Discovery suggests route to safer pain medications

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. For decades, scientists have attempted to develop drugs that selectively activate one type of opioid receptor to treat pain while not activating another type of opioid receptor linked to addiction. Unfortunately, those compounds can cause a different unwanted […]

Scientists alter fentanyl, aim to make it less lethal, less addictive

Fentanyl, a powerful opioid pain reliever, is the leading cause of overdose deaths in the United States. With the aim of improving the drug’s safety profile to make it less lethal and addictive without eliminating its ability to alleviate pain, a team of researchers, led by scientists at the Center for Clinical Pharmacology at Washington University School […]