“Multi-parametric Photoacoustic Microscopy: Auscultation of Hemodynamics and Energy Metabolism at the Microscopic Level”
NOTE The location for BME Seminars in the spring 2019 semester will be 012 Brauer Hall.
Host: Lori Setton (WashU Biomedical Engineering)
Abstract Capitalizing on the optical absorption of blood hemoglobin, photoacoustic microscopy (PAM) is ideally suited for label-free imaging of the microvasculature, which plays an essential and indispensable role in supplying oxygen to biological tissues and maintaining metabolic activity in vivo. In this talk, Dr. Hu will present their latest progress on the technical development and biomedical application of PAM. Integrating innovations in instrumentation and data analysis, multi-parametric PAM developed in Dr. Hu’s laboratory enables—for the very first time—comprehensive and quantitative characterization of the microvascular structure (diameter, tortuosity and density), mechanical property (resistance, wall shear stress, reactivity and permeability), hemodynamics (blood perfusion, oxygenation and flow), and tissue oxygen extraction and metabolism, all at the microscopic level. This enabling technology has opened up unprecedented opportunities in brain, cardiovascular, cancer, and regenerative medicine research.
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