WashU weekly Neuroscience publications

“The transcriptional landscape of Shh medulloblastoma” (2021) Nature Communications The transcriptional landscape of Shh medulloblastoma (2021) Nature Communications, 12 (1), art. no. 1749, .  Skowron, P.a b c , Farooq, H.a b c , Cavalli, F.M.G.a c , Morrissy, A.S.d e f , Ly, M.a b c , Hendrikse, L.D.a c g , Wang, E.Y.a c g , Djambazian, H.h i , Zhu, H.g j , Mungall, K.L.k , Trinh, Q.M.j , Zheng, T.l , Dai, S.m , Stucklin, A.S.G.a c , Vladoiu, M.C.a b c , Fong, V.a c , Holgado, B.L.a c , Nor, C.a c , Wu, […]

Seeing exponential growth for what it is

Understanding the spread of SARS-CoV-2, the virus responsible for COVID-19, requires understanding nonlinear growth, according to Jeffrey M. Zacks, PhD, associate chair and professor of psychological and brain sciences in Arts & Sciences, and of radiology at the School of Medicine, at Washington University in St. Louis. Whereas linear growth is intuitive, nonlinear growth is […]

Widening political rift in U.S. may threaten science, medicine

The lightning speed with which scientists developed and tested the COVID-19 vaccine is a true scientific triumph — one that would not have been possible without the more than 70,000 volunteers who participated in clinical trials of the vaccine. Public participation is critical to the success of any medical research. Yet recruiting volunteers for trials […]

WashU weekly Neuroscience publications

“Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis” (2021) Acta Neuropathologica Communications Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis (2021) Acta Neuropathologica Communications, 9 (1), art. no. 40, .  Celorrio, M.a , Abellanas, M.A.a c d , Rhodes, J.a , Goodwin, V.a , Moritz, J.a , Vadivelu, S.a , Wang, L.b , Rodgers, R.b , Xiao, S.a , Anabayan, […]

WashU weekly Neuroscience publications

"Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus" (2021) Communications Biology Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus(2021) Communications Biology, 4 (1), art. no. 260, .  Jansson, D.a b c , Dieriks, V.B.b d , Rustenhoven, J.e f , Smyth, L.C.D.g h , Scotter, E.a b , Aalderink, M.a b , Feng, S.a b , Johnson, R.a b , Schweder, P.i , Mee, E.i , Heppner, P.j , Turner, C.k , Curtis, M.b d , […]

WashU weekly Neuroscience publications

“Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel” (2021) Nature Communications Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel (2021) Nature Communications, 12 (1), art. no. 926, .  Arnold, W.R.a , Carnevale, L.N.a , Xie, Z.b , Baylon, J.L.c , Tajkhorshid, E.c , Hu, H.b , Das, A.d e a Department of Biochemistry, University of Illinois Urbana-Champaign, […]

WashU weekly Neuroscience publications

“A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors” (2021) Scientific Reports A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors (2021) Scientific Reports, 11 (1), art. no. 3858, .  Mattar, P.a f g , Jolicoeur, C.a , Dang, T.f g , Shah, S.f g , Clark, B.S.b c , Cayouette, M.a d e a Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada b John […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: evidence from economic decision-making” (2021) Cognitive Research: Principles and Implications Domain-general cognitive motivation: evidence from economic decision-making (2021) Cognitive Research: Principles and Implications, 6 (1), art. no. 4, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, Box 1125, St. Louis, MO 63130, United […]

WashU weekly Neuroscience publications

“Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury” (2021) Nature Communications Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury (2021) Nature Communications, 12 (1), art. no. 781, .  Brommer, B.a , He, M.a , Zhang, Z.a , Yang, Z.a , Page, J.C.a , Su, J.a , Zhang, Y.a , […]

WashU weekly Neuroscience publications

"A 2020 view of tension-based cortical morphogenesis" (2021) Proceedings of the National Academy of Sciences of the United States of America A 2020 view of tension-based cortical morphogenesis(2021) Proceedings of the National Academy of Sciences of the United States of America, 117 (52), pp. 32868-32879.  van Essen, D.C. Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, […]

WashU weekly Neuroscience publications

“‘It’s way more than just writing a prescription’: A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use disorder” (2021) Addiction Science and Clinical Practice “It’s way more than just writing a prescription”: A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use […]

Mirror, mirror on the monitor

Most people wouldn’t sit in front of a mirror for hours a day, checking themselves out, but the COVID-19 pandemic has found many doing just that. Video chatting services such as Zoom have become a common way to keep in touch with friends, family and co-workers. But it’s also forced people to sit face-to-face with […]

WashU weekly Neuroscience publications

“Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States” (2021) PLoS ONE Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States (2021) PLoS ONE, 15 (12 December), art. no. e0243188, .  Gildner, T.E.a b , Laugier, E.J.a c , Thayer, Z.M.a c a Department of […]

WashU weekly Neuroscience publications

“A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder” (2021) International Journal of Bipolar Disorders A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder (2021) International Journal of Bipolar Disorders Musket, C.W.a , […]

Psychonomic Society recognizes Zacks with Mid-career Award

Jeffrey Zacks, PhD, associate chair and professor of psychological and brain sciences in Arts & Sciences, and of radiology at the School of Medicine, received the Mid-career Award from the Psychonomic Society. Zacks studies perception and cognition at Washington University in St. Louis using behavioral experiments, functional MRI, computational modeling and testing of neurological patients. The Psychonomic Society is […]

Seeking to avoid ‘full lockdown,’ cells monitor ribosome collisions

Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along defective mRNA molecules. New research from Washington University in St. Louis shows […]

WashU weekly Neuroscience publications

"Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns" (2021) Annals of Emergency Medicine Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns(2021) Annals of Emergency Medicine, 77 (1), pp. 134-135.  Ellis, M.S., Kasper, Z.A., Cicero, T.J. Washington University in St. Louis, Department of Psychiatry, School of Medicine, St. Louis, MO, United States Document Type: LetterPublication Stage: FinalSource: Scopus "Prevalence, […]

WashU weekly Neuroscience publications

"Oral and maxillofacial surgeons’ assessment of the role of Pernkopf's atlas in surgical practice" (2021) Annals of Anatomy Oral and maxillofacial surgeons’ assessment of the role of Pernkopf’s atlas in surgical practice(2021) Annals of Anatomy, 234, art. no. 151614, .  Yee, A.a , Li, J.b , Lilly, J.b , Hildebrandt, S.c , Seidelman, W.E.d , Brown, D.e , Kopar, P.e , Coert, J.H.f , Mackinnon, S.E.a , Israel, H.A.b a Division of […]

Roediger honored for leadership, research contributions

The American Psychological Association has named Henry L. “Roddy” Roediger the recipient of its 2021 Award for Distinguished Scientific Contributions. In addition, the Psychonomic Society has awarded Roediger the Clifford T. Morgan Distinguished Leadership Award. Roediger, the James S. McDonnell Distinguished University Professor of Psychological & Brain Sciences in Arts & Sciences at Washington University in St. Louis, heads […]

WashU weekly Neuroscience publications

“Midfoot and ankle motion during heel rise and gait are related in people with diabetes and peripheral neuropathy” (2021) Gait and Posture Midfoot and ankle motion during heel rise and gait are related in people with diabetes and peripheral neuropathy (2021) Gait and Posture, 84, pp. 38-44.  Jeong, H.-J., Mueller, M.J., Zellers, J.A., Hastings, M.K. Program in Physical Therapy, […]

WashU weekly Neuroscience publications

“Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability” (2021) Neurobiology of Aging Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability (2021) Neurobiology of Aging, 98, pp. 116-123.  Meeker, K.L.a b , Ances, B.M.b , Gordon, B.A.c , Rudolph, C.W.a , Luckett, P.b , Balota, D.A.d , Morris, J.C.b , Fagan, A.M.b , Benzinger, T.L.c , Waring, J.D.a […]

WashU weekly Neuroscience publications

“Fronto-cerebellar connectivity mediating cognitive processing speed” (2021) NeuroImage Fronto-cerebellar connectivity mediating cognitive processing speed (2021) NeuroImage, 226, art. no. 117556, . Wong, C.H.Y.a b c , Liu, J.d e f l , Lee, T.M.C.b c j k , Tao, J.d e l , Wong, A.W.K.g h , Chau, B.K.H.a i , Chen, L.d e l , Chan, C.C.H.a i a Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong b Laboratory of Neuropsychology and Human Neuroscience, Department of […]

Building better vaccines for the elderly

As human lifespans have gotten longer, certain proteins in our bodies are increasingly prone to take on alternative shapes. These misfolded proteins can ultimately trigger neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Lou Gehrig’s disease, formally known as amyotrophic lateral sclerosis (ALS). Meredith Jackrel, PhD, assistant professor of chemistry in Arts & Sciences at Washington […]

Stronger memories can help us make sense of future changes

Memory is as much about the future as it is the past. Whether experiencing something new, or something we’ve experienced a hundred times, people use memories of the past to navigate subsequent encounters. Traditionally, psychologists believed that the more ingrained a memory of something was, the more difficult it would be to update your understanding […]

WashU weekly Neuroscience publications

“Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants” (2020) Developmental Cognitive Neuroscience Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants (2020) Developmental Cognitive Neuroscience, 46, art. no. 100877, . Humphreys, K.L.a , Camacho, M.C.b , Roth, M.C.a , Estes, E.C.a a Vanderbilt University, Department of Psychology and Human Development, 230 Appleton Place, #552, Nashville, […]

AAAS names 7 Washington University faculty as 2020 fellows

Seven faculty members at Washington University in St. Louis are among 489 new fellows selected by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. And four of those seven are School of Medicine faculty. The newly selected fellows from the medical school are: Aaron DiAntonio, MD, PhD; David H. Gutmann, […]

WashU weekly Neuroscience publications

"Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial" (2020) The Lancet Neurology Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the […]

Three Washington University scholars were Rhodes finalists

Two Washington University in St. Louis students and a recent alumnus were finalists for the prestigious Rhodes Scholarship.  They are:  Christopher Taylor Brown, 23,  a graduate student studying domestic social and economic development at the Brown School; Summer McKenna, 21, a senior majoring in modern Middle Eastern studies and philosophy-neuroscience-psychology in Arts & Sciences; and  […]

WashU weekly Neuroscience publications

“Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study” (2021) Neurobiology of Aging Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study (2021) Neurobiology of Aging, 97, pp. 65-72. Walker, K.A.a , Chawla, S.b , Nogueras-Ortiz, C.b , Coresh, J.c , Sharrett, A.R.c , Wong, D.F.d , Jack, C.R., Jr.e , Spychalla, […]

WashU weekly Neuroscience publications

"Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage" (2021) Brain Research Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage(2021) Brain Research, 1750, art. no. 147169, .  Athiraman, U.a , Liu, M.a , Jayaraman, K.b , Yuan, J.a , […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting Oct. 2, several faculty members were appointed or promoted with tenure or granted tenure, effective that day unless otherwise indicated… …Promotion with tenure Luis F.Z. Batista to associate professor of medicine and of developmental biology at the School of Medicine (tenure effective Jan. 1); Nico […]

WashU weekly Neuroscience publications

“N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury” (2021) Experimental Neurology N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury (2021) Experimental Neurology, 335, art. no. 113507, . Celorrio, M., Rhodes, J., Vadivelu, S., Davies, M., Friess, S.H. Division of Critical Care Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, One […]

A Wash U Professor Explains Why Daylight Saving Time Is Bad For Us

This weekend, weary Halloween revelers across the U.S. will dutifully set their clocks to “fall back” — signaling the end of daylight saving time for 2020. The annual ritual may give some people an extra hour of sleep on Saturday night, but for others, including parents of young children and shift workers, it’s an annoying […]

Fail Better: Celia McKee

(Video: Tom Malkowicz/Washington University) “My grant got rejected. I failed. So I’m saying it on Twitter. I don’t want sympathy. I just wish people would say stuff like this on Twitter.” Celia McKee, a doctoral student studying neuroscience at Washington University in St. Louis, had no idea those 140 characters would mean so much to […]

WashU weekly Neuroscience publications

“Relationships between accelerometry and general compensatory movements of the upper limb after stroke” (2020) Journal of NeuroEngineering and Rehabilitation Relationships between accelerometry and general compensatory movements of the upper limb after stroke (2020) Journal of NeuroEngineering and Rehabilitation, 17 (1), art. no. 138, . Barth, J.a , Klaesner, J.W.a d , Lang, C.E.a b c a Washington University School of Medicine, Program in Physical Therapy, St. Louis, […]

The path to the National Academy of Medicine

In this Q&A, Deanna Barch, PhD discusses her path to a research career, the importance of interdisciplinary inquiry in health and medicine, and the big questions that drive her work. Barch was recently elected to the National Academy of Medicine. A few weeks ago, on a late Friday afternoon just as the work week was […]

Barch, Bateman elected to National Academy of Medicine

Deanna M. Barch, PhD, an expert in cognitive and language deficits in psychological disorders, and Randall J. Bateman, MD, a leading Alzheimer’s disease researcher, have been elected to the National Academy of Medicine, a part of the National Academy of Sciences. Membership in the organization is extended to those who have demonstrated outstanding professional achievement and commitment […]

WashU weekly Neuroscience publications

“Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells” (2020) Brain Research Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells (2020) Brain Research, 1749, art. no. 147139, . Matsuhisa, K.a b , Cai, L.a , Saito, A.a b , Sakaue, F.b , Kamikawa, Y.b , Fujiwara, S.b , Asada, R.c , Kudo, Y.d , Imaizumi, K.a a Department of Biochemistry, […]

‘Honey bee, it’s me’

For a honey bee, few things are more important than recognizing your nestmates. Being able to tell a nestmate from an invader could mean the difference between a honey-stocked hive and a long, lean winter. New research from Washington University in St. Louis shows that honey bees rely on chemical cues related to their shared […]

WashU weekly Neuroscience publications

“Depression and Buprenorphine Treatment in Patients with Non-cancer Pain and Prescription Opioid Dependence without Comorbid Substance Use Disorders” (2021) Journal of Affective Disorders Depression and Buprenorphine Treatment in Patients with Non-cancer Pain and Prescription Opioid Dependence without Comorbid Substance Use Disorders (2021) Journal of Affective Disorders, 278, pp. 563-569. Scherrer, J.F.a , Salas, J.a , Grucza, R.a , Sullivan, M.D.b , Lustman, P.J.c d , […]

Hengen awarded $1.8M to study sleep’s contribution to brain function

Sleep is vitally important for brain function and survival. Yet sleep remains one of the most poorly understood features of life. Keith Hengen, assistant professor of biology in Arts & Sciences at Washington University in St. Louis, received a three-year $1.8 million grant from the National Institutes of Health (NIH) to study the role of […]

Brain & Behavior Research Foundation awards grants to three researchers

Three Washington University in St. Louis researchers have received Young Investigator Grants from the Brain & Behavior Research Foundation. The foundation is committed to alleviating the suffering caused by mental illness by supporting research that will lead to advances and breakthroughs in scientific research. The $70,000 grants help junior investigators launch innovative basic, translational and clinical research […]

WashU weekly Neuroscience publications

“Incidence of uveitis and macular edema among patients taking fingolimod 0.5 mg for multiple sclerosis” (2020) Journal of Ophthalmic Inflammation and Infection Incidence of uveitis and macular edema among patients taking fingolimod 0.5 mg for multiple sclerosis (2020) Journal of Ophthalmic Inflammation and Infection, 10 (1), art. no. 24, . Sonne, S.J.a , Smith, B.T.b c a St. Louis University School of Medicine, St. […]

Prenatal cannabis exposure associated with adverse outcomes during middle childhood

While cannabis use during pregnancy is on the rise, researchers at Washington University in St. Louis have found evidence that the resulting children are more likely to have psychopathology in middle childhood. The team’s analysis are the first steps in studying the effects of cannabis on children as attitudes surrounding its use change rapidly — […]

WashU weekly Neuroscience publications

“Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents” (2020) Journal of Controlled Release Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents (2020) Journal of Controlled Release, 328, pp. 276-285. Ye, D.a , Luan, J.a , Pang, H.b , Yang, Y.b , Nazeri, A.c , Rubin, J.B.d e , Chen, H.b f a Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, […]

WashU weekly Neuroscience publications

“Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites” (2020) Molecular Pharmacology Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites (2020) Molecular Pharmacology, 98 (4), pp. 280-291.  Germann, A.L., Reichert, D.E., Burbridge, A.B., Pierce, S.R., […]

Zacks receives $250K grant from James S. McDonnell Foundation

Jeffrey M. Zacks, associate chair and professor of psychological and brain sciences in Arts & Sciences and professor of radiology at the School of Medicine, received a four-year $250,000 grant from the James S. McDonnell Foundation to study event cognition “in the wild.” This project will take the research into the world, where people actually […]

Female faculty in psychological sciences survey present, chart future

Psychology has made some impressive gains in gender parity in recent years. In the United States, women comprise the vast majority of undergraduate students in psychology classrooms, and women earn 71% of psychology PhDs. But these gains don’t tell the entire story. To fill in the gaps, a group of nearly 60 women faculty members […]

WashU weekly Neuroscience publications

“Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction” (2020) Nature Communications Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction (2020) Nature Communications, 11 (1), art. no. 4358, . Ozawa, M.a b , Davis, P.a b c e , Ni, J.a , Maguire, J.a , Papouin, T.a d , Reijmers, L.a a Department of Neuroscience, School of Medicine, Tufts University, Boston, MA, United States b Graduate Program in […]