New Alzheimer’s treatment targets identified

A research team at Washington University School of Medicine in St. Louis has identified potential new treatment targets for Alzheimer’s disease, as well as existing drugs that have therapeutic potential against these targets. The potential targets are defective proteins that lead to the buildup of amyloid in the brain, contributing to the onset of problems […]

Draining brain’s debris enhances Alzheimer’s therapies in mice

Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from the brain, according to a […]

Alzheimer’s in adults with Down syndrome focus of multicenter NIH grant

Researchers from Washington University School of Medicine in St. Louis are taking part in a multisite study to investigate the biomarkers of Alzheimer’s disease in people with Down syndrome. By middle age, nearly all people with Down syndrome show signs of Alzheimer’s disease, and doctors have no way to prevent it or to stop the […]

Genes linked to Alzheimer’s risk, resilience ID’d

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer’s disease. Most genes implicated thus far in Alzheimer’s affect neurons that transmit messages, allowing different regions of the brain to communicate with one […]

New genetic clues to early-onset form of dementia

Culprit is lone error in one gene, but researchers find many potential therapeutic targets From the School of Medicine News… Unlike the more common Alzheimer’s disease, frontotemporal dementia tends to afflict young people. It accounts for an estimated 20 percent of all cases of early-onset dementia. Patients with the illness typically begin to suffer memory […]

Genes linked to Alzheimer’s contribute to damage in different ways

Understanding how specific genes trigger injury could lead to treatments From the WashU School of Medicine News… Multiple genes are implicated in Alzheimer’s disease. Some are linked to early-onset Alzheimer’s, a condition that develops in one’s 30s, 40s and 50s, while others are associated with the more common late-onset form of the disease. Eventually, all […]

Pursuing a precision paradigm

Why move from current standards of patient care to a more personalized approach to treatment? Experts at the School of Medicine describe today’s medical landscape as they plan for the care — and cures — of the future. From the WashU Newsroom… Of the top-grossing domestic movies of 2017 to date, three of the Top 5 […]