WashU weekly Neuroscience publications

“Sleep disturbances in Wolfram syndrome” (2019) Orphanet Journal of Rare Diseases Sleep disturbances in Wolfram syndrome (2019) Orphanet Journal of Rare Diseases, 14 (1), art. no. 188, .  Licis, A.a , Davis, G.d e , Eisenstein, S.A.b c , Lugar, H.M.b , Hershey, T.a b c a Department of Neurology, Washington University, School of Medicine, Campus Box 8111, 660 South Euclid Ave, […]

WashU weekly Neuroscience publications

“Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia” (2019) Scientific Reports Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia (2019) Scientific Reports, 9 (1), art. no. 10854, .  Bonham, L.W.a b , Steele, N.Z.R.a , Karch, C.M.c […]

WashU weekly Neuroscience publications

“A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings” (2019) Journal of Substance Abuse Treatment A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings (2019) Journal of Substance Abuse Treatment, 104, pp. 135-143.  Presnall, N.J.a b , Wolf, D.A.P.S.a , Brown, D.S.a , Beeler-Stinn, S.a , Grucza, R.A.b a Brown School of […]

Culver named Sherwood Moore Professor of Radiology

Joseph P. Culver, PhD, a professor of radiology recognized for helping develop optical neuroimaging technologies to map brain function in humans and animals, has been named the inaugural Sherwood Moore Professor of Radiology. Based at the university’s Mallinckrodt Institute of Radiology (MIR), Culver’s lab is notable for advancing diffuse optical tomography (DOT), a technology that uses light […]

WashU weekly Neuroscience publications

“CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)” (2019) Scientific Reports CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) (2019) Scientific Reports, 9 (1), art. no. 9891, .  Eaton, S.L.a , Proudfoot, C.a , Lillico, S.G.a , Skehel, P.b c , Kline, R.A.a , Hamer, K.e , Rzechorzek, N.M.d […]

BrainWorks: Theater production explores wonders of human brain

Two nationally renowned neurosurgeons at Washington University School of Medicine in St. Louis will present “BrainWorks,” a live theatrical performance that explores the wonders of the human brain by dramatizing real-life neurological cases. The performance, comprised of four one-act plays, will debut July 19-21 at the Loretto-Hilton Center for the Performing Arts at Webster University. Albert Kim, […]

WashU weekly Neuroscience publications

“A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation” (2019) Molecular Genetics and Metabolism Reports A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation (2019) Molecular Genetics and Metabolism Reports, 20, art. no. 100484, .  Ahmed, A.a , Ou, L.b , Rudser, K.c , […]

WashU weekly Neuroscience publications

“Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns” (2019) Nature Communications Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns (2019) Nature Communications, 10 (1), art. no. 2548, .  Czamara, D.a , Eraslan, G.b c , Page, C.M.d e , Lahti, J.f g , Lahti-Pulkkinen, M.f h , Hämäläinen, E.i […]

WashU weekly Neuroscience publications

“High-fidelity mapping of repetition-related changes in the parietal memory network” (2019) NeuroImage High-fidelity mapping of repetition-related changes in the parietal memory network (2019) NeuroImage, 199, pp. 427-439.  Gilmore, A.W.a , Nelson, S.M.h i j , Laumann, T.O.b c , Gordon, E.M.h i , Berg, J.J.a , Greene, D.J.c d , Gratton, C.b , Nguyen, A.L.b , Ortega, M.b , […]

WashU weekly Neuroscience publications

“A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ” (2019) Nature Communications A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ (2019) Nature Communications, 10 (1), art. no. 2448, .  Kim, W.S.a , Shalit, Z.A.a , Nguyen, S.M.b , Schoepke, E.c , Eastman, A.d , Burris, T.P.c , Gaur, A.B.b , Micalizio, G.C.a a Dartmouth College, Department of […]

Chen awarded Office of Naval Research grant for detection of TBI

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $470,500 research grant from the Office of Naval Research to detect traumatic brain injury (TBI) using ultrasound sensors. This research represents just one arm of a multi-faceted approach in the Chen […]

2019 McKelvey School Collaboration Initiation Grants awarded to four faculty members

Rajan Chakrabarty, Fangqiong Ling, Chuan Wang, and Patty Weisensee, all assistant professors in the McKelvey School of Engineering, have been awarded $25,000 Collaboration Initiation Grants from the school. The program awards one-year grants to projects that facilitate collaborative research outside of and within McKelvey Engineering departments for tenure-track faculty. The grants are a pathway for […]

Thorp to conclude term as Washington University provost

Holden Thorp, provost at Washington University in St. Louis, will leave his position effective July 15, according to Chancellor Andrew D. Martin. Thorp, who has served in his current role since 2013, plans to take a one-year sabbatical and then return to the university in a newly created leadership role in the drug discovery and […]

WashU weekly Neuroscience publications

“Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling” (2019) Current Opinion in Neurobiology Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling (2019) Current Opinion in Neurobiology, 59, pp. 59-68.  Goodman, J.V.a b , Bonni, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Medical Scientist Training Program, Washington […]

WashU weekly Neuroscience publications

“Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms” (2019) Nature Communications Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms (2019) Nature Communications, 10 (1), art. no. 2246, .  Li, P.a , Marshall, L.a , Oh, G.b , Jakubowski, J.L.a , Groot, D.b , He, Y.c , Wang, […]

E3 Nutrition Lab Links Child Nutrition, Economics and Evolution

A transdisciplinary laboratory at the Brown School is undertaking research across the world to address “hidden hunger”— poverty-related nutritional deficiencies in mothers and young children. The founder and director of the E3 Nutrition Lab is Lora Iannotti, associate professor and associate dean for public health. The three “E”s represent the lab’s principles for nutrition interventions: […]

WashU weekly Neuroscience publications

“Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power” (2019) NeuroImage Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power (2019) NeuroImage, 197, pp. 435-438.  Glasser, M.F.a b c , Coalson, T.S.a , Bijsterbosch, J.D.d , Harrison, S.J.d e , Harms, M.P.f , Anticevic, A.g , Van […]

WashU weekly Neuroscience publications

“Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8)” (2019) Scientific Reports Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8) (2019) Scientific Reports, 9 (1), art. no. 6400, .  Guo, P.a , Yu, Y.b […]

WashU weekly Neuroscience publications

“Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry” (2019) Scientific Reports Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry (2019) Scientific Reports, 9 (1), art. no. 6010, .  Lugar, H.M.a , Koller, J.M.a , Rutlin, J.a , Eisenstein, S.A.a , Neyman, O.a , Narayanan, A.a , Chen, L.c , Shimony, J.S.b , Hershey, […]

WashU weekly Neuroscience publications

“The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain” (2019) Nature Communications The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain (2019) Nature Communications, 10 (1), art. no. 1417, .  Karolis, V.R., Corbetta, M., Thiebaut de Schotten, M. Abstract Functional lateralisation is a fundamental principle of the human brain. […]

WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

Making waves: Researchers shed light on how cilia work

Human bodies have some built-in systems to care for themselves. The cells that line our lungs, nose, brain and reproductive system have cilia, which are tiny, hair-like structures designed to sweep out fluids, cells and microbes to stay healthy. But the mechanisms behind their motion are not well understood. The team of researchers (clockwise, from […]

WashU weekly Neuroscience publications

“Regeneration associated transcriptional signature of retinal microglia and macrophages” (2019) Scientific Reports Regeneration associated transcriptional signature of retinal microglia and macrophages (2019) Scientific Reports, 9 (1), art. no. 4768, .  Mitchell, D.M.a , Sun, C.a b , Hunter, S.S.c , New, D.D.c , Stenkamp, D.L.a a Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States b Ophthalmology, Washington University in […]

WashU weekly Neuroscience publications

“Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice” (2019) Scientific Reports Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice (2019) Scientific Reports, 9 (1), art. no. 4379, . Wozniak, D.F., Valnegri, P., Dearborn, J.T., Fowler, S.C., Bonni, A. Document Type: Article Publication Stage: Final Source: Scopus Access Type: Open Access “A […]

WashU weekly Neuroscience publications

“The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection” (2019) Journal of Memory and Language The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection (2019) Journal of Memory and Language, 106, pp. 77-94.  Maddox, G.B.a , Balota, D.A.b , Kumar, A.A.b , Millar, P.R.b , Churchill, L.b a Department of […]

Engineering treatments for the opioid epidemic

The U.S. is reeling from a public health crisis driven by the misuse of prescription and illicit opioids with nearly 12 million people abusing the drugs annually. The Midwest saw opioid overdoses increase 70 percent from July 2016 to September 2017, and every 15 minutes a baby is born suffering from opioid withdrawal as a […]

WashU weekly Neuroscience publications

“Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits” (2019) Scientific Reports Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits (2019) Scientific Reports, 9 (1), art. no. 2779, .  Maloney, S.E.a d f , Yuede, C.M.a b , […]

A new method for precision drug delivery: painting

If traditional drug delivery were a type of painting, it might be akin to paintball. With good aim, a majority of the paint ends on the bullseye, but it also drips and splashes, carrying streams of paint across the target. If the drug needs to enter the bloodstream and circulate throughout your body for treating […]

WashU weekly Neuroscience publications

“Predicting Alzheimer’s disease progression using multi-modal deep learning approach” (2019) Scientific Reports Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) Scientific Reports, 9 (1), art. no. 1952, .  Lee, G.a b , Nho, K.c d , Kang, B.a , Sohn, K.-A.a , Kim, D.b e , Weiner, M.W.f , Aisen, P.g , Petersen, R.h , Jack, C.R., Jr.h , […]

Hong Chen receives $1.6 million grant from the NIH’s National Institute of Biomedical Imaging and Bioengineering

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $1.6 million grant from the National Institutes of Health (NIH)’s National Institute of Biomedical Imaging and Bioengineering. The research will fund a broader understanding of Chen’s earlier work combining intranasal drug delivery […]

WashU weekly Neuroscience publications

“Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles” (2019) Channels (Austin, Tex.) Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles (2019) Channels (Austin, Tex.), 13 (1), pp. 72-87.  Wang, W.a , Mellor, R.L.a , Nerbonne, J.M.a b , Balke, C.W.a […]

WashU weekly Neuroscience publications

“Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease” (2019) Stroke Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease (2019) Stroke, 50 (2), pp. 266-273.  Guilliams, K.P.a b , Fields, M.E.b , Dowling, M.M.c a From the Department of Neurology (K.P.G.), Washington University School […]

WashU weekly Neuroscience publications

“Neuronal evidence for good-based economic decisions under variable action costs” (2019) Nature Communications Neuronal evidence for good-based economic decisions under variable action costs (2019) Nature Communications, 10 (1), art. no. 393, .  Cai, X.a b c d , Padoa-Schioppa, C.a e f a Department of Neuroscience, Washington University in St Louis, St Louis, MO 63110, United States b NYU Shanghai, 1555 Century Avenue, […]

New era in engineering to begin at Washington University

Renamed McKelvey School of Engineering will take innovation, technology and academics to new heights From the WashU Newsroom… Furthering its strong trajectory as a leader in research and innovation, the engineering school at Washington University in St. Louis is taking a major leap forward and reaffirming its commitment to tackling the world’s great engineering challenges […]

Silva, Ramani chosen as Inaugural WashU Faculty Fellows in Entrepreneurship

From the WashU Office of the Vice Chancellor for Research… Jennifer Silva, MD, associate professor of Pediatrics and Vijay Ramani, PhD, the  Roma B. & Raymond H. Wittcoff Professor of Energy, Environmental & Chemical Engineering have been selected as the inaugural entrepreneurial faculty fellows. These individuals advise WashU faculty and small companies founded by WashU personnel […]

WashU weekly Neuroscience publications

“Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury” (2019) Neurosurgery Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury (2019) Neurosurgery, 84 (2), pp. 362-377.  Khalifeh, J.M.a , Dibble, […]

WashU weekly Neuroscience publications

“Neuroimaging of individual differences: A latent variable modeling perspective” (2019) Neuroscience and Biobehavioral Reviews Neuroimaging of individual differences: A latent variable modeling perspective (2019) Neuroscience and Biobehavioral Reviews, 98, pp. 29-46.  Cooper, S.R., Jackson, J.J., Barch, D.M., Braver, T.S. Washington University in St. Louis, Psychological and Brain Sciences, St. Louis, MO, United States Abstract Neuroimaging data is being increasingly […]

New hope for stem cell approach to treating diabetes

Insulin-producing cells more responsive to fluctuating glucose levels From the WashU Newsroom… Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar. But there’s a major challenge: the amount of insulin produced by theses cells […]

WashU weekly Neuroscience publications

“Seizures as an early symptom of autosomal dominant Alzheimer’s disease” (2019) Neurobiology of Aging Seizures as an early symptom of autosomal dominant Alzheimer’s disease (2019) Neurobiology of Aging, 76, pp. 18-23.  Vöglein, J.a b , Noachtar, S.b , McDade, E.c , Quaid, K.A.d , Salloway, S.e , Ghetti, B.f , Noble, J.g , Berman, S.h , Chhatwal, J.i , […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

WashU weekly Neuroscience publications

“Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials” (2019) European Journal of Obstetrics Gynecology and Reproductive Biology Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials (2019) European Journal of Obstetrics Gynecology and Reproductive Biology, 233, pp. 98-106.  Felder, L.a , Saccone, G.b , […]

Bad Vibes: How Hits To The Head Are Transferred To The Brain

From NPR’s Morning Edition… It was a question about soccer that got Philip Bayly interested in brain injuries. Bayly, a mechanical engineer at Washington University in St. Louis, was approached by several doctors who wanted advice about some young soccer players they were treating. “They said, ‘Well, we’ve got some kids who have concussions and […]

WashU weekly Neuroscience publications

“Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network” (2019) Neurobiology of Aging Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network (2019) Neurobiology of Aging, 75, pp. 42-50.  Bussy, A.a b , Snider, B.J.a b , Coble, D.a […]

WashU weekly Neuroscience publications

“Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel” (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, 1864 (2), pp. 128-136.  Budelier, M.M.a , Cheng, W.W.L.a , […]

University receives new grant to fund Amgen Scholars Program

Undergraduate research experience supports science education and innovation From the WashU Newsroom… Washington University in St. Louis has received a new grant from the Amgen Foundation to provide hands-on laboratory experiences to undergraduate students through the Amgen Scholars Program. This marks the ninth year the university is participating in the program, which aims to inspire […]

WashU weekly Neuroscience publications

“Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries” (2019) Science of the Total Environment Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries (2019) Science […]

GUEST COMMENTARY: Girls must learn to see themselves as scientists

From the Times of Northwest Indiana… I recently visited an elementary school to lead a neuroscience demonstration for fifth-graders. The activities were going splendidly: my station demonstrating the brain’s plasticity (its ability to change and adapt with the environment) saw enthusiastic students who were also able to learn about proprioception (knowing where your body is […]