NGI Center Thursday Special Seminar: Hans-Ulrich Klein (Columbia University) – “Exploring the molecular mechanisms in the human amyloid plaque niche using spatial transcriptomics”

December 14, 2023
10:30 am - 11:30 am
4444 Forest Park Ave., Room 5103 (Medical Campus)

“Exploring the molecular mechanisms in the human amyloid plaque niche using spatial transcriptomics”


Hosted by the NeuroGenomics and Informatics Center (NGI)

Short bio: Dr. Hans-Ulrich Klein is a computational scientist with extensive experience in analyzing genome-wide datasets and developing innovative systems biology approaches and statistical models for large-scale demonic data. His overarching research objective is to gain insight into the molecular drivers of neurodegenerative diseases and identify potential drug targets. This is achieved through the integration and analysis of genetic risk factors, neuropathologies, clinical traits, and diverse omic data sources, such as epigenomic, transcriptomic, and proteomic data, from various cell types and tissues within and outside the central nervous system.

He has led the bioinformatics analyses of several complex studies involving human multi-omic datasets of neurodegenerative diseases. These studies have yielded new insights into the understanding of these diseases. At present, he is engaged in the analysis of glycoproteomic data, specifically studying the glycosylation and glycation of mitochondrial proteins. Furthermore, he is spearheading a project that employs spatial transcriptomic data to explore transcriptional programs in the neuritic plaque niche.

Full schedule, NGI Thursday Special Seminars

For inquiries contact the NGI Center.