Braver receives NIH award to study aging effects

Todd Braver, PhD, a professor of psychological and brain sciences in Arts & Sciences at Washington University in St. Louis, received a $442,135 grant from the National Institutes of Health (NIH) to study aging effects on the neural coding of proactive and reactive cognitive control. Originally published on The Source.

Multi-scale imaging technique may enable objective assessment of myofascial pain

About 50 million Americans experience chronic pain. For many, the pain involves the muscle and the fascia surrounding it, creating myofascial pain with trigger points. This chronic pain syndrome significantly affects patients’ daily functioning and quality of life. While there are treatments, including physical therapy, non-opioid and opioid medications and trigger point injections, adequately controlling […]

A sound approach for effective gene therapy delivery to brain

Researchers have been experimenting with different ways to deliver genes to the brain to treat central nervous system diseases and tumors. One of the obstacles, however, is the ability to penetrate the blood-brain barrier while having minimal effect on the other organs in the body. Hong Chen, PhD, associate professor of biomedical engineering at the […]

Biomarkers for Parkinson’s disease sought through imaging

More than 10 million people worldwide live with Parkinson’s disease, a progressive neurodegenerative disorder that affects movement, balance and thinking. Severity of the disease is measured through external symptoms, as there are no effective biomarkers that indicate the phase of the illness. A team of engineers, physicians and researchers at Washington University in St. Louis, […]

NIH grant supports Jha’s work on ethics of AI in imaging

An interdisciplinary project has received funding to help ensure that if — or more likely, when — certain imaging tools that use artificial intelligence (AI) are put to clinical use, their inherent uncertainty is considered as part of any subsequent clinical decisions, including guiding treatment. The project, led by Abhinav Jha, PhD, assistant professor of biomedical […]

Kamilov awarded second Scialog grant

Ulugbek Kamilov, PhD, assistant professor of electrical and systems engineering and of computer science at Washington University in St. Louis’ McKelvey School of Engineering, is among 21 early-career researchers awarded funding in the second year of Scialog: Advancing Bioimaging. The project is supported by the Research Corporation for Science Advancement, the Chan Zuckerberg Initiative, the […]

Garcia to study neurological developmental disorder

Benjamin Garcia, PhD, the Raymond H. Wittcoff Distinguished Professor and head of the Department of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St. Louis, along with Elizabeth Bhoj, at the University of Pennsylvania, received a five-year $2.6 million grant from the National Institutes of Health (NIH) for their research titled […]

Goodhill receives grant to monitor neurons in brain during sleep, wake

Although sleep consumes one-third of our lives and is a common feature among all animals, how the brain orchestrates sleep remains largely unexplained. To fill in this knowledge gap, Geoffrey Goodhill, PhD, professor of developmental biology and of neuroscience at Washington University School of Medicine in St. Louis, and colleagues will track each cell in the […]

Holy awarded grant to study mouse pheromones

For animals such as mice, olfaction is their primary route to pick up social information, whether that’s identifying the dominant male in a group or figuring out the reproductive status of females. In turn, these signals can influence animals’ behavior and physiology. Pheromones in male urine, for instance, can trigger early puberty in mice. While […]

Wang receives funding for preterm birth research

The factors that lead to preterm birth, which affects nearly 10% of pregnancies worldwide, are poorly understood. Its effects, however, are known. Among them: cerebral palsy, intellectual disability, and visual and hearing impairments. In order to better understand the cause of preterm birth, researchers need to better understand the uterine contractions patterns responsible for initiating […]

Head, Zacks to study aging, development

Denise Head, PhD, professor of psychological and brain sciences, and Jeffrey Zacks, PhD, associate chair and professor of psychological and brain sciences, both in Arts & Sciences at Washington University in St. Louis, won a five-year $2.5 million grant from the National Institutes of Health (NIH) for work on aging and development. Originally published on The Source.

Zhao receives grant to study proteomics in the brain

Guoyan Zhao, PhD, assistant professor in the Department of Neuroscience at Washington University School of Medicine in St. Louis, received a $433,000 grant from the National Institutes of Health (NIH) to apply a cutting-edge imaging technology to study subcellular features of brain tissue from Alzheimer’s patients. Read more.

Pappu lab untangles more IDR secrets

Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]

Padoa-Schioppa receives NIH grant

Camillo Padoa-Schioppa, PhD, professor of neuroscience at Washington University School of Medicine, as well as professor of biomedical engineering and of economics, received a five-year $2.3 million grant from the National Institute of Mental Health of the National Institutes of Health (NIH) for research titled “Neuronal mechanisms of good-based economic decisions.” Originally published on The […]

Samineni wins NIH research grant

Vijay K. Samineni, PhD, assistant professor of anesthesiology at the Washington University School of Medicine, received a five-year $2.34 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) for research titled “Neural mechanisms underlying IC/BPS.” Originally published on The Source.

Rutherford to study noise-induced hearing loss

Mark A. Rutherford, PhD, assistant professor of otolaryngology at Washington University School of Medicine in St. Louis, received a $3.5 million grant from the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health (NIH) for research on the pore-forming and auxiliary subunit molecular anatomy of AMPA-type glutamate receptors in the cochlea […]

NIH funds Barch research on neurodevelopment

In order to understand healthy neurodevelopment — and the threats to that health — researchers need a more comprehensive understanding of how the brain grows throughout childhood and young adulthood. To that end, the National Institutes of Health (NIH) has awarded a $753,181 grant to Deanna Barch, PhD, chair and professor of psychological and brain […]

NSF awards grant to Van Engen

Kristin Van Engen, PhD, assistant professor of psychological and brain sciences and of linguistics, both in Arts & Sciences at Washington University in St. Louis, has received a $433,242 National Science Foundation grant to support research into why some speakers are more difficult to understand than others and how listeners adjust to unfamiliar accents. Unlike […]

Saligrama part of team that received Wellcome Leap grant

Naresha Saligrama, PhD, an assistant professor of neurology and of pathology and immunology at the School of Medicine, is part of a team led by Lisa Wagar, of the University of California, Irvine, that has received a multiyear, multi-million-dollar grant through Wellcome Leap to use human tonsil organoids to study immune responses. Originally published on […]

DiAntonio, Bloom, Milbrandt win ALS grant

Aaron DiAntonio, MD, PhD, the Alan A. and Edith L. Wolff Professor of Developmental Biology;  Joseph Bloom, PhD, assistant professor of genetics; and Jeffrey Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics, all at the School of Medicine, received a two-year $300,000 grant from the ALS Finding a Cure and […]

Craver wins National Science Foundation grant

Carl F. Craver, PhD, a professor of philosophy and of philosophy-neuroscience-psychology in Arts & Sciences at Washington University in St. Louis, has won a grant of $282,603 from the National Science Foundation. The NSF grant will fund a new project titled “Time and Episodic Memory: Neuropsychology Meets Philosophy.” This will build on Craver’s previous investigations with R. […]

Li receives Whitehall grant

The Whitehall Foundation has awarded a three-year $225,000 grant to Tristan Qingyun Li, PhD, assistant professor of neuroscience and of genetics at Washington University School of Medicine. The funding will go to investigate the function of microglia, immune cells that reside in the brain and perform myriad critical functions during development, injury and disease. Microglia were once thought […]

Four neuroscience faculty members receive R01 grants

Four faculty members in the Department of Neuroscience at Washington University School of Medicine in St. Louis — Yao Chen, Thomas Papouin, Jason Yi and Guoyan Zhao — have been awarded their first R01 grants through the National Institutes of Health (NIH). This funding will support research critical to understanding the cellular and molecular processes occurring during neurodevelopment and […]

Goodhill awarded grant to advance brain imaging

Geoffrey Goodhill, PhD, professor of developmental biology and of neuroscience at the Washington University School of Medicine, has received a two-year $675,000 grant to enhance the capabilities of light field microscopy for brain imaging. The funds, awarded by the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative at the National Institutes of Health (NIH), will […]

Marcus receives NIH grant

Daniel Scott Marcus, PhD, professor of radiology at the School of Medicine, received a one-year $2 million grant from the National Institutes of Health (NIH) for research titled “A high performance research image repository (RIR) for the Washington University Center of High Performance Computing.” Originally published on The Source.

Kerschensteiner to research visual pathways

Daniel Kerschensteiner, MD, professor of ophthalmology and visual sciences, of biomedical engineering and of neuroscience the School of Medicine, received a five-year $2 million grant from the National Eye Institute of the National Institutes of Health (NIH)for research titled “Synaptic organization and function of retinal interneurons and downstream visual pathways.” Originally published on The Source.

Shaw to study sleep and Alzheimer’s disease

Paul J. Shaw, PhD, professor of neuroscience at the School of Medicine, received a one-year $2.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) for research titled “Bidirectional interactions between sleep and Alzheimer’s disease: Functional dissection of the brain transcriptome in humans and drosophila.” Originally published on The Source.

Mennerick receives NIH grant

Steven J. Mennerick, PhD, the John P. Feighner Professor of Neuropsychopharmacology and a professor of neuroscience at the School of Medicine, received a five-year $2.3 million grant from the National Institute of Mental Health of the National Institutes of Health (NIH) for research titled “GABAA receptor populations in hippocampus and thalamus.” Originally published on The […]

Raji to research imaging biomarkers in Alzheimer’s disease

Cyrus A. Raji, MD, PhD, assistant professor of radiology and of neurology at the School of Medicine, received a one-year $2.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) for research titled “Neuroinflammation and Alzheimer’s disease imaging biomarkers in midlife obesity.” Originally published on The Source.

Chen to study neurological disorders

Zhoufeng Chen, PhD, the Russell D. and Mary B. Shelden Professor of Anesthesiology, and professor of developmental biology, of medicine and of psychiatry, all at the School of Medicine, received a five-year $2.5 million grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) for research titled “Extramural […]

Saligrama to research pediatric onset multiple sclerosis

Naresha Saligrama, PhD, assistant professor of neurology at the School of Medicine, received a three-year $1.1 million grant from the Children’s Discovery Institute for research titled “Defining the role of adaptive immunity in pediatric-onset multiple sclerosis.” Originally published on The Source.

Sotiras to study heterogenity in Alzheimer’s disease

Aristeidis Sotiras, PhD, assistant professor of radiology at the School of Medicine, received a five-year $2.8 million grant from the National Institutes on Aging of the National Institutes of Health (NIH) for research titled “Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer’s disease.” Originally published on The Source.

Mitra wins grant to expand opportunities for underrepresented students

Robi D. Mitra, PhD, professor of genetics and the Alvin Goldfarb Distinguished Professor of Computational Biology at the School of Medicine, received a five-year $1.6 million grant from the National Human Genome Research Institute of the National Institutes of Health (NIH) for research titled “Expanding opportunities in genomic research for underrepresented students.” Originally published on The Source.

Colonna receives NIH grants

Marco Colonna, MD, the Robert Rock Belliveau Professor of Pathology and Immunology at the School of Medicine, received a four-year $1.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) for diabetes, digestive and kidney diseases extramural research, and a one-year $1.6 million grant from the National Institute […]

Bloom receives NIH grant for extramural research programs

Adam Joseph Bloom, assistant professor of genetics and of anesthesiology at the School of Medicine, received a five-year $2.9 million grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) for his research titled “Extramural Research Programs in the Neurosciences and Neurological Disorders.” Originally published on The Source.

Fitzpatrick receives grant for cutting-edge optical microscope

The National Institute of Mental Health, part of the National Institutes of Health (NIH), has awarded James Fitzpatrick, PhD a $600,000 grant to purchase a Zeiss LSM 980 Airyscan 2 microscope platform for the Washington University Center for Cellular Imaging (WUCCI). The instrument will complement the existing optical microscopes at WUCCI by expanding super-resolution imaging to a […]

McDonnell Foundation awards Roediger $750,000 for memory research

The James S. McDonnell Foundation has awarded $750,000 to Henry “Roddy” Roediger, the James S. McDonnell Distinguished University Professor of Psychological & Brain Sciences in Arts & Sciences at Washington University in St. Louis. The three-year award will fund the Collective Memory Collaborative, led by Roediger and co-principal investigator James Wertsch, the David R. Francis Distinguished Professor in anthropology […]

Chen receives Stein Innovation Award

Shiming Chen, PhD, professor of ophthalmology in the John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences at Washington University School of Medicine, has received a 2021 Stein Innovation Award from Research to Prevent Blindness. The $300,000 award provides flexible funding to scientists engaged in research to improve the understanding of the visual system […]

Yoo wins research grants

Andrew Yoo, PhD, associate professor of developmental biology at the School of Medicine, has received a two-year $486,844 grant from Brigham and Women’s Hospital in Boston for his project titled “Investigation of neurodegenerative pathways in directly reprogrammed, XDP patient neurons”; and a two-year $345,000 grant from the Cure Alzheimer’s Fund for his project titled “Neuronal subtype-specific modeling of Alzheimer’s […]

NIH funds Rudra, Jackrel to improve vaccines for elderly

The coronavirus pandemic has emphasized the importance of vaccines, particularly for the elderly, who have been disproportionately impacted by the virus. However, a decline in immune response as well as inflammation that accompanies aging require a booster to improve the immune response. Jai Rudra, PhD, assistant professor of biomedical engineering at the McKelvey School of […]

MRI’s magnetic field affects focused ultrasound technology

In a mouse model study of MRI-guided focused ultrasound-induced blood-brain barrier opening at MRI field strengths ranging from ­approximately 0 T (outside the magnetic field) to 4.7 T, the static magnetic field dampened the detected microbubble cavitation signal and decreased the BBB opening volume. (Image courtesy of Chen lab)

MRI-guided focused ultrasound combined with microbubbles can open the blood-brain barrier and allow therapeutic drugs to reach the diseased brain location under the guidance of MRI. It is a promising technique that has been shown safe in patients with various brain diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS) and glioblastoma. Chen While MRI […]

Kroll receives NIH grant

Kristen Kroll, PhD, professor of developmental biology at the School of Medicine, has received a four-year $2.09 million R01 research grant from National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) for her project titled “The cis-regulatory grammar and epigenetic control of human interneuron progenitor specification.” Originally published at The […]

Raji receives NIH grant for Alzheimer’s study

Cyrus Raji, MD, PhD, assistant professor of radiology and of neurology at the School of Medicine, received a three-year $2.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) for his research titled “Neuroinflammation and Alzheimer’s Disease Imaging Biomarkers in Midlife Obesity.” Originally published on The Source.

Grant funds research pushing limits of cyborg insects

The Office of Naval Research has awarded Barani Raman, PhD, professor of biomedical engineering at the McKelvey School of Engineering at Washington University in St. Louis, an $851,320 grant for research to determine just how sensitive locusts’ noses are when it comes to explosives — and how well researchers can interpret what the insects are […]

Graduate student in the Jackrel lab wins NIH fellowship

Macy Sprunger, a graduate student in Meredith Jackrel’s lab in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won a three-year $136,560 National Research Service Award from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH). The award supports Sprunger’s project “Defining the Molecular Drivers and Modulators of MATR3 Proteinopathy […]

FUSIN promising in therapeutic agent delivery to brain tumor

Brainstem glioma is often diagnosed in children and young adults and has a low survival rate. A multidisciplinary team at Washington University in St. Louis developed a technique that delivered a therapeutic agent to the gliomas using focused ultrasound with very promising results. Dezhuang Ye, a doctoral student in the lab of Hong Chen, PhD, […]

Mechanism behind heartbeat regulation, heart function uncovered

Jianmin Cui, PhD, professor of biomedical engineering at the McKelvey School of Engineering, and Po wei (Billy) Kang, an MD/PhD student at the School of Medicine who conducts research in Cui’s lab, led an international team that revealed new details on how two biomolecules modulate opening and closing of the KCNQ1 potassium channel. This channel […]

Brain & Behavior Research Foundation awards grants to three researchers

Three Washington University in St. Louis researchers have received Young Investigator Grants from the Brain & Behavior Research Foundation. The foundation is committed to alleviating the suffering caused by mental illness by supporting research that will lead to advances and breakthroughs in scientific research. The $70,000 grants help junior investigators launch innovative basic, translational and clinical research […]

Zacks receives $250K grant from James S. McDonnell Foundation

Jeffrey M. Zacks, associate chair and professor of psychological and brain sciences in Arts & Sciences and professor of radiology at the School of Medicine, received a four-year $250,000 grant from the James S. McDonnell Foundation to study event cognition “in the wild.” This project will take the research into the world, where people actually […]

Babulal receives five-year $4M grant from National Institute on Aging

Ganesh M. Babulal, assistant professor of neurology at the School of Medicine, received a five-year $3,984,843 grant from the National Institutes of Health (NIH)’s National Institute On Aging for research titled “The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older Adults.” This study will investigate how depression, preclinical Alzheimer’s disease and antidepressant […]