The Synapse Journal Club explores recent publications in the area of neuroscience and physiology with a focus on the neuronal synapse and its function. 

Explore the archives below.

Synapse Journal Club Schedule – Fall 2022
September 16, 2022

Rachel Hendrix (Cirrito lab, WashU Neurology)

WiP: “Glutamatergic and GABAergic contributions to Aβ activity-dependent release”

October 21, 2022

Xinguo Lu (Mennerick lab, WashU Psychiatry)

“Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice” Nature Communications (2022)

November 4, 2022

Samuel Wycoff (Cirrito lab, WashU Neurology)

“Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease” Brain (2022)

POSTPONED – November 18, 2022

Rutherford lab (WashU Otolaryngology)

CANCELLED – December 2, 2022

December 16, 2022

Geraldine Kress (WashU Neurology)

“Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory” eNeuro (2022)

Synapse Journal Club Schedule – Fall 2021/Spring 2022

September 17, 2021

Rachel Hendrix (Cirrito lab, WashU Neurology)

“Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau”  Cell Reports (2021)

October 15, 2021

Xinguo Lu (Mennerick lab, WashU Psychiatry)

“GABAergic interneurons excite neonatal hippocampus in vivo”  Science Advances (2020)

November 5, 2021


November 19, 2021

Mark Rutherford (WashU Otolaryngology)

“β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors”  Cell Reports (2021)

December 3, 2021

Samuel Wycoff (Cirrito lab, WashU Neurology)

“Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration”  Brain (2019)

December 17, 2021

Hybrid meeting (Zoom and in-person). To attend in person, please RSVP by email to Geraldine Kress. Space is limited.

Richard Ni, Sofia Salvatore Lannes (Mennerick lab, WashU Psychiatry)

“Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis” Neuropsychopharmacology (2019)

February 4, 2022

Kevin Gonzalez (Losonczy and Polleux labs; Neuroscience Dept, Columbia University)

February 18, 2022


March 4, 2022

POSTPONED to March 18

Kress lab (WashU Neurology)

March 18, 2022


Kress lab (WashU Neurology)

To present an article or for Zoom information, contact the organizer Dr. Geraldine Kress.

April 1, 2022

NOTE: HYBRID meeting, in-person location: Biotechnology 129 (Medical Campus)

Rachel Hendrix (Cirrito lab, WashU Neurology)

“Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease”  Translational Neurodegeneration (2022)

April 15, 2022

NOTE: HYBRID meeting, in-person location: Biotechnology 330 (Medical Campus)

Hanna Edwards (Cirrito lab, WashU Neurology)

“Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses”  Cell Reports (2022)

May 6, 2022 (Postponed to May 13)

May 13, 2022

NOTE: HYBRID meeting, in-person location: Biotechnology 330 (Medical Campus)

Mark Rutherford (WashU Otolaryngology)

WiP Talks
“Central and Peripheral Auditory Function in APP/PS1 mice”
“Update of ongoing adventures in AMPA receptor land”

May 20, 2022

NOTE: HYBRID meeting, in-person location: Biotechnology 330 (Medical Campus)

Sofia Salvatore Lannes (Mennerick lab, WashU Psychiatry)

“Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice”  Nature Communications (2022)

Synapse Journal Club Schedule – Fall 2020/Spring 2021

September 18, 2020

Rachel Hendrix (Cirrito lab, WashU Neurology)

“Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer’s model”  J. Biological Chemistry 2018

October 16, 2020

Lorenzo Lones (DiAntonio lab, WashU Developmental Biology)

“Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry”   Neuron 2020

November 6, 2020

Peter Lambert (Mennerick lab, WashU Psychiatry)

“An Astrocytic Influence on Impaired Tonic Inhibition in Hippocampal CA1 Pyramidal Neurons in a Mouse Model of Rett Syndrome”  Journal of Neuroscience 2020

November 20, 2020

Chen lab (WashU Dept. of Neuroscience)

“Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis” bioRxiv 2020

December 4, 2020

Mark Rutherford (WashU Otolaryngology)

“Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors”  Neuron 2018

December 18, 2020

Allison Soung (Klein lab, WashU Medicine)

“T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses”  Nature Neuroscience 2019

CANCELLED – February 5, 2021

February 19, 2021

Zhongxiao Fu (Kipnis lab, WashU Pathology and Immunology)

“Structure and function of a neocortical synapse”  Nature (2021)

March 5, 2021

Xinguo Lu (Mennerick lab, WashU Psychiatry)

“Alternating sources of perisomatic inhibition during behavior”  Neuron (2021)

March 19, 2021

Rachel Hendrix (Cirrito lab, WashU Neurology)

“An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy”   Cell Reports (2019)

April 2, 2021

Peter Lukasiewicz (WashU Ophthalmology & Visual Sciences)

“Deciphering the role of sleep on neuroinflammation in Alzheimer’ disease”  Neuron (2020)

April 16, 2021

Hannah Edwards (Cirrito lab, WashU Neurology)

“Early intervention attenuates synaptic plasticity impairment and neuroinflammation in 5xFAD mice”  Journal of Psychiatric Research (2021)

May 7, 2021

Peter Lambert (Mennerick lab, WashU Psychiatry)

“Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release”   Journal of Neuroscience (2021)

Synapse Journal Club Schedule – Fall 2019/Spring 2020

November 1, 2019

Rachel Hendrix (Cirrito lab, WashU Neurology)

“A vicious cycle of amyloid β-dependent neuronal hyperactivation” Science (2019)

November 15, 2019

Carla Yuede (WashU Psychiatry)

“Architecture of the Mouse Brain Synaptome” Neuron (2018)

CANCELLED – December 6, 2019

Geraldine Kress (WashU Neurology)

“Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model” Nature Communications (2019)

CANCELLED – December 20, 2019

Mark Rutherford (WashU Otolaryngology)

“Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics” Molecular Brain (2016)

February 14, 2020  

Mark Rutherford (WashU Otolaryngology) 

“Conformational pathway provides unique sensitivity to a synaptic mGluR” (Nature Communications (2019)

** From March 6 – March 20, Synapse J Club will meet jointly with the Nanocourse, “Autoimmune Disorders of the Synapse”.   
All are welcome to join!

March 6, 2020

combined Journal Club and Nanocourse

CANCELLED – March 13, 2020 Nanocourse    Cellular mechanisms of NMDAR encephalitis

CANCELLED – March 20, 2020 Nanocourse Pathogenicity

Synapse Journal Club Schedule – Fall 2018/Spring 2019

September 21, 2018

Andrew Sauerbeck
WashU Neurology

“Superresolution Imaging of Chemical Synapses in the Brain”  Neurotechnique (2010)

October 5, 2018

Rachel Hendrix
Cirrito Lab, WashU Neurology

“LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent” eLife (2017)

October 19, 2018

Peter Lambert
Mennerick Lab,  WashU Psychiatry

“Dedicated Population for Reward Coding in the Hippocampus” Neuron (2018)

November 16, 2018

Geraldine Kress
WashU Neurology

“Light Affects Mood and Learning through Distinct Retina-Brain Pathways” Cell (2018)

December 7, 2018

Luis Boero
Rutherford Lab , WashU Otolaryngology

“Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss” Journal of Neuroscience (2018)

February 1, 2019

Rachel Hendrix
Cirrito Lab, WashU Neurology

“Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo” Nature Neuroscience (2019)

February 15, 2019

Joseph Landers
Chen Lab, WashU Dept. of Neuroscience

“A Dendritic Substrate for the Cholinergic Control of Neocortical Output Neurons”  Neuron (2019)

March 1, 2019

Carson Platnick
Mennerick Lab, WashU Psychiatry

“Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity” Journal of Neuroscience (2018)

March 15, 2019

Xinguo Lu
Mennerick Lab, WashU Psychiatry

“Input-Specific Synaptic Location and Function of the α5 GABAA Receptor Subunit in the Mouse CA1 Hippocampal Neurons” Journal of Neuroscience (2019)

April 5, 2019

Geraldine Kress
WashU Neurology

“Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model”  Neuron (2019)

April 19, 2019

Mark Rutherford
WashU Otolaryngology

“Synaptic plasticity through activation of GluA3-containing AMPA-receptors”  eLIFE (2017)

Synapse Journal Club Schedule – Fall 2017/Spring 2018

September 15, 2017
Min-Yu Sun (Mennerick lab)
“Assembly rules for GABAA receptor complexes in the brain” eLife (2017)

November 3, 2017
Michael Strickland (1st year neuroscience student)
“Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held” J. Neurosci (2017)

November 17, 2017
Peter Lukasiewicz
“Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters” Neuron (2017)

December 1, 2017
Matt Tso (Herzog Lab)
“Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep Wake Cycle” Neuron (2017)

December 15, 2017
Steve Mennerick
“Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake” Cell Metab. (2017)

February 2, 2018
Jane Hettinger (Cirrito Lab, WashU Neurology)

“Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory” Nature (2018)

March 16, 2018
Jenny Shu (Mennerick Lab)

“Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites” Nat Struct Mol Biol. (2017)

April 6, 2018
Hannah Frye (Moron-Concepcion Lab)
“Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction.” Cell Reports (2018)

May 4, 2018
Mark Rutherford (Otolaryngology)
“Compartmentalization of antagonistic Ca(2+) signals in developing cochlear hair cells” PNAS (2018)

May 18, 2018
Carla Yuede (Neurology)
“Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus.” Cell (2018)

Synapse Journal Club Schedule – Spring 2017

February 3, 2017
Geraldine Kress

“REM sleep selectively prunes and maintains new synapses in development and learning” Nature Neuroscience (2017)

February 17, 2017
Courtney Sobieski (Mennerick lab)

“GLUT4 Mobilization Supports Energetic Demands of Active Synapses” Neuron (2017)

March 3, 2017
Jane Hettinger (Cirrito lab)

“Optogenetic control of synaptic composition and function” Neuron (2017)

March 17, 2017
Peter Lukasiewicz

“Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation” Nature Communications (2016)

March 31, 2017*** NOTE: 9a start; visiting applicants (and donuts!)
Steve Mennerick

“Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals” Neuron (2017)

April 21, 2017
Carla Yuede

“The Retromer Supports AMPA Receptor Trafficking During LTP” Neuron (2017)

May 5, 2017

John Cirrito


May 19, 2017
Min-Yu Sun (Mennerick lab)

“GARLH Family Proteins Stabilize GABAA Receptors at Synapses” Neuron (2017)

Synapse Journal Club Schedule – Fall 2013/Spring 2014

September 20, 2013
Jane Hettinger (Cirrito Lab)

“Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Ab Oligomer Bound to Cellular Prion Protein” Neuron (2013)

October 18, 2013
Christine Emnett (Mennerick Lab)

“Impaired D-Serine-Mediated Contransmission Mediates Cognitive Dysfunction in Epilepsy” JNeurosci (2013)

November 15, 2013
EJ Brace (DiAntonio Lab)

“Spontaneous and evoked release are independently regulated at individual active zones” JNeurosci (2013)

November 22, 2013
Courtney Sobieski (Mennerick Lab)

“Amyloid-β1–42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1” JNeurosci (2013)

December 13, 2013
Gerry Kress (Mennerick Lab)

“Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake” Nature Neuroscience (2013)

February 14, 2014
Jon Fisher (Cirrito Lab)

“5-HT4-Receptors Modulate Induction of Long-Term Depression but Not Potentiation at Hippocampal Output Synapses in Acute Rat Brain Slices” PLoS (2014)

February 21, 2014
Christine Emnett (Mennerick Lab)

“Pregnenolone Can Protect the Brain from Cannabis Intoxication” Science (2014)

March 28, 2014
Andy Linsenbardt (Mennerick Lab)

“Glutamate and Dopamine Transmission from Midbrain Dopamine Neurons Share Similar Release Properties But Are Differentially Affected by Cocaine” JNeurosci (2014)

April 11, 2014
Vera Valakh (DiAntonio Lab)

“Connexin 30 sets synaptic strength by controlling astroglial synapse invasion” Nature Neuroscience (2014)

April 18, 2014
Peter Lukasiewicz Lab

“Olfactory stimulation selectively modulates the OFF pathway in the retina of zebrafish” Neuron (2013)

April 25, 2014
Carla Yuede (Cirrito Lab)

“Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment” Cell (2014)