Locusts help uncover the mysteries of smell

Computational logic can describe how locusts recognize smells in a dynamic environment From the WashU Newsroom… Understanding how a sensory input becomes an experience — how molecules released by a blooming flower, for instance, become the internal experience of smelling a rose — has for millennia been a central question of philosophy. In more recent […]

WashU weekly Neuroscience publications

"Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum" (2018) Nature Communications Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum (2018) Nature Communications, 9 (1), art. no. 2710, .  Wolfman, S.L.a , Gill, D.F.a , Bogdanic, F.b , Long, K.c , Al-Hasani, R.d , McCall, J.G.d e f , Bruchas, M.R.e f , McGehee, […]

WashU weekly Neuroscience publications

Age at first birth in women is genetically associated with increased risk of schizophrenia (2018) Scientific Reports Age at first birth in women is genetically associated with increased risk of schizophrenia (2018) Scientific Reports, 8 (1), art. no. 10168, .  Ni, G.a b , Gratten, J.c d , Wray, N.R.c d , Lee, S.H.a b d , Ripke, S.e f , […]

New faculty join School of Engineering & Applied Science

A diverse group of new faculty joins the School of Engineering & Applied Science at Washington University in St. Louis, bringing the total number to 96.5 during the 2018-2019 academic year. From the WashU School of Engineering News… “Each year, we compete with the very best engineering schools to recruit extraordinary faculty members,” said Aaron […]

WashU weekly Neuroscience publications

"The Open Source GAITOR Suite for Rodent Gait Analysis" (2018) Scientific Reports The Open Source GAITOR Suite for Rodent Gait Analysis (2018) Scientific Reports, 8 (1), art. no. 9797, .  Jacobs, B.Y.a , Lakes, E.H.a , Reiter, A.J.b , Lake, S.P.b , Ham, T.R.c , Leipzig, N.D.c , Porvasnik, S.L.a , Schmidt, C.E.a , Wachs, R.A.a d , Allen, K.D.a a University […]

Uncovering molecular grammar

Collaborative team deciphers the protein sequence-encoded mechanism that drives phase separation From the WashU School of Engineering & Applied Science News… An international research collaboration including engineers from Washington University in St. Louis have discovered a protein sequence mechanism that triggers phase separation deep within a single cell. Their findings, published in Cell, could provide […]

WashU weekly Neuroscience publications

"Development of vestibular behaviors in zebrafish" (2018) Current Opinion in Neurobiology Development of vestibular behaviors in zebrafish (2018) Current Opinion in Neurobiology, 53, pp. 83-89.  Bagnall, M.W.a , Schoppik, D.b a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Departments of Otolaryngology, Neuroscience & Physiology, the Neuroscience Institute, New York University School of Medicine, New […]

WashU weekly Neuroscience publications

"Testing neurophysiological markers related to fear-potentiated startle" (2018) Psychiatry Research Testing neurophysiological markers related to fear-potentiated startle (2018) Psychiatry Research, 267, pp. 195-200.  Seligowski, A.V.a b , Bondy, E.c , Singleton, P.a b , Orcutt, H.K.d , Ressler, K.J.a b , Auerbach, R.P.b e f a Department of Psychiatry, Harvard Medical School, Boston, MA, United States b McLean Hospital, Belmont, MA, […]

WashU weekly Neuroscience publications

"Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states" (2018) Scientific Reports Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states (2018) Scientific Reports, 8 (1), art. no. 4103, .  Mahjoub, I.a b , Mahjoub, M.A.b , Rekik, I.a , Weiner, M.c , Aisen, P.d , Petersen, R.e , Jack, C.f , Jagust, W.g , Trojanowki, J.h […]

WashU weekly Neuroscience publications

"Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ϵ4" (2018) Scientific Reports Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer’s disease by interacting with APOE ϵ4 (2018) Scientific Reports, 8 (1), art. no. 8068, .  Zhang, A.a , Zhao, Q.b , Xu, D.a , […]

WashU weekly Neuroscience publications

"A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation" (2018) Nature Communications A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation (2018) Nature Communications, 9 (1), art. no. 2036, .  Voet, S.a b , Mc Guire, C.a b c d , Hagemeyer, N.e , Martens, A.a b , Schroeder, A.f g , Wieghofer, P.e n , Daems, C.h , Staszewski, O.e […]

WashU weekly Neuroscience publications

"ModCHIMERA: A novel murine closed-head model of moderate traumatic brain injury" (2018) Scientific Reports ModCHIMERA: A novel murine closed-head model of moderate traumatic brain injury (2018) Scientific Reports, 8 (1), art. no. 7677, .  Sauerbeck, A.D.a , Fanizzi, C.a b , Kim, J.H.a , Gangolli, M.c , Bayly, P.V.d , Wellington, C.L.e , Brody, D.L.a , Kummer, T.T.a a Department of Neurology, […]

WashU weekly Neuroscience publications

"Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21" (2018) Scientific Reports Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 (2018) Scientific Reports, 8 (1), art. no. 7352, .  Ostrom, Q.T.a b c , Kinnersley, B.d , Wrensch, […]

WashU weekly Neuroscience publications

"Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21" (2018) Scientific Reports Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 (2018) Scientific Reports, 8 (1), art. no. 7352, .  Ostrom, Q.T.a b c , Kinnersley, B.d , Wrensch, […]

WashU weekly Neuroscience publications

"Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors" (2018) Psychological Medicine Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors (2018) Psychological Medicine, pp. 1-10. Article in Press.  Richmond-Rakerd, L.S.a b , Trull, T.J.b , Gizer, I.R.b , McLaughlin, K.b , Scheiderer, E.M.b c , Nelson, E.C.d , Agrawal, A.d , Lynskey, […]

An ‘unprecedented look’ into the protein behind hypertension, epilepsy and other conditions

Washington University engineer will look into potential treatment candidates From the WashU Newsroom… The seemingly unrelated conditions of hypertension, epilepsy and overactive bladder may be linked by electrical activity in a protein long studied by a biomedical engineer at Washington University in St. Louis. After new technology recently revealed the structure of the protein, the lab […]

WashU weekly Neuroscience publications

"Focused Ultrasound-enabled Brain Tumor Liquid Biopsy" (2018) Scientific Reports Focused Ultrasound-enabled Brain Tumor Liquid Biopsy (2018) Scientific Reports, 8 (1), art. no. 6553, .  Zhu, L.a , Cheng, G.a , Ye, D.b , Nazeri, A.c , Yue, Y.b , Liu, W.d , Wang, X.d , Dunn, G.P.e f , Petti, A.A.g h , Leuthardt, E.C.a b e i j , Chen, […]

WashU weekly Neuroscience publications

"CXCR4 involvement in neurodegenerative diseases" (2018) Translational Psychiatry CXCR4 involvement in neurodegenerative diseases (2018) Translational Psychiatry, 8 (1), art. no. 73, .  Bonham, L.W.a , Karch, C.M.b , Fan, C.C.c , Tan, C.d , Geier, E.G.a , Wang, Y.e , Wen, N.b , Broce, I.J.d , Li, Y.d , Barkovich, M.J.d , Ferrari, R.f , Hardy, J.f , Momeni, P.g , […]

Noninvasive brain tumor biopsy on the horizon

New technique developed at Washington University in St. Louis uses blood test From the WashU Newsroom… Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple […]

WashU weekly Neuroscience publications

"CXCR4 involvement in neurodegenerative diseases" (2018) Translational Psychiatry CXCR4 involvement in neurodegenerative diseases (2018) Translational Psychiatry, 8 (1), art. no. 73, .  Bonham, L.W.a , Karch, C.M.b , Fan, C.C.c , Tan, C.d , Geier, E.G.a , Wang, Y.e , Wen, N.b , Broce, I.J.d , Li, Y.d , Barkovich, M.J.d , Ferrari, R.f , Hardy, J.f , Momeni, P.g , […]

Using tooth sensors to detect disease

Collaborative research team developing biological sensors that would analyze saliva, send information electronically to doctors From the WashU Newsroom… An interdisciplinary team of researchers from Washington University School of Medicine in St. Louis and the School of Engineering & Applied Science is redefining the notion of a wisdom tooth. The team is developing a smart-tooth […]

WashU weekly Neuroscience publications

"Distinct phase-amplitude couplings distinguish cognitive processes in human attention" (2018) NeuroImage Distinct phase-amplitude couplings distinguish cognitive processes in human attention (2018) NeuroImage, 175, pp. 111-121.  Chacko, R.V., Kim, B., Jung, S.W., Daitch, A.L., Roland, J.L., Metcalf, N.V., Corbetta, M., Shulman, G.L., Leuthardt, E.C. Abstract Spatial attention is the cognitive function that coordinates the selection of visual stimuli with appropriate […]

WashU weekly Neuroscience publications

"The choroid plexus is an important circadian clock component" (2018) Nature Communications The choroid plexus is an important circadian clock component (2018) Nature Communications, 9 (1), art. no. 1062, .  Myung, J.a b c d e , Schmal, C.f , Hong, S.b , Tsukizawa, Y.g , Rose, P.f , Zhang, Y.h , Holtzman, M.J.h , De Schutter, E.b , Herzel, H.f […]

Viewpoint: Brain Motion Under Impact

From Physics online… A numerical study suggests that head impacts primarily induce a few low-frequency, damped modes of vibration in brain tissue, a finding that could inform the design of sports helmets. Strike a bell or a drum and its sound will be dominated by a few vibrational patterns (“modes”), each of which has a […]

Genin named inaugural Faught Professor of Mechanical Engineering

From the WashU Newsroom… Guy Genin, an internationally renowned expert in mechanobiology, was installed as the Harold and Kathleen Faught Professor of Mechanical Engineering at Washington University in St. Louis Feb. 12. Genin, professor of mechanical engineering, studies interfaces and adhesion in nature, physiology and engineering. His research focuses on mechanobiology and aims to understand […]

3-D mapping babies’ brains

Examining brain folds — as unique to an individual as fingerprints — could hold key to new diagnostic tools From the WashU Newsroom… During the third trimester, a baby’s brain undergoes rapid development in utero. The cerebral cortex dramatically expands its surface area and begins to fold. Previous work suggests that this quick and very vital […]

Model Brains-on-a-Chip Reveal the Physics of Brain Folding

From Gizmodo.com… …Basically, by confining the growth to two dimensions, researchers were able to watch a developing set of stem cells turn into brain cells and fold. Why are the organoids folding? It appears that as the neurons develop, their cellular nuclei migrate to the outer end. As this occurs, the whole structure appears to buckle […]

Washington People: Michael S. Avidan

Anesthesiologist works to improve outcomes for patients during and after surgery From the WashU Newsroom… Michael Avidan and his colleagues sit in a windowless room in front of a panel of screens tapped into every operating room at Barnes-Jewish Hospital. It’s conceptually similar to an air traffic control tower, except they aren’t tracking airplanes. Relying on […]

PhD in imaging science launched

School of Engineering & Applied Science to offer unique degree From the WashU Newsroom… The field of imaging science — marked by rapidly changing and improving technology — plays a critical role in applications ranging from cancer diagnosis to virtual reality. With the aim of training the next leaders in imaging, the School of Engineering & […]

Research team developing new pediatric neuroimaging technology

Washington University researchers are developing a new way to look inside the brains of pediatric patients. From the WashU Newsroom… A team of scientists at Washington University in St. Louis is developing a new way to look inside the brains of the littlest patients — a technique that will provide precise measurements without requiring children to […]

Bear or chipmunk? Engineer finds how brain encodes sounds

From the WashU Newsroom… When you are out in the woods and hear a cracking sound, your brain needs to process quickly whether the sound is coming from, say, a bear or a chipmunk. In new research published in PLoS Biology, a biomedical engineer at Washington University in St. Louis has a new interpretation for an old observation, […]

Engineers developing self-powered brain activity recorders

Launched in 2013, the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is designed to fund research that will ultimately revolutionize the understanding of the human brain, from individual cells to complex neural circuits. From the WashU School of Engineering Newsroom… The National Institutes of Health recently awarded a two-year, BRAIN Initiative grant to engineers at […]

Penny-wise, pound-foolish decisions explained by neurons’ firing

Spending decisions influenced by adaptation in neural circuits From the WashU Newsroom… The British have a pithy way of describing people who dither over spending 20 cents more for premium ice cream but happily drop an extra $5,000 for a fancier house: penny wise and pound foolish. Now, a new study suggests that being penny wise […]

Pushing the imaging envelope

NIH grant to help engineers visualize Alzheimer’s From the WashU Newsroom… With support from the National Institutes of Health (NIH), an engineer at Washington University in St. Louis plans to push the envelope of microscopic imaging to better visualize the molecules involved in Alzheimer’s disease. Matthew Lew, assistant professor of electrical & systems engineering in the […]

Imaging a killer

International team finds high-resolution structural analysis of protein behind Huntington’s From the WashU Newsroom… Huntington’s disease is a progressive, fatal neurodegenerative disorder that is caused by mutations in one specific gene called huntingtin (Htt). In the 20-plus years since the Htt gene was identified, researchers have focused on the protein encoded by the Htt gene, […]