memory Clinic and Longevity Medicine, Ana Aslan International Foundation, Bucharest, Romania
^fq Centre de Référence Démences Rares, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France
^fr Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, United States
^fs Aristotle University of Thessaloniki, Memory and Dementia Center, 3rd Department of Neurology, George Papanicolau General Hospital of Thessaloniki, Thessaloniki, Greece
^ft Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium
^fu Neurology Department, University Hospitals Leuven, Leuven, Belgium, Belgium
^fv Departments of Neurology and Laboratory Medicine, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Nijmegen, Netherlands
^fw Molecular Biomarkers in Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
^fx McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada
^fy Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, United States
^fz Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
^ga Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany
^gb Center of Neurology, Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
^gc Department of Neurology, University of Pennsylvania, Philadelphia, United States
^gd Department of Nuclear Medicine, Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan
^ge Healthy Aging Research Center, Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
^gf Research-Scientific-Didactic Centre of Dementia-Related Diseases in Scinawa, Medical University of Wroclaw, Wroclaw, Poland
^gg Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
^gh Department of Neurodegenerative Disease, University College London (UCL), Queen Square Institute of Neurology, Queen Square, London, United Kingdom
^gi UK Dementia Research Institute, London, United Kingdom
^gj Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China, Hong Kong

Abstract
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. Objective: To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates. Design, Setting, and Participants: This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria. Exposures: Alzheimer disease biomarkers detected on PET or in CSF. Main Outcomes and Measures: Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations. Results: Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P =.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P =.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P =.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P =.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P =.18). Conclusions and Relevance: This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies. © 2022 American Medical Association. All rights reserved.