“Advances in Regenerating Musculoskeletal Tissues”
Hosted by the Department of Biomedical Engineering (BME)
We are excited to share our partnership with six leading BME departments to bring you a Spring 2021 seminar series called Open BME (http://www.openbme.org). Here we bring together BME faculty and trainees from across the US to share in the excitement of and conversation about cutting edge research. All Open BME seminars will take place at 3PM CST on Thursdays in a Webinar format with live-streaming on YouTube.
Register for this event by going here.
Abstract: Tissue engineering provides a viable means of regenerating bone and skeletal muscle tissues following injuries that lead to large volumetric defects. Our lab has developed advanced biomaterial and stem cell-based approaches to promote functional recovery following volumetric muscle loss and critical-sized craniofacial bone injuries. This presentation will focus on three areas of ongoing research: (1) I will present our lab’s efforts to regenerate vascularized and innervated skeletal muscle in mice including our recent studies using human pluripotent stem cells. (2) Recently, our group completed a study focused on designing biomaterials to guide bone regeneration in situ in minipigs using intraoperative protocols for combining autologous stem cells with 3D-printed scaffolds. (3) Understanding the interaction between vascular cells and osteoprogenitors is critical for developing effective treatment methods. I will describe recent studies in which we developed a quantitative imaging platform for characterizing the spatial relationships between cell populations in the native murine calvarium.
Speaker Biography: Dr. Warren L. Grayson is an assistant professor of biomedical engineering at Johns Hopkins University School of Medicine. His research examines the underlying mechanisms that regulate tissue development and uses computational and experimental tools to help engineer complex functional tissue constructs for use in regenerative medicine. The director of the Johns Hopkins Laboratory for Craniofacial and Orthopaedic Tissue Engineering, Dr. Grayson also serves on the faculty of the Translational Tissue Engineering Center and Institute for NanoBioTechnology, both at Johns Hopkins.
He earned his Ph.D. biomedical engineering from Florida State University and completed his postdoctoral training at Columbia University. He holds a B.Sc. in chemical and process engineering from The University of the West Indies. He joined the Johns Hopkins faculty in 2009.
His lab is currently looking at the spatial and temporal regulation of stem-cell differentiation in 3-D constructs with the goal of developing clinically useful engineered grafts. Dr. Grayson’s research on bioreactor design and engineering anatomically shaped bone grafts has garnered widespread national and international attention, with articles appearing in publications including The New York Times and Science Translational Medicine and on The BBC.
Dr. Grayson has authored a number of original and review articles and book chapters and holds two patents for bioreactor designs.
All Open BME seminars can be found here.
Full list, WashU Biomedical Engineering (BME) seminars
For inquiries contact Suesy Seel.