Leonard Petrucelli: “Mechanistic and Therapeutic Insights into c9FTD/ALS”
Brian Kaspar: “Gene Delivery Translation in Spinal Muscular Atrophy”
The Eighth Annual Hope Center Retreat will be held at the Danforth Plant Science Center.
2018 Retreat program
8:00a Shuttle departs from the Farrell LTC (66o S. Euclid)
8:30a Continental Breakfast
9:00a Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD
9:05a Hope Center Lecture – Leonard Petrucelli, PhD (Mayo Clinic Florida)
“Mechanistic and Therapeutic Insights into c9FTD/ALS”
10:05a Session 1: Neurodegeneration Group (Chair: Timothy Miller, MD PhD (Neurology))
- Kiersten Ruff, PhD (Pappu Lab, Biomedical Engineering)
“Polyglutamine length dependent structural properties and phase behavior of huntingtin exon 1” - Tien-Phat Huynh (Holtzman Lab, Neurology)
“Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis”
10:35a Break
11:00a Session 2: Lysosome Processing & Transport and NeuroRestorative Therapy Groups (Chairs: Bruno Benitez, MD and Albert Kim, MD & Fumihiko Urano, MD PhD (Medicine))
- Devi Annamalai, PhD (Kim Lab, Neurosurgery)
“Epigenomic reprogramming as a therapeutic strategy for malignant gliomas” - Sidhartha Mahali, PhD (Karch Lab, Psychiatry)
“Lysosomal dysfunction and altered tau metabolism in stem cell models of autosomal dominant Alzheimer’s disease”
11:30a Session 3: Neurovascular Injury & Repair Group (Chair: Jin-Moo Lee, MD, PhD (Neurology))
- Charise Garber (Klein Lab, Medicine)
“T-cells promote microglial activation and prevent cognitive recovery from viral encephalitis via interferon gamma” - Deepti Diwan, PhD (Zipfel Lab, Neurosurgery)
“Sirt1 mediates hypoxic conditioning-induced delayed cerebral ischemia protection in subarachnoid hemorrhage”
12:00p Lunch
1:15p Hope Center Lecture – Brian Kaspar, PhD (AveXis, Inc.)
“Gene Delivery Translation in Spinal Muscular Atrophy”
2:15p Session 4: Neurogenetics & Transcriptomics Group (Chair: Carlos Cruchaga, PhD (Psychiatry))
- Umber Dube (Cruchaga Lab, Psychiatry)
“Circular RNAs in Alzheimers disease brain tissues” - Denis Avey, PhD (Milbrant Lab, Genetics)
“Single cell RNA-seq facilitates characterization of glial and neuronal responses to morphine”
2:45p Session 5: Axon Injury & Repair Group (Chair: Valeria Cavalli, PhD (Neuroscience))
- Scott Karney-Grobe (DiAntonio Lab, Developmental Biology)
“HSP90 is a chaperone for DLK and is required for axon injury signaling” - Deng Pan (MacKinnon Lab, Developmental Biology)
“Reduced T cell accumulation in long gap nerve injuries inhibit peripheral nerve regeneration”
3:15p Poster set-up
3:30p Poster session
5:45p Shuttle departs
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For more information please contact Jan Konrad.