WashU weekly Neuroscience publications

“Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression” (2019) Scientific Reports Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression (2019) Scientific Reports, 9 (1), art. no. 5071, .  Moreno-Ortega, M.a b , Prudic, J.a , Rowny, S.a , Patel, G.H.a , Kangarlu, A.d , Lee, S.c , Grinband, J.a , Palomo, […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 1, the following faculty were appointed with tenure, promoted with tenure or granted tenure, effective July 1 unless otherwise noted. Appointment with tenure Kevin Michael Bennett as associate professor of radiology at the School of Medicine (tenure effective March 1); and Neal Patwari as professor […]

Tidying up: A new way to direct trash to autophagy

Marie Kondo herself couldn’t do it any better. Usually cells are good at recognizing what doesn’t spark joy. They’re constantly cleaning house — picking through their own stuff to clear out what no longer works. Damaged or superfluous organelles. Proteins that don’t fold just so. But what happens when the cell fails to recognize trash? […]

WashU weekly Neuroscience publications

“Regeneration associated transcriptional signature of retinal microglia and macrophages” (2019) Scientific Reports Regeneration associated transcriptional signature of retinal microglia and macrophages (2019) Scientific Reports, 9 (1), art. no. 4768, .  Mitchell, D.M.a , Sun, C.a b , Hunter, S.S.c , New, D.D.c , Stenkamp, D.L.a a Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States b Ophthalmology, Washington University in […]

Cannabis during pregnancy bumps psychosis risk in offspring

Pregnant women who use cannabis may slightly increase the risk their unborn child will develop psychosis later in life, suggests new research from Washington University in St. Louis. Fine “Our research shows that prenatal marijuana exposure after maternal knowledge of pregnancy is associated with a small increase in psychosis proneness during middle childhood or about […]

WashU weekly Neuroscience publications

“Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice” (2019) Scientific Reports Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice (2019) Scientific Reports, 9 (1), art. no. 4379, . Wozniak, D.F., Valnegri, P., Dearborn, J.T., Fowler, S.C., Bonni, A. Document Type: Article Publication Stage: Final Source: Scopus Access Type: Open Access “A […]

How team sports change a child’s brain

Adult depression has long been associated with shrinkage of the hippocampus, a brain region that plays an important role in memory and response to stress. Now, new research from Washington University in St. Louis has linked participation in team sports to larger hippocampal volumes in children and less depression in boys ages 9 to 11. […]

Washington People: Erik Herzog

Feeling a bit lethargic this week? It may have to do with the recent time change and a disruption to biological rhythms. Erik Herzog, professor of biology in Arts & Sciences and a frequent voice of reason on this topic, said that sticking with standard time makes public health sense. Time is what makes this scientist, […]

WashU weekly Neuroscience publications

“The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection” (2019) Journal of Memory and Language The immediate benefits and long-term consequences of briefly presented masked primes on episodic recollection (2019) Journal of Memory and Language, 106, pp. 77-94.  Maddox, G.B.a , Balota, D.A.b , Kumar, A.A.b , Millar, P.R.b , Churchill, L.b a Department of […]

Wash U Researchers Discuss Latest Findings About Suicidal Ideation Among Children, Young People

A study released this week by the National Institutes of Health indicates that nearly one-third of Americans between the ages of 10 and 12 “screened positive for suicide risk in emergency department settings.” Meanwhile, researchers at Washington University School of Medicine have been studying even younger children who think and talk about suicide – and their […]

WashU weekly Neuroscience publications

“Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits” (2019) Scientific Reports Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits (2019) Scientific Reports, 9 (1), art. no. 2779, .  Maloney, S.E.a d f , Yuede, C.M.a b , […]

WashU Expert: The eternal sunshine of perennial ‘wintertime’

Don’t be left in the dark: The movement to abolish clock-time changes each spring and autumn is gaining momentum. Enthusiasts point to examples from sunny locales. Hawaii has never switched between daylight saving time (DST) and standard time. The state keeps one clock throughout the year, and so does most of Arizona. In 2018, Florida […]

Engineering proteins to help counter devastating diseases

As human lifespans have gotten longer, certain proteins in our bodies are increasingly prone to take on alternative shapes. These misfolded proteins can ultimately trigger neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Lou Gehrig’s disease, formally known as amyotrophic lateral sclerosis (ALS). Meredith Jackrel, assistant professor of chemistry in Arts & Sciences at Washington University in St. […]

WashU weekly Neuroscience publications

“Correction to: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language (Nature Communications, (2018), 9, 1, (4619), 10.1038/s41467-018-06014-6)” (2019) Nature Communications Correction to: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language (Nature Communications, (2018), 9, 1, (4619), 10.1038/s41467-018-06014-6) (2019) Nature Communications, 10 (1), art. no. 883, .  Blok, […]

White receives grant from the National PKU Alliance

Desiree White, professor of psychological and brain sciences in Arts & Sciences, received a  $130,500 grant from the National PKU Alliance for a project titled “Validation of the NIH Toolbox for use in phenylketonuria clinical trials.” Read more.

Engineering the right protein

Chemists in Arts & Sciences are working to engineer proteins that may help counter devastating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. The proteins in our bodies have evolved over many millions of years to reach their current diversity of functions, spurring on the necessary chemical reactions occurring within our cells, and protecting us […]

WashU weekly Neuroscience publications

“Predicting Alzheimer’s disease progression using multi-modal deep learning approach” (2019) Scientific Reports Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) Scientific Reports, 9 (1), art. no. 1952, .  Lee, G.a b , Nho, K.c d , Kang, B.a , Sohn, K.-A.a , Kim, D.b e , Weiner, M.W.f , Aisen, P.g , Petersen, R.h , Jack, C.R., Jr.h , […]

Earning a bee’s wings

It is a classic coming-of-age story, in many ways. A honey bee hatches and grows up deep inside a hive. Surrounded by 40,000 of her closest relatives, this dark and constantly buzzing place is all that she knows. Only after she turns 21 days old does she leave the nest to look for pollen and […]

WashU weekly Neuroscience publications

“Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles” (2019) Channels (Austin, Tex.) Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles (2019) Channels (Austin, Tex.), 13 (1), pp. 72-87.  Wang, W.a , Mellor, R.L.a , Nerbonne, J.M.a b , Balke, C.W.a […]

WashU weekly Neuroscience publications

“Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease” (2019) Stroke Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease (2019) Stroke, 50 (2), pp. 266-273.  Guilliams, K.P.a b , Fields, M.E.b , Dowling, M.M.c a From the Department of Neurology (K.P.G.), Washington University School […]

WashU weekly Neuroscience publications

“Neuronal evidence for good-based economic decisions under variable action costs” (2019) Nature Communications Neuronal evidence for good-based economic decisions under variable action costs (2019) Nature Communications, 10 (1), art. no. 393, .  Cai, X.a b c d , Padoa-Schioppa, C.a e f a Department of Neuroscience, Washington University in St Louis, St Louis, MO 63110, United States b NYU Shanghai, 1555 Century Avenue, […]

Silva, Ramani chosen as Inaugural WashU Faculty Fellows in Entrepreneurship

From the WashU Office of the Vice Chancellor for Research… Jennifer Silva, MD, associate professor of Pediatrics and Vijay Ramani, PhD, the  Roma B. & Raymond H. Wittcoff Professor of Energy, Environmental & Chemical Engineering have been selected as the inaugural entrepreneurial faculty fellows. These individuals advise WashU faculty and small companies founded by WashU personnel […]

WashU weekly Neuroscience publications

“Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury” (2019) Neurosurgery Cost-Effectiveness Analysis of Combined Dual Motor Nerve Transfers versus Alternative Surgical and Nonsurgical Management Strategies to Restore Shoulder Function Following Upper Brachial Plexus Injury (2019) Neurosurgery, 84 (2), pp. 362-377.  Khalifeh, J.M.a , Dibble, […]

Children who battle mothers may struggle to find purpose as adults, study finds

Parent-child conflict in elementary years may hamper ‘adulting’ in early 20s From the WashU Newsroom… Children who have more conflict in relationships with their mothers during early years of elementary school may find it more difficult to find a sense of purpose in life as they reach adulthood, suggests new research from Washington University in […]

WashU weekly Neuroscience publications

“Neuroimaging of individual differences: A latent variable modeling perspective” (2019) Neuroscience and Biobehavioral Reviews Neuroimaging of individual differences: A latent variable modeling perspective (2019) Neuroscience and Biobehavioral Reviews, 98, pp. 29-46.  Cooper, S.R., Jackson, J.J., Barch, D.M., Braver, T.S. Washington University in St. Louis, Psychological and Brain Sciences, St. Louis, MO, United States Abstract Neuroimaging data is being increasingly […]

WashU weekly Neuroscience publications

“Seizures as an early symptom of autosomal dominant Alzheimer’s disease” (2019) Neurobiology of Aging Seizures as an early symptom of autosomal dominant Alzheimer’s disease (2019) Neurobiology of Aging, 76, pp. 18-23.  Vöglein, J.a b , Noachtar, S.b , McDade, E.c , Quaid, K.A.d , Salloway, S.e , Ghetti, B.f , Noble, J.g , Berman, S.h , Chhatwal, J.i , […]

Like a spelling bee, but for neuroscience: WashU Brain Bee set for Feb. 16

From the WashU Institute for School Partnerships… Erik Herzog was starting to get concerned. He was deep into the oral portion of the 2018 St. Louis Area Brain Bee and the unthinkable was on the horizon: He was running out of questions. “The contestants had never performed so well in the past,” said Herzog, professor […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

WashU weekly Neuroscience publications

“Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification” (2019) NeuroImage Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification (2019) NeuroImage, 188, pp. 473-482.  Yun, H.J.a b , Chung, A.W.a b , Vasung, L.a b , Yang, E.c , Tarui, T.a b d e […]

Science-based tips for a better, happier New Year

A positive psychologist’s guide to choosing, keeping life-changing resolutions From the WashU Newsroom… There is no secret to happiness, but there is a science to it, says Tim Bono, a psychology lecturer in Arts & Sciences who teaches courses on happiness at  Washington University in St. Louis. In his recent book, “When Likes Aren’t Enough: […]

WashU weekly Neuroscience publications

“Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials” (2019) European Journal of Obstetrics Gynecology and Reproductive Biology Perioperative gabapentin and post cesarean pain control: A systematic review and meta-analysis of randomized controlled trials (2019) European Journal of Obstetrics Gynecology and Reproductive Biology, 233, pp. 98-106.  Felder, L.a , Saccone, G.b , […]

2018 in review: Making strides and discoveries on campus and around the globe

From the WashU Newsroom… The Source looks back at some of our most read and most shared stories of 2018. Highlights include good news (a new chancellor), bad news (even light drinking increases risk of death) and who knew news (“collective narcissism” is real and Virginians have it).   Read more at the Source.

WashU weekly Neuroscience publications

“Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network” (2019) Neurobiology of Aging Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network (2019) Neurobiology of Aging, 75, pp. 42-50.  Bussy, A.a b , Snider, B.J.a b , Coble, D.a […]

Markson receives $49 K from the Russell Sage Foundation

Lori Markson, associate professor and director of graduate studies, and Rebecca Schwarzlose, postdoctoral research associate, both in the Department of Psychological & Brain Sciences in Arts & Sciences, received $49,000 from the Russell Sage Foundation for a research project titled “Conceptual understanding of skin color inheritance among American children and adults.” Read more.

WashU weekly Neuroscience publications

“Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel” (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, 1864 (2), pp. 128-136.  Budelier, M.M.a , Cheng, W.W.L.a , […]

University receives new grant to fund Amgen Scholars Program

Undergraduate research experience supports science education and innovation From the WashU Newsroom… Washington University in St. Louis has received a new grant from the Amgen Foundation to provide hands-on laboratory experiences to undergraduate students through the Amgen Scholars Program. This marks the ninth year the university is participating in the program, which aims to inspire […]

Scholars highlight impact of early adversity on developing brain, implications for criminal justice

From NPR’s St. Louis Public Radio… The early development of the human brain begins in utero and continues into a person’s early-to-mid-20s. In that time, various environmental factors such as poverty, toxins and violence can influence that development. Among adolescent youth, who are susceptible to engaging in risky behavior, the impact of such stressors can […]

WashU weekly Neuroscience publications

“Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries” (2019) Science of the Total Environment Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries (2019) Science […]

GUEST COMMENTARY: Girls must learn to see themselves as scientists

From the Times of Northwest Indiana… I recently visited an elementary school to lead a neuroscience demonstration for fifth-graders. The activities were going splendidly: my station demonstrating the brain’s plasticity (its ability to change and adapt with the environment) saw enthusiastic students who were also able to learn about proprioception (knowing where your body is […]

AAAS names 11 Washington University faculty as fellows

From the WashU Newsroom… Eleven faculty members at Washington University in St. Louis — the most in a decade-and-a-half — are among 416 new fellows selected by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. Samuel Achilefu; Victoria J. Fraser, MD; Robert W. Gereau; Kathleen B. Hall; Joseph […]

WashU weekly Neuroscience publications

"Touch engages visual spatial contextual processing" (2018) Scientific Reports Touch engages visual spatial contextual processing (2018) Scientific Reports, 8 (1), art. no. 16637, .  Pérez-Bellido, A.a b , Pappal, R.D.a c , Yau, J.M.a a Department of Neuroscience, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030, United States b Radboud University, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands […]

WashU weekly Neuroscience publications

“Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations” (2019) Current Opinion in Structural Biology Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations (2019) Current Opinion in Structural Biology, 56, pp. 1-10.  Ruff, K.M., Pappu, R.V., Holehouse, A.S. Department of Biomedical Engineering and Center for Biological […]

New maps hint at how electric fish got their big brains

From the WashU Newsroom… Helmet-heads of the freshwater fish world, African mormyrid fishes are known for having a brain-to-body size ratio that is similar to humans. But there’s actually a great deal of variation in the size of mormyrid brains. These differences provide an opportunity to look at what’s behind the bulk. Researchers from Washington […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

Hengen named 2018 Allen Institute Next Generation Leader

From the WashU Newsroom… Keith Hengen, assistant professor of biology in Arts & Sciences at Washington University in St. Louis, was selected by the Allen Institute as a 2018 Next Generation Leader. Hengen is one of six early-career neuroscientists who will participate in a special advisory council for the Allen Institute for Brain Science, a […]

More pregnant women in U.S. smoking pot

From Reuters… Even as alcohol and tobacco use continue to decline among pregnant women in the U.S., a new study offers fresh evidence that more American mothers are using cannabis during pregnancy. Other recent studies have also documented a rise in cannabis use among pregnant women of all ages, with some evidence of particularly sharp […]

Why the ‘None of the above’ answer is poor test design

A new study argues that some of the most common practices within a multiple choice test are not actually good for measuring learning. From Ladders… For those of us who hate standardized tests, we may suspect that multiple choice questions are designed more to trip us up than to actually help us learn. And we […]

How Daylight Saving Time Changes More Than Clocks

From WBUR (Boston) & NPR… Most of the country switched their clocks back an hour over the weekend, ending daylight saving time. And even though one hour might not sound like a lot, it has a noticeable impact. “In the long term, this one hour cumulatively can really have effects on our health,” says Erik Herzog, […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

Award for Education in Neuroscience Presented to Erik Herzog and Gönül Peker

From the Society for Neuroscience News… WASHINGTON, D.C. — The Society for Neuroscience (SfN) will award Erik Herzog, PhD, professor of biology at Washington University and director of the St. Louis Neuroscience Pipeline Program, and Gönül Peker, PhD, professor emeritus at Ege University, Turkey, this year’s Award for Education in Neuroscience. The honor recognizes individuals […]