WashU weekly Neuroscience publications

“Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling” (2019) Current Opinion in Neurobiology Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling (2019) Current Opinion in Neurobiology, 59, pp. 59-68.  Goodman, J.V.a b , Bonni, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Medical Scientist Training Program, Washington […]

Powderly to lead Institute of Clinical and Translational Sciences

William G. Powderly, MD, the Dr. J. William Campbell Professor of Medicine at Washington University School of Medicine in St. Louis, has been named director of the university’s Institute of Clinical and Translational Sciences (ICTS). The institute is funded by the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). […]

$9.5 million aimed at detecting autism earlier in childhood

A multicenter research team led jointly by Washington University School of Medicine in St. Louis and the University of North Carolina at Chapel Hill has received a five-year, $9.5 million grant to further evaluate whether brain imaging can help detect very high risk of autism spectrum disorder in early infancy. Researchers believe that if they […]

Imai awarded $1.6M from NIH’s National Institute on Aging

Shin-ichiro Imai, MD, PhD, professor of developmental biology at the School of Medicine, received a five-year, $1.6 million grant from the National Institute on Aging of the National Institutes of Health (NIH) for his project titled “eNAMPT-mediated adipo-hypothalamic communication for NAD+ production and aging.” Read more.

Michael Nelson to be Interim Head, Department of Obstetrics and Gynecology

Dear Colleagues, I am writing to let you know that D. Michael Nelson, MD, PhD, the Virginia S. Lang Professor of Obstetrics and Gynecology, has graciously agreed to serve as Interim Head of the Department of Obstetrics and Gynecology and he will start in the role on Monday June 3, 2019. George Macones, MD, MSCE, […]

Academy of Science-St. Louis honors faculty

The Academy of Science-St. Louis recently honored Washington University in St. Louis Chancellor Mark S. Wrighton for his leadership in science and three researchers at the School of Medicine for their work as outstanding scientists. The medical school faculty honored were Susan K. Dutcher, professor of genetics and of cell biology and physiology; Anne M. […]

WashU weekly Neuroscience publications

“Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms” (2019) Nature Communications Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms (2019) Nature Communications, 10 (1), art. no. 2246, .  Li, P.a , Marshall, L.a , Oh, G.b , Jakubowski, J.L.a , Groot, D.b , He, Y.c , Wang, […]

Metcalfe gift supports study of adversity’s effects on children’s brains

Compelled by the potential to improve the lives of vulnerable children, emeritus trustee Walter Metcalfe Jr. and his wife, Cynthia, have made a commitment of nearly $4 million through outright and estate gifts to support the work of Joan L. Luby, MD, a highly regarded child psychiatrist at Washington University School of Medicine in St. […]

Perlmutter receives Spirit of Hope Award

David H. Perlmutter, MD, executive vice chancellor for medical affairs and the George and Carol Bauer Dean of Washington University School of Medicine in St. Louis, has received the Christopher Hobler Spirit of Hope Award in recognition of his advocacy for neurological research. The award was presented April 25 by the nonprofit organization Hope Happens. […]

Students with sickle cell disease stay on track with help from St. Louis Children’s Hospital

Brandon Gardner graduated Friday on schedule with his class from Trinity Catholic High School in north St. Louis County. The rite of passage wasn’t always a certainty for Gardner, 18, who was born with sickle cell disease and has endured various complications including infections and chronic pain throughout childhood. In March of his junior year, […]

E3 Nutrition Lab Links Child Nutrition, Economics and Evolution

A transdisciplinary laboratory at the Brown School is undertaking research across the world to address “hidden hunger”— poverty-related nutritional deficiencies in mothers and young children. The founder and director of the E3 Nutrition Lab is Lora Iannotti, associate professor and associate dean for public health. The three “E”s represent the lab’s principles for nutrition interventions: […]

WashU weekly Neuroscience publications

“Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power” (2019) NeuroImage Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power (2019) NeuroImage, 197, pp. 435-438.  Glasser, M.F.a b c , Coalson, T.S.a , Bijsterbosch, J.D.d , Harrison, S.J.d e , Harms, M.P.f , Anticevic, A.g , Van […]

Creative workshops help kids relieve stress with art

Few, if any, of the children, teenagers and adults considered themselves artists. But then there were two women, smiling, encouraging their creativity, calling them “artists.” The women understood preoccupations persisted far different than art: Many of the young people struggled with difficult circumstances. Some worried about unstable family and home lives, or about getting in […]

Avidan named head of anesthesiology

Michael S. Avidan, MBBCh, has been named head of the Department of Anesthesiology at Washington University School of Medicine in St. Louis. In that position, he also will become anesthesiologist-in-chief at Barnes-Jewish Hospital. Avidan will begin in his new role July 1. Avidan currently is the Dr. Seymour and Rose T. Brown Professor of Anesthesiology at the […]

WashU weekly Neuroscience publications

“Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8)” (2019) Scientific Reports Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8) (2019) Scientific Reports, 9 (1), art. no. 6400, .  Guo, P.a , Yu, Y.b […]

Neuroscientists Peer Into The Mind’s Eye

It sounds like a sci-fi plot: Hook a real brain up to artificial intelligence, and let the two talk to each other. That’s the design of a new study in the journal Cell, in which artificial intelligence networks displayed images to monkeys, and then studied how the monkey’s neurons responded to the picture. The computer network could then […]

Colonna, Ley elected to National Academy of Sciences

Two physician-scientists at Washington University School of Medicine in St. Louis are among the 100 new members and 25 foreign associates elected to the National Academy of Sciences this year. Election to the academy — which was announced Tuesday, April 30 — is considered one of the highest honors that can be awarded to a U.S. scientist […]

Newfound autoimmune syndrome causes muscle pain, weakness

A previously unknown autoimmune muscle disease involving sudden onset of debilitating muscle pain and weakness has been identified by researchers at Washington University School of Medicine in St. Louis. The syndrome easily could be mistaken for other muscle diseases that require different treatment, so the findings are expected to help physicians treat patients appropriately, the […]

Physical therapy association honors Earhart

Gammon Earhart, PhD, director of the Program in Physical Therapy at Washington University School of Medicine in St. Louis, has been named a Catherine Worthingham Fellow of the American Physical Therapy Association. The award, the association’s highest honor, serves as an inspiration for physical therapists to attain professional excellence and recognizes physical therapists who have demonstrated unwavering […]

Experimental treatment could be ‘game-changing’ for genetic ALS, experts say

An experimental treatment for the rapidly progressive disease ALS, or amyotrophic lateral sclerosis, has been called potentially “game-changing.” The treatment, called tofersen, was found to slow the decline of muscular function associated with a genetic form of ALS in a study to be presented next week at the annual meeting of the American Academy of […]

Zipfel named head of neurosurgery

Gregory J. Zipfel, MD, a noted expert on aneurysms and other disorders of blood vessels in the brain, has been named head of the Department of Neurosurgery at Washington University School of Medicine in St. Louis. Zipfel also will become neurosurgeon-in-chief at Barnes-Jewish Hospital. He will begin his new roles July 1. David H. Perlmutter, MD, executive vice […]

Michael Avidan named head of anesthesiology

Dear Faculty, Staff and Students, With great pleasure, I am writing to you to announce that Dr. Michael Avidan has accepted the position of head of the Department of Anesthesiology, effective July 1. Michael is currently the Dr. Seymour and Rose T. Brown Professor of Anesthesiology, a professor of surgery, chief of the Division of […]

Perlmutter named scientific director of dystonia foundation

Joel S. Perlmutter, MD, the Elliot H. Stein Family Professor of Neurology at Washington University School of Medicine in St. Louis, has been named scientific director of the Dystonia Medical Research Foundation. Dystonia is a neurological disorder that causes excessive, involuntary muscle contractions and abnormal postures. An expert on Parkinson’s disease and related movement disorders […]

Wearable motion detectors identify subtle motor deficits in children

A wristwatch-like motion-tracking device can detect movement problems in children whose impairments may be overlooked by doctors and parents, according to a new study from Washington University School of Medicine in St. Louis. The findings, published April 26 in JAMA Network Open, could help identify children with subtle motor impairments so they can be treated […]

Pregnancy shifts the daily schedule forward

Add this to the list of what to expect: Getting up earlier, at least in the first trimester. New research from Washington University in St. Louis finds that women and mice both shift their daily schedules earlier by up to a few hours during the first third of their pregnancy. A new study by researchers […]

Cashen Named IRB Executive Chair

Dear Colleagues, We are delighted to announce Amanda Cashen, MD has accepted the positon of IRB Executive Chair for Washington University. Amanda previously served as the Interim IRB Executive Chair following Dr. Jonathan Green’s departure this past October. Dr. Cashen, Associate Professor of Medicine in the Division of Oncology, Section of Stem Cell Transplant/Leukemia, has […]

Gutmann receives $900K from Gilbert Family Foundation

David Gutmann, MD, the Donald O. Schnuck Professor of Neurology at the School of Medicine, has received a three-year, $900,000 grant from the Gilbert Family Foundation to study ways to restore sight to patients with neurofibromatosis type 1. Read more.

WashU weekly Neuroscience publications

“Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry” (2019) Scientific Reports Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry (2019) Scientific Reports, 9 (1), art. no. 6010, .  Lugar, H.M.a , Koller, J.M.a , Rutlin, J.a , Eisenstein, S.A.a , Neyman, O.a , Narayanan, A.a , Chen, L.c , Shimony, J.S.b , Hershey, […]

Lithium boosts muscle strength in mice with rare muscular dystrophy

Standing up from a chair, climbing stairs, brushing one’s hair – all can be a struggle for people with a rare form of muscular dystrophy that causes progressive weakness in the shoulders and hips. Over time, many such people lose the ability to walk or to lift their arms above their heads. This form of […]

Researchers receive $3 million to study how adversity affects offspring’s health

Washington University in St. Louis psychology researchers Ryan Bogdan and Thomas Oltmanns received a federal grant totaling more than $3 million to study how adversity may perpetuate racial health disparities and health outcomes within families. The National Institutes of Health (NIH)’s National Institute on Aging is providing the funding, spread over five years. Despite growing evidence […]

Ornitz receives grant from National Institutes of Health

David Ornitz, MD, PhD, the Alumni Endowed Professor of Developmental Biology, received a two-year, $456,853 grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH) for his project titled “Signaling mechanisms and mouse models for insulin-mediated pseudoacromegaly.” Read more.

WashU weekly Neuroscience publications

“The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF)” (2019) Journal of Psychiatric Research The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF) (2019) Journal of Psychiatric Research, 113, pp. 125-136.  Sackeim, H.A.a , Aaronson, S.T.b , Bunker, M.T.c , Conway, C.R.d , […]

Kepecs named BJC investigator

Adam Kepecs, PhD, recognized internationally for his research on neural circuits responsible for cognition and decision-making, has been named a BJC Investigator and a professor of neuroscience and psychiatry at Washington University School of Medicine in St. Louis. The BJC Investigators Program recruits to the School of Medicine scientists who bring innovative approaches to address […]

The Sleep-Dementia Connection

Among the many things that can shatter when Alzheimer’s disease tightens its grip is the steady rhythm of the body’s sleep-wake cycle. The problem is so common that one New York City nursing facility—the Hebrew Home at Riverdale—ran an all-night program for many years that took in afflicted community members for a dusk-to-dawn schedule of […]

Clinical fellow Findlay, grad student Rosenthal receive 2019 Hope Center Awards

Each year, the Hope Center for Neurological Disorders recognizes investigators who are early in their training and whose work best fulfills the mission of the Hope Center: To improve the lives of people living with neurological disorders, through collaborative research that aims to discover fundamental mechanisms of neurodegeneration and repair, and translate that new understanding into […]

WashU weekly Neuroscience publications

“The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain” (2019) Nature Communications The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain (2019) Nature Communications, 10 (1), art. no. 1417, .  Karolis, V.R., Corbetta, M., Thiebaut de Schotten, M. Abstract Functional lateralisation is a fundamental principle of the human brain. […]

Tang, Braver receive grant from NIH’s National Center for Complementary and Integrative Health

Catherine Tang, a graduate student working with Todd Braver, professor of psychological and brain sciences in Arts & Sciences, received a $39,000 grant from the National Institutes of Health (NIH)’s National Center for Complementary and Integrative Health for a project titled “Examining mindfulness training effects and mechanisms on cognitive control.” Read more.

Centene and Washington University collaborate to advance personalized medicine research

Centene Corp. and Washington University School of Medicine in St. Louis announced Monday, April 8, a partnership to transform and accelerate research into treatments for Alzheimer’s disease, breast cancer, diabetes and obesity. All are common, debilitating and often deadly diseases that affect millions of people worldwide, at all levels of income. As part of the […]

$10 million gift aimed at improving treatments for mental illness

Philanthropists Andrew and Barbara Taylor and the Crawford Taylor Foundation have committed $10 million to Washington University School of Medicine in St. Louis to continue research to investigate the scientific underpinnings of psychiatric illnesses, with the goal of improving diagnosis and treatment. The new gift will support the Taylor Family Institute for Innovative Psychiatric Research, established […]

WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Connor named head of occupational therapy program

Lisa Tabor Connor, PhD, noted for her extensive research into recovery from stroke, will be the next executive director of the Program in Occupational Therapy at Washington University School of Medicine in St. Louis. She will begin her new role July 1. Connor currently is chair of the Department of Occupational Therapy and associate director of research […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

‘Jumping genes’ drive many cancers

Mistakes in DNA are known to drive cancer growth. But a new study, from Washington University School of Medicine in St. Louis, heavily implicates a genetic phenomenon commonly known as “jumping genes” in the growth of tumors. The study is published March 29 in the journal Nature Genetics. Since jumping genes aren’t mutations — mistakes […]

Academy of Science – St. Louis 25th Annual Outstanding Scientists Awards

Since its inception, the Academy has promoted the recognition of the impressive scientists of St. Louis. This tradition continues with the 25th Annual Outstanding St. Louis Scientists Awards. Each award-winner represents an extraordinary caliber of expertise. We wish to focus the region’s attention upon individuals, institutions and corporations known worldwide for their scientific contributions to […]

Making waves: Researchers shed light on how cilia work

Human bodies have some built-in systems to care for themselves. The cells that line our lungs, nose, brain and reproductive system have cilia, which are tiny, hair-like structures designed to sweep out fluids, cells and microbes to stay healthy. But the mechanisms behind their motion are not well understood. The team of researchers (clockwise, from […]

Rineys give $15 million to develop, test therapies for neurodegenerative diseases

Washington University School of Medicine in St. Louis has received a $15 million gift from Paula and Rodger Riney aimed at accelerating research and developing new treatments for two major neurodegenerative diseases: Alzheimer’s disease and Parkinson’s disease. Of the gift, $10 million will support Alzheimer’s disease research, while $5 million will support studies of Parkinson’s […]

Washington People: Robert Gereau

Not too long after he started working in academic medicine, Robert W. Gereau IV, PhD — then on the faculty at Baylor College of Medicine in Houston — accepted an invitation to lecture about his work to doctors and scientists at the Washington University Pain Center. His research and training involved cellular changes in the brain in response […]

WashU weekly Neuroscience publications

“Regeneration associated transcriptional signature of retinal microglia and macrophages” (2019) Scientific Reports Regeneration associated transcriptional signature of retinal microglia and macrophages (2019) Scientific Reports, 9 (1), art. no. 4768, .  Mitchell, D.M.a , Sun, C.a b , Hunter, S.S.c , New, D.D.c , Stenkamp, D.L.a a Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States b Ophthalmology, Washington University in […]

Paul Taghert to be Interim Head, Department of Neuroscience

Dear School of Medicine Community, It is a pleasure for me to announce that Paul Taghert, PhD, has accepted the position of interim head of the Department of Neuroscience and will start in the role on July 1, 2019. Paul is professor of neurobiology and an exceptionally well-respected member of our faculty since establishing his […]