Archives: IDDRC Seminars (formerly, Autism Seminar Series)
A history of past seminars.
September 13, 2021
Tychele Turner (WashU Genetics)
“Insights from Short-read and Long-read Whole-genome Sequencing in Autism”
CANCELLED – October 11, 2021
Mirella Dapretto (University of California, Los Angeles)
“Brain-based markers of autism risk and resilience”
Supplemental reading
- “Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder” Cerebral Cortex, 2021
November 8, 2021
Sundari Chetty (Stanford University)
“Modeling brain overgrowth in autism using pluripotent stem cells”
Reading materials
December 13, 2021
Harrison Gabel (WashU Neuroscience)
“Investigating the Cellular and Molecular Basis of Overgrowth and Intellectual Disability Disorders”
January 10, 2022
Mariah Hoye (Duke University Medical Center)
“Molecular and Cellular Mechanisms of DDX3X Syndrome”
Reading materials
- “PathogenicDDX3XMutations Impair RNAMetabolism and Neurogenesis during Fetal CorticalDevelopment” Neuron (2020)
February 14, 2022
Joshua Ewen (Kennedy Krieger Institute)
“Testing competing theories of autism using large datasets”
March 14, 2022
Varun Warrier (University of Cambridge)
“Genetic Correlates of Phenotypic Heterogeneity in Autism”
April 11, 2022
Cynthia Rogers (WashU Psychiatry), Christopher Smyser (WashU Neurology), Damien Fair (University of Minnesota)
“Introduction to the HEALthy Brain and Child Development Study”
May 9, 2022
Stephan Sanders (University of California, San Francisco)
“Understanding the female protective effect in autism”
October 12, 2020
Kevin Pelphrey (University of Virginia)
“Toward Precision Medicine for Autism(s)”
November 9, 2020
Linda Richards (WashU Dept. of Neuroscience/University of Queensland)
“Wiring the brain for function”
December 14, 2020
Kelly Botteron (WashU Psychiatry)
“MRI based exploration of Early Brain Development in Infants with Down Syndrome: Comparison with Other Developmental Disabilities”
January 11, 2021
Brian O’Roak (Oregon Health & Science University)
“Genomic Approaches for Understanding Autism”
Mini Series: Toward advances in IDD treatment through maternal-fetal medicine
January 25, 2021
Gregor Kasprian (Medical University of Vienna)
“Fetal MRI in IDD”
February 8, 2021
Ritsuko Pooh (CRIFM Clinical Research Institute of Fetal Medicine Pooh Maternity Clinic, Osaka, Japan)
“Fetal Sonographic Neuroimaging in IDD”
March 8, 2021
Tania Attie-Bitach (Hospital Necker-Enfants Malades and Université Paris Descartes)
“Fetal Pathology in Monogenic IDD Syndromes”
April 12, 2021
Ebony Boyce Carter, Michael Bebbington (WashU Obstetrics/Gynecology)
“A Pregnancy Lifecourse Approach to Childhood Intellectual and Developmental Disabilities: The Role of Fetal Surgery”
May 10, 2021
Marsha Michi (Case Western University)
James DuBois (WashU Bioethics Research Centre)
“Ethical Considerations in Fetal Testing and Intervention in the Context of Genetic Risk for IDD”
September 16, 2019
Jeffrey Neil (WashU Neurology)
“Using Diffusion MRI to Study Early Cortical Development”
Relevant publication:
- “Using diffusion anisotropy to study cerebral cortical gray matter development” Kroenke, Journal of Magnetic Resonance (2018)
October 28, 2019
Ilya Monosov (WashU Dept. of Neuroscience)
“Cortical and sub-cortical mechanisms of information seeking and curiosity”
Relevant in press publication:
- “A neural network for information seeking” bioRxiv (2019)
November 18, 2019
Tychele Turner (WashU Genetics)
“Autism through the lens of the genome”
Relevant publications:
- “Genomic Patterns of De Novo Mutation in Simplex Autism” Cell (2017)
- “Loss of δ-catenin function in severe autism” Nature (2015)
CANCELLED (inclement weather) – December 16, 2019
Susan Perlman (WashU Psychiatry)
“Examining Interpersonal Neural Synchronization in Autism Spectrum Disorder”
Relevant publications:
- Perlman, et al. “Experimental manipulation of face-evoked activity in the fusiform gyrus of individuals with autism” Journal Social Neuroscience (2011)
- Quinones-Camacho, et al. “Parent–child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability” Journal of Child Psychology and Psychiatry (2019)
January 13, 2020 – NOTE time: 4:30-5:30p
Elizabeth Berry-Kravis (Rush University)
“Gene Based Clinical Trials in Neurological Disorders of Development: Presenting 2 WU Scientific Teams in Conversation with Liz Berry-Kravis”
Craig Zaidman (WashU Neurology) “Spinal Muscular Atrophy Gene Therapies”
Patricia Dickson (WashU Pediatrics) “Aromatic l-Amino Acid Decarboxylase (AADC) Deficiency”
February 17, 2020
Corina Anastasaki (Gutmann lab, WashU Neurology)
“Neurofibromatosis type 1: a model system to study cognition, behavior and brain development”
Related articles:
- “Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions” Expert Review of Neurotherapeutics (2014)
- “Human stem cell modeling in neurofibromatosis type 1 (NF1)” Experimental Neurology (2018)
CANCELLED – April 20, 2020
Natasha Marrus (WashU Psychiatry)
CANCELLED – May 18, 2020
September 17, 2018
Tamara Hershey
WashU Psychiatry, Neurology and Radiology
“Neurophenotyping a rare monogenic disorder: Lessons from Wolfram Syndrome”
related articles:
- “Neuroimaging evidence of deficient axon myelination in Wolfram syndrome” Lugar, et al. Scientific Reports 2016.
- “Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease” Rigoli et al. Pediatric Research 2018.
October 29, 2018
Matthew Lalli
Milbrandt and Mitra Labs, WashU Genetics
“CRANIUM – A Cas9-based platform to discover common mechanisms of rare disease genes”
related articles:
- “On the design of CRISPR-based single-cell molecular screens” Hill, et al. Nat Methods. 2018
- “Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes” Ho, et al. Stem Cell Reports. 2017
December 17, 2018
Jason Yi
WashU Dept. of Neuroscience
“Phenotypic and mechanistic insights from variant analysis of UBE3A”
related articles:
- “The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome” Yi, et al. J Biological Chemistry. 2017
- “An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A” Yi, et al. Cell. 2015
January 14, 2019
Annapurna Poduri
Harvard University
“Epilepsy Genetics: A Gateway to Mosaicism in Neurodevelopmental Disorders”
February 18, 2019
Harrison Gabel
WashU Dept. of Neuroscience
“From genetics to mechanism: understanding epigenetic disruption in autism and related disorders”
Related articles:
- “Novel genes for autism implicate both excitatory and inhibitory cell lineages in risk” Satterstrom, et al. bioRxiv (2018)
- “The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants [version 1; referees: 3 approved]” Tatton-Brown, et al. Wellcome Open Research (2018)
March 18, 2019
Gabriel Haller
Gurnett and Dobbs Lab, WashU Neurology and Orthopaedic Surgery
“High-throughput functional characterization of genetic variation in human disease”
Related articles:
- “Massively parallel single-nucleotide mutagenesis using reversibly terminated inosine” Haller, et al. Nature Methods (2016)
- “A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis” Haller, et al. Human Molecular Genetics (2016)
April 15, 2019
Laura Jansen
WashU Neurology
“Mechanistic Links Between Epilepsy and Autism in the mTORopathies”
Related articles:
- “Impaired maturation of cortical GABAA receptor expression in pediatric epilepsy” Jansen, et al. Epilepsia (2010)
- “PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia” Jansen, et al. Brain (2015)
May 20, 2019
Flash Talks
Cynthia Ortinau (WashU Pediatrics): “Altered prenatal brain development in congenital heart disease”
Rafael Galindo (WashU Neurology): “Neuroprotective actions of gonadotropins in the injured developing brain”
Stephanie Morris (WashU Neurology): “Genotype-Phenotype Correlation in NF1-ASD”
Bhooma Aravamuthan (WashU Neurology): “Pathophysiology of dystonia after neonatal brain injury”
Zachary Vesoulis (WashU Pediatrics): “Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury”
Jessica Chubiz (WashU Prematurity Research Center): “Prematurity Research Center (PRC) and Women & Infants Health Specimen Consortium (WIHSC) Resources”
September 25, 2017
NOTE: 4:00p Start Time
Pat Levitt
Keck School of Medicine at USC
“Addressing the Biological Origins of Autism Heterogeneity”
October 16, 2017
Anna Kukekova
University of Illinois, Urbana-Champaign
“What can tame and aggressive foxes tell us about genetics of interactive social behavior?”
Related articles:
- Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes)
- Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes)
December 18, 2017
Meghan Swanson
University of North Carolina
“Learning to Talk: The Neurodevelopment of Emerging Language”
Related articles:
- Naturalistic Language Recordings Reveal “Hypervocal” Infants at High Familial Risk for Autism
- Splenium development and early spoken language in human infants
January 22, 2018
Nathan Kopp
Dougherty Lab, WashU Genetics
“Current and emerging approaches to understanding Williams Syndrome using human genetics and mouse models”
Related article:
February 19, 2018
NOTE: 4:00p Start Time
Suma Jacob
University of Minnesota
“Common versus heterogeneous pathways in autism: examples from neuropeptide and phenotype studies”
March 19, 2018
Pamela Valnegri
Bonni Lab, WashU Dept. of Neuroscience
“Deregulation of Ubiquitin Signaling in Autism Spectrum Disorders”
Related article:
April 16, 2018
Peter Tsai
University of Texas, Southwestern
“Cerebro-Cerebellar Circuits in Autism”
Related articles:
- Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
- Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
May 21, 2018
John Pruett Jr.
WashU Psychiatry
“MRI-Based ASD Outcome Prediction”
Related articles:
October 17, 2016
Claire Weichselbaum and John Constantino
WashU Psychiatry
“Infant Eye Movement Links Genetic Susceptibility with Social Impairment in Autism”
Related article:
November 28, 2016
Joseph Dougherty
WashU Genetics
“Using Genetics and Gene Expression to Define Candidate Circuits for ASD and Neurogenetic Disorder”
Related article:
December 19, 2016
Kristen Kroll
WashU Developmental Biology
“Modeling Neurodevelopmental Disorders in Human Pluripotent Stem Cell-Derived Neurons”
Related article:
January 17, 2017
Mike Wong
WashU Neurology
“Tuberous Sclerosis as a Model of Autism and Intellectual Disability”
Related articles:
- Symptom profiles of autism spectrum disorder in tuberous sclerosis complex
- Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex.
- Rapamycin Prevents Epilepsy in a Mouse Model of Tuberous Sclerosis Complex
February 20, 2017
Terra Barnes
WashU Dept. of Neuroscience
“Towards an Animal Model of Stuttering”
March 20, 2017
Mike Gaffrey
WashU Psychiatry
“Early Preventive Intervention for Autism During Infancy: An Emerging Program at WashU”
April 17, 2917
Anna Kukekova
University of Illinois, Urbana-Champaign
May 15, 2017
Vitaly Klyachko
WashU Biomedical Engineering/Cell Biology & Physiology
“Presynaptic dysfunction in Fragile X syndrome”
September 21, 2015
Harrison Gabel
WUSTL Anatomy & Neurobiology
“The neuron-specific epigenome in development and disease”
Related articles:
- Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
- Global Epigenomic Reconfi guration During Mammalian Brain Development
October 19, 2015
John Constantino
WUSTL Psychiatry
“Presenting the new Intellectual and Developmental Disabilities Research Center at W.U. by way of example: A plan to tap its diverse core structure to help elucidate the neurobiology of risk and resilience in familial autism”
Related articles:
- Molecular Autism Complexities of X Chromosome Inactivation Status in Female Human Induced Pluripotent Stem Cells—A brief review and scientific update for autism research
- Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression
- The female protective effect in autism spectrum disorder is not mediated by a single genetic locus
November 16, 2015
Anish Mitra
WUSTL Radiology
“Spontaneous infra-slow brain activity and Autism”
Related articles:
- Largely Typical Patterns of Resting-State Functional Connectivity in High-Functioning Adults with Autism
- Temporal dynamics in fMRI resting state activity
Jeffery Lichtenhan
WUSTL Otolaryngology
“Strong medial olivocochlear reflexes in children with Autism are mediated by hyperacusis, not Autism per se”
December 21, 2015
Adam Eggebrecht
WUSTL Radiology
“How do we bridge genetics, brain structure and function and behavior to understand neurodevelopmental disorders?”
Related articles:
- Correlated gene expression supports synchronous activity in brain networks
- Atypical Functional Brain Connectivity during Rest in Autism Spectrum Disorders
- Canonical genetic signatures of the adult human brain
January 19, 2016
Christina Gurnett
WUSTL Neurology
“Interpretation of human gene variation with high-throughput functional analysis”
February 15, 2016
Dustin Baldridge
WUSTL Psychiatry
“An Update on Clinical Whole Exome Sequencing at Washington University: A Resource for Translational Research in Autism”
Related articles:
March 21, 2016
Susan Maloney
WUSTL Genetics
“Early Environmental Insult: Using genetic tools to dissect circuitry mediating long-term behavioral outcomes”
Related articles:
- Prenatal factors associated with autism spectrum disorder (ASD)
- The Disruption of Celf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors
Sabine Mous
WUSTL Psychiatry
“Autism spectrum symptomatology in genetic neurocognitive developmental disorders: focus on Tuberous Sclerosis Complex and Fragile X syndrome “
Related articles:
- Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis
- The fragile X syndrome–autism comorbidity: what do we really know?
April 18, 2016
Andrew Yoo
WUSTL Developmental Biology
“Generation of specific subtypes of human neurons by direct conversion of fibroblasts for modeling neurological diseases”
Related article:
May 16, 2016
Zohreh Talebizadeh
University of Missouri, Kansas City
“Genetics of autism: integrated approaches and thinking outside the box!”
Related articles:
November 15, 2014
Dr. Barbara Warner
WUSTL Pediatrics
Related publications:
- Microbiota and neurodevelopmental windows: implications for brain disorders
- Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
- Patterned progression of bacterial populations in the premature infant gut
- Gut-brain axis: how the microbiome influences anxiety and depression
December 15, 2014
Dr. Jeanne Nerbonne
WUSTL Developmental Biology
Related publications:
- Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation
- Fragile X Mental Retardation Protein Regulates Protein Expression and mRNA Translation of the Potassium Channel Kv4.2
January 10, 2015
Dr. Joseph Dougherty
WUSTL Genetics
“Arising opportunities from human genetics for developing new autism models”
Related publications:
- One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
- Synaptic, transcriptional and chromatin genes disrupted in autism
February 9, 2015
Dr. Daniel Povinelli
University of Louisiana
Susan Fitzpatrick
President, James S. McDonnell Foundation
“On the ‘rise’ of autism and its early detection: experimental, societal, and ethical implications”
Related Publications:
- Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees
- 2,500-year Evolution of the Term Epidemic
April 20, 2015
Natasha Marrus
WUSTL Psychiatry
Bryan McGill
WUSTL Neurology
Related publications:
- “From early markers to neuro-developmental mechanisms of autism”
- “Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months”
May 9, 2015
Ju Huang
WUSTL Anatomy & Neurobiology
“Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain”
Related Publications:
