The Mechanisms and Diseases of Aging Journal Club discusses recent and impactful publications in the field of aging ranging from molecular biology to behavior and worms to humans.

Explore the archives below.

Mechanisms and Diseases of Aging Journal Club – Spring 2020

January 24, 2020

Luba Ezerskiy (Miller lab, WashU Neurology)

“Increase in 4R tau in astrocytes promotes their dysfunction”

February 7, 2020

Michael Strickland (Holtzman lab, WashU Neurology)

“Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain” Nature Neuroscience (2020)

February 21, 2020

Andrea Scharf (Kornfeld lab, WashU Developmental Biology)

“Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans”  Science (2020)

March 6, 2020

Jiang Zhu (Weihl lab, WashU Neurology)

“The Role of VCP on Proteopathic Seeding Activities”

CANCELLED – March 20, 2020

Tom Mahan (Holtzman lab, WashU Neurology)

“Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome”  Neurobiology of Disease (2020)

NOTE: no April meetings, instead participate in the Neuroscience Revisit weekend and the American Society for Neurochemistry annual meeting!

CANCELLED – May 1, 2020

Brian Lananna (Imai lab, WashU Developmental Biology)

CANCELLED – May 15, 2020

Nathan Pomper (Miller lab, WashU Neurology)

Mechanisms and Diseases of Aging Journal Club – Summer 2019

July 12, 2019

Kyle Burbach
Yoo lab, WashU Developmental Biology

“Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease” Nature Neuroscience 2018

August 9, 2019

Denis Mogilenko
Artyomov lab, WashU Pathology and Immunology

“Single-cell analysis reveals T cell infiltration in old neurogenic niches” Nature 2019

Mechanisms and Diseases of Aging Journal Club – Spring 2019

January 23, 2019

Nathan Pomper
Miller lab, WashU Neurology

“Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone” Aging 2019

February 6, 2019

Luba Ezerskiy
Miller lab, WashU Neurology

“Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice” Scientific Reports (2019)

Beginning February 22
new location – Farrell LTC 205 and new day – Friday

February 22, 2019

Sydney Reitz
Kummer lab, WashU Neurology

“Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice” Journal of Neurotrauma 2019

March 8, 2019

Michael Strickland
Holtzman lab, WashU Neurology

“L1 drives IFN in senescent cells and promotes age-associated inflammation”  Nature 2019 

March 22, 2019

Diana Christian
Gabel lab, WashU Dept. of Neuroscience

“Global Reorganization of the Nuclear Landscape in Senescent Cells”  Cell Reports 2015

CANCELLED April 5, 2019

April 19, 2019 – NOTE location: Mid-Campus Center (MCC) 2057

Denis Mogilenko
Artyomov lab, WashU Pathology and Immunology

“NAD + metabolism governs the proinflammatory senescence-associated secretome | Nature Cell Biology”  Nature Cell Biology 2019

May 3, 2019

Rocio Bengoechea Ibaceta
Weihl lab, WashU Neurology

“Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet” Aging Cell 2019

May 17, 2019

Lucia Capano
Yoo lab, WashU Developmental Biology

WiP – “Modeling tauopathies in patient-derived, directly reprogrammed neurons” 

June 14, 2019

Percy Griffin, Celia McKee
Musiek lab, WashU Neurology

Celia McKee: “The Astrocyte Circadian Clock Regulates Amyloid Beta Deposition and Degradation”
Percy Griffin: “Circadian Regulation of Neuroinflammation and Neurodegeneration by Rev-Erba”

Mechanisms of Aging Journal Club Schedule – Summer/Fall 2018

July 18, 2018

Kristen Funk
Klein Lab, WashU Medicine

“Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection” Neuron 2018

August 1, 2018

Celia McKee
Musiek Lab, WashU Neurology

“Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease” Nature  2018

August 15, 2018

Riley Bannon
Miller Lab, WashU Neurology

“The age-regulated zinc fnger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis” Nature 2017

September 12, 2018

Brian Lananna
Musiek Lab (WashU Neurology)

“Human umbilical cord plasma proteins revitalize hippocampal function in aged mice” Neuron 2018

September 26, 2018

Lorenzo Lones
DiAntonio Lab, WashU Developmental Biology

“Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period” Neuron 2018

October 10, 2018

Pat Sheehan
Musiek Lab, WashU Neurology

“Tau protein aggregation is associated with cellular senescence in the brain” Aging Cell 2018

October 24, 2018

Percy Griffin
Musiek Lab, WashU Neurology

“Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice” Aging Cell 2018

November 7, 2018

Marwa Mikati
Miller Lab, WashU Neurology

“RbAp48 Protein Is a Critical Component of GPR158/ OCN Signaling and Ameliorates Age-Related Memory Loss” Cell 2018

CANCELLED November 21, 2018

Happy Thanksgiving!

CANCELLED December 5, 2018

December 19, 2018

Collin Nadarajah
Musiek Lab, WashU Neurology

“Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy” Nature Neuroscience 2018