NIH grant awarded to create neurotech training program

The National Institutes of Health has awarded Daniel Moran, PhD, professor of biomedical engineering in the McKelvey School of Engineering, more than $1 million over five years to create the Translational Neuroscience and Neurotechnology Training Program. This interdisciplinary program will train students to use engineering tools to develop technology that address neurological issues such as […]

A one-two punch for photoacoustic imaging

Scientists use photoacoustic microscopy to measure various biomarkers in the body, but some of these measurements can be inaccurate due to limitations of the light-focusing beam that produces out-of-focus images. Engineers in the McKelvey School of Engineering at Washington University in St. Louis have designed a new technique that combines hardware and software innovations as […]

Podcast: Giving stroke patients a hand

Brain-computer interfaces connect activity in the brain to an external device by means of a computer. Research has shown it’s possible to use such interfaces to move robotic arms and perform other tasks. Almost 30 years ago, Washington University researcher Eric Leuthardt, MD, a professor of neurosurgery, demonstrated that he could hook electrodes to the brains […]

Wearable ultrasound sensors for human brain in development

A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to […]

New structure found in cells

Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor […]

Early to serve as interim CRE2 director

Gerald Early, PhD, the Merle King Professor of Modern Letters in Arts & Sciences, will serve as interim director of the Center for the Study of Race, Ethnicity & Equity (CRE2) at Washington University in St. Louis, effective July 1. The center provides programs and partnerships for Danforth and Medical campus faculty researching issues related to race […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting May 6, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure Andrew Clark as associate professor of electrical and systems engineering at the McKelvey School of Engineering; Xianglin Li as associate professor of mechanical […]

Lew lab sheds new light on cell membranes

Research from the lab of Matthew Lew, PhD at Washington University in St. Louis offers entirely new ways to see the very small. The research — two papers by PhD students at the McKelvey School of Engineering — was published in the journals Optica and Nano Letters. They have developed novel hardware and algorithms that allow them to visualize the […]

WashU weekly Neuroscience publications: May 9, 2022

“Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study” (2022) Nature Communications Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study(2022) Nature Communications, 13 (1), art. no. 2217, .  Chen, J.a b c d , Tam, A.a b c d , Kebets, V.a b c d , Orban, C.a b c d , Ooi, L.Q.R.a b c d e , Asplund, C.L.b c d f g h , Marek, S.i , Dosenbach, N.U.F.j k l m , […]

BME Day 2022 showcases senior design projects and student innovation

The Department of Biomedical Engineering at the McKelvey School of Engineering welcomed students, judges and guests back May 2 for the first in-person BME Day since 2019. The celebration rounds out a year of learning with senior design competitions, research awards, faculty presentation and the Frank C.P. and Grace C. Yin Distinguished Lecture. Student teams […]

Pappu lab untangles more IDR secrets

Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]

Cui to seek better drugs for irregular heartbeat

Irregular heartbeat, or arrhythmia, affects about 5 million people in the United States, and interestingly, some of the drugs used to treat the condition can also cause it. A biomedical engineer in the McKelvey School of Engineering at Washington University in St. Louis is going deep into the basic mechanisms that lead to arrhythmia to […]

Bayly-led team to study mechanical strains, stresses in traumatic brain injury

Naval warfighters may be exposed to explosions, impacts or high accelerations that increase their risk for traumatic brain injury. A team of researchers led by Philip Bayly, PhD, at Washington University in St. Louis plans a comprehensive study of skull-brain mechanics using imaging, computer and preclinical models to study the strains and stresses of the […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 4, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Carlos A. Botero to associate professor of biology in Arts & Sciences; Caitlyn M. Collins to associate professor of sociology in Arts & […]

Predicting the chaos in Tourette syndrome tics

During the pandemic, news reports surfaced of a surge of young adults showing up at doctors’ offices with unexplainable movement disorders that looked, perhaps to a nonspecialist, a little bit like Tourette syndrome. But when those patients were sent to see a specialist, “They’d say, ‘that doesn’t look at all like any of my first […]

Low-cost, 3D printed device may broaden focused ultrasound use

Researchers and clinicians have been working to use focused ultrasound combined with microbubbles to open the blood-brain barrier (BBB) for both noninvasive diagnostic use as well as to deliver treatments to the brain for tumors and neurodegenerative diseases. However, the few existing devices for preclinical research are expensive, bulky and lack the precision needed for […]

The ‘surprisingly simple’ arithmetic of smell

Smell a cup of coffee. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni — even at a pizza parlor with a scone! — coffee smells like coffee. Why don’t other smells or different environmental factors “get in the way,” so to speak, […]

Understanding features that help cells stay organized

The labs of Tanja Mittag, PhD at St. Jude and Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor of biomedical engineering at the McKelvey School of Engineering, created a stickers-and-spacers model to discern the rules underlying the driving forces for phase separation. The “stickers” and “spacers” are different types of amino acids along the […]

International team finds new mechanism critical for formation of membrane vesicles

Researchers from the McKelvey School of Engineering at Washington University in St. Louis, Université de Montréal and McGill University have discovered a new mechanism by which membrane vesicles are made. The roles played by these self-contained nanoparticles are essential to the normal function of our cells. Their dysfunction is implicated in diseases ranging from cancers […]

Paola Cepeda named Director of Postdoctoral Affairs

Dear Colleagues, I am pleased to announce that, after a nationwide search, Paola Cepeda, PhD, has been named Director of Postdoctoral Affairs in the Office of the Vice Chancellor for Research, effective January 4, 2022. Paola currently serves as the Program Manager for Graduate and Postdoctoral Professional Development at Stony Brook University. In the role […]

IpsiHand stroke-recovery device named product of year by science society

The IpsiHand, an innovative stroke-recovery device that helps stroke patients recover significant arm and hand function by retraining their brains, has received the 2021 Pantheon Product of the Year Award from California Life Sciences. The organization advocates for the state’s life sciences sector and its innovation pipeline by supporting companies of all sizes, from early-stage […]

Covey, Milbrandt, Moran named to National Academy of Inventors

The National Academy of Inventors has elected three faculty members from Washington University in St. Louis to its 2021 cohort of fellows: Psychiatry professor Douglas F. Covey, PhD, geneticist Jeffrey Milbrandt, MD, PhD, both at the School of Medicine; and bioengineer Daniel Moran, PhD, at the McKelvey School of Engineering. The NAI fellowship is the highest professional distinction reserved solely […]

WashU weekly Neuroscience publications

“Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury” (2022) Pediatric Neurology Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury (2022) Pediatric Neurology, 126, pp. 114-119.  Surtees, T.-L.a , Kumar, I.b , Garton, H.J.L.c , Rivas-Rodriguez, F.d , Parmar, H.d , McCaffery, H.b , Riebe-Rodgers, J.b , Shellhaas, R.A.b a Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United Statesb Departments […]

Minton appointed vice chancellor for technology and chief information officer

Jessie Minton, vice provost and chief information officer at the University of Oregon, has been appointed vice chancellor for technology and chief information officer at Washington University in St. Louis, effective April 15, according to Shantay Bolton, executive vice chancellor and chief administrative officer. Minton will succeed Stephanie L. Reel, who has served as interim chief […]

Less energy, better quality PAM images with machine learning

Photoacoustic microscopy (PAM) allows researchers to see the smallest vessels inside a body, but it can generate some unwanted signals or noise. A team of researchers at the McKelvey School of Engineering at Washington University in St. Louis found a way to significantly reduce the noise and maintain image quality while reducing the laser energy […]

WashU weekly Neuroscience publications

“Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes” (2022) Medical Image Analysis Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes(2022) Medical Image Analysis, 75, art. no. 102304, .  Wen, J.a , Varol, E.b , Sotiras, A.c , Yang, Z.a , Chand, G.B.d , Erus, G.a , Shou, H.a e , Abdulkadir, A.a , Hwang, G.a , Dwyer, D.B.f , Pigoni, A.g , Dazzan, P.h , Kahn, R.S.i , Schnack, H.G.j , Zanetti, M.V.k , […]

Inventive pathways

Moving innovations out of the so-called ivory tower and into the public domain holds enormous power to treat disease and improve quality of life. But while academic researchers and physicians may imagine promising clinical solutions, some are unprepared to navigate commercialization: pitching themselves, attracting investors, wrangling with intellectual property law, designing rigorous proof-of-concept studies, locating […]

WashU weekly Neuroscience publications

“Personalized networks of social anxiety disorder and depression and implications for treatment” (2022) Journal of Affective Disorders Personalized networks of social anxiety disorder and depression and implications for treatment(2022) Journal of Affective Disorders, 298, pp. 262-276.  Piccirillo, M.L., Rodebaugh, T.L. Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, United States AbstractIntroduction: Social […]

Lodge to depart Washington University

Jennifer K. Lodge, PhD, vice chancellor for research at Washington University in St. Louis and the David T. Blasingame Professor, will leave the university at the end of the year. Lodge will be joining Duke University as vice president for research and innovation in January. “Dr. Lodge has served Washington University during extraordinary times, providing […]

WashU weekly Neuroscience publications

“Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome” (2022) Pediatric Neurology Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome(2022) Pediatric Neurology, 126, pp. 65-73.  Steele, J.L.a , Morrow, M.M.b , Sarnat, H.B.c , Alkhunaizi, E.d , Brandt, T.b , Chitayat, D.A.d , DeFilippo, C.P.e , Douglas, G.V.b , Dubbs, H.A.f , Elloumi, H.Z.b , Glassford, M.R.g , Hannibal, M.C.g , Héron, B.h , Kim, […]

Noninvasive brain biopsy shows improved sensitivity in tumor detection

Glioblastomas are aggressive brain tumors that are commonly diagnosed through a risky and invasive surgical biopsy. A team of researchers led by Hong Chen, PhD at Washington University in St. Louis has developed a noninvasive diagnostic method that may one day replace the tissue biopsy with a simple blood test. Chen, associate professor of biomedical engineering at […]

Seáñez receives NIH-funded research career development award

Ismael Seáñez, PhD, assistant professor of biomedical engineering at the McKelvey School of Engineering and of neurosurgery at the School of Medicine at Washington University in St. Louis, has been selected as a K12 scholar by the Interdisciplinary Rehabilitation Engineering Research Career Development Program in Movement and Rehabilitation Sciences funded by the National Institutes of […]

WashU weekly Neuroscience publications

“Contribution of animal models toward understanding resting state functional connectivity” (2021) NeuroImage Contribution of animal models toward understanding resting state functional connectivity(2021) NeuroImage, 245, art. no. 118630, .  Pais-Roldán, P.a , Mateo, C.b , Pan, W.-J.c , Acland, B.d , Kleinfeld, D.b e , Snyder, L.H.d , Yu, X.f , Keilholz, S.c a Medical Imaging Physics, Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich52425, Germanyb Department of Physics, University of […]

WashU weekly Neuroscience publications

“The relationship between diffusion heterogeneity and microstructural changes in high-grade gliomas using Monte Carlo simulations” (2022) Magnetic Resonance Imaging The relationship between diffusion heterogeneity and microstructural changes in high-grade gliomas using Monte Carlo simulations(2022) Magnetic Resonance Imaging, 85, pp. 108-120.  Lee, C.-Y.a , Bennett, K.M.b , Debbins, J.P.c , Choi, I.-Y.a d e f , Lee, P.a e f a Hoglund Biomedical Imaging Center, University of Kansas Medical Center, […]

WashU weekly Neuroscience publications

“Equivalent learning, but unequal participation: Male bumble bees learn comparably to females, but participate in cognitive assessments at lower rates” (2021) Behavioural Processes Equivalent learning, but unequal participation: Male bumble bees learn comparably to females, but participate in cognitive assessments at lower rates (2021) Behavioural Processes, 193, art. no. 104528, . Manning, T.H.a b , Austin, M.W.a b c , MuseMorris, K.a , Dunlap, A.S.a b  a Department […]

WashU weekly Neuroscience publications

“Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids” (2021) Nature Communications Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids (2021) Nature Communications, 12 (1), art. no. 5763, .  Jones, J.R.a b , Chaturvedi, S.a , Granados-Fuentes, D.a , Herzog, E.D.a a Department of Biology, Washington University, St. Louis, St. Louis, MO, United States b Department of Biology, Texas […]

WashU weekly Neuroscience publications

“Spectral signature of attentional reorienting in the human brain” (2021) NeuroImage Spectral signature of attentional reorienting in the human brain (2021) NeuroImage, 244, art. no. 118616, .  Spadone, S.a , Betti, V.b c , Sestieri, C.a , Pizzella, V.a , Corbetta, M.d e f , Della Penna, S.a a Department of Neuroscience, Imaging and Clinical Sciences – and ITAB, Institute for Advanced Biomedical Technologies, G. d’Annunzio University of Chieti-Pescara, […]

WashU weekly Neuroscience publications

“A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging” (2021) Journal of Biomechanics A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging (2021) Journal of Biomechanics, 129, art. […]

WashU weekly Neuroscience publications

“A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging” (2021) Journal of Biomechanics A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging (2021) Journal of Biomechanics, 129, art. […]

WashU weekly Neuroscience publications

“Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease” (2021) Alzheimer’s Research and Therapy Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease (2021) Alzheimer’s Research and Therapy, 13 (1), art. no. 153, .  Hassenstab, J.a b , Nicosia, J.a , LaRose, M.a , Aschenbrenner, A.J.a , Gordon, B.A.b c , Benzinger, T.L.S.c , Xiong, C.a d , Morris, J.C.a a Charles F. and […]