Inventive pathways

Moving innovations out of the so-called ivory tower and into the public domain holds enormous power to treat disease and improve quality of life. But while academic researchers and physicians may imagine promising clinical solutions, some are unprepared to navigate commercialization: pitching themselves, attracting investors, wrangling with intellectual property law, designing rigorous proof-of-concept studies, locating […]

Noninvasive brain biopsy shows improved sensitivity in tumor detection

Glioblastomas are aggressive brain tumors that are commonly diagnosed through a risky and invasive surgical biopsy. A team of researchers led by Hong Chen, PhD at Washington University in St. Louis has developed a noninvasive diagnostic method that may one day replace the tissue biopsy with a simple blood test. Chen, associate professor of biomedical engineering at […]

‘First-in-class’ tool for potential treatment of brain disorders

New methods to treat human brain disorders is one of the top priorities of the National Institutes of Health’s ambitious BRAIN Initiative. To find noninvasive tools that are equally or more effective is a kind of Holy Grail for neuroscience, and a biomedical engineer at Washington University in St. Louis has it in her sights. […]

MRI’s magnetic field affects focused ultrasound technology

In a mouse model study of MRI-guided focused ultrasound-induced blood-brain barrier opening at MRI field strengths ranging from ­approximately 0 T (outside the magnetic field) to 4.7 T, the static magnetic field dampened the detected microbubble cavitation signal and decreased the BBB opening volume. (Image courtesy of Chen lab)

MRI-guided focused ultrasound combined with microbubbles can open the blood-brain barrier and allow therapeutic drugs to reach the diseased brain location under the guidance of MRI. It is a promising technique that has been shown safe in patients with various brain diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS) and glioblastoma. Chen While MRI […]

New tool activates deep brain neurons by combining ultrasound, genetics

Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 5, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Ruopeng An to associate professor at the Brown School; Arpita Bose to associate professor of biology in Arts & Sciences; Hong […]

Brain Tumor Center established at Siteman Cancer Center

Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital have established the Brain Tumor Center, a multidisciplinary practice of physicians and scientists whose mission is to provide leading-edge, patient-centric care for brain tumor patients while also developing transformative basic, translational and clinical research to develop new therapies and improve patient outcomes. Neurosurgeon and scientist Albert H. Kim, […]

FUSIN promising in therapeutic agent delivery to brain tumor

Brainstem glioma is often diagnosed in children and young adults and has a low survival rate. A multidisciplinary team at Washington University in St. Louis developed a technique that delivered a therapeutic agent to the gliomas using focused ultrasound with very promising results. Dezhuang Ye, a doctoral student in the lab of Hong Chen, PhD, […]

Targeting ultrasound at the brain for noninvasive diagnosis of brain cancer

Brain tumors are typically diagnosed using MRI imaging, as taking a sample for a tissue biopsy is risky and may not be possible due to tumor location or a patient’s poor health conditions. Researchers at Washington University in St. Louis are developing a method to diagnose brain tumors without any incisions. The method is developed […]

Chen receives $500,000 grant to study new technique in pediatric brain cancer model

In Australia, brain cancer kills more children than any other disease. But it is difficult to treat without significant risks from surgical or drug treatment. Hong Chen, assistant professor of biomedical engineering in the Washington University in St. Louis McKelvey School of Engineering and of radiation oncology in the School of Medicine, will address the […]

Chen receives early career award for research in therapeutic ultrasound

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, has been selected to receive the 2020 Frederic Lizzi Early Career Award from the International Society of Therapeutic Ultrasound (ISTU). The award recognizes individuals early in their professional career who have contributed substantially […]

Chen awarded $310K from National Institute on Aging of the NIH

Hong Chen, assistant professor at the McKelvey School of Engineering and at the School of Medicine, received a $309,909 grant from the National Institute on Aging of the National Institutes of Health (NIH) to explore the application of a focused ultrasound-mediated drug delivery technique for treating Alzheimer’s disease. Read more.

Chen awarded Office of Naval Research grant for detection of TBI

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $470,500 research grant from the Office of Naval Research to detect traumatic brain injury (TBI) using ultrasound sensors. This research represents just one arm of a multi-faceted approach in the Chen […]

A new method for precision drug delivery: painting

If traditional drug delivery were a type of painting, it might be akin to paintball. With good aim, a majority of the paint ends on the bullseye, but it also drips and splashes, carrying streams of paint across the target. If the drug needs to enter the bloodstream and circulate throughout your body for treating […]

Hong Chen receives $1.6 million grant from the NIH’s National Institute of Biomedical Imaging and Bioengineering

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, received a $1.6 million grant from the National Institutes of Health (NIH)’s National Institute of Biomedical Imaging and Bioengineering. The research will fund a broader understanding of Chen’s earlier work combining intranasal drug delivery […]

Focused delivery for brain cancers

Interdisciplinary research brings together imaging, aerosols and pediatric neuro oncology to fight tumors From the WashU Newsroom… A person’s brainstem controls some of the body’s most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating. Not only can such a growth […]

Brain Initiative grants Chen $2.7 million for neuroscience study

An interdisciplinary team of WashU researchers will be developing a non-invasive neuromodulation tool From the WashU School of Engineering & Applied Science News… Hong Chen, assistant professor of biomedical engineering in the School of Engineering & Applied Science and radiation oncology in the School of Medicine, has received a $2.7 million grant from the National Institutes of […]

Noninvasive brain tumor biopsy on the horizon

New technique developed at Washington University in St. Louis uses blood test From the WashU Newsroom… Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple […]