Archives: IDDRC Seminars (formerly, Autism Seminar Series)
A history of past seminars.
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2020/2021 Schedule
The seminars are offered via Zoom webinar and have the same link throughout the 2020/2021 series. Contact iddrc@kids.wustl.edu with any questions.
October 12, 2020
Kevin Pelphrey (University of Virginia)
“Toward Precision Medicine for Autism(s)”
November 9, 2020
Linda Richards (WashU Dept. of Neuroscience/University of Queensland)
“Wiring the brain for function”
December 14, 2020
Kelly Botteron (WashU Psychiatry)
“MRI based exploration of Early Brain Development in Infants with Down Syndrome: Comparison with Other Developmental Disabilities”
January 11, 2021
Brian O’Roak (Oregon Health & Science University)
“Genomic Approaches for Understanding Autism”
Mini Series: Toward advances in IDD treatment through maternal-fetal medicine
January 25, 2021
Gregor Kasprian (Medical University of Vienna)
“Fetal MRI in IDD”
February 8, 2021
Ritsuko Pooh (CRIFM Clinical Research Institute of Fetal Medicine Pooh Maternity Clinic, Osaka, Japan)
“Fetal Sonographic Neuroimaging in IDD”
March 8, 2021
Tania Attie-Bitach (Hospital Necker-Enfants Malades and Université Paris Descartes)
“Fetal Pathology in Monogenic IDD Syndromes”
April 12, 2021
Ebony Boyce Carter, Michael Bebbington (WashU Obstetrics/Gynecology)
“A Pregnancy Lifecourse Approach to Childhood Intellectual and Developmental Disabilities: The Role of Fetal Surgery”
May 10, 2021
Marsha Michi (Case Western University)
James DuBois (WashU Bioethics Research Centre)
“Ethical Considerations in Fetal Testing and Intervention in the Context of Genetic Risk for IDD”
2019/2020 Schedule
All seminars occur from 4:00-5:30 in McDonnell Medical Sciences, Room 928. Check back for the full list of speakers!
September 16, 2019
Jeffrey Neil (WashU Neurology)
“Using Diffusion MRI to Study Early Cortical Development”
Relevant publication:
- “Using diffusion anisotropy to study cerebral cortical gray matter development” Kroenke, Journal of Magnetic Resonance (2018)
October 28, 2019
Ilya Monosov (WashU Dept. of Neuroscience)
“Cortical and sub-cortical mechanisms of information seeking and curiosity”
Relevant in press publication:
- “A neural network for information seeking” bioRxiv (2019)
November 18, 2019
Tychele Turner (WashU Genetics)
“Autism through the lens of the genome”
Relevant publications:
- “Genomic Patterns of De Novo Mutation in Simplex Autism” Cell (2017)
- “Loss of δ-catenin function in severe autism” Nature (2015)
CANCELLED (inclement weather) – December 16, 2019
Susan Perlman (WashU Psychiatry)
“Examining Interpersonal Neural Synchronization in Autism Spectrum Disorder”
Relevant publications:
- Perlman, et al. “Experimental manipulation of face-evoked activity in the fusiform gyrus of individuals with autism” Journal Social Neuroscience (2011)
- Quinones-Camacho, et al. “Parent–child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability” Journal of Child Psychology and Psychiatry (2019)
January 13, 2020 – NOTE time: 4:30-5:30p
Elizabeth Berry-Kravis (Rush University)
“Gene Based Clinical Trials in Neurological Disorders of Development: Presenting 2 WU Scientific Teams in Conversation with Liz Berry-Kravis”
Craig Zaidman (WashU Neurology) “Spinal Muscular Atrophy Gene Therapies”
Patricia Dickson (WashU Pediatrics) “Aromatic l-Amino Acid Decarboxylase (AADC) Deficiency”
February 17, 2020
Corina Anastasaki (Gutmann lab, WashU Neurology)
“Neurofibromatosis type 1: a model system to study cognition, behavior and brain development”
Related articles:
- “Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions” Expert Review of Neurotherapeutics (2014)
- “Human stem cell modeling in neurofibromatosis type 1 (NF1)” Experimental Neurology (2018)
The remaining dates for the IDDRC Seminar Series have been cancelled.
CANCELLED – April 20, 2020
Natasha Marrus (WashU Psychiatry)
CANCELLED – May 18, 2020
2018/2019 Schedule
Third Monday of the month
McDonnell Sciences Building, Room 928
4:00-5:30p unless noted
Note that individual events also are listed on the ONR Calendar.
For inquiries, please contact Daniel Gray (Program Manager, IDDRC).
September 17
Tamara Hershey
WashU Psychiatry, Neurology and Radiology
“Neurophenotyping a rare monogenic disorder: Lessons from Wolfram Syndrome”
related articles:
- “Neuroimaging evidence of deficient axon myelination in Wolfram syndrome” Lugar, et al. Scientific Reports 2016.
- “Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease” Rigoli et al. Pediatric Research 2018.
October 29 – NOTE 4:30p start
Matthew Lalli
Milbrandt and Mitra Labs, WashU Genetics
“CRANIUM – A Cas9-based platform to discover common mechanisms of rare disease genes”
related articles:
- “On the design of CRISPR-based single-cell molecular screens” Hill, et al. Nat Methods. 2018
- “Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes” Ho, et al. Stem Cell Reports. 2017
December 17
Jason Yi
WashU Dept. of Neuroscience
“Phenotypic and mechanistic insights from variant analysis of UBE3A”
related articles:
- “The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome” Yi, et al. J Biological Chemistry. 2017
- “An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A” Yi, et al. Cell. 2015
January 14
Annapurna Poduri
Harvard University
“Epilepsy Genetics: A Gateway to Mosaicism in Neurodevelopmental Disorders”
February 18
Harrison Gabel
WashU Dept. of Neuroscience
“From genetics to mechanism: understanding epigenetic disruption in autism and related disorders”
Related articles:
- “Novel genes for autism implicate both excitatory and inhibitory cell lineages in risk” Satterstrom, et al. bioRxiv (2018)
- “The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants [version 1; referees: 3 approved]” Tatton-Brown, et al. Wellcome Open Research (2018)
March 18
Gabriel Haller
Gurnett and Dobbs Lab, WashU Neurology and Orthopaedic Surgery
“High-throughput functional characterization of genetic variation in human disease”
Related articles:
- “Massively parallel single-nucleotide mutagenesis using reversibly terminated inosine” Haller, et al. Nature Methods (2016)
- “A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis” Haller, et al. Human Molecular Genetics (2016)
April 15
Laura Jansen
WashU Neurology
“Mechanistic Links Between Epilepsy and Autism in the mTORopathies”
Related articles:
- “Impaired maturation of cortical GABAA receptor expression in pediatric epilepsy” Jansen, et al. Epilepsia (2010)
- “PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia” Jansen, et al. Brain (2015)
May 20
Flash Talks
Cynthia Ortinau (WashU Pediatrics): “Altered prenatal brain development in congenital heart disease”
Rafael Galindo (WashU Neurology): “Neuroprotective actions of gonadotropins in the injured developing brain”
Stephanie Morris (WashU Neurology): “Genotype-Phenotype Correlation in NF1-ASD”
Bhooma Aravamuthan (WashU Neurology): “Pathophysiology of dystonia after neonatal brain injury”
Zachary Vesoulis (WashU Pediatrics): “Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury”
Jessica Chubiz (WashU Prematurity Research Center): “Prematurity Research Center (PRC) and Women & Infants Health Specimen Consortium (WIHSC) Resources”
2017/2018 Schedule
Mondays
McDonnell Sciences Building, Room 928
4:30-6p unless noted
Note that individual events also are listed on the ONR Calendar.
For inquiries, please contact Daniel Gray (Program Manager, IDDRC).
September 25
NOTE: 4:00p Start Time
Pat Levitt
Keck School of Medicine at USC
“Addressing the Biological Origins of Autism Heterogeneity”
October 16
Anna Kukekova
University of Illinois, Urbana-Champaign
“What can tame and aggressive foxes tell us about genetics of interactive social behavior?”
Related articles:
December 18
Meghan Swanson
University of North Carolina
“Learning to Talk: The Neurodevelopment of Emerging Language”
Related articles:
January 22
Nathan Kopp
Dougherty Lab, WashU Genetics
“Current and emerging approaches to understanding Williams Syndrome using human genetics and mouse models”
Related article:
February 19
NOTE: 4:00p Start Time
Suma Jacob
University of Minnesota
“Common versus heterogeneous pathways in autism: examples from neuropeptide and phenotype studies”
March 19
Pamela Valnegri
Bonni Lab, WashU Dept. of Neuroscience
“Deregulation of Ubiquitin Signaling in Autism Spectrum Disorders”
Related article:
April 16
Peter Tsai
University of Texas, Southwestern
“Cerebro-Cerebellar Circuits in Autism”
Related articles:
May 21
John Pruett Jr.
WashU Psychiatry
“MRI-Based ASD Outcome Prediction”
Related articles:
- Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age
- Early brain development in infants at high risk for autism spectrum disorder
2016/2017 Schedule
Monday, October 17
Claire Weichselbaum and John Constantino
WashU Psychiatry
“Infant Eye Movement Links Genetic Susceptibility with Social Impairment in Autism”
Related article:
Monday, November 28
Joseph Dougherty
WashU Genetics
“Using Genetics and Gene Expression to Define Candidate Circuits for ASD and Neurogenetic Disorder”
Related article:
Monday, December 19
Kristen Kroll
WashU Developmental Biology
“Modeling Neurodevelopmental Disorders in Human Pluripotent Stem Cell-Derived Neurons”
Related article:
* Tuesday, January 17
Mike Wong
WashU Neurology
“Tuberous Sclerosis as a Model of Autism and Intellectual Disability”
Related articles:
- Symptom profiles of autism spectrum disorder in tuberous sclerosis complex
- Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex.
- Rapamycin Prevents Epilepsy in a Mouse Model of Tuberous Sclerosis Complex
Monday, February 20
Terra Barnes
WashU Dept. of Neuroscience
“Towards an Animal Model of Stuttering”
Monday, March 20
Mike Gaffrey
WashU Psychiatry
“Early Preventive Intervention for Autism During Infancy: An Emerging Program at WashU”
CANCELLED: Monday, April 17
Anna Kukekova
University of Illinois, Urbana-Champaign
Monday, May 15
Vitaly Klyachko
WashU Biomedical Engineering/Cell Biology & Physiology
“Presynaptic dysfunction in Fragile X syndrome”
2015/2016 Schedule
September 21
Harrison Gabel
WUSTL Anatomy & Neurobiology
“The neuron-specific epigenome in development and disease”
Related articles:
October 19
WUSTL Psychiatry
“Presenting the new Intellectual and Developmental Disabilities Research Center at W.U. by way of example: A plan to tap its diverse core structure to help elucidate the neurobiology of risk and resilience in familial autism”
- Molecular Autism Complexities of X Chromosome Inactivation Status in Female Human Induced Pluripotent Stem Cells—A brief review and scientific update for autism research
- Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression
- The female protective effect in autism spectrum disorder is not mediated by a single genetic locus
November 16
Anish Mitra
WUSTL Radiology
“Spontaneous infra-slow brain activity and Autism”
Related articles:
- Largely Typical Patterns of Resting-State Functional Connectivity in High-Functioning Adults with Autism
- Temporal dynamics in fMRI resting state activity
Jeffery Lichtenhan
WUSTL Otolaryngology
“Strong medial olivocochlear reflexes in children with Autism are mediated by hyperacusis, not Autism per se”
December 21
Adam Eggebrecht
WUSTL Radiology
“How do we bridge genetics, brain structure and function and behavior to understand neurodevelopmental disorders?”
- Correlated gene expression supports synchronous activity in brain networks
- Atypical Functional Brain Connectivity during Rest in Autism Spectrum Disorders
- Canonical genetic signatures of the adult human brain
January 19 (Note: will be held on Tuesday, due to the holiday)
Christina Gurnett
WUSTL Neurology
“Interpretation of human gene variation with high-throughput functional analysis”
February 15
Dustin Baldridge
WUSTL Psychiatry
“An Update on Clinical Whole Exome Sequencing at Washington University: A Resource for Translational Research in Autism”
Related articles:
March 21
Susan Maloney
WUSTL Genetics
“Early Environmental Insult: Using genetic tools to dissect circuitry mediating long-term behavioral outcomes”
- Prenatal factors associated with autism spectrum disorder (ASD)
- The Disruption of Celf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors
Sabine Mous
WUSTL Psychiatry
“Autism spectrum symptomatology in genetic neurocognitive developmental disorders: focus on Tuberous Sclerosis Complex and Fragile X syndrome “
- Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis
- The fragile X syndrome–autism comorbidity: what do we really know?
April 18
Andrew Yoo
WUSTL Developmental Biology
“Generation of specific subtypes of human neurons by direct conversion of fibroblasts for modeling neurological diseases”
May 16
Zohreh Talebizadeh
University of Missouri, Kansas City
“Genetics of autism: integrated approaches and thinking outside the box!”
2014/2015 Schedule
Saturday, Nov 15
Dr. Barbara Warner
WUSTL Pediatrics
Related publications:
- Microbiota and neurodevelopmental windows: implications for brain disorders
- Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
- Patterned progression of bacterial populations in the premature infant gut
- Gut-brain axis: how the microbiome influences anxiety and depression
Monday, Dec 15
Dr. Jeanne Nerbonne
Related publications:
- Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation
- Fragile X Mental Retardation Protein Regulates Protein Expression and mRNA Translation of the Potassium Channel Kv4.2
Saturday, Jan 10
Dr. Joseph Dougherty
WUSTL Genetics
“Arising opportunities from human genetics for developing new autism models”
Related publications:
- One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
- Synaptic, transcriptional and chromatin genes disrupted in autism
Monday, Feb 9
Dr. Daniel Povinelli
University of Louisiana
Susan Fitzpatrick
President, James S. McDonnell Foundation
“On the ‘rise’ of autism and its early detection: experimental, societal, and ethical implications”
Related Publications:
- Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees
- 2,500-year Evolution of the Term Epidemic
Saturday, Mar 14 : CANCELLED
Monday, Apr 20
Natasha Marrus
WUSTL Psychiatry
Bryan McGill
WUSTL Neurology
Related publications:
- “From early markers to neuro-developmental mechanisms of autism”
- “Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months”
Saturday, May 9
Ju Huang
WUSTL Anatomy & Neurobiology
“Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain”
Related Publications:
- A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain
- Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective
