A common sleep aid restores healthier sleep patterns and protects mice from the brain damage seen in neurodegenerative disorders, such as Alzheimer’s disease, according to new research from Washington University School of Medicine in St. Louis. The drug, lemborexant, prevents the harmful buildup of an abnormal form of a protein called tau in the brain, […]
Washington University School of Medicine in St. Louis has received a three-year $4.5 million grant from the Carol and Gene Ludwig Family Foundation, aimed at advancing research on neuroimmunology and neurodegeneration with the ultimate goal of developing new treatments for Alzheimer’s disease. Administered by WashU Medicine’s Brain Immunology & Glia (BIG) Center, the Carol and Gene […]
Washington University School of Medicine in St. Louis faculty members David M. Holtzman, MD, the Barbara Burton and Reuben M. Morriss III Distinguished Professor of Neurology, and Xiaoying Chen, PhD, an instructor in neurology, were awarded the inaugural Jeffrey L. Morby Prize from Cure Alzheimer’s Fund, a nonprofit dedicated to supporting the most promising research to prevent, slow […]
Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer’s drugs — the first proven to change the course of the disease — work by tagging amyloid for […]
Breaking link between early, late stages of disease may prevent dementia
University launches new era of progress in neuroscience Understanding the brain and nervous system is one of the most pressing challenges in medicine. To meet this challenge, WashU Medicine has built and is opening the Neuroscience Research Building, a 609,000-square-foot facility expected to be among the nation’s premier neuroscience research hubs. Read more.
In Alzheimer’s disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau. Wherever tau builds up, nearby brain tissue starts to degenerate and die. Now, researchers at Washington University School of Medicine in St. Louis have found — in mice — that Alzheimer’s-like tau deposits in […]
Two pathologies drive the progression of Alzheimer’s disease. Early on, amyloid beta plaques lead the way, but around the time cognitive symptoms arise, tau tangles take over as the driving force and cognition steadily declines. Tracking the course of the disease in individual patients has been challenging because there’s been no easy way to measure […]
Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer’s disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms. Many of the immunity-focused Alzheimer’s drugs under development are aimed at […]
A growing pile of evidence indicates that the tens of trillions of microbes that normally live in our intestines — the so-called gut microbiome — have far-reaching effects on how our bodies function. Members of this microbial community produce vitamins, help us digest food, prevent the overgrowth of harmful bacteria and regulate the immune system, […]
Memory loss is often the first sign of Alzheimer’s disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain — the memory area — before spreading to parts of the brain important for […]
Carlos Cruchaga, PhD, has received a 2022 Zenith Fellow Award from the Alzheimer’s Association. The annual award is given to scientists who have made significant contributions to the field of Alzheimer’s disease research and are likely to make additional, substantial contributions in the future. Funding attached to the fellowships also helps support high- risk, high-reward projects in […]
When you live with dementia, your sleep breaks apart, the nights a strobe-lit blur, the grayed days lost to catnaps. Physicians — and families — have known this for years. But what no one realized, until landmark research at Washington University in 2009 set a series of studies in motion, was that fragmented sleep might […]
Neuroscience leaders and other faculty and staff at Washington University School of Medicine in St. Louis got an up-close look at the Neuroscience Research Building during a recent tour of the construction site. The framework of all 11 stories has been built, and the process of wrapping the building in glass is underway. On the […]
People with sleep apnea wake up tired in the morning, no matter how many hours they actually sleep. The condition causes them to briefly stop and restart breathing dozens or even hundreds of times a night. Even though such breathing interruptions often don’t awaken those with apnea, they prevent them from sinking into deep, refreshing […]
Alzheimer’s disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study by researchers at Washington University School of Medicine in St. Louis has shown that targeting astrocytes — an inflammatory cell in the brain — reduces tau-related brain […]
The TV sitcom grandpa character who always seems to fall asleep at unfortunate moments is so common it’s almost a cliché. But daytime napping and disjointed sleep at night aren’t normal parts of aging. Sleep disturbances can be an early sign of a neurodegenerative condition, and they may be treatable. Researchers at Washington University School […]
A blood test developed at Washington University School of Medicine in St. Louis has proven highly accurate in detecting early signs of Alzheimer’s disease in a study involving nearly 500 patients from across three continents, providing further evidence that the test should be considered for routine screening and diagnosis. The study is available in the […]
Like so many other good things in life, sleep is best in moderation. A multiyear study of older adults found that both short and long sleepers experienced greater cognitive decline than people who slept a moderate amount, even when the effects of early Alzheimer’s disease were taken into account. The study was led by researchers […]
By the time people with Alzheimer’s disease start exhibiting difficulty remembering and thinking, the disease has been developing in their brains for two decades or more, and their brain tissue already has sustained damage. As the disease progresses, the damage accumulates, and their symptoms worsen. Researchers at Washington University School of Medicine in St. Louis […]
Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from the brain, according to a […]
Alzheimer’s researchers David M. Holtzman, MD, and Celeste Karch, PhD, of Washington University School of Medicine in St. Louis, have been recognized by the Rainwater Charitable Foundation for scientific achievements that could lead to new, effective treatments for neurodegenerative diseases associated with the accumulation of tau protein in the brain. Alzheimer’s is the best known such disease. […]
The Rainwater Charitable Foundation, one of the largest independent funders of neurodegenerative disease research, today announced Dr. David M. Holtzman (the Andrew B. and Gretchen P. Jones Professor and Chair of Neurology, Washington University School of Medicine in St. Louis) and Dr. Celeste Karch (Associate Professor of Psychiatry, Washington University School of Medicine in St. Louis) as this year’s recipients of the Rainwater Annual Prize for […]
As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise […]
Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood. Researchers at Washington University School of Medicine in St. […]
As the brain reigns supreme over the human body, the immune system works 24/7 to defend the body from foreign invaders. For decades, however, the brain and the immune system were thought to operate independently of one another. But a growing body of evidence suggests the two are intimately connected in keeping the body healthy. […]
Consumer genetic tests can sometimes result in a terrible surprise appearing in the same report that divulges whether one has a cilantro aversion or wet or dry earwax. Test takers may receive the devastating news that they have a version of a gene—apolipoprotein E epsilon 4 (APOE e4)—that greatly increases their chances of getting Alzheimer’s disease. The […]
Washington University in St. Louis will begin construction in March on what will be one of the largest neuroscience research buildings in the country. Located on the School of Medicine campus, the 11-story, state-of-the-art research facility will merge, cultivate and advance some of the world’s leading neuroscience research. The 609,000-square-foot facility and interconnected projects initially […]
Dementia is one of the most debilitating consequences of Parkinson’s disease, a progressive neurological condition characterized by tremors, stiffness, slow movement and impaired balance. Eighty percent of people with Parkinson’s develop dementia within 20 years of the diagnosis, and patients who carry a particular variant of the gene APOE are at especially high risk. In new research, […]
Brain scientists are offering a new reason to control blood sugar levels: It might help lower your risk of developing Alzheimer’s disease. “There’s many reasons to get [blood sugar] under control,” says David Holtzman, chairman of neurology at Washington University in St. Louis. “But this is certainly one.” Holtzman moderated a panel Sunday at the Society […]
Messy tangles of a protein called tau can be found in the brains of people with Alzheimer’s disease and some other neurodegenerative diseases. In Alzheimer’s, the tangles coalesce just before tissue damage becomes visible in brain scans and people start to become forgetful and confused. Now, a new study has found that brain immune cells […]
David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology at Washington University School of Medicine in St. Louis, has received the August M. Watanabe Prize in Translational Research from the Indiana Clinical and Translational Sciences Institute. He was recognized for his work uncovering the causes of Alzheimer’s disease […]
Washington University is working with unparalleled research capabilities to make personalized medicine a reality. The medical school is pioneering individualized treatment approaches in obesity, diabetes, breast cancer and Alzheimer’s disease. Watch the video spotlight.
For decades, researchers have sought a blood test for beta amyloid, the protein that is a hallmark of Alzheimer’s disease. Several groups and companies have made progress, and on Thursday, scientists at Washington University in St. Louis reported that they had devised the most sensitive blood test yet. The test will not be available for […]
Years before symptoms of Alzheimer’s disease appear, two kinds of damaging proteins silently collect in the brain: amyloid beta and tau. Clumps of amyloid accumulate first, but tau is particularly noxious. Wherever tangles of the tau protein appear, brain tissue dies, triggering the confusion and memory loss that are hallmarks of Alzheimer’s. Now, researchers at […]
From Forbes… Brains do a lot of work while we sleep—far from being a passive behavior, sleep is actually critical to brain health, and as a result, mental and cognitive health. A few new studies in recent weeks underline how important sleep is, and how detrimental lack of sleep can be. And not just chronic […]
Study in mice, people explains why poor sleep linked to Alzheimer’s From the WashU Newsroom… Poor sleep has long been linked with Alzheimer’s disease, but researchers have understood little about how sleep disruptions drive the disease. Now, studying mice and people, researchers at Washington University School of Medicine in St. Louis have found that sleep […]
From US News & World Report… EXPERTS HAVE LONG warned about the negative effects of sleep deprivation, and new research suggests that people with Alzheimer’s disease may be particularly affected. In a study of mice and humans, researchers at Washington University School of Medicine in St. Louis found that sleep deprivation increases levels of the […]
Doctors may soon be able to predict, prevent Alzheimer’s disease From the WashU Outlook Magazine… Caring for an aging relative with Alzheimer’s disease, watching memories slowly slip away, is an exhausting and heartbreaking ordeal. For those with the condition, modern medicine can offer little in the way of treatment as the disease inexorably strips away […]
Toxic brain protein tau elevated in older people who sleep poorly From the WashU School of Medicine News… Poor sleep is a hallmark of Alzheimer’s disease. People with the disease tend to wake up tired, and their nights become even less refreshing as memory loss and other symptoms worsen. But how and why restless nights […]
From the WashU Newsroom… Years before people start showing characteristic symptoms of Alzheimer’s disease, sticky plaques begin forming in their brains, damaging nearby cells. For decades, doctors have sought ways to clear out these plaques as a way to prevent or treat the disease. The sticky clumps, known as amyloid plaques, are composed primarily of a […]
Study shows sleepless night taxes brain’s waste-disposal abilities From the WashU Newsroom… Have you resolved to take better care of yourself in the new year? Here’s a relatively painless way to do it: Catch a few more zzz’s every night. A third of American adults don’t get enough sleep, according to the Centers for Disease Control […]
Achilefu, Holtzman, Leuthardt honored for innovation From the WashU Newsroom… Noted innovators Samuel Achilefu, PhD, David Holtzman, MD, and Eric Leuthardt, MD – faculty members at Washington University School of Medicine in St. Louis – have been named fellows of the National Academy of Inventors (NAI). The 2017 class of NAI fellows was announced Tuesday. They are recognized as fellows […]
APOE is major Alzheimer’s risk gene From the WashU Newsroom… People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer’s disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by […]
Why move from current standards of patient care to a more personalized approach to treatment? Experts at the School of Medicine describe today’s medical landscape as they plan for the care — and cures — of the future. From the WashU Newsroom… Of the top-grossing domestic movies of 2017 to date, three of the Top 5 […]
Former head of neurology specialized in movement disorders From the WashU Newsroom… William M. Landau, MD, a professor emeritus of neurology, died in his sleep Thursday, Nov. 2, 2017, at his home in University City. He was 93. Landau wasa professor of neurology at Washington University School of Medicine in St. Louis from 1954 to 2012 […]
Study suggests role of inflammation in brain disease is complicated From the WashU Newsroom… Scientists drilling down to the molecular roots of Alzheimer’s disease have encountered a good news/bad news scenario. A major player is a gene called TREM2, mutations of which can substantially raise a person’s risk of the disease. The bad news is that […]
Blocking ApoE4 in brain may prevent nerve cell death, inflammation From the WashU Newsroom… Nearly a quarter century ago, a genetic variant known as ApoE4 was identified as a major risk factor for Alzheimer’s disease — one that increases a person’s chances of developing the neurodegenerative disease by up to 12 times. However, it was never […]