$13.7 million to further adolescent brain development study

Washington University scientists will receive $13.7 million in additional funding for ongoing research into adolescent brain development. Their work is part of the largest long-term study of brain development ever conducted in the United States. Washington University is one of 21 study sites around the country participating in the project. Launched in 2015, the Adolescent Brain […]

On the front lines: Jay Piccirillo

Otolaryngologist Jay Piccirillo, MD, professor of otolaryngology at Washington University School of Medicine in St. Louis, discusses the loss of smell and/or taste that is sometimes associated with the virus that causes COVID-19. Read more and watch.

Podcast: Global study tests chloroquine to protect health workers from COVID-19

More than 10% of those with serious COVID-19 infections have been front-line health-care workers. Now, an international group led by researchers at Washington University School of Medicine in St. Louis is launching a trial to see whether the drug chloroquine might help those workers. The drug trial won’t treat doctors, nurses and others after they […]

Global study to test malaria drug to protect health workers from COVID-19

With $9 million in philanthropic support, an international group of physicians and scientists is establishing a research network to evaluate promising therapies for COVID-19. The group, called the COVID-19 Research Outcomes Worldwide Network (CROWN) Collaborative, is testing whether the antimalaria drug chloroquine can prevent COVID-19 infection or decrease its severity in front-line health-care workers. An […]

Flies sleep when need arises to adapt to new situations

Flies that cannot take to the air respond by sleeping more as they learn to adapt to their flightlessness, according to a study from Washington University School of Medicine in St. Louis. The findings, published May 8 in Science Advances, suggest that sleep may be an evolutionary tool that helps animals adapt to challenging new […]

Stroke evaluations drop by nearly 40% during COVID-19 pandemic

The number of people evaluated for signs of stroke at U.S. hospitals has dropped by nearly 40% during the COVID-19 pandemic, according to a study led by researchers from Washington University School of Medicine in St. Louis who analyzed stroke evaluations at more than 800 hospitals across 49 states and the District of Columbia. The […]

Gutmann receives Advocate of Hope award

David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor and vice chair for research affairs in the Department of Neurology at Washington University School of Medicine in St. Louis, has received the Advocate of Hope Award from the national Neurofibromatosis (NF) Network. The NF Network is a nonprofit dedicated to helping people living […]

New targets for childhood brain tumors identified

Children with the genetic condition neurofibromatosis type 1 (NF1) can develop brain and nerve tumors. If a tumor develops within the optic nerve, which connects the eye and the brain, the child may lose his or her vision. New research at Washington University School of Medicine in St. Louis indicates that the growth of these […]

Potential biomarker for autism identified in infants

Researchers at Washington University School of Medicine in St. Louis and Stanford University have identified a biomarker in newborns that may signal autism spectrum disorder months or even years before troubling symptoms develop and such diagnoses typically are made. The researchers found that babies diagnosed with autism later in childhood had in their cerebrospinal fluid, […]

Diabetes reversed in mice with genetically edited stem cells derived from patients

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice […]

Podcast: Preserving mental, physical health while isolating at home

The St. Louis region and most of the United States are under stay-at-home orders, meaning that aside from reporting to “essential” jobs that require attendance, and trips to the grocery store, drug store or other necessary errands, most people are spending more time at home than ever before. This week’s podcast features experts in maintaining […]

Podcast: Clinical trials launch to evaluate antimalarial, antidepressant drugs to treat COVID-19

Although anecdotal reports have suggested certain therapies help some patients, there still are no proven treatments for the disorder. In this episode, we discuss repurposing existing drugs to treat COVID-19. One study involves treating hospitalized patients. Another involves providing infected patients with a drug to take at home as a way to prevent them from […]

Study to evaluate antidepressant as potential COVID-19 treatment

Researchers at Washington University School of Medicine in St. Louis are launching a clinical trial in patients who have tested positive for COVID-19 but who are not sick enough to be hospitalized. The trial is investigating whether the antidepressant medication fluvoxamine, which is currently used to treat patients with obsessive-compulsive disorder (OCD), can be repurposed […]

Pagliarini named BJC investigator

Dave Pagliarini, PhD, whose studies of the so-called “powerhouses of the cell” have shed light on a set of rare but devastating diseases, has been named a BJC Investigator and will join the Department of Cell Biology & Physiology at Washington University School of Medicine in St. Louis. He will have secondary appointments in the biochemistry and […]

Social distancing has graduate students defending theses online

Across campus, centrifuges have stopped spinning, incubators have been shut off, and lab benches sit empty as graduate students, postdoctoral researchers and technicians at Washington University School of Medicine in St. Louis obey state and local shelter-at-home orders. Only researchers investigating ways to stop COVID-19 or performing other essential duties are allowed in the usually […]

Insight into Alzheimer’s early stages provides clues to treatment strategies

Alzheimer’s disease is the most common form of dementia, affecting more than 5 million people in the U.S., but doctors have limited advice on how to protect against it. The disease develops silently in the brain for two decades or more before people begin showing the characteristic signs of forgetfulness and confusion. Understanding that silent […]

Richards named head of neuroscience

Linda J. Richards, PhD, recognized internationally for her expertise in brain development and developmental disorders, has been named head of the Department of Neuroscience and the Edison Professor of Neurobiology at Washington University School of Medicine in St. Louis. She will take the helm Jan. 1. Richards is a professor of neuroscience and the deputy director of […]

Medical students lead effort to collect masks, gowns, gloves, eye protection

With cases of the novel coronavirus on the rise in the St. Louis region, Washington University in St. Louis is anticipating shortages of personal protective equipment (PPE) — such as masks, gowns, gloves and eyewear — at university-affiliated hospitals and clinics. As work is reduced in university laboratories, medical students are asking researchers to collect […]

Lang honored by physical therapy association

Catherine Lang, PT, PhD, professor of physical therapy, of neurology and of occupational therapy, and associate director of the Movement Science Program at Washington University School of Medicine in St. Louis, has been named a Catherine Worthingham Fellow of the American Physical Therapy Association. The award, the association’s highest honor, serves as an inspiration for physical therapists […]

2020 Distinguished Faculty Awards announced

Washington University School of Medicine faculty members nominate their peers for Distinguished Faculty Awards. The honors are recognition of their colleagues’ wide-ranging achievements, talents and dedication. The recipients, recognized for excellence in clinical care, community service, research and teaching, received the awards in a ceremony Feb. 26 at the Eric P. Newman Education Center on […]

Brain and Behavior Research Foundation awards grants to five researchers

Five researchers at Washington University School of Medicine in St. Louis have received Young Investigators Grants from the Brain and Behavior Research Foundation. The foundation is committed to alleviating the suffering caused by mental illness by supporting research that will lead to advances and breakthroughs in scientific research. The $70,000 grants help junior investigators launch […]

Collaboration with SLU leads to purchase of $5 million microscope

From snapshots of the molecular structure of Zika virus to 3D maps of tiny blood vessels in the lungs, images captured by the Washington University Center for Cellular Imaging (WUCCI) have provided insight into countless biological phenomena and aided investigations into myriad aspects of human health and disease. Now, the center is poised to expand […]

Gene ID’d as potential therapeutic target for dementia in Parkinson’s

Dementia is one of the most debilitating consequences of Parkinson’s disease, a progressive neurological condition characterized by tremors, stiffness, slow movement and impaired balance. Eighty percent of people with Parkinson’s develop dementia within 20 years of the diagnosis, and patients who carry a particular variant of the gene APOE are at especially high risk. In new research, […]

Noise-induced hearing loss blocked with drug compound

Loud noise can damage the inner ear and cause hearing loss. Studying mice, researchers at Washington University School of Medicine in St. Louis and the University of Iowa have shown that a drug compound can block damage caused by loud noise, raising the possibility of medication that prevents noise-induced hearing loss. The study is published […]

Fitzpatrick elected to microscopy society governing council

James Fitzpatrick, PhD, a professor of neuroscience and of cell biology and physiology at Washington University School of Medicine in St. Louis, has been elected biological sciences director of the Microscopy Society of America. He will serve a three-year term on the society’s governing council beginning in 2020. An expert in biological imaging, Fitzpatrick is […]

Timothy Miller receives international innovation prize

Timothy Miller, MD, PhD, the David Clayson Professor of Neurology at Washington University School of Medicine in St. Louis, and a group of his colleagues have received the inaugural Healey Center International Prize for innovation in amyotrophic lateral sclerosis (ALS) research from the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital. […]

Hogan elected officer of American Epilepsy Society

R. Edward Hogan, MD, a professor of neurology and head of the Adult Epilepsy Section at Washington University School of Medicine in St. Louis, has been elected second vice president of the American Epilepsy Society. In 2022, he will become the organization’s president. Hogan’s research interests include neuroimaging in epilepsy. Among other accomplishments, he has […]

Zipfel named Dacey Distinguished Professor of Neurological Surgery

Gregory J. Zipfel, MD, the recently named head of the Department of Neurosurgery at Washington University School of Medicine in St. Louis and neurosurgeon-in-chief at Barnes-Jewish Hospital (BJH), is also now the inaugural Ralph G. Dacey Distinguished Professor of Neurological Surgery. The professorship was funded by dozens of friends, colleagues and admirers of Dacey, the Henry G. & Edith R. […]

Restoring arm, hand function after spinal cord injury focus of clinical trial

Spinal cord injuries caused by accidents, violence and disease paralyze from the neck down more than 5,000 people every year. In the first few months after injury, some people regain some movement and sensation in their limbs. Those who do not show improvement in the first few months are unlikely to ever recover. Now, a […]

Washington People: James DuBois

James DuBois believes in second chances. DuBois, DSc, PhD, the Steven J. Bander Professor of Medical Ethics and Professionalism at Washington University School of Medicine in St. Louis, founded the first national training program for researchers who have had lapses in laboratory compliance or research ethics, providing strategies and resources to help them get back […]

Halting opioid abuse aim of several grants from NIH, CDC

Tapped for their work aimed at stemming opioid abuse and halting what has become an epidemic in the United States, researchers at Washington University School of Medicine in St. Louis have received federal grants totaling more than $10 million from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC). […]

AI helps identify gene, environment networks that shape personality

Using artificial intelligence techniques, researchers studying the role of genes and the environment in shaping our personalities have identified gene networks largely responsible for the development of and variation in personality. Those networks include 972 individual genes linked to aspects of personality, such as self-awareness, intentionality — which has to do with a person being […]

Major Alzheimer’s study to open 5 new Latin American sites

A major international Alzheimer’s disease research initiative will open five new sites in Latin America to help researchers understand the development of early-onset Alzheimer’s in Latino populations. For more than a decade, the Dominantly Inherited Alzheimer Network (DIAN) – funded in large part by the National Institutes of Health (NIH) and led by Washington University School of […]

Kipnis named BJC Investigator

Jonathan Kipnis, PhD, an internationally recognized scientific leader in how the nervous and immune systems interact in neurodegenerative, neuroinflammatory and neurodevelopmental disorders, has been named a BJC Investigator at Washington University School of Medicine in St. Louis. He will join the Department of Pathology and Immunology, with secondary appointments in the neurology, neuroscience, and neurosurgery departements. Kipnis […]

López named BJC Investigator

Carolina López, PhD, recognized internationally for her research on viral infections, has been named a BJC Investigator and will join the faculty of the Department of Molecular Microbiology at Washington University School of Medicine in St. Louis. She also will become a member of the faculty at the school’s Center for Women’s Infectious Disease Research. The BJC Investigators Program recruits […]

Vogel-Hammen receives award for research in child, adolescent psychiatry

Alecia Vogel-Hammen, MD, PhD, an instructor in child psychiatry at Washington University School of Medicine in St. Louis, has received the American Academy of Child & Adolescent Psychiatry’s 2019 Pilot Research Award for Attention Disorders. The award, supported by the academy’s Elaine Schlosser Lewis Fund, provides up to $15,000 in funding to junior faculty and […]

New antidepressants on horizon

More than 14 million Americans suffer from clinical depression, yet one in three doesn’t experience relief from approved antidepressant drugs. A new treatment approach involving drugs called neurosteroids is on the horizon, however. Neurosteroids occur naturally in the brain and help regulate and modulate the activity of brain cells, but similar molecules also can be […]

Targeting immune cells may be potential therapy for Alzheimer’s

Messy tangles of a protein called tau can be found in the brains of people with Alzheimer’s disease and some other neurodegenerative diseases. In Alzheimer’s, the tangles coalesce just before tissue damage becomes visible in brain scans and people start to become forgetful and confused. Now, a new study has found that brain immune cells […]

Scientists find timekeepers of gut’s immune system

As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal […]

Holtzman awarded Watanabe Prize in Translational Research

David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology at Washington University School of Medicine in St. Louis, has received the August M. Watanabe Prize in Translational Research from the Indiana Clinical and Translational Sciences Institute. He was recognized for his work uncovering the causes of Alzheimer’s disease […]

Atkinson awarded Presidential Gold Medal from rheumatology society

Physician-scientist and rheumatologist John P. Atkinson, MD, the Samuel B. Grant Professor of Medicine at Washington University School of Medicine in St. Louis, has been awarded the Presidential Gold Medal by the American College of Rheumatology. The highest award bestowed by the organization, the medal honors a lifetime of outstanding achievements in clinical medicine, research, education and […]

School of Medicine establishes Division of Physician-Scientists

Addressing a nationwide shortage of physician-scientists, Washington University School of Medicine in St. Louis has established a Division of Physician-Scientists to help nurture the career development of physicians who treat patients and also want to conduct scientific research. The division will provide resources, mentorships, and research and leadership programs to encourage and inspire physicians interested […]

Gutmann wins prestigious neuro-oncology prize

David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor and vice chair for research affairs in the Department of Neurology at Washington University School of Medicine in St. Louis, has received the Abhijit Guha Award from the Society for Neuro-Oncology and the Section on Tumors of the American Association of Neurological Surgeons/Congress of […]

Childhood obesity in low-income Missouri families aim of CDC grant

Obesity researchers from around Missouri, led by scientists at Washington University School of Medicine in St. Louis, have received a grant to help evaluate and put in place family-focused weight-management programs designed to reduce childhood obesity, particularly among children from low-income families. With a five-year, $3.7 million grant from the Centers for Disease Control and […]

For gut microbes, not all types of fiber are created equal

Certain human gut microbes with links to health thrive when fed specific types of ingredients in dietary fibers, according to a new study from Washington University School of Medicine in St. Louis. The work — conducted in mice colonized with human gut bacteria and using new technologies for measuring nutrient processing — is a step […]

McNeill named Larry J. Shapiro and Carol-Ann Uetake-Shapiro Professor

Helen McNeill, PhD, a world leader in developmental biology and a BJC Investigator at the School of Medicine, has been named the inaugural Larry J. Shapiro and Carol-Ann Uetake-Shapiro Professor at Washington University School of Medicine in St. Louis. McNeill was installed by then-Washington University Chancellor Mark S. Wrighton and David H. Perlmutter, MD, executive […]

Stable home lives improve prospects for preemies

As they grow and develop, children who were born at least 10 weeks before their due dates are at risk for attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder and anxiety disorders. They also have a higher risk than children who were full-term babies for other neurodevelopmental issues, including cognitive problems, language difficulties and motor delays. Researchers […]

Blood test is highly accurate at identifying Alzheimer’s before symptoms arise

Up to two decades before people develop the characteristic memory loss and confusion of Alzheimer’s disease, damaging clumps of protein start to build up in their brains. Now, a blood test to detect such early brain changes has moved one step closer to clinical use. Researchers from Washington University School of Medicine in St. Louis […]

Culver named Sherwood Moore Professor of Radiology

Joseph P. Culver, PhD, a professor of radiology recognized for helping develop optical neuroimaging technologies to map brain function in humans and animals, has been named the inaugural Sherwood Moore Professor of Radiology. Based at the university’s Mallinckrodt Institute of Radiology (MIR), Culver’s lab is notable for advancing diffuse optical tomography (DOT), a technology that uses light […]

Covey named Taylor Distinguished Professor of Psychiatry

Douglas F. Covey, PhD, a leader in the development of a new class of drugs — neurosteroids — to treat mental illness, has been installed as the inaugural Andrew C. and Barbara B. Taylor Distinguished Professor of Psychiatry at Washington University School of Medicine in St. Louis. The professorship was established through a gift from […]