“UK Biobank: imaging data from 100,000 individuals”

This special lecture is hosted by the Mallinckrodt Institute of Radiology (MIR).

Background: UK Biobank is a prospective epidemiological resource gathering extensive questionnaires, physical and cognitive measures, and biological samples (including genotyping) in a cohort of 500,000 participants (aged 40–69 years at recruitment between 2006-10). An imaging extension to the existing UK Biobank study was funded to scan 100,000 subjects from the existing cohort, aiming to complete by 2022 (to date, imaging data from over 26,000 subjects has been acquired). Imaging includes MRI of the brain, heart and body, low-dose X-ray bone and joint scans, and ultrasound of the carotid arteries. The potential of this large-scale resource to identify disease risk factors should increase over time with emerging clinical outcomes (participants consent to allow access to their full health records from the UK National Health Service). For example, in the imaged cohort, 1,800 participants are expected to develop Alzheimer’s disease by 2022, rising to 6,000 by 2027 (diabetes: 8,000 rising to 14,000; stroke: 1,800 to 4,000; Parkinson’s: 1,200 to 2,800). In this talk she will provide a general introduction to the available imaging and non-imaging data, MRI processing pipeline, and imaging-derived phenotypes (MRI summary measures). She will discuss similarities and differences with the HCP, and practicalities of obtaining and using the data.

For inquiries contact Cathy Gezella.