The Mechanisms and Diseases of Aging Journal Club discusses recent and impactful publications in the field of aging ranging from molecular biology to behavior and worms to humans.
Explore the archives below.
Mechanisms and Diseases of Aging Journal Club – Spring 2020
January 24, 2020
Luba Ezerskiy (Miller lab, WashU Neurology)
“Increase in 4R tau in astrocytes promotes their dysfunction”
February 7, 2020
Michael Strickland (Holtzman lab, WashU Neurology)
“Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain” Nature Neuroscience (2020)
February 21, 2020
Andrea Scharf (Kornfeld lab, WashU Developmental Biology)
“Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans” Science (2020)
March 6, 2020
Jiang Zhu (Weihl lab, WashU Neurology)
“The Role of VCP on Proteopathic Seeding Activities”
CANCELLED – March 20, 2020
Tom Mahan (Holtzman lab, WashU Neurology)
“Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome” Neurobiology of Disease (2020)
NOTE: no April meetings, instead participate in the Neuroscience Revisit weekend and the American Society for Neurochemistry annual meeting!
CANCELLED – May 1, 2020
Brian Lananna (Imai lab, WashU Developmental Biology)
CANCELLED – May 15, 2020
Nathan Pomper (Miller lab, WashU Neurology)
Mechanisms and Diseases of Aging Journal Club – Summer 2019
July 12, 2019
Kyle Burbach
Yoo lab, WashU Developmental Biology
“Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease” Nature Neuroscience 2018
August 9, 2019
Denis Mogilenko
Artyomov lab, WashU Pathology and Immunology
“Single-cell analysis reveals T cell infiltration in old neurogenic niches” Nature 2019
Mechanisms and Diseases of Aging Journal Club – Spring 2019
January 23, 2019
Nathan Pomper
Miller lab, WashU Neurology
February 6, 2019
Luba Ezerskiy
Miller lab, WashU Neurology
“Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice” Scientific Reports (2019)
Beginning February 22
new location – Farrell LTC 205 and new day – Friday
February 22, 2019
Sydney Reitz
Kummer lab, WashU Neurology
“Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice” Journal of Neurotrauma 2019
March 8, 2019
Michael Strickland
Holtzman lab, WashU Neurology
“L1 drives IFN in senescent cells and promotes age-associated inflammation” Nature 2019
March 22, 2019
Diana Christian
Gabel lab, WashU Dept. of Neuroscience
“Global Reorganization of the Nuclear Landscape in Senescent Cells” Cell Reports 2015
CANCELLED April 5, 2019
April 19, 2019 – NOTE location: Mid-Campus Center (MCC) 2057
Denis Mogilenko
Artyomov lab, WashU Pathology and Immunology
“NAD + metabolism governs the proinflammatory senescence-associated secretome | Nature Cell Biology” Nature Cell Biology 2019
May 3, 2019
Rocio Bengoechea Ibaceta
Weihl lab, WashU Neurology
“Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet” Aging Cell 2019
May 17, 2019
Lucia Capano
Yoo lab, WashU Developmental Biology
WiP – “Modeling tauopathies in patient-derived, directly reprogrammed neurons”
June 14, 2019
Percy Griffin, Celia McKee
Musiek lab, WashU Neurology
Celia McKee: “The Astrocyte Circadian Clock Regulates Amyloid Beta Deposition and Degradation”
Percy Griffin: “Circadian Regulation of Neuroinflammation and Neurodegeneration by Rev-Erba”
Mechanisms of Aging Journal Club Schedule – Summer/Fall 2018
July 18, 2018
Kristen Funk
Klein Lab, WashU Medicine
August 1, 2018
Celia McKee
Musiek Lab, WashU Neurology
“Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease” Nature 2018
August 15, 2018
Riley Bannon
Miller Lab, WashU Neurology
September 12, 2018
Brian Lananna
Musiek Lab (WashU Neurology)
“Human umbilical cord plasma proteins revitalize hippocampal function in aged mice” Neuron 2018
September 26, 2018
Lorenzo Lones
DiAntonio Lab, WashU Developmental Biology
“Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period” Neuron 2018
October 10, 2018
Pat Sheehan
Musiek Lab, WashU Neurology
“Tau protein aggregation is associated with cellular senescence in the brain” Aging Cell 2018
October 24, 2018
Percy Griffin
Musiek Lab, WashU Neurology
“Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice” Aging Cell 2018
November 7, 2018
Marwa Mikati
Miller Lab, WashU Neurology
CANCELLED November 21, 2018
Happy Thanksgiving!
CANCELLED December 5, 2018
December 19, 2018
Collin Nadarajah
Musiek Lab, WashU Neurology
“Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy” Nature Neuroscience 2018
