The Ion Channels Journal Club explores recent publications in ion channel and excitability research, from fundamental mechanisms to disease.
Explore the archives below.
CANCELLED – September 20, 2021
Erik Nolan (Ben-Shahar lab, WashU Biology)
September 27, 2021
Mark Arcario (Cheng lab, WashU Anesthesiology)
“A Streamlined, General Approach for Computing Ligand Binding Free Energies and Its Application to GPCR-Bound Cholesterol” J. Chem. Theory Comput. (2018)
October 11, 2021
Juan Hong (Sah lab, WashU Medicine)
“The Mechanosensitive Piezo1 Channel Mediates Heart Mechano-chemo Transduction” Nature Communications (2021)
October 18, 2021
Nicole Migotsky (Silva lab, WashU Orthopaedic Surgery)
“Mechanosensitive Ca2+ Signaling and Coordination is Diminished in Osteocytes of Aged Mice During Ex Vivo Tibial Loading” Connective Tissue Research (2020)
CANCELLED – October 25, 2021
Nathan Zelt (Robertson lab, WashU Biochemistry and Molecular Biophysics)
November 8, 2021
Kaitlyn Broz (Tang lab, WashU Orthopaedic Surgery)
“Mechanotransduction Via the Piezo1-Akt Pathway Underlies Sost Suppression in Osteocytes” Biochemical and Biophysical Research Communications (2020)
CANCELLED – November 15, 2021
Sudlow Lee (Berezin lab, WashU Radiology)
November 22, 2021
Vinaykumar Idikuda (Chanda lab, WashU Anesthesiology)
“Single-Molecule Imaging With Cell-Derived Nanovesicles Reveals Early Binding Dynamics at a Cyclic Nucleotide-Gated Ion Channel” Nature Communications (2021)
November 29, 2021
Bridget Matikainen-Ankney (Kravitz lab, WashU Psychiatry)
“Diet-induced Obesity Enhances Prelimbic Inputs Onto Accumbal D1-SPNs and Increases Effort of Food Seeking”
December 13, 2021
Jonathan Mount (Yuan lab, WashU Cell Biology & Physiology)
“Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK” Molecular Microbiology (2007)
CANCELLED – December 20, 2021
Verena Burtscher (Chanda lab, WashU Anesthesiology)
April 25, 2022
Alex Hanson (Nichols lab, WashU Cell Biology and Physiology)
“STIM1-Dependent Peripheral Coupling Governs the Contractility of Vascular Smooth Muscle Cells” eLife (2022)
August 17, 2020
Jian Gao (Nichols lab, WashU Cell Biology and Physiology)
- Supplemental publication: “A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating”. Neuron, . 2008
August 24, 2020
Conor McClenaghan (Nichols lab, WashU Cell Biology and Physiology)
“A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans” Current Biology 2020
- Supplementary publication: “Endogenous Opioids Contribute to Insensitivity to Pain in Humans and Mice Lacking Sodium Channel Nav1.7”. Nature Communications 2015
September 14, 2020
Sunjoo Lee (Nichols lab, WashU Cell Biology & Physiology)
“Site-Specific Incorporation of Two ncAAs for Two-Color Bioorthogonal Labeling and Crosslinking of Proteins on Live Mammalian Cells” Cell Reports 2020
September 21, 2020
Nathan York (Nichols lab, WashU Cell Biology & Physiology)
“Enhanced Expression of β Cell CaV3.1 Channels Impairs Insulin Release and Glucose Homeostasis” PNAS 2020
September 28, 2020
Yihao Jiang (Chanda lab, WashU Anesthesiology)
“Structure of the Human Sodium Leak Channel NALCN” Nature (2020)
October 12, 2020
John Petroff (Cheng lab, WashU Anesthesiology)
“Shared Structural Mechanisms of General Anaesthetics and Benzodiazepines” Nature (2020)
October 19, 2020
Mimi Guo (Huebsch lab, WashU Biomedical Engineering)
“Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes” Nature Communications (2020)
October 26, 2020
Kathryn Mangold (Silva lab, WashU Biomedical Engineering)
“Predicting Functional Effects of Missense Variants in Voltage-gated Sodium and Calcium Channels” Science Translational Medicine (2020)
November 9, 2020
Zhihui He (Yuan lab, WashU Cell Biology and Physiology)
“Structural Basis for pH Gating of the Two-pore Domain K+ Channel TASK2” Nature (2020)
November 16, 2020
Ryan Bitter (Yuan lab, WashU Cell Biology and Physiology)
“Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport” Biophysical Journal (2016)
November 23, 2020
Vinay Idikuda (Chanda lab, WashU Anesthesiology)
“CNGA3 Acts as a Cold Sensor in Hypothalamic Neurons” eLife (2020)
November 30, 2020
Ashutosh Kumar (Sah lab, WashU Medicine)
“PIEZO2 in sensory neurons and urothelial cells coordinates urination” Nature 2020
December 14, 2020
Daniel Simmons (Huebsch lab, WashU Biomedical Engineering)
“Human Induced Pluripotent Stem Cell–Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers” Circulation: Arrhythmia and Electrophysiology (2018)
December 21, 2020
Willy Carrasquel (Chanda lab, WashU Anesthesiology)
“Viral rhodopsins 1 are an unique family of light-gated cation channels” Nature Communications (2020)
January 11, 2021
Maximilian Lyon (Santi lab, WashU Obstetrics and Gynecology)
“3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice” eLife (2020)
January 25, 2021
Rob Tryon (Nichols lab, WashU Cell Biology and Physiology)
February 8, 2021
Suhaila Rahman (Yuan lab, WashU Cell Biology and Physiology)
“Gating by Ionic Strength and Safety Check by Ciclic-di-AMP in the ABC Transporter OpuA” Science Advances (2020)
CANCELLED – February 15, 2021
Anthony Frosio (Nerbonne lab, WashU Medicine)
CANCELLED – February 22, 2021
Jenna Lin (Chanda lab, WashU Anesthesiology)
For Zoom information contact Paula Reynolds.
March 8, 2021
Satyanarayana Murthy Chintala (Evers lab, WashU Anesthesiology)
“Selection of DNA-Encoded Chemical Libraries Against Endogenous Membrane Proteins on Live Cells” Nature Chemistry (2020)
March 15, 2021
Remy Walk (Tang lab, WashU Orthopaedic Surgery)
“Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration” Cell Proliferation (2020)
CANCELLED – March 22, 2021
Sarah Clippinger (Greenberg lab, WashU Biochemistry and Molecular Biophysics)
March 29, 2021
Emily Wagner (Silva lab, WashU Biomedical Engineering)
“A Role of PIEZ01 in Iron Metabolism in Mice and Humans” Cell (2021)
April 12, 2021
Soma Singareddy (Nichols lab, WashU Cell Biology and Physiology)
“All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds” Cell (2020)
April 19, 2021
Chen Kang (Sah lab, WashU Medicine)
“TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells” American Journal of Physiology, Cell Physiology (2019)
April 26, 2021
Lindsey Kent (England lab, WashU Obstetrics and Gynecology)
“Intellectual Disability-Associated UNC80 Mutations Reveal Inter-Subunit Interaction and Dendritic Function of the NALCN Channel Complex” Nature Communications (2020)
CANCELLED – May 10, 2021
Tingting Guo (Cao lab, WashU Anesthesiology)
May 17, 2021
Jian Gao (Nichols lab, WashU Cell Biology and Physiology)
“Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor” Nature Biotechnology (2020)
September 16, 2019
Zengqin Deng (Yuan lab, WashU Cell Biology and Physiology)
“Regulatory Switch at the Cytoplasmic Interface Controls TRPV Channel Gating” eLife 2019
September 23, 2019
Juan Jose Ferreira (Santi lab, WashU Obstetrics & Gynecology)
“Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility” Cell 2019
September 30, 2019
Nathan York (Nichols lab, WashU Cell Biology & Physiology)
CANCELLED – October 21, 2019
Shaul Yahil (Remedi lab, WashU Medicine)
October 28, 2019
Garrett Easson (Tang lab, WashU Orthopaedic Surgery)
“The Mechanosensitive Piezo1 Channel is Required for Bone Formation” eLife 2019
November 11, 2019
Sun Joo Lee (Nichols lab, WashU Cell Biology & Physiology)
“Local membrane charge regulates β2 adrenergic receptor coupling to Gi3” Nature Communications (2019)
December 9, 2019
Emily Wagner (Silva lab, WashU Biomedical Engineering)
“RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation” Molecular Cell (2019)
December 16, 2019
Ashutosh Kumar (Sah lab, WashU Medicine)
“Lipid-gated Monovalent Ion Fluxes Regulate Endocytic Rraffic and Support Immune Surveillance” Science (2019)
January 13, 2020
Rahul Chadda (Robertson lab, WashU Biochemistry and Molecular Biophysics)
“Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane” Molecular Biology of the Cell (2019)
January 27, 2020
Daniel Simmons (Huebsch lab, WashU Biomedical Engineering)
February 10, 2020
Alex Hanson (Nichols lab, WashU Cell Biology & Physiology)
CANCELLED – February 17, 2020
Kayla Berry (Brett lab, WashU Medicine)
February 24, 2020
Po Wei (Billy) Kang (Silva lab, WashU Biomedical Engineering)
“TACAN Is an Ion Channel Involved in Sensing Mechanical Pain” (Cell 2020)
March 9, 2020
Monali Prabagaran (England lab, WashU Obstetrics and Gynecology)
“Loss of Ca2+ entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages” Journal of Cell Science (2020)
Due to the latest University policy announcement on non-essential events in context of the Covid-19 threat, Ion Channels Journal Club is cancelled through the end of the semester.
CANCELLED – March 16, 2020
Wei (David) Wang (Nerbonne lab, WashU Medicine)
“The Two-Pore Domain Potassium Channel TREK- Mediates Cardiac Fibrosis and Diastolic Dysfunction” J Clin Invest (2018)
CANCELLED – March 23, 2020
Tingting Guo (Cao lab, WashU Anesthesiology)
CANCELLED – March 30, 2020
Max Lyon (Santi lab, WashU Obstetrics and Gynecology)
CANCELLED – April 13, 2020
Amanda Dicks (Guilak lab, WashU Orthopaedic Surgery)
CANCELLED – April 27, 2020
Sarah Clippinger (Greenberg lab, WashU Biochemistry and Molecular Biophysics)
CANCELLED – May 11, 2020
Rob Tryon (Nichols lab, WashU Cell Biology and Physiology)
September 10, 2018
Amanda Dicks
Guilak Lab, WashU Orthopaedic Surgery
“TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis” Cell. 2012
September 17, 2018
Remy Walk
Tang Lab, WashU Orthopaedic Surgery
“Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration” Redox Biology 2018
September 24, 2018
Marco Matamoros-Campos
Nichols Lab, WashU Cell Biology & Physiology
October 15, 2018
Kristina Maxwell
Millman Lab, WashU Medicine
“SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity” Diabetes 2016
October 22, 2018
Sunjoo Lee
Nichols Lab, WashU Cell Biology & Physiology
“Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels” Protein Cell 2018
CANCELLED – November 12, 2018
Carmel Martin-Fairey
England and Herzog Labs, WashU Obstetrics & Gynecology and Biology
November 19, 2018
Kate Mangold
Silva Lab, WashU Biomedical Engineering
“Structure of the human voltage-gated sodium channel Nav1.4 in complex with b1” Science 2018
December 10, 2018
Zeenat Shyr
Remedi Lab, WashU Medicine
“Endoplasmic Reticulum Stress Alters Ryanodine Receptor Function in the Murine Pancreatic β Cell” J Biol Chem 2018
December 17, 2018
Michael DiGruccio
Piston Lab, WashU Cell Biology & Physiology
“Beta Cell Heterogeneity”
February 11, 2019
Josh Brettmann
Nichols Lab, WashU Cell Biology & Physiology
“Shifts in the Selectivity Filter Dynamics Cause Modal Gating in K+ Channel” Nature Communications (2019)
March 18, 2019
David Yang
Lu Lab, WashU Computer Science and Engineering
“Centipedes Subdue Giant Prey by Blocking KCNQ Channels” PNAS (2018)
April 8, 2019
Yaoheng (Mack) Yang
Chen Lab, WashU Biomedical Engineering
“Wireless Magnetothermal Deep Brain Stimulation” Science (2015)
April 22, 2019
Zili Xie
Hu Lab, WashU Anesthesiology
“Dietary Fatty Acids Fine-tune Piezo1 Mechanical Response” Nature Communications (2019)
May 20, 2019
Kelsey Collins
Guilak Lab, WashU Orthopaedic Surgery
“A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology”