WashU weekly Neuroscience publications

“Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel” (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel (2019) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, 1864 (2), pp. 128-136.  Budelier, M.M.a , Cheng, W.W.L.a , […]

University receives new grant to fund Amgen Scholars Program

Undergraduate research experience supports science education and innovation From the WashU Newsroom… Washington University in St. Louis has received a new grant from the Amgen Foundation to provide hands-on laboratory experiences to undergraduate students through the Amgen Scholars Program. This marks the ninth year the university is participating in the program, which aims to inspire […]

Scholars highlight impact of early adversity on developing brain, implications for criminal justice

From NPR’s St. Louis Public Radio… The early development of the human brain begins in utero and continues into a person’s early-to-mid-20s. In that time, various environmental factors such as poverty, toxins and violence can influence that development. Among adolescent youth, who are susceptible to engaging in risky behavior, the impact of such stressors can […]

WashU weekly Neuroscience publications

“Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries” (2019) Science of the Total Environment Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries (2019) Science […]

GUEST COMMENTARY: Girls must learn to see themselves as scientists

From the Times of Northwest Indiana… I recently visited an elementary school to lead a neuroscience demonstration for fifth-graders. The activities were going splendidly: my station demonstrating the brain’s plasticity (its ability to change and adapt with the environment) saw enthusiastic students who were also able to learn about proprioception (knowing where your body is […]

AAAS names 11 Washington University faculty as fellows

From the WashU Newsroom… Eleven faculty members at Washington University in St. Louis — the most in a decade-and-a-half — are among 416 new fellows selected by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. Samuel Achilefu; Victoria J. Fraser, MD; Robert W. Gereau; Kathleen B. Hall; Joseph […]

WashU weekly Neuroscience publications

"Touch engages visual spatial contextual processing" (2018) Scientific Reports Touch engages visual spatial contextual processing (2018) Scientific Reports, 8 (1), art. no. 16637, .  Pérez-Bellido, A.a b , Pappal, R.D.a c , Yau, J.M.a a Department of Neuroscience, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030, United States b Radboud University, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands […]

WashU weekly Neuroscience publications

“Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations” (2019) Current Opinion in Structural Biology Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations (2019) Current Opinion in Structural Biology, 56, pp. 1-10.  Ruff, K.M., Pappu, R.V., Holehouse, A.S. Department of Biomedical Engineering and Center for Biological […]

New maps hint at how electric fish got their big brains

From the WashU Newsroom… Helmet-heads of the freshwater fish world, African mormyrid fishes are known for having a brain-to-body size ratio that is similar to humans. But there’s actually a great deal of variation in the size of mormyrid brains. These differences provide an opportunity to look at what’s behind the bulk. Researchers from Washington […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

Hengen named 2018 Allen Institute Next Generation Leader

From the WashU Newsroom… Keith Hengen, assistant professor of biology in Arts & Sciences at Washington University in St. Louis, was selected by the Allen Institute as a 2018 Next Generation Leader. Hengen is one of six early-career neuroscientists who will participate in a special advisory council for the Allen Institute for Brain Science, a […]

More pregnant women in U.S. smoking pot

From Reuters… Even as alcohol and tobacco use continue to decline among pregnant women in the U.S., a new study offers fresh evidence that more American mothers are using cannabis during pregnancy. Other recent studies have also documented a rise in cannabis use among pregnant women of all ages, with some evidence of particularly sharp […]

Why the ‘None of the above’ answer is poor test design

A new study argues that some of the most common practices within a multiple choice test are not actually good for measuring learning. From Ladders… For those of us who hate standardized tests, we may suspect that multiple choice questions are designed more to trip us up than to actually help us learn. And we […]

How Daylight Saving Time Changes More Than Clocks

From WBUR (Boston) & NPR… Most of the country switched their clocks back an hour over the weekend, ending daylight saving time. And even though one hour might not sound like a lot, it has a noticeable impact. “In the long term, this one hour cumulatively can really have effects on our health,” says Erik Herzog, […]

WashU weekly Neuroscience publications

“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74.  Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]

WashU weekly Neuroscience publications

“Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study” (2019) Multiple Sclerosis and Related Disorders Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the […]

WashU weekly Neuroscience publications

“Symptoms of social anxiety disorder and major depressive disorder: A network perspective” (2019) Journal of Affective Disorders Symptoms of social anxiety disorder and major depressive disorder: A network perspective (2019) Journal of Affective Disorders, 243, pp. 531-538.  Langer, J.K.a , Tonge, N.A.a c , Piccirillo, M.a c , Rodebaugh, T.L.a c , Thompson, R.J.a c , Gotlib, I.H.b d […]

Grad students Hailun Li and Weikang Shi win 2018 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition.  The 2018 winners: Short Talks: Hailun Li (Neuroscience Program; DiAntonio lab) “A neuromodulatory circuit regulating the glial capacity to buffer K+” Posters: Weikang Shi (Neuroscience program; Padoa-Schioppa lab) “Establishing […]

WashU weekly Neuroscience publications

“Associations between depression, anxious arousal and manifestations of psychological inflexibility” (2019) Journal of Behavior Therapy and Experimental Psychiatry Associations between depression, anxious arousal and manifestations of psychological inflexibility (2019) Journal of Behavior Therapy and Experimental Psychiatry, 62, pp. 88-96.  Gilbert, K.E.a , Tonge, N.A.b , Thompson, R.J.b a Department of Psychiatry, Washington University School of Medicine, Washington University in St. […]

Psychology Building to be named in honor of Somers family

From the WashU Newsroom… Alumni and longtime Washington University supporters Nick and Barrie Somers have made a significant commitment to the university for long-range capital needs. In recognition, the Psychology Building — which houses the Department of Psychological & Brain Sciences in Arts & Sciences — will be named Somers Family Hall. “We are exceptionally […]

WashU weekly Neuroscience publications

“Examining the Role of Cone-expressed RPE65 in Mouse Cone Function” (2018) Scientific Reports Examining the Role of Cone-expressed RPE65 in Mouse Cone Function (2018) Scientific Reports, 8 (1), art. no. 14201, .  Kolesnikov, A.V.a , Tang, P.H.b c , Kefalov, V.J.a a Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, United States b Department of Ophthalmology, […]

Metabolomics for the masses

Lowering the ‘data burden’ to put better interpretation in reach From the WashU Newsroom… Gary Patti, the Michael and Tana Powell Associate Professor of Chemistry in Arts & Sciences at Washington University in St. Louis, has been awarded $4.8 million in two separate National Institutes of Health (NIH) grants focused on improving the accessibility of […]

WashU weekly Neuroscience publications

“Distinct modes of functional connectivity induced by movie-watching” (2019) NeuroImage Distinct modes of functional connectivity induced by movie-watching (2019) NeuroImage, 184, pp. 335-348.  Demirtaş, M.a b , Ponce-Alvarez, A.b , Gilson, M.b , Hagmann, P.d , Mantini, D.e f , Betti, V.g h , Romani, G.L.i , Friston, K.j , Corbetta, M.k l , Deco, G.b c m n […]

For better multiple-choice tests, avoid tricky questions, study finds

From the WashU Newsroom… Multiple-choice tests and quizzes are an effective tool for: a) assessing a student’s mastery of facts and concepts; b) helping students learn and retain facts and concepts. While some educators might see this as a trick question, the correct answer appears to be: c) all of the above, suggests new research […]

WashU weekly Neuroscience publications

“Statistical learning and spelling: Evidence from Brazilian prephonological spellers” (2019) Cognition Statistical learning and spelling: Evidence from Brazilian prephonological spellers (2019) Cognition, 182, pp. 1-7.  Treiman, R.a , Cardoso-Martins, C.b , Pollo, T.C.c , Kessler, B.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, United States b Departamento de Psicologia, Universidade Federal de Minas Gerais, Brazil c Departamento […]

WashU weekly Neuroscience publications

“Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation” (2018) World Neurosurgery Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation (2018) World Neurosurgery, 119, pp. 233-236.  Baksh, B.S.a , Sinha, N.b , Salehi, A.a , Han, R.H.a , Miller, B.A.a d , Dahiya, S.b , Gauvain, K.M.c , Limbrick, D.D., Jr.a a Department of Neurological […]

‘The Curren(t)cy of Frankenstein’

Event to explore bioethics and medical practice Sept. 28-30 From the WashU Newsroom… Patient care. Informed consent. Genetics and transplantation. Mary Shelley’s “Frankenstein” is a thrilling adventure but also a prescient guidebook to the moral and ethical dilemmas of 20th and 21st century medicine. This month, Washington University in St. Louis’ School of Medicine and […]

Diving in to how our brains process information

Engineering, ArtSci researchers will use fMRI and twins to better understand cognitive control From the WashU Newsroom… How our brains process information is intimately tied to the kinds of goals we have or the tasks we need to perform. For example, when showed the word “yellow,” our brains process it differently depending on whether we […]

WashU weekly Neuroscience publications

“Altered functional network connectivity relates to motor development in children born very preterm” (2018) NeuroImage Altered functional network connectivity relates to motor development in children born very preterm (2018) NeuroImage, 183, pp. 574-583.  Wheelock, M.D.a , Austin, N.C.b , Bora, S.c , Eggebrecht, A.T.d , Melzer, T.R.e , Woodward, L.J.f , Smyser, C.D.d g h a Department of Psychiatry, Washington […]

Quick learners remember more over time

From the WashU Newsroom… Healthy adults who learn information more quickly than their peers also have better long-term retention for the material despite spending less time studying it, a new study from psychologists at Washington University in St. Louis finds. “Quicker learning appears to be more durable learning,” said Christopher L. Zerr, lead author and […]

WashU weekly Neuroscience publications

“Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol” (2018) Contemporary Clinical Trials Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol (2018) Contemporary Clinical Trials, 72, pp. 117-125.  Wilfley, D.E.a , Fitzsimmons-Craft, E.E.a , Eichen, D.M.b , Van Buren, D.J.a , Welch, […]

In sync: How cells make connections could impact circadian rhythm

From the WashU Newsroom… If you’ve ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism, from sleep-wake cycles to body temperature to digestion. Every cell in the body has a circadian clock, but researchers were unclear about how networks of cells connect with each other over […]

WashU weekly Neuroscience publications

“Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model” (2018) Translational Psychiatry Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model (2018) Translational Psychiatry, 8 (1), art. no. 158, .  Duan, J.a b , Göring, H.H.H.c , Sanders, A.R.a b , Moy, W.a b , Freda, J.a , Drigalenko, E.I.d , Kos, M.c […]

WashU weekly Neuroscience publications

“Dynamic contrast enhancement and flexible odor codes” (2018) Nature Communications Dynamic contrast enhancement and flexible odor codes (2018) Nature Communications, 9 (1), art. no. 3062, .  Nizampatnam, S.a b , Saha, D.a , Chandak, R.a , Raman, B.a b a Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, United States b Department of Electrical and Systems Engineering, Washington University in […]

WashU weekly Neuroscience publications

“Matrine inhibits itching by lowering the activity of calcium channel” (2018) Scientific Reports Matrine inhibits itching by lowering the activity of calcium channel (2018) Scientific Reports, 8 (1), art. no. 11328, .  Geng, X.a , Shi, H.a , Ye, F.a , Du, H.b , Qian, L.a , Gu, L.a , Wu, G.a , Zhu, C.a , Yang, Y.a , Wang, C.a […]

A path to diversity in neuroscience

ENDURE fosters community in undergraduate research From the WashU Newsroom… When Washington University in St. Louis student Sneha Chaturvedi walks into a laboratory, she knows what to expect: sterile white floors, test tubes lining the shelves, a chemical smell wafting between benches and men in lab coats. Few of the scientists are women or underrepresented […]

Botero receives NSF EAGER grant

From WashU Research Wire… Carlos Botero, assistant professor of biology in Arts & Sciences, was awarded a one-year $149,729 National Science Foundation EAGER grant for the project “Removing barriers to macro-ecoevolutionary studies of the avian brain.” The new award will allow Botero to build out a dataset that integrates studies on brain size variation with […]

WashU weekly Neuroscience publications

“Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo” (2018) Nature Communications Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo (2018) Nature Communications, 9 (1), art. no. 2734, .  Li, L.a , Shemetov, A.A.b , Baloban, M.b , Hu, P.c , Zhu, L.c d , Shcherbakova, D.M.b , […]

WashU weekly Neuroscience publications

"Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum" (2018) Nature Communications Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum (2018) Nature Communications, 9 (1), art. no. 2710, .  Wolfman, S.L.a , Gill, D.F.a , Bogdanic, F.b , Long, K.c , Al-Hasani, R.d , McCall, J.G.d e f , Bruchas, M.R.e f , McGehee, […]

Unless we spot changes, most life experiences are fabricated from memories

Change detection plays key role in how we construct reality, new model suggests From the WashU Newsroom… We may not be able to change recent events in our lives, but how well we remember them plays a key role in how our brains model what’s happening in the present and predict what is likely to […]

WashU weekly Neuroscience publications

Age at first birth in women is genetically associated with increased risk of schizophrenia (2018) Scientific Reports Age at first birth in women is genetically associated with increased risk of schizophrenia (2018) Scientific Reports, 8 (1), art. no. 10168, .  Ni, G.a b , Gratten, J.c d , Wray, N.R.c d , Lee, S.H.a b d , Ripke, S.e f , […]

Perfectionism in young children may indicate OCD risk

Study involving behavior, brain scans may help ID issues early in life From the WashU School of Medicine News… Studying young children, researchers at Washington University School of Medicine in St. Louis found that kids who possess tendencies toward perfectionism and excessive self-control are twice as likely as other children to develop obsessive-compulsive disorder (OCD) […]

WashU weekly Neuroscience publications

"The Open Source GAITOR Suite for Rodent Gait Analysis" (2018) Scientific Reports The Open Source GAITOR Suite for Rodent Gait Analysis (2018) Scientific Reports, 8 (1), art. no. 9797, .  Jacobs, B.Y.a , Lakes, E.H.a , Reiter, A.J.b , Lake, S.P.b , Ham, T.R.c , Leipzig, N.D.c , Porvasnik, S.L.a , Schmidt, C.E.a , Wachs, R.A.a d , Allen, K.D.a a University […]

VIP neurons hold master key to jet lag response

A tiny population of neurons can unlock the body’s clock From the WashU Newsroom… Travel by airplane has opened the door to experiencing different cultures and exploring natural wonders. That is, if you can get past the jet lag. But what if you could take control of the brain’s daily timing system? Biologists at Washington […]

WashU weekly Neuroscience publications

"Development of vestibular behaviors in zebrafish" (2018) Current Opinion in Neurobiology Development of vestibular behaviors in zebrafish (2018) Current Opinion in Neurobiology, 53, pp. 83-89.  Bagnall, M.W.a , Schoppik, D.b a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Departments of Otolaryngology, Neuroscience & Physiology, the Neuroscience Institute, New York University School of Medicine, New […]

WashU weekly Neuroscience publications

"Testing neurophysiological markers related to fear-potentiated startle" (2018) Psychiatry Research Testing neurophysiological markers related to fear-potentiated startle (2018) Psychiatry Research, 267, pp. 195-200.  Seligowski, A.V.a b , Bondy, E.c , Singleton, P.a b , Orcutt, H.K.d , Ressler, K.J.a b , Auerbach, R.P.b e f a Department of Psychiatry, Harvard Medical School, Boston, MA, United States b McLean Hospital, Belmont, MA, […]

Barch receives $3.5 million for research on brain, mental illness

From the WashU Newsroom… Mental health researcher Deanna Barch, of Washington University in St. Louis, has been awarded a $3.5 million MERIT award from the National Institute of Mental Health, part of the National Institutes of Health (NIH). Barch Barch is chair of the Department of Psychological & Brain Sciences in Arts & Sciences and the Gregory […]

WashU weekly Neuroscience publications

"Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states" (2018) Scientific Reports Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states (2018) Scientific Reports, 8 (1), art. no. 4103, .  Mahjoub, I.a b , Mahjoub, M.A.b , Rekik, I.a , Weiner, M.c , Aisen, P.d , Petersen, R.e , Jack, C.f , Jagust, W.g , Trojanowki, J.h […]

WashU weekly Neuroscience publications

"Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ϵ4" (2018) Scientific Reports Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer’s disease by interacting with APOE ϵ4 (2018) Scientific Reports, 8 (1), art. no. 8068, .  Zhang, A.a , Zhao, Q.b , Xu, D.a , […]