Zeroing out their own zap

Electric fish generate electric pulses to communicate with other fish and sense their surroundings. Some species broadcast shorter electric pulses, while others send out long ones. But all that zip-zapping in the water can get confusing. The fish need to filter out their own pulses so they can identify external messages and only respond to […]

Aging memories may not be ‘worse,’ just ‘different’

“Memory is the first thing to go.” Everyone has heard it, and decades of research studies seem to confirm it: While it may not always be the first sign of aging, some faculties, including memory, do get worse as people age. It may not be that straightforward. Zachariah Reagh, assistant professor of psychological and brain […]

WashU weekly Neuroscience publications

“Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease” (2020) The Journal of Experimental Medicine Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease (2020) The Journal of Experimental Medicine, 217 (11), . Barthélemy, N.R.a , Horie, K.a , Sato, C.a , Bateman, R.J.a b c a Department of Neurology, Washington University School of Medicine, St. Louis, MO b Hope Center for Neurological Disorders, […]

WashU weekly Neuroscience publications

"Gait asymmetry, and bilateral coordination of gait during a six-minute walk test in persons with multiple sclerosis" (2020) Scientific Reports Gait asymmetry, and bilateral coordination of gait during a six-minute walk test in persons with multiple sclerosis(2020) Scientific Reports, 10 (1), art. no. 12382, .  Plotnik, M.a b c , Wagner, J.M.d , Adusumilli, G.e , Gottlieb, A.a , Naismith, R.T.e a Center of Advanced Technologies in Rehabilitation, […]

WashU weekly Neuroscience publications

“A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation” (2020) Communications Biology A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation (2020) Communications Biology, 3 (1), art. no. 385, . Liu, Y.a , Xu, X.b , Gao, J.c , Naffaa, M.M.a , Liang, H.a , Shi, J.a , Wang, H.Z.c , Yang, N.-D.a , Hou, P.a , Zhao, W.a , White, K.M.F.a , Kong, W.a , Dou, A.a , Cui, A.a , Zhang, […]

Zacks awarded $2M grant from NIH

Jeffrey Zacks, professor of psychological and brain sciences in Arts & Sciences, received a nearly $2 million grant from the National Institutes of Health (NIH) in support of a multiyear project titled “Improving Everyday Memory in Healthy Aging and Early Alzheimer’s Disease.” Read more.

WashU weekly Neuroscience publications

“Quantification of brain oxygen extraction and metabolism with (15O)-gas PET: A technical review in the era of PET-MRI” (2020) NeuroImage Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI (2020) NeuroImage, 220, art. no. 117136, .  Fan, A.P.a b , An, H.c , Moradi, F.a , Rosenberg, J.a , Ishii, Y.a […]

WashU weekly Neuroscience publications

“A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine” (2020) Nature Communications A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine (2020) Nature Communications, 11 (1), art. no. 3368, . Guo, Y.a b c , Rist, P.M.a b c , Daghlas, I.a b , Giulianini, F.a , Gormley, P.e f g h , Anttila, V.f g i , Winsvold, B.S.j k l , Palta, P.m , Esko, T.f n o , Pers, T.H.f o p q , Farh, K.-H.f i r , Cuenca-Leon, E.e f g s , Muona, […]

WashU weekly Neuroscience publications

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Praesent euismod, quam at feugiat commodo, turpis orci feugiat justo, nec porta nibh lectus vitae dui. Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9) (2020) Scientific Reports Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific […]

WashU weekly Neuroscience publications

“Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples” (2020) Translational Psychiatry Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples (2020) Translational Psychiatry, 10 (1), art. no. 196, . Barr, P.B.a , Ksinan, A.b , Su, J.c , Johnson, E.C.d , […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting May 1, several faculty members were appointed or promoted with tenure, effective July 1 unless otherwise indicated. Appointment with tenure  …Jonathan Kipnis as professor of pathology and immunology at the School of Medicine; Carolina B. Lopez as professor of molecular microbiology at the School of Medicine […]

WashU weekly Neuroscience publications

“Entropy, mutual information, and systematic measures of structured spiking neural networks” (2020) Journal of Theoretical Biology Entropy, mutual information, and systematic measures of structured spiking neural networks (2020) Journal of Theoretical Biology, 501, art. no. 110310, . Li, W.a , Li, Y.b a Department of Mathematics and Statistics, Washington University, St. Louis, MO 63130, United States b Department […]

Patti a finalist for prestigious Blavatnik young scientist award

Gary Patti is among the 31 finalists for the Blavatnik National Awards for Young Scientists, selected from 305 nominations across the United States, the organization announced June 17. He is the first honoree from Washington University in St. Louis in the award’s seven-year history. Patti Patti, the Michael and Tina Powell Associate Professor of Chemistry in […]

WashU weekly Neuroscience publications

“GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors” (2020) Scientific Reports GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors (2020) Scientific Reports, 10 (1), art. no. 9027, . Fu, Y.a b , Liu, C.J.a b , Kobayashi, D.K.a b , Johanns, T.M.b c , Bowman-Kirigin, J.A.a , Schaettler, M.O.a , Mao, D.D.a , Bender, D.b , Kelley, D.G.d , Uppaluri, R.e , Bi, W.L.f , Dunn, I.F.g , […]

Braver receives $433K grant from NIH

Todd Braver, professor of psychological and brain sciences in Arts & Sciences, received a $432,938 grant from the National Institutes of Health (NIH) to support a project titled “Healthy Aging and the Cost of Cognitive Effort.” Read more.

WashU weekly Neuroscience publications

“Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program” (2020) Nature Communications Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program (2020) Nature Communications, 11 (1), art. no. 2611, .  Karagiannis, T.T.a b , Cleary, J.P., Jr.b c , Gok, B.b d , Henderson, A.J.e , Martin, N.G.f , Yajima, M.g , Nelson, […]

WashU weekly Neuroscience publications

“Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia” (2020) Nature Communications Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia (2020) Nature Communications, 11 (1), art. no. 2552, .  Wang, P.L.a b , Yim, A.K.Y.b , Kim, K.-W.a , Avey, D.b , Czepielewski, R.S.a , Colonna, M.a , Milbrandt, J.b , Randolph, G.J.a a Division […]

$13.7 million to further adolescent brain development study

Washington University scientists will receive $13.7 million in additional funding for ongoing research into adolescent brain development. Their work is part of the largest long-term study of brain development ever conducted in the United States. Washington University is one of 21 study sites around the country participating in the project. Launched in 2015, the Adolescent Brain […]

WashU weekly Neuroscience publications

“The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity” (2020) Operative Neurosurgery (Hagerstown, Md.) The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity (2020) Operative Neurosurgery (Hagerstown, Md.), 18 (6), pp. 583-589. Segreto, F.A.a b , Passias, P.G.a b , Brown, A.E.a b , Horn, S.R.a b , Bortz, C.A.a b , Pierce, K.E.a b , Alas, H.a b , […]

WashU weekly Neuroscience publications

“Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model” (2020) Scientific Reports Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model (2020) Scientific Reports, 10 (1), art. no. 7449, .  Pacia, C.P.a , Zhu, L.a , Yang, Y.a , Yue, Y.a , Nazeri, A.b , Michael Gach, H.a b […]

‘Thank you, #WashU20’ features Claire Weichselbaum, Kow Essuman

To the Class of 2020: Thank you. For your commitment to academic excellence. For your service to the St. Louis community. For your support of your fellow students. For your devotion to your labs, your teams, your campus organizations. You made Washington University in St. Louis better. We wish we could express our gratitude to […]

WashU weekly Neuroscience publications

“The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective registry” (2020) International Journal of Bipolar Disorders The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective […]

Nikhil Aggarwal wins 2020 Quatrano Prize

Nikhil Aggarwal, a senior majoring in the neuroscience track of biology in Arts & Sciences at Washington University in St. Louis, has been awarded the 2020 Ralph S. Quatrano Prize. Established through a generous donation by Katherine Day Reinleitner, the Quatrano Prize is awarded to the thesis showing greatest evidence of creativity in design, research […]

WashU weekly Neuroscience publications

“Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review” (2020) Radiology Case Reports Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review (2020) Radiology Case Reports, 15 (7), pp. 863-866.  Samara, A.a , Eldaya, R.W.b a Department of Psychiatry, Washington University School of Medicine, 4525 Scott Ave, St. Louis, MO 63110, […]

Manasvi Verma wins 2020 Spector Prize

Manasvi Verma, a senior majoring in biology in Arts & Sciences at Washington University in St. Louis, has been awarded the 2020 Spector Prize. Each year, the Department of Biology in Arts & Sciences at Washington University in St. Louis awards a prize to a graduating senior in memory of Marion Smith Spector, a 1938 […]

WashU weekly Neuroscience publications

“The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease” (2020) Current Opinion in Neurobiology The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease (2020) Current Opinion in Neurobiology, 63, pp. 59-66.  Figley, M.D.a , DiAntonio, A.a b a Department of Developmental Biology, Washington University […]

WashU weekly Neuroscience publications

“cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons” (2020) Experimental Neurology cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons (2020) Experimental Neurology, 329, art. no. 113252, .  Sasaki, Y.a , Engber, T.M.b , Hughes, R.O.b , Figley, M.D.c , Wu, T.a , Bosanac, T.b , Devraj, […]

Juniors Eisner, Klapow awarded prestigious Truman Scholarship

Chancellor Andrew D. Martin (lower image) surprises Truman Scholars  Max Klapow (left) and Zach Eisner. (Video: Tom Malkowicz/Washington University) Roommates and best friends Zach Eisner and Max Klapow, juniors at Washington University in St. Louis, have both won a Truman Scholarship, the premier graduate fellowship in the United States for those pursuing careers as public service leaders. […]

Research in most university labs moved from bench to internet

When Washington University Vice Chancellor for Research Jennifer K. Lodge first sounded the alarm about the disruptive impact COVID-19 likely would have on labs across the university, the research community heeded her warning, taking steps to shut down lab work and move as much as possible online. Those in position to do so began pivoting their research […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 6, several faculty members were appointed, promoted or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure  Stephanie Li as professor of English in Arts & Sciences;  Alessandro Vindigni as professor of medicine, of pathology and immunology, and of biochemistry and molecular biophysics at […]

WashU weekly Neuroscience publications

“Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective” (2020) Neurobiology of Stress Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective (2020) Neurobiology of Stress, 12, art. no. 100215, .  Paul, S.M.a b c , Pinna, G.d , Guidotti, A.d e a Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States b The Taylor Family Institute for […]

WashU Expert: Grieving in the time of a pandemic

Some 23,000 people across the globe — including more than 1,000 Americans — have died as a result of COVID-19 as of March 26. Along with many aspects of life since the virus took hold, grieving also has become more complicated for the friends and families of those who died. “There are two reasons,” said Brian […]

Coping during coronavirus

Tim Bono is an assistant dean in Arts & Sciences and a lecturer in psychological and brain sciences at Washington University in St. Louis. Bono is also author of Happiness 101: Simple Secrets to Smart Living & Well-Being. Bono As precautions surrounding the coronavirus pandemic have shut down our favorite restaurants, social activities and beloved university traditions, […]

Medical students lead effort to collect masks, gowns, gloves, eye protection

With cases of the novel coronavirus on the rise in the St. Louis region, Washington University in St. Louis is anticipating shortages of personal protective equipment (PPE) — such as masks, gowns, gloves and eyewear — at university-affiliated hospitals and clinics. As work is reduced in university laboratories, medical students are asking researchers to collect […]

WashU weekly Neuroscience publications

“Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study” (2020) Journal of Stroke and Cerebrovascular Diseases Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study (2020) Journal of Stroke and Cerebrovascular Diseases, 29 (4), art. no. 104645, .  Cross, D.B.a , Tiu, J.c , Medicherla, C.a , Ishida, K.a , Lord, A.a , Czeisler, B.a , Wu, C.a , Golub, D.a […]

Washington University to break ground on major neuroscience research hub

Washington University in St. Louis will begin construction in March on what will be one of the largest neuroscience research buildings in the country. Located on the School of Medicine campus, the 11-story, state-of-the-art research facility will merge, cultivate and advance some of the world’s leading neuroscience research. The 609,000-square-foot facility and interconnected projects initially […]

WashU weekly Neuroscience publications

“Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology” (2020) Scientific Reports Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) Scientific Reports, 10 (1), art. no. 2975, .  Shen, X.a , Ma, S.a , Vemuri, P.b , Simon, G.a , Weiner, M.W.c , Aisen, P.d , Petersen, R.b , Jack, C.R.b , Saykin, A.J.e , […]

WashU weekly Neuroscience publications

“Genomic prediction of alcohol-related morbidity and mortality” (2020) Translational Psychiatry Genomic prediction of alcohol-related morbidity and mortality (2020) Translational Psychiatry, 10 (1), art. no. 23, .  Kiiskinen, T.a f , Mars, N.J.f , Palviainen, T.f , Koskela, J.f , Rämö, J.T.f , Ripatti, P.f , Ruotsalainen, S.f , Palotie, A.f g h , Madden, P.A.F.b , Rose, R.J.c , Kaprio, J.d […]

Lent, Self-Control And Some Tips For More Successful Attempts At Lifestyle Changes

’Tis the season for attempted lifestyle changes and vice-forsaking of all sorts. For the more resolute, perhaps a new 2020 goal has really started to stick after two months of hard-fought discipline. Others, particularly many Christians, are just beginning to give something up for Lent, a 40-day period leading up to the celebration of Easter. […]

WashU weekly Neuroscience publications

“Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex” (2020) Communications Biology Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex (2020) Communications Biology, 3 (1), art. no. 64, .  Zhang, M.a c , Kwon, S.E.b d , Ben-Johny, M.a e , O’Connor, D.H.b , Issa, J.B.a f a Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, […]

Barch elected to head AAAS psychology section

The American Association for the Advancement of Science (AAAS) has elected Deanna Barch the chair-elect of its Section on Psychology, one of 24 specialized AAAS sections. Barch Barch is professor and chair of psychological and brain sciences in Arts & Sciences at Washington University in St. Louis. She is also the Gregory B. Couch Professor of Psychiatry and professor […]

WashU weekly Neuroscience publications

“Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures” (2020) Scientific Reports Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures (2020) Scientific Reports, 10 (1), art. no. 1980, .  Iskandar, H.N.a , Linan, E.E.b , Patel, A.c , Moore, R.d , Lasanajak, Y.d , Gyawali, C.P.b , Sayuk, G.S.b e , Ciorba, […]

Suicidal thoughts in 9- and 10-year-olds correlate to family dynamics, study found

Death by suicide in children has reached a 30-year high in the United States. During middle and high school, 10% to 15% of kids have thoughts of suicide, according to the Centers for Disease Control and Prevention. How early in a child’s life do these thoughts begin? New research from Washington University in St. Louis […]

WashU weekly Neuroscience publications

“Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy” (2020) Nature Communications Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy (2020) Nature Communications, 11 (1), art. no. 595, .  Hengel, H.a b , Bosso-Lefèvre, C.c d , Grady, G.e , Szenker-Ravi, E.c , Li, H.f , Pierce, S.g , Lebigot, É.h , Tan, T.-T.i , Eio, M.Y.i , […]

WashU weekly Neuroscience publications

“FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease” (2020) Nature Communications FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2020) Nature Communications, 11 (1), art. no. 411, .  Yan, T.a , Liang, J.b , Gao, J.a , Wang, L.a , Fujioka, H.c , Weiner, M.W.d , Schuff, N.d , Rosen, H.J.d , Miller, B.L.d , […]

Rodebaugh named APS fellow

The Association for Psychological Science (APS) has named Thomas Rodebaugh an APS Fellow. Rodebaugh is professor of psychological and brain sciences and director of clinical training for that department in Arts & Sciences at Washington University in St. Louis. The association awards fellow status to members who have made sustained and outstanding contributions to the science of psychology in […]

Snyder receives 5 year $2.55M grant from National Eye Institute of the NIH

Lawrence H. Snyder, MD, PhD, professor of neuroscience at the School of Medicine and of psychological and brain sciences in  Arts  & Sciences, received a five-year $2.55 million grant from the National Eye Institute of the National Institutes of Health (NIH) for research titled “Interhemispheric communication underlying bimanual and eye-hand coordination.” Read more.

Understanding accented speech: AKA, understanding speech

Kristin Van Engen studies the dynamic back-and-forth between communicators, including the impact that noise and accent have on intelligibility and comprehension. Communication among people with different accents is particularly challenging because of the way that our brains expect to hear sounds. People don’t always hear the comfortable sounds they have learned to expect, leading some […]