Kepecs named BJC investigator

Adam Kepecs, PhD, recognized internationally for his research on neural circuits responsible for cognition and decision-making, has been named a BJC Investigator and a professor of neuroscience and psychiatry at Washington University School of Medicine in St. Louis. The BJC Investigators Program recruits to the School of Medicine scientists who bring innovative approaches to address […]

Centene and Washington University collaborate to advance personalized medicine research

Centene Corp. and Washington University School of Medicine in St. Louis announced Monday, April 8, a partnership to transform and accelerate research into treatments for Alzheimer’s disease, breast cancer, diabetes and obesity. All are common, debilitating and often deadly diseases that affect millions of people worldwide, at all levels of income. As part of the […]

$10 million gift aimed at improving treatments for mental illness

Philanthropists Andrew and Barbara Taylor and the Crawford Taylor Foundation have committed $10 million to Washington University School of Medicine in St. Louis to continue research to investigate the scientific underpinnings of psychiatric illnesses, with the goal of improving diagnosis and treatment. The new gift will support the Taylor Family Institute for Innovative Psychiatric Research, established […]

WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Connor named head of occupational therapy program

Lisa Tabor Connor, PhD, noted for her extensive research into recovery from stroke, will be the next executive director of the Program in Occupational Therapy at Washington University School of Medicine in St. Louis. She will begin her new role July 1. Connor currently is chair of the Department of Occupational Therapy and associate director of research […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

‘Jumping genes’ drive many cancers

Mistakes in DNA are known to drive cancer growth. But a new study, from Washington University School of Medicine in St. Louis, heavily implicates a genetic phenomenon commonly known as “jumping genes” in the growth of tumors. The study is published March 29 in the journal Nature Genetics. Since jumping genes aren’t mutations — mistakes […]

Academy of Science – St. Louis 25th Annual Outstanding Scientists Awards

Since its inception, the Academy has promoted the recognition of the impressive scientists of St. Louis. This tradition continues with the 25th Annual Outstanding St. Louis Scientists Awards. Each award-winner represents an extraordinary caliber of expertise. We wish to focus the region’s attention upon individuals, institutions and corporations known worldwide for their scientific contributions to […]

Making waves: Researchers shed light on how cilia work

Human bodies have some built-in systems to care for themselves. The cells that line our lungs, nose, brain and reproductive system have cilia, which are tiny, hair-like structures designed to sweep out fluids, cells and microbes to stay healthy. But the mechanisms behind their motion are not well understood. The team of researchers (clockwise, from […]

Rineys give $15 million to develop, test therapies for neurodegenerative diseases

Washington University School of Medicine in St. Louis has received a $15 million gift from Paula and Rodger Riney aimed at accelerating research and developing new treatments for two major neurodegenerative diseases: Alzheimer’s disease and Parkinson’s disease. Of the gift, $10 million will support Alzheimer’s disease research, while $5 million will support studies of Parkinson’s […]

Washington People: Robert Gereau

Not too long after he started working in academic medicine, Robert W. Gereau IV, PhD — then on the faculty at Baylor College of Medicine in Houston — accepted an invitation to lecture about his work to doctors and scientists at the Washington University Pain Center. His research and training involved cellular changes in the brain in response […]

WashU weekly Neuroscience publications

“Regeneration associated transcriptional signature of retinal microglia and macrophages” (2019) Scientific Reports Regeneration associated transcriptional signature of retinal microglia and macrophages (2019) Scientific Reports, 9 (1), art. no. 4768, .  Mitchell, D.M.a , Sun, C.a b , Hunter, S.S.c , New, D.D.c , Stenkamp, D.L.a a Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States b Ophthalmology, Washington University in […]

Paul Taghert to be Interim Head, Department of Neuroscience

Dear School of Medicine Community, It is a pleasure for me to announce that Paul Taghert, PhD, has accepted the position of interim head of the Department of Neuroscience and will start in the role on July 1, 2019. Paul is professor of neurobiology and an exceptionally well-respected member of our faculty since establishing his […]

Lisa Tabor Connor to be next executive director of the Program in Occupational Therapy

Dear Faculty, Staff and Students: I am pleased to announce that Lisa Tabor Connor, PhD, has accepted our offer to become the next executive director of the Program in Occupational Therapy, beginning July 1, 2019. Dr. Connor is currently professor and chair of the Department of Occupational Therapy and associate director of research programs at […]

Cannabis during pregnancy bumps psychosis risk in offspring

Pregnant women who use cannabis may slightly increase the risk their unborn child will develop psychosis later in life, suggests new research from Washington University in St. Louis. Fine “Our research shows that prenatal marijuana exposure after maternal knowledge of pregnancy is associated with a small increase in psychosis proneness during middle childhood or about […]

WashU weekly Neuroscience publications

“Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice” (2019) Scientific Reports Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice (2019) Scientific Reports, 9 (1), art. no. 4379, . Wozniak, D.F., Valnegri, P., Dearborn, J.T., Fowler, S.C., Bonni, A. Document Type: Article Publication Stage: Final Source: Scopus Access Type: Open Access “A […]

Bateman receives Potamkin Award for Alzheimer’s research

Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, has been awarded the Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases. He will receive the award May 6 at the American Academy of Neurology’s annual meeting in Philadelphia. Sometimes […]

WashU weekly Neuroscience publications

“The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection” (2019) Journal of Memory and Language The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection (2019) Journal of Memory and Language, 106, pp. 77-94.  Maddox, G.B.a , Balota, D.A.b , Kumar, A.A.b , Millar, P.R.b , Churchill, L.b a Department of […]

Kefalov receives Bressler Prize for vision research

Vladimir Kefalov, PhD, a professor of ophthalmology and visual sciences, has beenawarded the 2019 Bressler Prize by the Lighthouse Guild, an organization dedicated to reducing the burden of living with vision loss. Established in 2001, the Bressler Prize recognizes mid-career vision scientists whose leadership, research and service have led to substantive advancements in the understanding […]

Blunting pain’s emotional component

Chronic pain involves more than just hurting. People suffering from pain often experience sadness, depression and lethargy. That’s one reason opioids can be so addictive — they not only dampen the pain but also make people feel euphoric. What if it were possible to develop a pain killer that could curb the negative emotions associated […]

Mobile phone technology to screen, help treat college students

A research team led by Washington University School of Medicine in St. Louis has received a five-year, $3.8 million grant to evaluate the use of smartphones in treating psychiatric problems that are common among college students. “Not enough services are available to meet the mental health needs of students on college campuses,” said principal investigator Denise […]

Doctors address mental health crisis among Rohingya refugees

COX’S BAZAR DISTRICT, Bangladesh — A 12-year-old Rohingya boy flatly, stoically tells of how, within three hours one day in August 2017, the Myanmar military murdered 56 members of his family in their village in western Myanmar. Of his immediate family, his parents and three sisters were slain; only he and his brothers — ages […]

Wash U Researchers Discuss Latest Findings About Suicidal Ideation Among Children, Young People

A study released this week by the National Institutes of Health indicates that nearly one-third of Americans between the ages of 10 and 12 “screened positive for suicide risk in emergency department settings.” Meanwhile, researchers at Washington University School of Medicine have been studying even younger children who think and talk about suicide – and their […]

$10 million to help study noise-induced hearing loss

Researchers at Washington University School of Medicine in St. Louis have received $10.5 million from the Department of the Army to investigate whether an anti-seizure drug can prevent noise-induced hearing loss when given several hours before exposure to extremely loud noise. Loud noise that can permanently damage hearing is a common hazard, whether that noise […]

WashU weekly Neuroscience publications

“Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits” (2019) Scientific Reports Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits (2019) Scientific Reports, 9 (1), art. no. 2779, .  Maloney, S.E.a d f , Yuede, C.M.a b , […]

Grad students Essuman, Mitra awarded 2019 O’Leary Prize

Congratulations to the 2019 winners of the James L. O’Leary Prize for Excellence in Neuroscience Research! Kow Essuman MD/PhD candidate Milbrandt Lab Anish Mitra MD/PhD candidate Raichle Lab Winners were selected based on presentations by graduate student and post doc finalists at the March 5, 2019 competition.  Each winner receives a $1000 prize.  For more […]

Young kids with suicidal thoughts understand concept of death

Depressed children ages 4 to 6 who think and talk about committing suicide understand what it means to die better than other kids, according to new research at Washington University School of Medicine in St. Louis. Such children with suicidal thoughts and words — what psychiatrists call suicidal ideation — were more than three times […]

WashU weekly Neuroscience publications

“Correction to: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language (Nature Communications, (2018), 9, 1, (4619), 10.1038/s41467-018-06014-6)” (2019) Nature Communications Correction to: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language (Nature Communications, (2018), 9, 1, (4619), 10.1038/s41467-018-06014-6) (2019) Nature Communications, 10 (1), art. no. 883, .  Blok, […]

A new method for precision drug delivery: painting

If traditional drug delivery were a type of painting, it might be akin to paintball. With good aim, a majority of the paint ends on the bullseye, but it also drips and splashes, carrying streams of paint across the target. If the drug needs to enter the bloodstream and circulate throughout your body for treating […]

Computational biology project aims to better understand protein folding

When Greg Bowman presents a slideshow about the proteins he studies, their 3D shapes and folding patterns play out as animations on a big screen. As he describes these molecules, it might be easy to miss the fact that he can’t really see his own presentation, at least not the way the audience does. Bowman, […]

WashU weekly Neuroscience publications

“Predicting Alzheimer’s disease progression using multi-modal deep learning approach” (2019) Scientific Reports Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) Scientific Reports, 9 (1), art. no. 1952, .  Lee, G.a b , Nho, K.c d , Kang, B.a , Sohn, K.-A.a , Kim, D.b e , Weiner, M.W.f , Aisen, P.g , Petersen, R.h , Jack, C.R., Jr.h , […]

Wang named Loewentheil Distinguished Professor

Ting Wang, PhD, whose work sits at the intersection of biology and computer science, has been named the inaugural Sanford C. and Karen P. Loewentheil Distinguished Professor of Medicine at Washington University School of Medicine in St. Louis. Wang was installed by Washington University Chancellor Mark S. Wrighton and David H. Perlmutter, MD, executive vice […]

Hong Chen receives $1.6 million grant from the NIH’s National Institute of Biomedical Imaging and Bioengineering

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $1.6 million grant from the National Institutes of Health (NIH)’s National Institute of Biomedical Imaging and Bioengineering. The research will fund a broader understanding of Chen’s earlier work combining intranasal drug delivery […]

Needlemans commit $15 million aimed at therapies for chronic diseases

Washington University School of Medicine in St. Louis has received a $15 million commitment from longtime benefactors Philip and Sima Needleman to support two cutting-edge research centers aimed at developing new treatments for diseases that collectively affect millions. The Needlemans have a long relationship with the university; Philip served as head of the former Department […]

Yi awarded Sloan Research Fellowship

Jason Yi, PhD, an assistant professor of neuroscience at Washington University School of Medicine in St. Louis, has received a prestigious 2019 Sloan Research Fellowship, which supports promising early-career scientists. Yi studies how genetic variations perturb key developmental programs in neuronal development, leading to neurological disorders such as intellectual disability and autism. Yi is one […]

WashU weekly Neuroscience publications

“Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles” (2019) Channels (Austin, Tex.) Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles (2019) Channels (Austin, Tex.), 13 (1), pp. 72-87.  Wang, W.a , Mellor, R.L.a , Nerbonne, J.M.a b , Balke, C.W.a […]

School of Medicine expands mission of McDonnell Genome Institute

The McDonnell Genome Institute at Washington University School of Medicine in St. Louis is entering a new era of genomic medicine, expanding its capacities beyond genome sequencing and adding a new and vital focus on understanding how genetics influences health and disease. Jeffrey Milbrandt, MD, PhD, recently appointed executive director of the McDonnell Genome Institute, says the […]

WashU weekly Neuroscience publications

“Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease” (2019) Stroke Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease (2019) Stroke, 50 (2), pp. 266-273.  Guilliams, K.P.a b , Fields, M.E.b , Dowling, M.M.c a From the Department of Neurology (K.P.G.), Washington University School […]

Nerve transfer surgery gives hope to children with rare paralyzing illness

At Brandon Noblitt’s first appointment with Washington University surgeon Amy Moore, MD, a year ago, he was barely able to walk, mostly using a wheelchair to get around. Only 6 years old at the time, Brandon had come down with a cold. A week later, he was unable to move his right arm and leg. “One […]

Bauer awarded $2.1 million grant from the National Institutes of Health (NIH)’s NINDS

Adam Q. Bauer, assistant professor of radiology at the School of Medicine, received a $2.1 million grant from the National Institutes of Health (NIH)’s National Institute of Neurological Disorders and Stroke for a research project titled “Optogenetic Mapping of Cell Specific Connections in the Mouse Brain After Stroke.” Stroke is the leading cause of adult […]

Soranno receives grant from the Alzheimer’s Association

Andrea Soranno, assistant professor of biochemistry and molecular biophysics at the School of Medicine, received a three-year, $150,000 research grant from the Alzheimer’s Association for his work titled “Conformational analysis of ApoE isoforms and their role in AD mechanism.” Read more.

Less anesthesia during surgery doesn’t prevent post-op delirium

Many older adults who have major surgery experience postoperative delirium in the days after their operations. Previous research has suggested that closely monitoring the brain during surgery and making adjustments to protect the brain from too much anesthesia could reduce risk of postoperative delirium. But in a new study of more than 1,200 older surgical […]

Scans Show Women’s Brains Remain Youthful As Male Brains Wind Down

From NPR’s All Things Considered… Women tend to have more youthful brains than their male counterparts — at least when it comes to metabolism. While age reduces the metabolism of all brains, women retain a higher rate throughout the lifespan, researchers reported Monday in the journal Proceedings of the National Academy of Sciences. “Females had a younger brain […]

Women’s brains appear three years younger than men’s

Time wears differently on women’s and men’s brains. While the brain tends to shrink with age, men’s diminish faster than women’s. The brain’s metabolism slows as people grow older, and this, too, may differ between men and women. A new study from Washington University School of Medicine in St. Louis finds that women’s brains appear […]

WashU weekly Neuroscience publications

“Neuronal evidence for good-based economic decisions under variable action costs” (2019) Nature Communications Neuronal evidence for good-based economic decisions under variable action costs (2019) Nature Communications, 10 (1), art. no. 393, .  Cai, X.a b c d , Padoa-Schioppa, C.a e f a Department of Neuroscience, Washington University in St Louis, St Louis, MO 63110, United States b NYU Shanghai, 1555 Century Avenue, […]

Why it’s key to identify preschoolers with anxiety and depression

New research shows these kids have mental and physical problems as they grow older From Science News… …Maybe, says Joan Luby, a psychiatrist at the Washington University School of Medicine in St. Louis. Luby’s research has shown that treating preschoolers with depression helps the youngsters feel joy again, at least in the short term. “When […]

Silva, Ramani chosen as Inaugural WashU Faculty Fellows in Entrepreneurship

From the WashU Office of the Vice Chancellor for Research… Jennifer Silva, MD, associate professor of Pediatrics and Vijay Ramani, PhD, the  Roma B. & Raymond H. Wittcoff Professor of Energy, Environmental & Chemical Engineering have been selected as the inaugural entrepreneurial faculty fellows. These individuals advise WashU faculty and small companies founded by WashU personnel […]

WashU weekly Neuroscience publications

“Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury” (2019) Neurosurgery Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury (2019) Neurosurgery, 84 (2), pp. 362-377.  Khalifeh, J.M.a , Dibble, […]

Just One Night Of Sleep Loss Can Affect Body And Mind, Studies Find

From Forbes… Brains do a lot of work while we sleep—far from being a passive behavior, sleep is actually critical to brain health, and as a result, mental and cognitive health. A few new studies in recent weeks underline how important sleep is, and how detrimental lack of sleep can be. And not just chronic […]