Exploring the neurobiological mechanisms of ketamine, psychedelics, and other rapid antidepressants

The recent development of novel, fast acting, and durable antidepressant treatments such as Ketamine, Brexanolone, and Psilocybin has disrupted our view of the neuroscience and treatment of mood disorders. Our focus is research into the basic and translational science of how these drugs work.

Anyone interested is welcome to participate!

When: 3rd Monday of the month, 3:00p
Where: HYBRID: Couch Building 2nd floor conference room (Medical Campus) and Zoom
Organizer: Joshua Siegel (Resident, WashU Psychiatry)

Note that individual events are listed on the ONR Calendar.

2022/2023 Schedule

For inquiries contact Joshua Siegel.

July 18, 2022

Amelia Christensen (Kepecs lab, WashU Neuroscience)

“Interactions between psychedelic agonism of 5ht2a receptors and dopamine dependent reinforcement learning”

August 15, 2022

NOTE 3:00p start time

Rick Reneau (Braver lab, WashU Psychological & Brain Sciences)

“Imaging the effect of ketamine on synaptic density (SV2A) in the living brain” Molecular Psychiatry (2022)

September 19, 2022

Oliver Krentzman (Kepecs lab, WashU Neuroscience)

“Oxytocin-dependent reopening of a social reward learning critical period with MDMA” (Nature 2019)

October 17, 2022

Peter Lambert (Mennerick lab, WashU Psychiatry)

“Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2” (Neuron 2022)

November 21, 2022

Joshua Siegel (Nicol lab, WashU Psychiatry)
Jonah Padawer-Curry (Bauer lab, WashU Radiology)

WiP: “Neural and neurovascular effects of 5-HT2A receptor modulation (psychedelic, non-psychedelic agonism, and antagonism)”

December 19, 2022

January 16, 2023

February 20, 2023

March 20, 2023

April 17, 2023

May 15, 2023

June 19, 2023