WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

Making waves: Researchers shed light on how cilia work

Human bodies have some built-in systems to care for themselves. The cells that line our lungs, nose, brain and reproductive system have cilia, which are tiny, hair-like structures designed to sweep out fluids, cells and microbes to stay healthy. But the mechanisms behind their motion are not well understood. The team of researchers (clockwise, from […]

WashU weekly Neuroscience publications

“Regeneration associated transcriptional signature of retinal microglia and macrophages” (2019) Scientific Reports Regeneration associated transcriptional signature of retinal microglia and macrophages (2019) Scientific Reports, 9 (1), art. no. 4768, .  Mitchell, D.M.a , Sun, C.a b , Hunter, S.S.c , New, D.D.c , Stenkamp, D.L.a a Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States b Ophthalmology, Washington University in […]

WashU weekly Neuroscience publications

“Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice” (2019) Scientific Reports Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice (2019) Scientific Reports, 9 (1), art. no. 4379, . Wozniak, D.F., Valnegri, P., Dearborn, J.T., Fowler, S.C., Bonni, A. Document Type: Article Publication Stage: Final Source: Scopus Access Type: Open Access “A […]

WashU weekly Neuroscience publications

“The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection” (2019) Journal of Memory and Language The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection (2019) Journal of Memory and Language, 106, pp. 77-94.  Maddox, G.B.a , Balota, D.A.b , Kumar, A.A.b , Millar, P.R.b , Churchill, L.b a Department of […]

Engineering treatments for the opioid epidemic

The U.S. is reeling from a public health crisis driven by the misuse of prescription and illicit opioids with nearly 12 million people abusing the drugs annually. The Midwest saw opioid overdoses increase 70 percent from July 2016 to September 2017, and every 15 minutes a baby is born suffering from opioid withdrawal as a […]

WashU weekly Neuroscience publications

“Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits” (2019) Scientific Reports Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits (2019) Scientific Reports, 9 (1), art. no. 2779, .  Maloney, S.E.a d f , Yuede, C.M.a b , […]

A new method for precision drug delivery: painting

If traditional drug delivery were a type of painting, it might be akin to paintball. With good aim, a majority of the paint ends on the bullseye, but it also drips and splashes, carrying streams of paint across the target. If the drug needs to enter the bloodstream and circulate throughout your body for treating […]

WashU weekly Neuroscience publications

“Predicting Alzheimer’s disease progression using multi-modal deep learning approach” (2019) Scientific Reports Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) Scientific Reports, 9 (1), art. no. 1952, .  Lee, G.a b , Nho, K.c d , Kang, B.a , Sohn, K.-A.a , Kim, D.b e , Weiner, M.W.f , Aisen, P.g , Petersen, R.h , Jack, C.R., Jr.h , […]

Hong Chen receives $1.6 million grant from the NIH’s National Institute of Biomedical Imaging and Bioengineering

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $1.6 million grant from the National Institutes of Health (NIH)’s National Institute of Biomedical Imaging and Bioengineering. The research will fund a broader understanding of Chen’s earlier work combining intranasal drug delivery […]

WashU weekly Neuroscience publications

“Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles” (2019) Channels (Austin, Tex.) Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles (2019) Channels (Austin, Tex.), 13 (1), pp. 72-87.  Wang, W.a , Mellor, R.L.a , Nerbonne, J.M.a b , Balke, C.W.a […]

WashU weekly Neuroscience publications

“Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease” (2019) Stroke Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease (2019) Stroke, 50 (2), pp. 266-273.  Guilliams, K.P.a b , Fields, M.E.b , Dowling, M.M.c a From the Department of Neurology (K.P.G.), Washington University School […]

WashU weekly Neuroscience publications

“Neuronal evidence for good-based economic decisions under variable action costs” (2019) Nature Communications Neuronal evidence for good-based economic decisions under variable action costs (2019) Nature Communications, 10 (1), art. no. 393, .  Cai, X.a b c d , Padoa-Schioppa, C.a e f a Department of Neuroscience, Washington University in St Louis, St Louis, MO 63110, United States b NYU Shanghai, 1555 Century Avenue, […]

New era in engineering to begin at Washington University

Renamed McKelvey School of Engineering will take innovation, technology and academics to new heights From the WashU Newsroom… Furthering its strong trajectory as a leader in research and innovation, the engineering school at Washington University in St. Louis is taking a major leap forward and reaffirming its commitment to tackling the world’s great engineering challenges […]

Silva, Ramani chosen as Inaugural WashU Faculty Fellows in Entrepreneurship

From the WashU Office of the Vice Chancellor for Research… Jennifer Silva, MD, associate professor of Pediatrics and Vijay Ramani, PhD, the  Roma B. & Raymond H. Wittcoff Professor of Energy, Environmental & Chemical Engineering have been selected as the inaugural entrepreneurial faculty fellows. These individuals advise WashU faculty and small companies founded by WashU personnel […]

WashU weekly Neuroscience publications

“Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury” (2019) Neurosurgery Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury (2019) Neurosurgery, 84 (2), pp. 362-377.  Khalifeh, J.M.a , Dibble, […]

WashU weekly Neuroscience publications

“Neuroimaging of individual differences: A latent variable modeling perspective” (2019) Neuroscience and Biobehavioral Reviews Neuroimaging of individual differences: A latent variable modeling perspective (2019) Neuroscience and Biobehavioral Reviews, 98, pp. 29-46.  Cooper, S.R., Jackson, J.J., Barch, D.M., Braver, T.S. Washington University in St. Louis, Psychological and Brain Sciences, St. Louis, MO, United States Abstract Neuroimaging data is being increasingly […]

New hope for stem cell approach to treating diabetes

Insulin-producing cells more responsive to fluctuating glucose levels From the WashU Newsroom… Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar. But there’s a major challenge: the amount of insulin produced by theses cells […]

WashU weekly Neuroscience publications

“Seizures as an early symptom of autosomal dominant Alzheimer’s disease” (2019) Neurobiology of Aging Seizures as an early symptom of autosomal dominant Alzheimer’s disease (2019) Neurobiology of Aging, 76, pp. 18-23.  Vöglein, J.a b , Noachtar, S.b , McDade, E.c , Quaid, K.A.d , Salloway, S.e , Ghetti, B.f , Noble, J.g , Berman, S.h , Chhatwal, J.i , […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

WashU weekly Neuroscience publications

“Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials” (2019) European Journal of Obstetrics Gynecology and Reproductive Biology Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials (2019) European Journal of Obstetrics Gynecology and Reproductive Biology, 233, pp. 98-106.  Felder, L.a , Saccone, G.b , […]

Bad Vibes: How Hits To The Head Are Transferred To The Brain

From NPR’s Morning Edition… It was a question about soccer that got Philip Bayly interested in brain injuries. Bayly, a mechanical engineer at Washington University in St. Louis, was approached by several doctors who wanted advice about some young soccer players they were treating. “They said, ‘Well, we’ve got some kids who have concussions and […]

WashU weekly Neuroscience publications

“Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network” (2019) Neurobiology of Aging Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network (2019) Neurobiology of Aging, 75, pp. 42-50.  Bussy, A.a b , Snider, B.J.a b , Coble, D.a […]

WashU weekly Neuroscience publications

“Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel” (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, 1864 (2), pp. 128-136.  Budelier, M.M.a , Cheng, W.W.L.a , […]

University receives new grant to fund Amgen Scholars Program

Undergraduate research experience supports science education and innovation From the WashU Newsroom… Washington University in St. Louis has received a new grant from the Amgen Foundation to provide hands-on laboratory experiences to undergraduate students through the Amgen Scholars Program. This marks the ninth year the university is participating in the program, which aims to inspire […]

WashU weekly Neuroscience publications

“Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries” (2019) Science of the Total Environment Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries (2019) Science […]

GUEST COMMENTARY: Girls must learn to see themselves as scientists

From the Times of Northwest Indiana… I recently visited an elementary school to lead a neuroscience demonstration for fifth-graders. The activities were going splendidly: my station demonstrating the brain’s plasticity (its ability to change and adapt with the environment) saw enthusiastic students who were also able to learn about proprioception (knowing where your body is […]

WashU weekly Neuroscience publications

"Touch engages visual spatial contextual processing" (2018) Scientific Reports Touch engages visual spatial contextual processing (2018) Scientific Reports, 8 (1), art. no. 16637, .  Pérez-Bellido, A.a b , Pappal, R.D.a c , Yau, J.M.a a Department of Neuroscience, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030, United States b Radboud University, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands […]

Dantas, Stappenbeck and Moon awarded $3.5 million from NIH’s National Center for Complementary and Integrative Health

The National Center for Complementary and Integrative Health of the National Institutes of Health (NIH) has awarded a $3.5 million grant to study how live bacteria can be used for drug delivery to Gautam Dantas, professor of pathology and immunology, and Thaddeus Stappenbeck, the Conan Professor of Laboratory and Genomic Medicine, both at the School of Medicine, and Tae Seok Moon, associate professor of […]

WashU weekly Neuroscience publications

“Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations” (2019) Current Opinion in Structural Biology Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations (2019) Current Opinion in Structural Biology, 56, pp. 1-10.  Ruff, K.M., Pappu, R.V., Holehouse, A.S. Department of Biomedical Engineering and Center for Biological […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

WashU weekly Neuroscience publications

“Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study” (2019) Multiple Sclerosis and Related Disorders Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the […]

WashU weekly Neuroscience publications

“Symptoms of social anxiety disorder and major depressive disorder: A network perspective” (2019) Journal of Affective Disorders Symptoms of social anxiety disorder and major depressive disorder: A network perspective (2019) Journal of Affective Disorders, 243, pp. 531-538.  Langer, J.K.a , Tonge, N.A.a c , Piccirillo, M.a c , Rodebaugh, T.L.a c , Thompson, R.J.a c , Gotlib, I.H.b d […]

Grad students Hailun Li and Weikang Shi win 2018 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition.  The 2018 winners: Short Talks: Hailun Li (Neuroscience Program; DiAntonio lab) “A neuromodulatory circuit regulating the glial capacity to buffer K+” Posters: Weikang Shi (Neuroscience program; Padoa-Schioppa lab) “Establishing […]

WashU weekly Neuroscience publications

“Associations between depression, anxious arousal and manifestations of psychological inflexibility” (2019) Journal of Behavior Therapy and Experimental Psychiatry Associations between depression, anxious arousal and manifestations of psychological inflexibility (2019) Journal of Behavior Therapy and Experimental Psychiatry, 62, pp. 88-96.  Gilbert, K.E.a , Tonge, N.A.b , Thompson, R.J.b a Department of Psychiatry, Washington University School of Medicine, Washington University in St. […]

WashU weekly Neuroscience publications

“Examining the Role of Cone-expressed RPE65 in Mouse Cone Function” (2018) Scientific Reports Examining the Role of Cone-expressed RPE65 in Mouse Cone Function (2018) Scientific Reports, 8 (1), art. no. 14201, .  Kolesnikov, A.V.a , Tang, P.H.b c , Kefalov, V.J.a a Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, United States b Department of Ophthalmology, […]

WashU weekly Neuroscience publications

“Distinct modes of functional connectivity induced by movie-watching” (2019) NeuroImage Distinct modes of functional connectivity induced by movie-watching (2019) NeuroImage, 184, pp. 335-348.  Demirtaş, M.a b , Ponce-Alvarez, A.b , Gilson, M.b , Hagmann, P.d , Mantini, D.e f , Betti, V.g h , Romani, G.L.i , Friston, K.j , Corbetta, M.k l , Deco, G.b c m n […]

WashU weekly Neuroscience publications

“Statistical learning and spelling: Evidence from Brazilian prephonological spellers” (2019) Cognition Statistical learning and spelling: Evidence from Brazilian prephonological spellers (2019) Cognition, 182, pp. 1-7.  Treiman, R.a , Cardoso-Martins, C.b , Pollo, T.C.c , Kessler, B.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, United States b Departamento de Psicologia, Universidade Federal de Minas Gerais, Brazil c Departamento […]

WashU weekly Neuroscience publications

“Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation” (2018) World Neurosurgery Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation (2018) World Neurosurgery, 119, pp. 233-236.  Baksh, B.S.a , Sinha, N.b , Salehi, A.a , Han, R.H.a , Miller, B.A.a d , Dahiya, S.b , Gauvain, K.M.c , Limbrick, D.D., Jr.a a Department of Neurological […]

Diving in to how our brains process information

Engineering, ArtSci researchers will use fMRI and twins to better understand cognitive control From the WashU Newsroom… How our brains process information is intimately tied to the kinds of goals we have or the tasks we need to perform. For example, when showed the word “yellow,” our brains process it differently depending on whether we […]

WashU weekly Neuroscience publications

“Altered functional network connectivity relates to motor development in children born very preterm” (2018) NeuroImage Altered functional network connectivity relates to motor development in children born very preterm (2018) NeuroImage, 183, pp. 574-583.  Wheelock, M.D.a , Austin, N.C.b , Bora, S.c , Eggebrecht, A.T.d , Melzer, T.R.e , Woodward, L.J.f , Smyser, C.D.d g h a Department of Psychiatry, Washington […]

Focused delivery for brain cancers

Interdisciplinary research brings together imaging, aerosols and pediatric neuro oncology to fight tumors From the WashU Newsroom… A person’s brainstem controls some of the body’s most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating. Not only can such a growth […]

WashU weekly Neuroscience publications

“Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol” (2018) Contemporary Clinical Trials Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol (2018) Contemporary Clinical Trials, 72, pp. 117-125.  Wilfley, D.E.a , Fitzsimmons-Craft, E.E.a , Eichen, D.M.b , Van Buren, D.J.a , Welch, […]

‘Blink’ and you won’t miss amyloids

Engineering team just found new way to see proteins that cause Alzheimer’s, other diseases From the WashU Newsroom… Tiny protein structures called amyloids are key to understanding certain devastating age-related diseases. Aggregates, or sticky clumped-up amyloids, form plaques in the brain, and are the main culprits in the progression of Alzheimer’s and Huntington’s diseases. Amyloids […]

Brain Initiative grants Chen $2.7 million for neuroscience study

An interdisciplinary team of WashU researchers will be developing a non-invasive neuromodulation tool From the WashU School of Engineering & Applied Science News… Hong Chen, assistant professor of biomedical engineering in the School of Engineering & Applied Science and radiation oncology in the School of Medicine, has received a $2.7 million grant from the National Institutes of […]

In sync: How cells make connections could impact circadian rhythm

From the WashU Newsroom… If you’ve ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism, from sleep-wake cycles to body temperature to digestion. Every cell in the body has a circadian clock, but researchers were unclear about how networks of cells connect with each other over […]

WashU weekly Neuroscience publications

“Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model” (2018) Translational Psychiatry Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model (2018) Translational Psychiatry, 8 (1), art. no. 158, .  Duan, J.a b , Göring, H.H.H.c , Sanders, A.R.a b , Moy, W.a b , Freda, J.a , Drigalenko, E.I.d , Kos, M.c […]