The Ion Channels Journal Club explores recent publications in ion channel and excitability research, from fundamental mechanisms to disease.

Explore the archives below.

Ion Channels Journal Club Schedule – Fall 2021/Spring 2022

CANCELLED – September 20, 2021

Erik Nolan (Ben-Shahar lab, WashU Biology)

September 27, 2021

Mark Arcario (Cheng lab, WashU Anesthesiology)

“A Streamlined, General Approach for Computing Ligand Binding Free Energies and Its Application to GPCR-Bound Cholesterol” J. Chem. Theory Comput. (2018)

October 11, 2021

Juan Hong (Sah lab, WashU Medicine)

“The Mechanosensitive Piezo1 Channel Mediates​ Heart Mechano-chemo Transduction”  Nature Communications (2021)

October 18, 2021

Nicole Migotsky (Silva lab, WashU Orthopaedic Surgery)

“Mechanosensitive Ca2+ Signaling and Coordination is Diminished in Osteocytes of Aged Mice During Ex Vivo Tibial Loading”  Connective Tissue Research (2020)

CANCELLED – October 25, 2021

Nathan Zelt (Robertson lab, WashU Biochemistry and Molecular Biophysics)

November 8, 2021

Kaitlyn Broz (Tang lab, WashU Orthopaedic Surgery)

“Mechanotransduction Via the Piezo1-Akt Pathway Underlies Sost Suppression in Osteocytes” Biochemical and Biophysical Research Communications (2020)

CANCELLED – November 15, 2021

Sudlow Lee (Berezin lab, WashU Radiology)

November 22, 2021

Vinaykumar Idikuda (Chanda lab, WashU Anesthesiology)

“Single-Molecule Imaging With Cell-Derived Nanovesicles Reveals Early Binding Dynamics at a Cyclic Nucleotide-Gated Ion Channel”  Nature Communications (2021)

November 29, 2021

Bridget Matikainen-Ankney (Kravitz lab, WashU Psychiatry)

“Diet-induced Obesity Enhances Prelimbic Inputs Onto Accumbal D1-SPNs and Increases Effort of Food Seeking”

December 13, 2021

Jonathan Mount (Yuan lab, WashU Cell Biology & Physiology)

“Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK” Molecular Microbiology (2007)

CANCELLED – December 20, 2021

Verena Burtscher (Chanda lab, WashU Anesthesiology)

April 25, 2022

Alex Hanson (Nichols lab, WashU Cell Biology and Physiology)

“STIM1-Dependent Peripheral Coupling Governs the Contractility of Vascular Smooth Muscle Cells”  eLife (2022)

Ion Channels Journal Club Schedule – Fall 2020/Spring 2021

August 17, 2020

Jian Gao (Nichols lab, WashU Cell Biology and Physiology)

“Macrolides Selectively Inhibit Mutant KCNJ5 Potassium Channels That Cause Aldosterone-producing Adenoma”JCI 2020

August 24, 2020

Conor McClenaghan (Nichols lab, WashU Cell Biology and Physiology)

“A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans”  Current Biology 2020

September 14, 2020

Sunjoo Lee (Nichols lab, WashU Cell Biology & Physiology)

“Site-Specific Incorporation of Two ncAAs for Two-Color Bioorthogonal Labeling and Crosslinking of Proteins on Live Mammalian Cells”  Cell Reports 2020

September 21, 2020

Nathan York (Nichols lab, WashU Cell Biology & Physiology)

“Enhanced Expression of β Cell CaV3.1 Channels Impairs Insulin Release and Glucose Homeostasis”    PNAS 2020

September 28, 2020

Yihao Jiang (Chanda lab, WashU Anesthesiology)

“Structure of the Human Sodium Leak Channel NALCN”  Nature (2020)

October 12, 2020

John Petroff (Cheng lab, WashU Anesthesiology)

“Shared Structural Mechanisms of General Anaesthetics and Benzodiazepines”  Nature (2020)

October 19, 2020

Mimi Guo (Huebsch lab, WashU Biomedical Engineering)

“Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes”  Nature Communications (2020)

October 26, 2020

Kathryn Mangold (Silva lab, WashU Biomedical Engineering)

“Predicting Functional Effects of Missense Variants in Voltage-gated Sodium and Calcium Channels” Science Translational Medicine (2020)

November 9, 2020

Zhihui He (Yuan lab, WashU Cell Biology and Physiology)

“Structural Basis for pH Gating of the Two-pore Domain K+ Channel TASK2”  Nature (2020)

November 16, 2020

Ryan Bitter (Yuan lab, WashU Cell Biology and Physiology)

“Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport” Biophysical Journal (2016)

November 23, 2020

Vinay Idikuda (Chanda lab, WashU Anesthesiology)

“CNGA3 Acts as a Cold Sensor in Hypothalamic Neurons”  eLife (2020)

November 30, 2020

Ashutosh Kumar (Sah lab, WashU Medicine)

“PIEZO2 in sensory neurons and urothelial cells coordinates urination” Nature 2020

December 14, 2020

Daniel Simmons (Huebsch lab, WashU Biomedical Engineering)

“Human Induced Pluripotent Stem Cell–Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers” Circulation: Arrhythmia and Electrophysiology (2018)

December 21, 2020

Willy Carrasquel (Chanda lab, WashU Anesthesiology)

“Viral rhodopsins 1 are an unique family of light-gated cation channels”  Nature Communications (2020)

January 11, 2021

Maximilian Lyon (Santi lab, WashU Obstetrics and Gynecology)

“3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice”   eLife (2020)

January 25, 2021

Rob Tryon (Nichols lab, WashU Cell Biology and Physiology)

“Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish”  PNAS (2020)

February 8, 2021

Suhaila Rahman (Yuan lab, WashU Cell Biology and Physiology)

“Gating by Ionic Strength and Safety Check by Ciclic-di-AMP in the ABC Transporter OpuA”  Science Advances (2020)

CANCELLED – February 15, 2021

Anthony Frosio (Nerbonne lab, WashU Medicine)

CANCELLED – February 22, 2021

Jenna Lin (Chanda lab, WashU Anesthesiology)

For Zoom information contact Paula Reynolds.

March 8, 2021

Satyanarayana Murthy Chintala (Evers lab, WashU Anesthesiology)

​“Selection of DNA-Encoded Chemical Libraries Against Endogenous Membrane Proteins on Live Cells”    Nature Chemistry (2020)

March 15, 2021

Remy Walk (Tang lab, WashU Orthopaedic Surgery)

“Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration”  Cell Proliferation (2020)

CANCELLED – March 22, 2021

Sarah Clippinger (Greenberg lab, WashU Biochemistry and Molecular Biophysics)

March 29, 2021

Emily Wagner (Silva lab, WashU Biomedical Engineering)

“A Role of PIEZ01 in Iron Metabolism in Mice and Humans”  Cell (2021)

April 12, 2021

Soma Singareddy (Nichols lab, WashU Cell Biology and Physiology)

“All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds”  Cell (2020)

April 19, 2021

Chen Kang (Sah lab, WashU Medicine)

“TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells” American Journal of Physiology, Cell Physiology (2019)

April 26, 2021

Lindsey Kent (England lab, WashU Obstetrics and Gynecology)

“Intellectual Disability-Associated UNC80 Mutations Reveal Inter-Subunit Interaction and Dendritic Function of the NALCN Channel Complex”  Nature Communications (2020)

CANCELLED – May 10, 2021

Tingting Guo (Cao lab, WashU Anesthesiology)

May 17, 2021

Jian Gao (Nichols lab, WashU Cell Biology and Physiology)

“Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor”  Nature Biotechnology (2020)

Ion Channels Journal Club Schedule – Fall 2019/Spring 2020

September 16, 2019

Zengqin Deng (Yuan lab, WashU Cell Biology and Physiology)

“Regulatory Switch at the Cytoplasmic Interface Controls TRPV Channel Gating” eLife 2019

September 23, 2019

Juan Jose Ferreira (Santi lab, WashU Obstetrics & Gynecology)

“Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility” Cell 2019

September 30, 2019

Nathan York (Nichols lab, WashU Cell Biology & Physiology)

“Opening of ATP-sensitive Potassium Channels Causes Migraine Attacks: A New Target for the Treatment of Migraine” Brain 2019

CANCELLED – October 21, 2019

Shaul Yahil (Remedi lab, WashU Medicine)

October 28, 2019

Garrett Easson (Tang lab, WashU Orthopaedic Surgery)

“The Mechanosensitive Piezo1 Channel is Required for Bone Formation” eLife 2019

November 11, 2019

Sun Joo Lee (Nichols lab, WashU Cell Biology & Physiology)

“Local membrane charge regulates β2 adrenergic receptor coupling to Gi3” Nature Communications (2019)

December 9, 2019

Emily Wagner (Silva lab, WashU Biomedical Engineering)

“RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation” Molecular Cell (2019)

December 16, 2019

Ashutosh Kumar (Sah lab, WashU Medicine)

“Lipid-gated Monovalent Ion Fluxes Regulate Endocytic Rraffic and Support Immune Surveillance” Science (2019)

January 13, 2020

Rahul Chadda (Robertson lab, WashU Biochemistry and Molecular Biophysics)

“Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane” Molecular Biology of the Cell (2019)

January 27, 2020

Daniel Simmons (Huebsch lab, WashU Biomedical Engineering)

February 10, 2020

Alex Hanson (Nichols lab, WashU Cell Biology & Physiology)

“KCNQ5 Activation is a Unifying Molecular Mechanism Shared by Genetically and Culturally Diverse Botanical Hypotensive Folk Medicines” Cell (2019)

CANCELLED – February 17, 2020

Kayla Berry (Brett lab, WashU Medicine)

February 24, 2020

Po Wei (Billy) Kang (Silva lab, WashU Biomedical Engineering)

“TACAN Is an Ion Channel Involved in Sensing Mechanical Pain”  (Cell 2020)

March 9, 2020

Monali Prabagaran (England lab, WashU Obstetrics and Gynecology)

“Loss of Ca2+ entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages”  Journal of Cell Science (2020)

Due to the latest University policy announcement on non-essential events in context of the Covid-19 threat, Ion Channels Journal Club is cancelled through the end of the semester.

CANCELLED – March 16, 2020

Wei (David) Wang (Nerbonne lab, WashU Medicine)

“The Two-Pore Domain Potassium Channel TREK- Mediates Cardiac Fibrosis and Diastolic Dysfunction”  J Clin Invest (2018)

CANCELLED – March 23, 2020

Tingting Guo (Cao lab, WashU Anesthesiology)

CANCELLED – March 30, 2020

Max Lyon (Santi lab, WashU Obstetrics and Gynecology)

CANCELLED – April 13, 2020

Amanda Dicks (Guilak lab, WashU Orthopaedic Surgery)

CANCELLED – April 27, 2020

Sarah Clippinger (Greenberg lab, WashU Biochemistry and Molecular Biophysics)

CANCELLED – May 11, 2020

Rob Tryon (Nichols lab, WashU Cell Biology and Physiology)

Ion Channels Journal Club Schedule – Fall 2018/Spring 2019

September 10, 2018

Amanda Dicks
Guilak Lab, WashU Orthopaedic Surgery

“TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis” Cell. 2012

September 17, 2018

Remy Walk
Tang Lab, WashU Orthopaedic Surgery

“Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration” Redox Biology 2018

September 24, 2018

Marco Matamoros-Campos
Nichols Lab, WashU Cell Biology & Physiology

“Protein Interactions Central to Stabilizing the K+ Channel Selectivity Filter in a Four-Sited Configuration for Selective K+ Permeation” PNAS 2011

October 15, 2018

Kristina Maxwell
Millman Lab, WashU Medicine

“SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity” Diabetes 2016

October 22, 2018

Sunjoo Lee
Nichols Lab, WashU Cell Biology & Physiology

“Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels” Protein Cell 2018 

CANCELLED – November 12, 2018

Carmel Martin-Fairey
England and Herzog Labs, WashU Obstetrics & Gynecology and Biology

November 19, 2018

Kate Mangold
Silva Lab, WashU Biomedical Engineering

“Structure of the human voltage-gated sodium channel Nav1.4 in complex with b1” Science 2018

December 10, 2018

Zeenat Shyr
Remedi Lab, WashU Medicine

“Endoplasmic Reticulum Stress Alters Ryanodine Receptor Function in the Murine Pancreatic β Cell” J Biol Chem 2018

December 17, 2018

Michael DiGruccio
Piston Lab, WashU Cell Biology & Physiology

“Beta Cell Heterogeneity”

February 11, 2019

Josh Brettmann
Nichols Lab, WashU Cell Biology & Physiology

“Shifts in the Selectivity Filter Dynamics Cause Modal Gating in K+ Channel” Nature Communications (2019)

March 18, 2019

David Yang
Lu Lab, WashU Computer Science and Engineering

“Centipedes Subdue Giant Prey by Blocking KCNQ Channels”  PNAS (2018)

April 8, 2019

Yaoheng (Mack) Yang
Chen Lab, WashU Biomedical Engineering

“Wireless Magnetothermal Deep Brain Stimulation”  Science (2015)

April 22, 2019

Zili Xie
Hu Lab, WashU Anesthesiology

“Dietary Fatty Acids Fine-tune Piezo1 Mechanical Response”  Nature Communications (2019)

May 20, 2019

Kelsey Collins
Guilak Lab, WashU Orthopaedic Surgery

“A Fat-Free Mouse Model to Study the Contributions of Metabolic Disturbance to Cartilage Physiology and Pathology”