“Interrogating Memory Circuits to Uncover Sleep Function”

Hosted by the Center on Biological Rhythms and Sleep (COBRAS)

Abstract: Although the precise function of sleep remains unknown, there is little question that sleep is required for maintaining optimal cognitive performance. Using behavioral genetics, we have mapped a minimal circuit that supports short-term memory in flies. Using pharmacological and genetic tools to experimentally enhance sleep, we have begun to identify molecular mechanisms that are used by sleep to reverse memory impairments in flies with catastrophic lesions in their primary memory center. We expect that understanding how sleep can fix broken brains will provide new insight into the function of sleep.

COBRAS is a multi-disciplinary, cross-departmental center dedicated to enhancing research related to sleep, circadian Rhythms, and disease at WashU.

For inquiries contact Ellen Fischbach.