WashU weekly Neuroscience publications

“Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases” (2022) Neural Regeneration Research Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases (2022) Neural Regeneration Research, 17 (4), pp. 867-874.  Li, H., Knight, W., Xu, J. Department of Radiology, Washington University School of Medicine, St. Louis, […]

Who’s in cognitive control?

Are you able to start a task and stick with it, all the way through, ignoring the temptations of the internet or the sudden realization that you should probably do the laundry? Or maybe you should be doing something else right this moment? The faculty that allows people to make plans or goals, and carry […]

Sabin Nettles receives SfN Next Generation Award

Sabin Nettles, a neuroscience PhD student in the laboratory of Dr. Harrison Gabel, is the recipient of the Pre-/ Post-Doctoral Next Generation Award from the Society for Neuroscience (SfN). The Next Generation Award recognizes SfN chapter members who have made outstanding contributions to public communication, outreach, and education about neuroscience through activities such as classroom […]

WashU weekly Neuroscience publications

“The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons” (2021) Cell and Bioscience The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons (2021) Cell and Bioscience, 11 (1), art. no. 167, .  Zhang, Y.a b f , Ma, S.a b , Ke, X.a b , Yi, Y.a b , Yu, H.a b , Yu, D.a b , Li, Q.c , Shang, Y.b d , Lu, […]

WashU weekly Neuroscience publications

"A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System" (2021) Scientific Reports A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System(2021) Scientific Reports, 11 (1), art. no. 16896, .  Camilleri, J.A.a b , Eickhoff, S.B.a b , Weis, S.a b , Chen, J.a b c , Amunts, J.a b , Sotiras, A.d , […]

Neurons in visual cortex of the brain ‘drift’ over time

Although other studies have documented “representational drift” in neurons in the parts of the brain associated with odor and spatial memory, this result is surprising because neural activity in the primary visual cortex is thought to be relatively stable. The study published Aug. 27 in Nature Communications was led by Ji Xia, PhD, a recent PhD graduate of […]

WashU weekly Neuroscience publications

“Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia” (2021) Psychiatry Research – Neuroimaging Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia (2021) Psychiatry Research – Neuroimaging, 317, art. no. 111352, .  Cobia, D.a e , Rich, C.b , Smith, M.J.c , Mamah, D.d , Csernansky, J.G.e , Wang, L.e f g a Department of Psychology and Neuroscience Center, Brigham Young University, 1036 KMBL, Provo, UT 84602, United […]

Brain trust: Symposium brings together diverse community of undergraduate neuroscientists

The WUSTL ENDURE program, which hosts the annual symposium, partners with groups across WashU and local institutions to attract top talent, provide training and mentorship opportunities, and improve the diversity of the neuroscience field. “What would happen if you lost your heart?” Ephraim Oyetunji, a rising junior studying neuroscience in the Department of Biology and […]

Cannabis use disorder: another COVID risk factor

Should doctors take particular care to talk to patients about the potential dangers of COVID-19 if those patients have a problematic relationship with pot? New research from Washington University in St. Louis suggests perhaps they should. Diabetes, obesity and a history of smoking cigarettes are all considered risk factors for poorer COVID-19 outcomes. Warnings and […]

WashU weekly Neuroscience publications

“Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice” (2021) Communications Biology Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice (2021) Communications Biology, 4 (1), art. no. 955, .  Spencer, N.J.a , Travis, L.a , Wiklendt, L.b , Costa, M.a , Hibberd, T.J.a , Brookes, S.J.a , Dinning, P.b , Hu, H.c , Wattchow, […]

17-year study of children associates poverty with smaller, slower-growing subcortical regions

Children in poverty are more likely to have cognitive and behavioral difficulties than their better-off peers. Plenty of past research has looked into the physical effects of childhood poverty, or documented mental health disparities between socioeconomic classes. But Deanna Barch, chair and professor in the Department of Psychological & Brain Sciences in Arts & Sciences at […]

WashU weekly Neuroscience publications

"Chronic neuroleptic treatment combined with a high fat diet elevated (3H) flunitrazepam binding in the cerebellum (2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum(2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry, 112, art. no. 110407, .  Richardson, B.a b , Swenson, S.a , Hamilton, J.a b , Leonard, K.c , Delis, F.d , […]

WashU weekly Neuroscience publications

“Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons” (2021) Nature Communications Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons (2021) Nature Communications, 12 (1), art. no. 4251, .  Pearson, T.S.a b , Gupta, N.a , San Sebastian, W.a , Imamura-Ching, J.a , Viehoever, A.c , Grijalvo-Perez, A.c , […]

NIH funds Rudra, Jackrel to improve vaccines for elderly

The coronavirus pandemic has emphasized the importance of vaccines, particularly for the elderly, who have been disproportionately impacted by the virus. However, a decline in immune response as well as inflammation that accompanies aging require a booster to improve the immune response. Jai Rudra, PhD, assistant professor of biomedical engineering at the McKelvey School of […]

WashU weekly Neuroscience publications

“A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq” (2021) Developmental Biology A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq (2021) Developmental Biology, 478, pp. 41-58.  Shiau, F.a , Ruzycki, P.A.a , Clark, B.S.a b a John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of […]

WashU weekly Neuroscience publications

"Comparing stress prediction models using smartwatch physiological signals and participant self-reports" (2021) Computer Methods and Programs in Biomedicine Comparing stress prediction models using smartwatch physiological signals and participant self-reports(2021) Computer Methods and Programs in Biomedicine, 208, art. no. 106207, .  Dai, R.a , Lu, C.a , Yun, L.b , Lenze, E.c , Avidan, M.b , Kannampallil, T.b d a Department of Computer Science, McKelvey School of Engineering, United […]

WashU weekly Neuroscience publications

“Critical tests of the continuous dual-process model of recognition” (2021) Cognition Critical tests of the continuous dual-process model of recognition (2021) Cognition, 215, art. no. 104827, .  Cha, J., Dobbins, I.G. Department of Psychological and Brain Sciences, Washington University in Saint Louis, United States Abstract Dual process recognition models assume recognition depends upon context recollection and/or item familiarity. While most […]

WashU weekly Neuroscience publications

“Advanced cognitive impairment among older nursing home residents” (2021) BMC Geriatrics Advanced cognitive impairment among older nursing home residents (2021) BMC Geriatrics, 21 (1), art. no. 382, .  Gracner, T.a , Stone, P.W.b , Agarwal, M.c , Sorbero, M.d , Mitchell, S.L.e f , Dick, A.W.g a RAND Corporation, 1776 Main Street, Santa Monica, CA 90401, United States b Center for Health Policy, Columbia University School of Nursing, 560 […]

Washington University collaborates with Agilent, Merck to expand metabolomics research

A collaborative effort between Washington University in St. Louis, Agilent Technologies and the biopharmaceutical company Merck aims to expand research in the field of metabolomics, the comprehensive study of small molecules within a biological system. Using top-of-the-line research instrumentation from Agilent, scientists in the Department of Chemistry in Arts & Sciences will develop new metabolomics […]

WashU weekly Neuroscience publications

“GPS driving: a digital biomarker for preclinical Alzheimer disease” (2021) Alzheimer’s Research and Therapy GPS driving: a digital biomarker for preclinical Alzheimer disease (2021) Alzheimer’s Research and Therapy, 13 (1), art. no. 115, .  Bayat, S.a b , Babulal, G.M.c d e , Schindler, S.E.c d , Fagan, A.M.c d f , Morris, J.C.c d f g h i , Mihailidis, A.a b j , Roe, C.M.c d a Institute of Biomedical Engineering, University of Toronto, 550 University Avenue, Toronto, ON M5G 1X5, […]

WashU weekly Neuroscience publications

“Epigenetic regulation in Huntington’s disease” (2021) Neurochemistry International Epigenetic regulation in Huntington’s disease (2021) Neurochemistry International, 148, art. no. 105074, .  Hyeon, J.W.a , Kim, A.H.a b c d e , Yano, H.a b c e a Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States b Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States c Department of Genetics, Washington University […]

WashU weekly Neuroscience publications

“In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community” (2021) BMC Medical Genomics In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community (2021) BMC Medical Genomics, 14 (1), art. no. 139, .  Bourdon, J.L.a , Dorsey, A.b , Zalik, M.b , Pietka, A.b , Salyer, P.b , Bray, […]

WashU weekly Neuroscience publications

“Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis” (2021) Communications Biology Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis (2021) Communications Biology, 4 (1), art. no. 607, .  Karlow, J.A.a , Miao, B.a b , Xing, X.a , Wang, T.a c , Zhang, B.a b a The Edison Family Center for Genome Sciences and Systems […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting May 7, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Megan Tierney Baldridge, MD, PhD, to associate professor of medicine at the School of Medicine; Trevor G. Gardner II to professor of […]

WashU weekly Neuroscience publications

“Interhemispheric Parietal-Frontal Connectivity Predicts the Ability to Acquire a Nondominant Hand Skill” (2021) Brain Connectivity Interhemispheric Parietal-Frontal Connectivity Predicts the Ability to Acquire a Nondominant Hand Skill (2021) Brain Connectivity, 11 (4), pp. 308-318.  Philip, B.A.a b , McAvoy, M.P.c , Frey, S.H.b a Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, United States b Department of Psychological Sciences, University of […]

Electric fish — and humans — pause before communicating key points

American writer and humorist Mark Twain, a master of language and noted lecturer, once offered, “The right word may be effective, but no word was ever as effective as a rightly timed pause.” Electric fish and today’s TED talk speakers take a page from Twain’s playbook. They pause before sharing something particularly meaningful. Pauses also […]

WashU weekly Neuroscience publications

“Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain” (2021) Scientific Reports Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain (2021) Scientific Reports, 11 (1), art. no. 9798, .  Jiang, J.a d , Giri, T.a , Raghuraman, N.b , Cahill, A.G.c , Palanisamy, A.a b a Department of Anesthesiology, Washington University School of Medicine, St. […]

Association recognizes two psychology students for quality research

The Federation of Associations in Behavioral & Brain Sciences (FABBS) has named Katherine Lopez and Megan Maxwell recipients of Research Excellence Awards. Both are students in the Department of Psychological & Brain Sciences in Arts & Sciences at Washington University in St. Louis. Lopez Lopez, a PhD student, received the Doctoral Dissertation Research Excellence Award for her dissertation, […]

WashU weekly Neuroscience publications

“Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study” (2021) Epilepsy and Behavior Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, […]

WashU weekly Neuroscience publications

“New guidance to seekers of autism biomarkers: an update from studies of identical twins” (2021) Molecular Autism New guidance to seekers of autism biomarkers: an update from studies of identical twins (2021) Molecular Autism, 12 (1), art. no. 28, .  Constantino, J.N. Department of Psychiatry, Washington University in St. Louis, 660 S Euclid Ave, Campus Box 8504, St. Louis, MO 63110, […]

St. Louis Area Brain Bee winners reflect on experience

St. Louis Area Brain Bee 2020 and 2021 winners Sriharsha Gonuguntla and Rohan Rao, respectively, reflect on how the regional and national competitions influenced their interest in neurobiology. The event that high school students across the St. Louis metropolitan area get excited for each year, theSt. Louis Area Brain Bee (SLABB) competition, took place online […]

WashU weekly Neuroscience publications

“White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study” (2021) Journal of Neurodevelopmental Disorders White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study (2021) Journal of Neurodevelopmental Disorders, 13 (1), art. no. 17, .  Bazydlo, A.a , Zammit, M.a , Wu, M.b , Dean, D.a c , Johnson, S.a c d , Tudorascu, […]

Sum of incentives dictate efforts

When there’s a difficult task at hand, intuition tells us that the more motivated we are to complete it — the stronger the incentives — the harder we’ll work. And the assumption has been that the relationship is linear — the better the incentives, the harder people will work. Rarely, however, do people have just […]

WashU weekly Neuroscience publications

“Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease” (2021) BMC Neurology Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease (2021) BMC Neurology, 21 (1), art. no. 154, .  Gregori-Pla, C.a , Mesquita, R.C.b , Favilla, C.G.c , Busch, D.R.d , Blanco, […]

WashU weekly Neuroscience publications

"Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma" (2021) Acta Neuropathologica Communications Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma(2021) Acta Neuropathologica Communications, 9 (1), art. no. 61, .  Schieffer, K.M.a , Feldman, A.Z.b , Kautto, E.A.a , […]

Graduate student in the Jackrel lab wins NIH fellowship

Macy Sprunger, a graduate student in Meredith Jackrel’s lab in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won a three-year $136,560 National Research Service Award from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH). The award supports Sprunger’s project “Defining the Molecular Drivers and Modulators of MATR3 Proteinopathy […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 5, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Ruopeng An to associate professor at the Brown School; Arpita Bose to associate professor of biology in Arts & Sciences; Hong […]

WashU weekly Neuroscience publications

"TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro" (2021) Nature Communications TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro(2021) Nature Communications, 12 (1), art. no. 1924, .  Baek, M.a , Choe, Y.-J.a , Bannwarth, S.b , Kim, J.H.a , Maitra, S.a , Dorn, G.W., IIc , Taylor, J.P.d , Paquis-Flucklinger, V.b , Kim, N.C.a a Department of Pharmacy Practice and Pharmaceutical […]

Reagh named APS ‘Rising Star’

The Association for Psychological Sciences (APS) has named Zachariah Reagh, PhD a “Rising Star.” Reagh is assistant professor of psychological and brain sciences in Arts & Sciences at Washington University in St. Louis. His research focuses on representation and remembrance of experiences and how they change as we age. The Rising Star designation is given to […]

WashU weekly Neuroscience publications

“Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders” (2021) Journal of Neurodevelopmental Disorders Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders (2021) Journal of Neurodevelopmental Disorders, 13 (1), art. no. 10, .  Rahn, R.M.a b c , Weichselbaum, C.T.a b d , Gutmann, D.H.d e , Dougherty, J.D.a b d , Maloney, S.E.b d a Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO […]

Chemo for glioblastoma may work better in morning than evening

An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study from Washington University in St. Louis suggests that a minor adjustment […]

WashU weekly Neuroscience publications

“The transcriptional landscape of Shh medulloblastoma” (2021) Nature Communications The transcriptional landscape of Shh medulloblastoma (2021) Nature Communications, 12 (1), art. no. 1749, .  Skowron, P.a b c , Farooq, H.a b c , Cavalli, F.M.G.a c , Morrissy, A.S.d e f , Ly, M.a b c , Hendrikse, L.D.a c g , Wang, E.Y.a c g , Djambazian, H.h i , Zhu, H.g j , Mungall, K.L.k , Trinh, Q.M.j , Zheng, T.l , Dai, S.m , Stucklin, A.S.G.a c , Vladoiu, M.C.a b c , Fong, V.a c , Holgado, B.L.a c , Nor, C.a c , Wu, […]

Seeing exponential growth for what it is

Understanding the spread of SARS-CoV-2, the virus responsible for COVID-19, requires understanding nonlinear growth, according to Jeffrey M. Zacks, PhD, associate chair and professor of psychological and brain sciences in Arts & Sciences, and of radiology at the School of Medicine, at Washington University in St. Louis. Whereas linear growth is intuitive, nonlinear growth is […]

Widening political rift in U.S. may threaten science, medicine

The lightning speed with which scientists developed and tested the COVID-19 vaccine is a true scientific triumph — one that would not have been possible without the more than 70,000 volunteers who participated in clinical trials of the vaccine. Public participation is critical to the success of any medical research. Yet recruiting volunteers for trials […]

WashU weekly Neuroscience publications

“Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis” (2021) Acta Neuropathologica Communications Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis (2021) Acta Neuropathologica Communications, 9 (1), art. no. 40, .  Celorrio, M.a , Abellanas, M.A.a c d , Rhodes, J.a , Goodwin, V.a , Moritz, J.a , Vadivelu, S.a , Wang, L.b , Rodgers, R.b , Xiao, S.a , Anabayan, […]

WashU weekly Neuroscience publications

"Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus" (2021) Communications Biology Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus(2021) Communications Biology, 4 (1), art. no. 260, .  Jansson, D.a b c , Dieriks, V.B.b d , Rustenhoven, J.e f , Smyth, L.C.D.g h , Scotter, E.a b , Aalderink, M.a b , Feng, S.a b , Johnson, R.a b , Schweder, P.i , Mee, E.i , Heppner, P.j , Turner, C.k , Curtis, M.b d , […]

WashU weekly Neuroscience publications

“Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel” (2021) Nature Communications Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel (2021) Nature Communications, 12 (1), art. no. 926, .  Arnold, W.R.a , Carnevale, L.N.a , Xie, Z.b , Baylon, J.L.c , Tajkhorshid, E.c , Hu, H.b , Das, A.d e a Department of Biochemistry, University of Illinois Urbana-Champaign, […]

WashU weekly Neuroscience publications

“A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors” (2021) Scientific Reports A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors (2021) Scientific Reports, 11 (1), art. no. 3858, .  Mattar, P.a f g , Jolicoeur, C.a , Dang, T.f g , Shah, S.f g , Clark, B.S.b c , Cayouette, M.a d e a Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada b John […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: evidence from economic decision-making” (2021) Cognitive Research: Principles and Implications Domain-general cognitive motivation: evidence from economic decision-making (2021) Cognitive Research: Principles and Implications, 6 (1), art. no. 4, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, Box 1125, St. Louis, MO 63130, United […]

WashU weekly Neuroscience publications

“Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury” (2021) Nature Communications Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury (2021) Nature Communications, 12 (1), art. no. 781, .  Brommer, B.a , He, M.a , Zhang, Z.a , Yang, Z.a , Page, J.C.a , Su, J.a , Zhang, Y.a , […]