Washington University School of Medicine in St. Louis has launched the Center for Rare, Undiagnosed and Genetic Diseases, supported by an $8.5 million grant from Children’s Discovery Institute (CDI), a partnership with St. Louis Children’s Hospital, St. Louis Children’s Hospital Foundation and WashU Medicine. The new center brings together WashU Medicine researchers and the rare […]
Remarkably, Doug Whitney, 75, has escaped genetic destiny. Like many members of his family, Whitney inherited a rare genetic mutation that all but guarantees he would develop early-onset Alzheimer’s disease. But Whitney, whose relatives first showed symptoms of cognitive decline in their early 50s, remains mentally sharp with no signs of the devastating disease, and […]
A new era for public health has begun at Washington University in St. Louis, marked by a two-day celebration welcoming Sandro Galea, MD, DrPH, as the inaugural Margaret C. Ryan Dean of the School of Public Health and the Eugene S. and Constance Kahn Distinguished Professor in Public Health. The events, held Jan. 29 and […]
As a leading researcher of rare diseases that affect children’s brains, Jonathan D. Cooper, PhD, thought little about the gastrointestinal (GI) system. That is, until the parents of children with a condition that Cooper studies urged him to investigate why debilitating digestive issues troubled their kids, who suffer from an incurable and fatal neurodegenerative brain condition […]
People with severe, treatment-resistant depression who received a nerve-stimulating therapy showed significant improvement in depressive symptoms, quality of life and ability to complete everyday tasks after a year, according to the results of a national, multicenter clinical trial led by Washington University School of Medicine in St. Louis. The findings are published Dec. 18 in a […]
Demand for weight-loss medications sold under brand names such as Ozempic and Wegovy continues to surge, with a recent study reporting one in eight Americans has taken or is currently using the drugs to treat diabetes, heart disease or obesity. Formally, these drugs are known as glucagon-like peptide-1 receptor agonists (GLP-1RA) and include Mounjaro and […]
Researchers at Washington University School of Medicine in St. Louis have been awarded $7.5 million from the National Institutes of Health (NIH) to investigate a form of dementia caused by cerebral small vessel disease, the second-leading cause of dementia after Alzheimer’s disease. The grant funds the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center, […]
Andrew Taylor, an emeritus trustee of Washington University in St. Louis, and his wife, Barbara, have made a $50 million gift to WashU Medicine’s neurosurgery department to enhance groundbreaking research, innovative patient care and the training of the next generation of neurosurgery leaders. In recognition of the Taylors’ generosity, the department has been named the Taylor […]
Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day. Knowing local time […]
Alzheimer’s disease and frontotemporal dementia are devastating disorders that emerge following the buildup of misfolded proteins in the brain. The newest generation of Alzheimer’s therapeutics targets accumulations of the protein amyloid beta with engineered antibodies, but the results have been underwhelming, with some adverse effects, not to mention using engineered antibodies can be prohibitively expensive. […]
Roughly 4% of the population is affected by a congenital brain malformation that has eluded researchers’ efforts to find causes and treatments. For the condition, Chiari type-1 malformation, the diagnosis is straightforward: the lower part of the brain, known as the cerebellum, protrudes at least five millimeters through the gap in the skull that connects […]
Washington University School of Medicine and BJC Health System, both located in St. Louis, have launched the joint Center for Health AI to harness the power of cutting-edge artificial intelligence (AI) and fundamentally change the way health care is provided. The center will focus on making care more personalized and effective for patients and more […]
Even treated with the most advanced therapies, patients with glioblastoma — an aggressive brain cancer — typically survive less than two years after diagnosis. Efforts to treat this cancer with the latest immunotherapies have been unsuccessful, likely because glioblastoma cells have few, if any, natural targets for the immune system to attack. In a cell-based […]
Most people who visit a doctor when they feel unwell seek a diagnosis and a treatment plan. But for some 30 million Americans with rare diseases, their symptoms don’t match well-known disease patterns, sending families on diagnostic odysseys that can last years or even lifetimes. But a cross-disciplinary team of researchers and physicians from Washington […]
Harnessing this process may offer therapies for neuroinflammatory diseases such as MS, mouse study suggests
Enrollment in Medicaid was associated with higher risk of death from a central nervous system (CNS) tumor, with an almost two-fold higher risk for young CNS tumor patients enrolled at diagnosis, finds a study from the Brown School at Washington University in St. Louis. “We found a higher risk for those insured through Medicaid than […]
When trying to understand how genetic influences factor into youth behavior, researchers at Washington University in St. Louis have taken the “big trawl” approach, casting their net wide to pull in all the measured traits, behaviors and environments that make up who we are and examine associations with the genetic building blocks comprising risk for […]
Public health is often the unseen force that keeps our communities thriving. From ensuring clean water to managing vaccination programs and regulating food safety, it is the vital infrastructure that promotes healthier lifestyles and safeguards our environments. Without it, communities are left vulnerable to emerging threats, underscoring the critical need to reinforce this infrastructure. What […]
Mindfulness-based approaches are mental health practices intended to ground people, help them focus attention, and teach them how to think through overwhelming emotions and problems, but that is just the start. The more people are taught ways to better handle stress, the better protected they may be from the physiological problems that stress produces, including […]
As digital health tools grow in popularity due to rapid technological advancements and the shift toward personalized medicine, a new study highlights the critical need to focus on equity in their design. Today’s digital health tools are transforming care: wearable devices offer continuous monitoring and early warnings; telemedicine provides virtual consultations, especially in underserved areas; […]
People with multiple sclerosis (MS) are far less likely than those without the condition to have the molecular hallmarks of Alzheimer’s disease, according to new research from Washington University School of Medicine in St. Louis. The discovery suggests a new avenue of research through which to seek Alzheimer’s treatments, said Matthew Brier, MD PhD, an assistant […]
By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments. With a goal of understanding and addressing immunotherapy’s limitations, researchers at Washington University School of Medicine in St Louis have found that […]
Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer’s disease. They have devised a method to study aged neurons in the lab without a brain biopsy, an advancement that could contribute to a better understanding of the disease and […]
Neurologists diagnose cognitive impairment with a clinical exam of memory and thinking skills. To determine whether Alzheimer’s disease is the cause of the cognitive impairment, evidence of the specific brain changes that characterize Alzheimer’s must be obtained, typically via a brain scan or spinal tap. Identifying people whose cognitive symptoms are due to Alzheimer’s disease […]
The risk of developing long COVID has decreased significantly over the course of the COVID-19 pandemic, according to an analysis of data led by Washington University School of Medicine in St. Louis. Researchers attributed about 70% of the risk reduction to vaccination against COVID-19 and 30% to changes over time, including the SARS-CoV-2 virus’s evolving […]
Racial disparities in dementia are due to social determinants of health, with genetic ancestry playing no role, according to a new study led by researchers at Washington University School of Medicine in St. Louis. The study, which was based on a long-running population-based survey in four Latin American countries, helps explain why people of predominantly […]
A migraine is not just a bad headache. It is a much-dreaded part of a neurologic disorder that has an array of possible symptoms, including pulsating cranial pain, waves of queasiness, bouts of vomiting, and hypersensitivity to light and sound. They frequently materialize unannounced and at the most inopportune of moments. Pubescent girls with a […]
Researchers at Washington University in St. Louis and Dartmouth College have discovered a connection between toddler hair cortisol levels — a long-term stress biomarker — and maternal prenatal depression. The findings, published in the American Journal of Human Biology, suggest that a child’s long-term stress physiology — or how the body responds to stress — may […]
Scientists are trying to understand how cannabis may affect long-term neurodevelopment when people were exposed to it in the womb. Previous work by Washington University in St. Louis researchers Sarah Paul and David Baranger in the Behavioral Research and Imaging Neurogenetics (BRAIN) lab led by Ryan Bogdan, PhD, found associations between prenatal cannabis exposure and potential mental health conditions in childhood […]
Infections and neurodegenerative diseases cause inflammation in the brain. But for unknown reasons, patients with brain inflammation often develop muscle problems that seem to be independent of the central nervous system. Now, researchers at Washington University School of Medicine in St. Louis have revealed how brain inflammation releases a specific protein that travels from the […]
As the deadly disease that came to be known as COVID-19 started spreading in late 2019, scientists rushed to answer a critical question: Who is most at risk? They quickly recognized that a handful of characteristics — including age, smoking history, high body mass index (BMI) and the presence of other diseases such as diabetes […]
s psychedelic-assisted therapy gains mainstream acceptance, the role of social workers, who provide a significant portion of mental health services in the United States, will become increasingly important in this emerging field, says an expert on mental health in the Brown School at Washington University in St. Louis. Psychedelics such as psilocybin, MDMA and ketamine […]
Every 40 seconds, someone in the United States suffers a stroke, in which blood flow to the brain is blocked. For the survivors, the ensuing brain damage can lead to lifelong disabilities, making mundane tasks, such as using the toilet and taking a shower, risky ventures. One in eight of those who experience a stroke […]
Opioid overdoses for pregnant people are at an all-time high in the United States, even as overall numbers are improving. Attention deficit hyperactivity disorder (ADHD) is highly correlated with substance use disorders, yet treatment protocols to help expecting parents manage opioid use disorders and ADHD together are essentially nonexistent. New research from Washington University School […]
General anesthesia makes it possible for millions of patients each year to undergo lifesaving surgeries while unconscious and free of pain. But the 176-year-old medical staple uses powerful drugs that have stoked fears of adverse effects on the brain — particularly if used in high doses. New findings published June 10 in the Journal of […]
Researchers who had been using Fitbit data to help predict surgical outcomes have a new method to more accurately gauge how patients may recover from spine surgery. Using machine-learning techniques developed at the AI for Health Institute at Washington University in St. Louis, Chenyang Lu, PhD, the Fullgraf Professor at the university’s McKelvey School of Engineering, collaborated with Jacob […]
New findings on long COVID — long-term effects on health experienced by many who have had COVID-19 — present a good-news, bad-news situation, according to a study at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system. The bad news: COVID-19 patients who were hospitalized within the […]
Roughly one in five cancer patients benefits from immunotherapy – a treatment that harnesses the immune system to fight cancer. Such an approach to beating cancer has seen significant success in lung cancer and melanoma, among others. Optimistic about its potential, researchers are exploring strategies to improve immunotherapy for cancers that don’t respond well to […]
Washington University in St. Louis announced today that Sandro Galea, MD, DrPH, one of the world’s most influential public health leaders, will become the inaugural Margaret C. Ryan Dean of the university’s planned School of Public Health, effective Jan. 1. In this critical leadership role, Galea will help shape and launch WashU’s first new school […]
Osteoarthritis, a degenerative joint disease, limits the mobility of 32 million people nationwide, many to the point of significant disability. Affected individuals face limited options, as there are no drugs to cure or substantially lessen the disease, and invasive joint replacement is often the only option when it reaches its later stages. With the goal […]
There are basic resources every baby needs for the best possible chance to develop as a healthy well-functioning human. Start with good nutrition, breast milk if possible. That baby is going to need stimulation, lots of looking, reciprocal interactions, exposure to language and interesting stimuli. If at all possible, you should live in a place […]
Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient. When up to 70% of such patients do […]
Social determinants of health are increasing the risk of Alzheimer’s disease and related dementia, finds a recent study from the Brown School and the School of Medicine at Washington University in St. Louis. “It is central for prevention of Alzheimer’s and related dementia to set up public policies addressing social determinants from very early on in […]
Preschoolers with clinical depression are more likely than their peers to have attempted suicide or to have had thoughts of killing themselves by age 12, according to a new study from researchers at Washington University in St. Louis. The findings, published recently in the Journal of the American Academy of Child & Adolescent Psychiatry, suggest […]
There lies a paradox in sleep. Its apparent tranquility juxtaposes with the brain’s bustling activity. The night is still, but the brain is far from dormant. During sleep, brain cells produce bursts of electrical pulses that cumulate into rhythmic waves — a sign of heightened brain cell function. But why is the brain active when we […]
A simple blood test to diagnose Alzheimer’s disease soon may replace more invasive and expensive screening methods such as spinal taps and brain scans. A study by researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden shows that a blood test can be as good at detecting molecular signs […]
Researchers at Washington University School of Medicine in St. Louis have new insight on what goes on inside people’s heads as they make decisions to obtain information about the future. The scientists identified a set of mental rules that governs decision-making about physical rewards — for example, food or money — and cognitive rewards – […]
The first-floor walls at 4240 Duncan Ave. — home to Washington University in St. Louis’ Office of Technology Management (OTM) — are running out of room. And that’s a good thing. The logos of Washington University startup companies launched to shepherd promising university-owned diagnostics, therapeutics or other technologies to the marketplace are prominently displayed on the walls. […]
An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice. The study, from researchers at Washington University School of Medicine in St. Louis, is published Jan. 3 […]
Washington University in St. Louis and Deerfield Management, a health-care investment firm, today announced the launch of VeritaScience, a new private R&D collaboration designed to advance the discovery, clinical development and commercialization of promising therapeutic and diagnostic candidates with potential to benefit human health. To support projects that originate from the collaboration, Deerfield has committed up to […]