Hosted by the Department of Electrical and Systems Engineering (ESE)

Abstract: The brain’s remarkable adaptability across different behavioral states – such as happiness vs. sadness, and sleep vs. wakefulness – is essential for long-term survival and function. These state transitions are mediated by biochemical signals. Similar to how the dynamics of electrical signals are encoded and decoded by the brain, the dynamics of biochemical signals carry vital information essential for brain functions. However, the absence of real-time monitoring and manipulation tools has historically led us to consider brain state transitions as static processes. One of the most significant gaps in neuroscience is understanding how molecular and cellular signals translate into behavioral outcomes.

Our lab aims to close this gap between molecular and systems neuroscience. We develop cutting-edge optical biosensors, light-activated molecular actuators, and advanced microscopy techniques. These tools enable us to elucidate how the dynamics of biochemical signals encode information and how the brain decodes this information to execute its functions. To achieve this, we employ a systems approach that combines optical, electrophysiological, molecular, biochemical, behavioral, and computational methods to study biochemical signaling dynamics in vivo. Our research focuses on three critical brain state transitions: those driven by neuromodulators, sleep, and learning.

View schedule, ESE seminar calendar

For inquiries contact Aaron Beagle.