Chemo for glioblastoma enhanced by tapping into cell’s daily rhythms

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Glioblastoma is an aggressive brain cancer that has no cure. A recent chart study of patients with glioblastoma found that taking chemotherapy in the morning was associated with a three- to six-month increase in median survival. Now a study from Washington University in St. Louis reports that glioblastoma cells have built-in circadian rhythms that create better […]

WashU leads new multi-omics production center for NIH research consortium

Multi-omics is a research approach that leverages the power of several different “omics” data types at once to build a detailed picture of factors that contribute to human health and disease. The National Institutes of Health (NIH) is channeling $50.3 million over the next five years into a new consortium dedicated to advancing the generation […]

Cancer cells rev up synthesis, compared with neighbors

Tumors are composed of rapidly multiplying cancer cells. Understanding which biochemical processes fuel their relentless growth can provide hints at therapeutic targets. Researchers from Washington University in St. Louis have developed a technology to study tumor growth in another dimension — literally. The scientists established a new method to watch what nutrients are used at […]

Sugar metabolism is surprisingly conventional in cancer

For over a century, cancer cell metabolism has been viewed as something of a paradox. New work from researchers at Washington University in St. Louis shows that it might not be such an anomaly after all. The study is published Aug. 15 in Molecular Cell. Glucose, a common sugar in food, is one of the most […]

Washington University collaborates with Agilent, Merck to expand metabolomics research

A collaborative effort between Washington University in St. Louis, Agilent Technologies and the biopharmaceutical company Merck aims to expand research in the field of metabolomics, the comprehensive study of small molecules within a biological system. Using top-of-the-line research instrumentation from Agilent, scientists in the Department of Chemistry in Arts & Sciences will develop new metabolomics […]

Patti a finalist for prestigious Blavatnik young scientist award

Gary Patti is among the 31 finalists for the Blavatnik National Awards for Young Scientists, selected from 305 nominations across the United States, the organization announced June 17. He is the first honoree from Washington University in St. Louis in the award’s seven-year history. Patti Patti, the Michael and Tina Powell Associate Professor of Chemistry in […]

Metabolomics for the masses

Lowering the ‘data burden’ to put better interpretation in reach From the WashU Newsroom… Gary Patti, the Michael and Tana Powell Associate Professor of Chemistry in Arts & Sciences at Washington University in St. Louis, has been awarded $4.8 million in two separate National Institutes of Health (NIH) grants focused on improving the accessibility of […]