“Immunoengineering with Supramolecular Peptide Biomaterials”

Hosted by the Department of Biomedical Engineering

Abstract: Innovations in vaccine research have been influenced by the emerging field of ‘immunoengineering,’ which describes collaborative efforts between engineers and immunologists to study and modulate the immune system. We are particularly invested in the development of supramolecular peptide nanofibers as self-adjuvanting and inflammation-free vaccine carriers. These fibrillar scaffolds are attractive due to the ability of peptides to fold into specific secondary structures such as a-helices and ß-sheets and the rich chemistry with which their function can be manipulated. The highly modular nature of supramolecular assembly allows one to mix multiple functional moieties (antigens, adjuvants, cytokines, etc.) with stoichiometric precision and offers a powerful platform for the development of therapies with fine-tuned immunogenicity. In this talk, Dr. Rudra will discuss his efforts to develop supramolecular peptide nanofibers as self- adjuvanting and inflammation-free vaccine carriers.

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