Discussing WIPs and recent papers in aging biology and age-associated disease

If you have questions or would like to be added to the mailing list, please contact Virginia Hsu or Cecilia Lei. All are welcome to attend!

When: 12pm, Thursdays bi-weekly
Where: Farrell LTC 304 (Medical Campus)
OrganizersVirginia Hsu (Graduate student, Neuroscience Program), Cecilia Lei (Graduate student, Molecular Genetics & Genomics Program)

Note individual events are listed on the ONR Calendar.

2024 Spring Schedule

We need presenters for the spring semester!

If you have a WiP or paper you’d like to share, please sign up on the spreadsheet here. There is also a list of interesting papers covering a wide range of topics in the field of aging / age-associated diseases that you are welcome to choose from. 

January 25, 2024

Virginia Hsu (Imai lab, WashU Developmental Biology)

“Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice” Cell Metabolism (2023)

CANCELLED February 8, 2024

February 22, 2024 – NOTE location: Couch 4001B

Prashant Kuntala (Wang lab, WashU Genetics)

Thesis Proposal brainstorming: “Epigenetic Determinants of Exceptional Longevity in Humans

March 7, 2024

Logan Thrasher Collins (Curiel lab, WashU Radiation Oncology)

WiP: “Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy’s neutralizing antibody problem”

March 21, 2024

Thomas Mahan (Yoo lab, WashU Developmental Biology)

“Developing human cell based models of Alzheimer disease in Trisomy 21”

April 4, 2024

Yudong Ren (Yoo lab, WashU Developmental Biology)

April 18, 2024

May 2, 2024

May 16, 2024

Ruiyi Tian (Vagelos DBBS Biomedical Informatics and Data Science Program)

Practice Talk: “Accelerated aging and early-onset GI cancer”

If you have a WiP or paper you’d like to share, please sign up on the spreadsheet here

2023 Schedule
March 9, 2023

Brian Lananna (Imai lab, WashU Pathology & Immunology)

“Loss of epigenetic information as a cause of mammalian aging” Cell 2023

March 23, 2023

Christian Suarez (Weihl lab, WashU Neurology)

“Epigenetic regulation of proteasome activity” (QE practice)

April 6, 2023

Reed Trende (Boon lab, WashU Immunology)

“Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing” Nature Cell Biology 2023

April 20, 2023

Virginia Hsu (Imai lab, WashU Developmental Biology)

“Ageing-associated changes in transcriptional elongation influence longevity” (Science 2023)

May 4, 2023

Kyohei Tokizane (Imai lab, WashU Developmental Biology)

“Hypothalamic Menin regulates systemic aging and cognitive decline” PLoS Biology (2023)

May 18, 2023

Prashant Kuntala (Wang lab, WashU Genetics)

QE Practice

“Understanding the Role of DNA methylation of Transposable Elements in Exceptional Longevity”

June 1, 2023

Jason Colasanti (Apte lab, WashU Ophthalmology & Visual Sciences)

“The role of miR-34a in age-related macular degeneration”

June 29, 2023

Thomas Mahan (Yoo lab, WashU Developmental Biology)

“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain” Molecular Psychiatry (2021)

July 13, 2023

Kentaro Mori (Imai lab, WashU Developmental Biology)

WiP: “Anti-aging effects of novel myokine via inter-tissue communication”

July 27, 2023

Yudong Ren (Yoo lab, WashU Developmental Biology)

WiP (QE): “Elucidating the mechanism of neuroprotective role of Lamivudine (3TC) on late-onset Alzheimer’s reprogrammed cortical neuronsAnti-aging effects of novel myokine via inter-tissue communication”

September 21, 2023

Wangchao Xu (Kipnis lab, WashU Pathology & Immunology)

WiP: “A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan”

October 5, 2023

Prashant Kuntala (Wang lab, WashU Genetics)

“Profiling epigenetic age in single cells” Nature Aging (2021)

October 19, 2023

Brian Lananna (Imai lab, WashU Developmental Biology)

“Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease” Cell Metabolism (2023)

November 2, 2023

Ena Haseljic (Vagelos DBBS Molecular Genetics & Genomics Program)

QE practice: “Investigating neuronal activity-dependent DNA repair”

November 16, 2023

Cecilia Lei (Imai lab, WashU Developmental Biology)

“Taurine deficiency as a driver of aging” Science (2023)