“Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide”
We are pleased to invite curious minds to participate in the Motor Control & Brain Plasticity Virtual Journal Club. The sessions will happen bi-weekly on Thursdays at 12PM CST beginning 12/10/20 through 05/20/21, with a break during holidays.
There will be 12 virtual sessions with key speakers in the following topics: epistemology of science, stroke recovery and brain reorganization, insights from fMRI about motor function, OPTIMAL theory of motor learning, novel biomarker of movement quality, synergies during task switching, spasticity and motor control, learning effects of non-invasive brain stimulation, EEG neuroimaging and neuromodulation, and visuomotor coordination. The general format of the sessions consists of a space to critically discuss the selected reading after a short talk to engage discussion.
Topic: Post-stroke subcortical atrophy and sensorimotor outcomes
Abstract: Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Subcortical regions play critical roles in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behavior at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioral data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behavior to non-lesioned subcortical volumes (Bonferroni-corrected, p<0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time.
For inquiries contact Daniela Mattos or Valeria Andrade.