WashU weekly Neuroscience publications

“Identifying reproducible individual differences in childhood functional brain networks: An ABCD study” (2019) Developmental Cognitive Neuroscience Identifying reproducible individual differences in childhood functional brain networks: An ABCD study (2019) Developmental Cognitive Neuroscience, 40, art. no. 100706, .  Marek, S.a , Tervo-Clemmens, B.b , Nielsen, A.N.c , Wheelock, M.D.a , Miller, R.L.d , Laumann, T.O.a , Earl, E.f , Foran, W.W.e […]

Hengen receives McKnight Scholar Award

Keith Hengen, assistant professor of biology in Arts & Sciences, received a McKnight Scholar Award from the McKnight Foundation. The award supports neuroscientists in the early stages of their careers who are focusing on disorders of learning and memory. Read more.

WashU weekly Neuroscience publications

“Alzheimer Disease: An Update on Pathobiology and Treatment Strategies” (2019) Cell Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) Cell, 179 (2), pp. 312-339.  Long, J.M., Holtzman, D.M. Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, United States Abstract Long […]

Brain tunes itself to criticality, maximizing information processing

Researchers long wondered how the billions of independent neurons in the brain come together to reliably build a biological machine that easily beats the most advanced computers. All of those tiny interactions appear to be tied to something that guarantees an impressive computational capacity. Over the past 20 years, evidence mounted in support of a […]

WashU weekly Neuroscience publications

“Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers” (2019) Neurobiology of Aging Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers (2019) Neurobiology of Aging, 83, pp. 54-62.  Chen, Q.a b , Boeve, B.F.c , Schwarz, C.G.b , Reid, R.b , Tosakulwong, N.d , Lesnick, T.G.d , Bove, J.e , Brannelly, P.f , Brushaber, […]

Yang Shi and Tamara Markovic win 2019 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition. Congratulations to the 2019 Thach Award winners: Short Talks: Yang Shi, PhD (Holtzman lab, WashU Neurology) “Microglia drive neurodegeneration and mediate APOE’s effect on neurodegeneration in a tauopathy mouse […]

WashU weekly Neuroscience publications

“The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability” (2019) NeuroImage The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability (2019) NeuroImage, 202, art. no. 115990, .  Betzel, R.F.a b c , Bertolero, M.A.a , Gordon, E.M.d e , Gratton, C.f g , Dosenbach, N.U.F.f h i , […]

Childhood obesity in low-income Missouri families aim of CDC grant

Obesity researchers from around Missouri, led by scientists at Washington University School of Medicine in St. Louis, have received a grant to help evaluate and put in place family-focused weight-management programs designed to reduce childhood obesity, particularly among children from low-income families. With a five-year, $3.7 million grant from the Centers for Disease Control and […]

Too Much Training Can Tax Athletes’ Brains

Too much physical exertion appears to make the brain tired. That’s the conclusion of a study of triathletes published Thursday in the journal Current Biology. Researchers found that after several weeks of overtraining, athletes became more likely to choose immediate gratification over long-term rewards. At the same time, brain scans showed the athletes had decreased activity in an […]

Jackrel receives $300K from ALS Association

Meredith Jackrel, assistant professor of chemistry in Arts & Sciences, received a $300,000 grant from the ALS Association to support a project titled “Countering the aggregation of TDP-43, FUS, DPRS, and Matrin 3 with engineered protein disaggregases.” Read more.

WashU weekly Neuroscience publications

“Pioglitazone improves working memory performance when administered in chronic TBI” (2019) Neurobiology of Disease Pioglitazone improves working memory performance when administered in chronic TBI (2019) Neurobiology of Disease, 132, art. no. 104611, .  McGuire, J.L.a , Correll, E.A.a , Lowery, A.C.b , Rhame, K.c , Anwar, F.N.d , McCullumsmith, R.E.e , Ngwenya, L.B.a f a Department of Neurosurgery, University of Cincinnati, […]

Bogdan awarded $265K from NIH

Ryan Bogdan, associate professor of psychological and brain sciences in Arts & Sciences, received a two-year, $264,938 grant from the National Institutes of Health (NIH) to study the effects of alcohol on the maturing brain. The study will look at genome-wide association studies to longitudinal neuroimaging studies of adolescents and young adults in order to […]

WashU weekly Neuroscience publications

“Large posttraumatic stress disorder improvement and antidepressant medication adherence” (2020) Journal of Affective Disorders Large posttraumatic stress disorder improvement and antidepressant medication adherence (2020) Journal of Affective Disorders, 260, pp. 119-123.  Salas, J.a b , Scherrer, J.F.a b , Tuerk, P.c , van den Berk-Clark, C.a , Chard, K.M.d , Schneider, F.D.e , Schnurr, P.P.f , Friedman, M.J.f , […]

WashU weekly Neuroscience publications

“Alternative ecological strategies lead to avian brain size bimodality in variable habitats” (2019) Nature Communications Alternative ecological strategies lead to avian brain size bimodality in variable habitats (2019) Nature Communications, 10 (1), art. no. 3818, .  Fristoe, T.S.a b , Botero, C.A.b a Department of Biology, University of Konstanz, Universitätsstraße 10, Konstanz, 78464, Germany b Department of Biology, Washington University in St. Louis, […]

Cindy Brantmeier named inaugural WashU Faculty Fellow in International Research

Dear Colleagues, I am pleased to announce that Dr. Cindy Brantmeier has been selected to serve as the first Faculty Fellow in International Research for the School of Medicine and Danforth Campus. The Faculty Fellow in International Research will advise faculty on conducting international research and achieving effective collaborations with international partners that are compliant […]

Brain Scans, Saliva Tests, and Baby Teeth: Inside the Massive, Government-Funded Effort to Understand How Kids’ Brains Develop

Researchers expect this massive endeavor, receiving $30 million in federal funding per year, will transform our understanding of brain development. Neuroscientists are positively giddy about ABCD, and for good reason: It is larger and more racially and socioeconomically diverse than any comparable study to date. “We’re going to be working with this dataset for decades,” […]

WashU weekly Neuroscience publications

“Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter” (2019) Scientific Reports Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter (2019) Scientific Reports, 9 (1), art. no. 12246, .  Fukutomi, H.a b , Glasser, M.F.c d , Murata, K.e , […]

WashU weekly Neuroscience publications

"Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex" (2019) Scientific Reports Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex(2019) Scientific Reports, 9 (1), art. no. 11700, .  Maranesi, M.a , Bruni, S.a b , Livi, A.a c , Donnarumma, F.d , Pezzulo, G.d , Bonini, L.a a Department of Medicine […]

Jackrel lab makes protein finding that could help fight disease

Researchers in the laboratory of Meredith Jackrel, assistant professor of chemistry in Arts & Sciences at Washington University in St. Louis, discovered that proteins implicated in Ewing’s sarcoma and liposarcoma can be dissolved by protein disaggregases, a finding that could be used to combat disease. The new research is published in the Journal of Biological […]

McDermott wins Psychonomic Society award

Kathleen McDermott, professor of psychological and brain sciences in Arts & Sciences at Washington University in St. Louis, is one of two recipients of the 2019 Psychonomic Society Mid-career Award. The award is given to raise the visibility of the experimental study of cognition and of the best mid-career scientists within the field, within awardees’ institutions, […]

WashU weekly Neuroscience publications

“Sleep disturbances in Wolfram syndrome” (2019) Orphanet Journal of Rare Diseases Sleep disturbances in Wolfram syndrome (2019) Orphanet Journal of Rare Diseases, 14 (1), art. no. 188, .  Licis, A.a , Davis, G.d e , Eisenstein, S.A.b c , Lugar, H.M.b , Hershey, T.a b c a Department of Neurology, Washington University, School of Medicine, Campus Box 8111, 660 South Euclid Ave, […]

Rethinking seizures associated with cardiac disease

Most people with a medical condition called long QT syndrome have a mutation in a gene that causes bouts of fast, chaotic heartbeats. They also experience fainting spells and seizures. The clinical approach has largely assumed that when the heart beats erratically, the brain eventually does not get enough oxygen — which in turn causes […]

WashU weekly Neuroscience publications

“Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia” (2019) Scientific Reports Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia (2019) Scientific Reports, 9 (1), art. no. 10854, .  Bonham, L.W.a b , Steele, N.Z.R.a , Karch, C.M.c […]

WashU weekly Neuroscience publications

“A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings” (2019) Journal of Substance Abuse Treatment A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings (2019) Journal of Substance Abuse Treatment, 104, pp. 135-143.  Presnall, N.J.a b , Wolf, D.A.P.S.a , Brown, D.S.a , Beeler-Stinn, S.a , Grucza, R.A.b a Brown School of […]

Bugg elected fellow of Association for Psychological Science

Bugg Julie Bugg, associate professor of psychological and brain sciences in Arts & Sciences, was elected a fellow of the Association for Psychological Science. Bugg joined Washington University in St. Louis in 2012 as an assistant professor. Her lab’s research lies at the intersection between attention and memory and aims to characterize mechanisms of cognitive control […]

WashU weekly Neuroscience publications

“CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)” (2019) Scientific Reports CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) (2019) Scientific Reports, 9 (1), art. no. 9891, .  Eaton, S.L.a , Proudfoot, C.a , Lillico, S.G.a , Skehel, P.b c , Kline, R.A.a , Hamer, K.e , Rzechorzek, N.M.d […]

WashU weekly Neuroscience publications

“A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation” (2019) Molecular Genetics and Metabolism Reports A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation (2019) Molecular Genetics and Metabolism Reports, 20, art. no. 100484, .  Ahmed, A.a , Ou, L.b , Rudser, K.c , […]

WashU weekly Neuroscience publications

“Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns” (2019) Nature Communications Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns (2019) Nature Communications, 10 (1), art. no. 2548, .  Czamara, D.a , Eraslan, G.b c , Page, C.M.d e , Lahti, J.f g , Lahti-Pulkkinen, M.f h , Hämäläinen, E.i […]

WashU weekly Neuroscience publications

“High-fidelity mapping of repetition-related changes in the parietal memory network” (2019) NeuroImage High-fidelity mapping of repetition-related changes in the parietal memory network (2019) NeuroImage, 199, pp. 427-439.  Gilmore, A.W.a , Nelson, S.M.h i j , Laumann, T.O.b c , Gordon, E.M.h i , Berg, J.J.a , Greene, D.J.c d , Gratton, C.b , Nguyen, A.L.b , Ortega, M.b , […]

WashU weekly Neuroscience publications

“A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ” (2019) Nature Communications A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ (2019) Nature Communications, 10 (1), art. no. 2448, .  Kim, W.S.a , Shalit, Z.A.a , Nguyen, S.M.b , Schoepke, E.c , Eastman, A.d , Burris, T.P.c , Gaur, A.B.b , Micalizio, G.C.a a Dartmouth College, Department of […]

The fractal brain, from a single neuron’s perspective

Hacking into brain signals may be more straightforward than once thought. Physicists studying the brain at Washington University in St. Louis have shown how measuring signals from a single neuron may be as good as capturing information from many neurons at once using big, expensive arrays of electrodes. Wessel The new work continues the discussion […]

Thorp to conclude term as Washington University provost

Holden Thorp, provost at Washington University in St. Louis, will leave his position effective July 15, according to Chancellor Andrew D. Martin. Thorp, who has served in his current role since 2013, plans to take a one-year sabbatical and then return to the university in a newly created leadership role in the drug discovery and […]

WashU weekly Neuroscience publications

“Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling” (2019) Current Opinion in Neurobiology Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling (2019) Current Opinion in Neurobiology, 59, pp. 59-68.  Goodman, J.V.a b , Bonni, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Medical Scientist Training Program, Washington […]

WashU weekly Neuroscience publications

“Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms” (2019) Nature Communications Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms (2019) Nature Communications, 10 (1), art. no. 2246, .  Li, P.a , Marshall, L.a , Oh, G.b , Jakubowski, J.L.a , Groot, D.b , He, Y.c , Wang, […]

E3 Nutrition Lab Links Child Nutrition, Economics and Evolution

A transdisciplinary laboratory at the Brown School is undertaking research across the world to address “hidden hunger”— poverty-related nutritional deficiencies in mothers and young children. The founder and director of the E3 Nutrition Lab is Lora Iannotti, associate professor and associate dean for public health. The three “E”s represent the lab’s principles for nutrition interventions: […]

English receives $431K NIH grant

Tammy English, assistant professor of psychological and brain sciences in Arts & Sciences, received a $431,000 National Institutes of Health (NIH) grant in support of research on mild cognitive impairment and emotion regulation in naturalistic contexts. Read more.

WashU weekly Neuroscience publications

“Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power” (2019) NeuroImage Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power (2019) NeuroImage, 197, pp. 435-438.  Glasser, M.F.a b c , Coalson, T.S.a , Bijsterbosch, J.D.d , Harrison, S.J.d e , Harms, M.P.f , Anticevic, A.g , Van […]

Undergraduate Mather wins Harrison D. Stalker Award

Rory Mather has been awarded the 2019 Harrison D. Stalker Award from the Department of Biology in Arts & Sciences at Washington University in St. Louis. The award honors the late Harrison D. Stalker, a renowned evolutionary biologist and a world-class photographer. The award is given annually to a graduating biology major whose undergraduate career […]

Undergraduate Hsu wins Spector Prize

Each year, the Department of Biology in Arts & Sciences at Washington University in St. Louis awards a prize to a graduating senior in memory of Marion Smith Spector, a 1938 graduate who studied zoology under the late Viktor Hamburger. This year’s recipient is Eric Hsu, who worked in the laboratory of David L. Brody, […]

Undergraduate Chin wins Quatrano Prize

Iris Marie Chin, a senior majoring in biology in Arts & Sciences at Washington University in St. Louis, has been awarded the 2019 Ralph S. Quatrano Prize. Established through a generous donation by Katherine Day Reinleitner, the Quatrano Prize is awarded to the thesis showing greatest evidence of creativity in design, research methodology or broader […]

WashU weekly Neuroscience publications

“Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8)” (2019) Scientific Reports Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells (Scientific Reports, (2017), 7, 1, (11569), 10.1038/s41598-017-11885-8) (2019) Scientific Reports, 9 (1), art. no. 6400, .  Guo, P.a , Yu, Y.b […]

Pregnancy shifts the daily schedule forward

Add this to the list of what to expect: Getting up earlier, at least in the first trimester. New research from Washington University in St. Louis finds that women and mice both shift their daily schedules earlier by up to a few hours during the first third of their pregnancy. A new study by researchers […]

WashU weekly Neuroscience publications

“Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry” (2019) Scientific Reports Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry (2019) Scientific Reports, 9 (1), art. no. 6010, .  Lugar, H.M.a , Koller, J.M.a , Rutlin, J.a , Eisenstein, S.A.a , Neyman, O.a , Narayanan, A.a , Chen, L.c , Shimony, J.S.b , Hershey, […]

Women’s Society recognizes students with awards, scholarships

The Women’s Society of Washington University presented the Harriet K. Switzer Leadership Award and the Elizabeth Gray Danforth Scholarships to four deserving students at their annual membership meeting April 10. Wendy Olk, chair of the group’s Leadership Committee, handed out the Switzer Leadership Award to this year’s honorees. Nominees for the award are selected based […]

Researchers receive $3 million to study how adversity affects offspring’s health

Washington University in St. Louis psychology researchers Ryan Bogdan and Thomas Oltmanns received a federal grant totaling more than $3 million to study how adversity may perpetuate racial health disparities and health outcomes within families. The National Institutes of Health (NIH)’s National Institute on Aging is providing the funding, spread over five years. Despite growing evidence […]

WashU weekly Neuroscience publications

“The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF)” (2019) Journal of Psychiatric Research The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF) (2019) Journal of Psychiatric Research, 113, pp. 125-136.  Sackeim, H.A.a , Aaronson, S.T.b , Bunker, M.T.c , Conway, C.R.d , […]

WashU weekly Neuroscience publications

“The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain” (2019) Nature Communications The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain (2019) Nature Communications, 10 (1), art. no. 1417, .  Karolis, V.R., Corbetta, M., Thiebaut de Schotten, M. Abstract Functional lateralisation is a fundamental principle of the human brain. […]

WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

Tidying up: A new way to direct trash to autophagy

Marie Kondo herself couldn’t do it any better. Usually cells are good at recognizing what doesn’t spark joy. They’re constantly cleaning house — picking through their own stuff to clear out what no longer works. Damaged or superfluous organelles. Proteins that don’t fold just so. But what happens when the cell fails to recognize trash? […]