WashU weekly Neuroscience publications

Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review
(2022) Current Oncology, 29 (4), pp. 2550-2563. 

Johnson, G.W.^a , Han, R.H.^a , Smyth, M.D.^b , Leuthardt, E.C.^a c , Kim, A.H.^a c

^a Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, United States
^b Department of Neurosurgery, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, United States
^c Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, United States

Abstract
Laser interstitial thermal therapy (LITT) has become an increasingly utilized alternative to surgical resection for the treatment of glioma in patients. However, treatment outcomes in isocitrate dehydrogenase 1 and 2 (IDH1/2) mutant glioma, specifically, have not been reported. The objective of this study was to characterize a single institution’s cohort of IDH1/2 mutant grade 2/3 glioma patients treated with LITT. We collected data on patient presentation, radiographic features, tumor molecular profile, complications, and outcomes. We calculated progression-free survival (PFS) and tested factors for significant association with longer PFS. Overall, 22.7% of our cohort experienced progression at a median follow up of 1.8 years. The three-and five-year estimates of PFS were 72.5% and 54.4%, respectively. This is the first study to characterize outcomes in patients with IDH1/2 mutant glioma after LITT. Our results suggest that LITT is an effective treatment option for IDH1/2 mutant glioma. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Author Keywords
astrocytoma;  glioma;  IDH1 mutation;  IDH2 mutation;  laser interstitial thermal therapy;  oligodendroglioma

Funding details
American Cancer SocietyACS

Brain charts for the human lifespan
(2022) Nature, 604 (7906), pp. 525-533. Cited 1 time.

Bethlehem, R.A.I.^a b , Seidlitz, J.^c d e , White, S.R.^f g , Vogel, J.W.^c h , Anderson, K.M.ⁱ , Adamson, C.^j k , Adler, S.^l , Alexopoulos, G.S.^m , Anagnostou, E.^n o , Areces-Gonzalez, A.^p q , Astle, D.E.^r , Auyeung, B.^s t , Ayub, M.^u v , Bae, J.^w , Ball, G.^j x , Baron-Cohen, S.^s y , Beare, R.^j k , Bedford, S.A.^s , Benegal, V.^z , Beyer, F.^aa , Blangero, J.^ab , Blesa Cábez, M.^ac , Boardman, J.P.^ac , Borzage, M.^ad , Bosch-Bayard, J.F.^ae af , Bourke, N.^ag ah , Calhoun, V.D.^ai , Chakravarty, M.M.^af aj , Chen, C.^ak , Chertavian, C.^e , Chetelat, G.^al , Chong, Y.S.^am an , Cole, J.H.^ao ap , Corvin, A.^aq , Costantino, M.^ar as , Courchesne, E.^at au , Crivello, F.^av , Cropley, V.L.^aw , Crosbie, J.^ax , Crossley, N.^ay az ba , Delarue, M.^al , Delorme, R.^bb bc , Desrivieres, S.^bd , Devenyi, G.A.^be bf , Di Biase, M.A.^aw bg , Dolan, R.^bh bi , Donald, K.A.^bj bk , Donohoe, G.^bl , Dunlop, K.^bm , Edwards, A.D.^bn bo bp , Elison, J.T.^bq , Ellis, C.T.^i br , Elman, J.A.^bs , Eyler, L.^bt bu , Fair, D.A.^bq , Feczko, E.^bq , Fletcher, P.C.^bv bw , Fonagy, P.^bx by , Franz, C.E.^bs , Galan-Garcia, L.^bz , Gholipour, A.^ca , Giedd, J.^cb cc , Gilmore, J.H.^cd , Glahn, D.C.^ce cf , Goodyer, I.M.^f , Grant, P.E.^cg , Groenewold, N.A.^bk ch , Gunning, F.M.^ci , Gur, R.E.^c e , Gur, R.C.^c e , Hammill, C.F.^ax cj , Hansson, O.^ck cl , Hedden, T.^cm cn , Heinz, A.^co , Henson, R.N.^f r , Heuer, K.^cp cq , Hoare, J.^cr , Holla, B.^cs ct , Holmes, A.J.^cu , Holt, R.^s , Huang, H.^cv cw , Im, K.^ce , Ipser, J.^cx , Jack, C.R., Jr^cy , Jackowski, A.P.^cz da , Jia, T.^db dc dd , Johnson, K.A.^{cf de df dg} , Jones, P.B.^f bw , Jones, D.T.^cy dh , Kahn, R.S.^di , Karlsson, H.^dj dk , Karlsson, L.^dj dk , Kawashima, R.^dl , Kelley, E.A.^dm , Kern, S.^dn do , Kim, K.W.^{dp dq dr ds} , Kitzbichler, M.G.^f dt , Kremen, W.S.^bs , Lalonde, F.^du , Landeau, B.^al , Lee, S.^dv , Lerch, J.^dw dx , Lewis, J.D.^dy , Li, J.^dz , Liao, W.^dz , Liston, C.^ea , Lombardo, M.V.^s eb , Lv, J.^aw ec , Lynch, C.^bm , Mallard, T.T.^ed , Marcelis, M.^ee ef , Markello, R.D.^eg , Mathias, S.R.^ce , Mazoyer, B.^av eh , McGuire, P.^az , Meaney, M.J.^eh ei , Mechelli, A.^ej , Medic, N.^f , Misic, B.^eg , Morgan, S.E.^f ek el , Mothersill, D.^em en eo , Nigg, J.^ep , Ong, M.Q.W.^eq , Ortinau, C.^er , Ossenkoppele, R.^es et , Ouyang, M.^cv , Palaniyappan, L.^eu , Paly, L.^al , Pan, P.M.^ev ew , Pantelis, C.^ex ey ez , Park, M.M.^fa , Paus, T.^fb fc , Pausova, Z.^ax fd , Paz-Linares, D.^p fe , Pichet Binette, A.^ff fg , Pierce, K.^at , Qian, X.^eq , Qiu, J.^fh , Qiu, A.^fi , Raznahan, A.^du , Rittman, T.^fj , Rodrigue, A.^ce , Rollins, C.K.^fk fl , Romero-Garcia, R.^f fm , Ronan, L.^f , Rosenberg, M.D.^fn , Rowitch, D.H.^fo , Salum, G.A.^fp fq , Satterthwaite, T.D.^c h , Schaare, H.L.^fr fs , Schachar, R.J.^ax , Schultz, A.P.^cf de ft , Schumann, G.^fu fv , Schöll, M.^fw fx fy , Sharp, D.^ag fz , Shinohara, R.T.^ak ga , Skoog, I.^dn do , Smyser, C.D.^gb , Sperling, R.A.^cf de df , Stein, D.J.^gc , Stolicyn, A.^gd , Suckling, J.^f bw , Sullivan, G.^ac , Taki, Y.^dl , Thyreau, B.^dl , Toro, R.^cq ge , Traut, N.^ge gf , Tsvetanov, K.A.^fj gg , Turk-Browne, N.B.^i gh , Tuulari, J.J.^dj gi gj , Tzourio, C.^gk , Vachon-Presseau, É.^gl , Valdes-Sosa, M.J.^bz , Valdes-Sosa, P.A.^dz gm , Valk, S.L.^gn go , van Amelsvoort, T.^gp , Vandekar, S.N.^gq , Vasung, L.^eg , Victoria, L.W.^ci , Villeneuve, S.^ff fg gr , Villringer, A.^aa gs , Vértes, P.E.^f el , Wagstyl, K.^bi , Wang, Y.S.^{gt gu gv gw} , Warfield, S.K.^ca , Warrier, V.^f , Westman, E.^gx , Westwater, M.L.^f , Whalley, H.C.^gd , Witte, A.V.^aa gs gy , Yang, N.^{gt gu gv gw} , Yeo, B.^gz ha hb , Yun, H.^hc , Zalesky, A.^aw , Zar, H.J.^ch hd , Zettergren, A.^dn , Zhou, J.H.^eq gz he , Ziauddeen, H.^f bw hf , Zugman, A.^ew hg hh , Zuo, X.N.^{gs gt gu gv hi} , Bullmore, E.T.^f , Alexander-Bloch, A.F.^c d e , 3R-BRAIN^hj , AIBL^hk , Alzheimer’s Disease Neuroimaging Initiative^hl , Alzheimer’s Disease Repository Without Borders Investigators^hm , CALM Team^hn , Cam-CAN^ho , CCNP^hp , COBRE^hq , cVEDA^hr , ENIGMA Developmental Brain Age Working Group^hs , Developing Human Connectome Project^ht , FinnBrain^hu , Harvard Aging Brain Study^hv , IMAGEN^hw , KNE96^hx , Mayo Clinic Study of Aging^hy , NSPN^hz , POND^ia , PREVENT-AD Research Group^ib , VETSA^ic

^a Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
^b Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
^c Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States
^d Department of Child and Adolescent Psychiatry and Behavioral Science, Children’s Hospital of Philadelphia, PA, Philadelphia, United States
^e Lifespan Brain Institute, Children’s Hospital of Philadelphia and Penn Medicine, PA, Philadelphia, United States
^f Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
^g MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom
^h Lifespan Informatics & Neuroimaging Center, University of Pennsylvania, PA, Philadelphia, United States
ⁱ Department of Psychology, Yale University, CT, New Haven, United States
^j Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, VIC, Australia
^k Department of Medicine, Monash University, Melbourne, VIC, Australia
^l UCL Great Ormond Street Institute for Child Health, London, United Kingdom
^m Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell MedicineNY, United States
ⁿ Department of Pediatrics University of Toronto, Toronto, Canada
^o Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada
^p Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, University of Electronic Science and Technology of China, Chengdu, China
^q University of Pinar del Río “Hermanos Saiz Montes de Oca”Pinar del Río, Cuba
^r MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
^s Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
^t Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, United Kingdom
^u Queen’s University, Department of Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, Canada
^v University College London, Mental Health Neuroscience Research Department, Division of Psychiatry, London, United Kingdom
^w Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea
^x Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
^y Cambridge Lifetime Asperger Syndrome Service (CLASS), Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom
^z Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India
^aa Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
^ab Department of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, TX, Edinburg, United States
^ac MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
^ad Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
^ae McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological Institute, Montreal, QC, Canada
^af McGill University, Montreal, QC, Canada
^ag Department of Brain Sciences, Imperial College London, London, United Kingdom
^ah Care Research and Technology Centre, Dementia Research Institute, London, United Kingdom
^ai Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, United States
^aj Computational Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada
^ak Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, Informatics, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
^al Normandie Univ, UNICAEN, INSERM, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Caen, France
^am Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
^an Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
^ao Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom
^ap Dementia Research Centre (DRC), University College London, London, United Kingdom
^aq Department of Psychiatry, Trinity College, Dublin, Ireland
^ar Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada
^as Undergraduate program in Neuroscience, McGill University, Montreal, QC, Canada
^at Department of Neuroscience, University of California, San Diego, San Diego, CA, USA
^au Autism Center of Excellence, University of California, San Diego, San Diego, CA, USA
^av Institute of Neurodegenerative Disorders, CNRS UMR5293, CEA, University of Bordeaux, Bordeaux, France
^aw Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
^ax Hospital for Sick Children, Toronto, ON, Canada
^ay Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de ChileSantiago, Chile
^az Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
^ba Instituto Milenio Intelligent Healthcare EngineeringSantiago, Chile
^bb Child and Adolescent Psychiatry Department, Robert Debré University Hospital, AP-HP, Paris, France
^bc Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
^bd Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
^be Cerebral Imaging Centre, McGill Department of Psychiatry, Douglas Mental Health University Institute, QC, Montreal, Canada
^bf Department of Psychiatry, McGill University, QC, Montreal, Canada
^bg Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States
^bh Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom
^bi Wellcome Centre for Human Neuroimaging, London, United Kingdom
^bj Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa
^bk Neuroscience Institute, University of Cape Town, Cape Town, South Africa
^bl Center for Neuroimaging, Cognition & Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland
^bm Weil Family Brain and Mind Research Institute, Department of Psychiatry, Weill Cornell Medicine, NY, NY, United States
^bn Centre for the Developing Brain, King’s College London, London, United Kingdom
^bo Evelina London Children’s Hospital, London, United Kingdom
^bp MRC Centre for Neurodevelopmental Disorders, London, United Kingdom
^bq Institute of Child Development, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, MN, Minneapolis, United States
^br Haskins Laboratories, CT, New Haven, United States
^bs Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA
^bt Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA
^bu Department of Psychiatry, University of California San Diego, Los Angeles, CA, USA
^bv Department of Psychiatry, University of Cambridge, Wellcome Trust MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
^bw Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom
^bx Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom
^by Anna Freud National Centre for Children and Families, London, United Kingdom
^bz Cuban Center for Neuroscience, La Habana, Cuba
^ca Computational Radiology Laboratory, Boston Children’s Hospital, MA, Boston, United States
^cb Department of Child and Adolescent Psychiatry, University of California, San Diego, San Diego, CA, USA
^cc Department of Psychiatry, University of California San Diego, San Diego, CA, USA
^cd Department of Psychiatry, University of North Carolina, Chapel Hill, United States
^ce Department of Psychiatry, Boston Children’s Hospital and Harvard Medical School, MA, Boston, United States
^cf Harvard Medical School, MA, Boston, United States
^cg Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, MA, Boston, United States
^ch Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa
^ci Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine, NY, NY, United States
^cj Mouse Imaging Centre, Toronto, ON, Canada
^ck Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
^cl Memory Clinic, Skåne University Hospital, Malmö, Sweden
^cm Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, NY, United States
^cn Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States
^co Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Psychotherapy, Charité Campus MitteBerlin, Germany
^cp Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
^cq Université de Paris, Paris, France
^cr Department of Psychiatry, University of Cape Town, Cape Town, South Africa
^cs Department of Integrative Medicine, NIMHANS, Bengaluru, India
^ct Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS), Department of Psychiatry, NIMHANS, Bengaluru, India
^cu Departments of Psychology and Psychiatry, Yale University, CT, New Haven, United States
^cv Radiology Research, Children’s Hospital of Philadelphia, PA, Philadelphia, United States
^cw Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
^cx Department of Psychiatry and Mental Health, Clinical Neuroscience Institute, University of Cape Town, Cape Town, South Africa
^cy Department of Radiology, Mayo Clinic, MN, Rochester, United States
^cz Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil
^da National Institute of Developmental PsychiatryBeijing, China
^db Institute of Science and Technology for Brain-Inspired Intelligence, Fudan UniversityShanghai, China
^dc Key Laboratory of Computational Neuroscience and BrainInspired Intelligence (Fudan University), Ministry of EducationShanghai, China
^dd Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King’s College London, London, United Kingdom
^de Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, MA, Boston, United States
^df Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, MA, Boston, United States
^dg Department of Radiology, Massachusetts General Hospital, MA, Boston, United States
^dh Department of Neurology, Mayo Clinic, MN, Rochester, United States
^di Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, United States
^dj Department of Clinical Medicine, Department of Psychiatry and Turku Brain and Mind Center, FinnBrain Birth Cohort Study, University of Turku and Turku University Hospital, Turku, Finland
^dk Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland
^dl Institute of Development, Aging and Cancer, Tohoku University, Seiryocho ,Aobaku, Sendai, Japan
^dm Queen’s University, Departments of Psychology and Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, Canada
^dn Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden
^do Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Gothenburg, Sweden
^dp Department of Brain and Cognitive Sciences, Seoul National University College of Natural SciencesSeoul, South Korea
^dq Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea
^dr Department of Psychiatry, Seoul National University College of MedicineSeoul, South Korea
^ds Institute of Human Behavioral Medicine, SNU-MRCSeoul, South Korea
^dt Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
^du Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, MD, Bethesda, United States
^dv Department of Brain & Cognitive Sciences, Seoul National University College of Natural SciencesSeoul, South Korea
^dw Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
^dx Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom
^dy Montreal Neurological Institute, McGill University, Montreal, QC, Canada
^dz Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China
^ea Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, NY, NY, United States
^eb Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
^ec School of Biomedical Engineering and Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia
^ed Department of Psychology, University of Texas, TX, Austin, United States
^ee Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, Netherlands
^ef Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, Netherlands
^eg McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
^eh Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Montreal, QC, Canada
^ei Singapore Institute for Clinical Sciences, Singapore
^ej Bordeaux University Hospital, Bordeaux, France
^ek Department of Computer Science and Technology, University of Cambridge, Cambridge, United Kingdom
^el Alan Turing Institute, London, United Kingdom
^em Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland
^en School of Psychology and Center for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland
^eo Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
^ep Department of Psychiatry, School of Medicine, Oregon Health and Science University, ORPortland, United States
^eq Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
^er Department of Pediatrics, Washington University in St Louis, St Louis, MO, USA
^es Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
^et Lund University, Clinical Memory Research Unit, Lund, Sweden
^eu Robarts Research Institute and The Brain and Mind Institute, University of Western Ontario, London, ON, Canada
^ev Department of Psychiatry, Federal University of Sao Poalo (UNIFESP), Sao Poalo, Brazil
^ew National Institute of Developmental Psychiatry for Children and Adolescents (INPD), Sao Poalo, Brazil
^ex Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton SouthVIC, Australia
^ey Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia
^ez Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia
^fa Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
^fb Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada
^fc Departments of Psychiatry and Psychology, University of Toronto, Toronto, ON, Canada
^fd Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada
^fe Cuban Neuroscience CenterHavana, Cuba
^ff Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada
^fg Douglas Mental Health University Institute, Montreal, QC, Canada
^fh School of Psychology, Southwest UniversityChongqing, China
^fi Department of Biomedical Engineering, N.1 Institute for Health, National University of Singapore, Singapore
^fj Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
^fk Department of Neurology, Harvard Medical School, MA, Boston, United States
^fl Department of Neurology, Boston Children’s Hospital, MA, Boston, United States
^fm Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla, Dpto. de Fisiología Médica y Biofísica, Seville, Spain
^fn Department of Psychology and Neuroscience Institute, University of Chicago, Chicago, United States
^fo Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
^fp Department of Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
^fq National Institute of Developmental Psychiatry (INPD), São Paulo, Brazil
^fr Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
^fs Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Juelich, Juelich, Germany
^ft Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA, Charlestown, United States
^fu Centre for Population Neuroscience and Stratified Medicine (PONS), Institute for Science and Technology for Brain-inspired Intelligence, Fudan UniversityShanghai, China
^fv Charite Mental Health, Dept of Psychiatry and Psychotherapy, Charite Campus MitteBerlin, Germany
^fw Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
^fx Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden
^fy Dementia Research Centre, University College London, Queen’s Square Institute of Neurology, London, United Kingdom
^fz Care Research and Technology Centre, UK Dementia Research Institute, London, United Kingdom
^ga Center for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
^gb Departments of Neurology, Pediatrics, and Radiology, Washington University School of Medicine, St Louis, MO, USA
^gc SA MRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
^gd Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
^ge Department of Neuroscience, Institut Pasteur, Paris, France
^gf Center for Research and Interdisciplinarity (CRI), Université Paris Descartes, Paris, France
^gg Department of Psychology, University of Cambridge, Cambridge, United Kingdom
^gh Yale University, CT, New Haven, United States
^gi Department of Clinical Medicine, University of Turku, Turku, Finland
^gj Turku Collegium for Science, Medicine and Technology, University of Turku, Turku, Finland
^gk Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, U1219, CHU Bordeaux, Bordeaux, France
^gl Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada
^gm Alan Edwards Centre for Research on Pain (AECRP), McGill University, Montreal, QC, Canada
^gn Institute for Neuroscience and Medicine 7, Forschungszentrum Jülich ,Jülich, Germany
^go Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
^gp Department of Psychiatry and Neurosychology, Maastricht University, Maastricht, Netherlands
^gq Department of Biostatistics, Vanderbilt University, TN, Nashville, United States
^gr Department of Biostatistics, Vanderbilt University Medical Center, TN, Nashville, United States
^gs Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany
^gt State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversityBeijing, China
^gu Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal UniversityBeijing, China
^gv National Basic Science Data CenterBeijing, China
^gw Research Center for Lifespan Development of Brain and Mind, Institute of Psychology, Chinese Academy of SciencesBeijing, China
^gx Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska InstitutetStockholm, Sweden
^gy Faculty of Medicine, University of Leipzig, Leipzig, Germany
^gz Department of Electrical and Computer Engineering, National University of Singapore, Singapore
^ha Centre for Sleep and Cognition and Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
^hb N.1 Institute for Health & Institute for Digital Medicine, National University of Singapore, Singapore
^hc Integrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore
^hd Department of Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia
^he Center for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
^hf Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
^hg National Institute of Mental Health (NIMH), National Institutes of Health (NIH), MD, Bethesda, United States
^hh Department of Psychiatry, Escola Paulista de Medicina, São Paulo, Brazil
^hi Key Laboratory of Brain and Education, School of Education Science, Nanning Normal University, Nanning, China

Abstract
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes. © 2022. The Author(s).

Usability and Acceptability of Clinical Decision Support Based on the KIIDS-TBI Tool for Children with Mild Traumatic Brain Injuries and Intracranial Injuries
(2022) Applied Clinical Informatics, 13 (2), pp. 456-467. 

^a Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, United States
^b McKelvey School of Engineering, Washington University School of Medicine in St. Louis, St. Louis, MO, United States
^c Department of Emergency Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, United States
^d Brown School of Social Work, Washington University School of Medicine in St. Louis, St. Louis, MO, United States
^e Department of Emergency Medicine, University of California Davis, Davis, CA, United States
^f Institute for Informatics, Washington University School of Medicine in St. Louis, St. Louis, MO, United States

Abstract
BACKGROUND:  The Kids Intracranial Injury Decision Support tool for Traumatic Brain Injury (KIIDS-TBI) tool is a validated risk prediction model for managing children with mild traumatic brain injuries (mTBI) and intracranial injuries. Electronic clinical decision support (CDS) may facilitate the clinical implementation of this evidence-based guidance. OBJECTIVE:  Our objective was to evaluate the acceptability and usability of an electronic CDS tool for managing children with mTBI and intracranial injuries. METHODS:  Emergency medicine and neurosurgery physicians (10 each) from 10 hospitals in the United States were recruited to participate in usability testing of a novel CDS prototype in a simulated electronic health record environment. Testing included a think-aloud protocol, an acceptability and usability survey, and a semi-structured interview. The prototype was updated twice during testing to reflect user feedback. Usability problems recorded in the videos were categorized using content analysis. Interview transcripts were analyzed using thematic analysis. RESULTS:  Among the 20 participants, most worked at teaching hospitals (80%), freestanding children’s hospitals (95%), and level-1 trauma centers (75%). During the two prototype updates, problems with clarity of terminology and navigating through the CDS interface were identified and corrected. Corresponding to these changes, the number of usability problems decreased from 35 in phase 1 to 8 in phase 3 and the number of mistakes made decreased from 18 (phase 1) to 2 (phase 3). Through the survey, participants found the tool easy to use (90%), useful for determining a patient’s level of care (95%), and likely to improve resource use (90%) and patient safety (79%). Interview themes related to the CDS’s ability to support evidence-based decision-making and improve clinical workflow proposed implementation strategies and potential pitfalls. CONCLUSION:  After iterative evaluation and refinement, the KIIDS-TBI CDS tool was found to be highly usable and useful for aiding the management of children with mTBI and intracranial injuries. Thieme. All rights reserved.