WashU weekly Neuroscience publications

“Identifying reproducible individual differences in childhood functional brain networks: An ABCD study” (2019) Developmental Cognitive Neuroscience Identifying reproducible individual differences in childhood functional brain networks: An ABCD study (2019) Developmental Cognitive Neuroscience, 40, art. no. 100706, .  Marek, S.a , Tervo-Clemmens, B.b , Nielsen, A.N.c , Wheelock, M.D.a , Miller, R.L.d , Laumann, T.O.a , Earl, E.f , Foran, W.W.e […]

Ezerskiy and Llibre Guerra, 2019 Poletsky Award Recipients

Lubov Ezerskiy, neuroscience PhD candidate in the Timothy Miller lab, and Jorge Llibre Guerra, MD, a DIAN Trials Unit Fellow in the Randall Bateman lab, have been honored with the 2019 Poletsky Award. The Poletsky Award is presented annually by the Knight Alzheimer’s Disease Research Center (Knight ADRC) at Washington University, and is intended to […]

NIH gives major boost to microbiome research on Medical Campus

Tens of trillions of microbes, including bacteria, viruses, parasites and fungi, live in and on the human body. Their microbial genomes, collectively known as the microbiome, contain at least 100 times more genes than our human genome. Such microbial genes provide us with capabilities that we have not evolved on our own, including the ability […]

Targeting immune cells may be potential therapy for Alzheimer’s

Messy tangles of a protein called tau can be found in the brains of people with Alzheimer’s disease and some other neurodegenerative diseases. In Alzheimer’s, the tangles coalesce just before tissue damage becomes visible in brain scans and people start to become forgetful and confused. Now, a new study has found that brain immune cells […]

Where’s my car? WashU researchers to study short-term working memory

When we drive to a place and park the car, most of us walk away without giving any thought about how to find the car when we want to leave. A team of researchers at Washington University in St. Louis plans to study how and where the brain stores this type of information so that […]

Scientists find timekeepers of gut’s immune system

As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal […]

Holtzman awarded Watanabe Prize in Translational Research

David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology at Washington University School of Medicine in St. Louis, has received the August M. Watanabe Prize in Translational Research from the Indiana Clinical and Translational Sciences Institute. He was recognized for his work uncovering the causes of Alzheimer’s disease […]

WashU weekly Neuroscience publications

“Alzheimer Disease: An Update on Pathobiology and Treatment Strategies” (2019) Cell Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) Cell, 179 (2), pp. 312-339.  Long, J.M., Holtzman, D.M. Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, United States Abstract Long […]

Atkinson awarded Presidential Gold Medal from rheumatology society

Physician-scientist and rheumatologist John P. Atkinson, MD, the Samuel B. Grant Professor of Medicine at Washington University School of Medicine in St. Louis, has been awarded the Presidential Gold Medal by the American College of Rheumatology. The highest award bestowed by the organization, the medal honors a lifetime of outstanding achievements in clinical medicine, research, education and […]

Leading the way for personalized medicine

Washington University is working with unparalleled research capabilities to make personalized medicine a reality. The medical school is pioneering individualized treatment approaches in obesity, diabetes, breast cancer and Alzheimer’s disease. Watch the video spotlight.

Collective power

When Greg Bowman was in second grade, he began to have trouble reading the board in his classroom. Playing goalie for his soccer team also became difficult. Over the following year, he lost most of his central vision due to an inherited genetic disorder, a form of juvenile macular degeneration. “It gradually dawned on me […]

Chen awarded $310K from National Institute on Aging of the NIH

Hong Chen, assistant professor at the McKelvey School of Engineering and at the School of Medicine, received a $309,909 grant from the National Institute on Aging of the National Institutes of Health (NIH) to explore the application of a focused ultrasound-mediated drug delivery technique for treating Alzheimer’s disease. Read more.

Gutmann to be fellow at Berlin Institute of Health

Gutmann David Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology at the School of Medicine, has received a second Einstein Visiting Fellowship from the Berlin Institute of Health to study how immune cells in the brain known as microglia are linked to cancer, vision loss and behavioral problems in the disease neurofibromatosis type […]

Human gut microbes could make processed foods healthier

A new study from Washington University School of Medicine in St. Louis sheds light on how human gut microbes break down processed foods — especially potentially harmful chemical changes often produced during modern food manufacturing processes. Eating processed foods such as breads, cereals and sodas is associated with negative health effects, including insulin resistance and […]

WashU weekly Neuroscience publications

“Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers” (2019) Neurobiology of Aging Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers (2019) Neurobiology of Aging, 83, pp. 54-62.  Chen, Q.a b , Boeve, B.F.c , Schwarz, C.G.b , Reid, R.b , Tosakulwong, N.d , Lesnick, T.G.d , Bove, J.e , Brannelly, P.f , Brushaber, […]

Alzheimer’s research reset

After some costly and disappointing drug trial failures, the field welcomes a funding surge, tools for tracking disease, and interdisciplinary collaborations to tackle one of science’s most stubborn puzzles. In the last five years, as several large clinical trials testing drugs for Alzheimer’s disease failed, the field came to a stark conclusion: These approaches did […]

Yang Shi and Tamara Markovic win 2019 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition. Congratulations to the 2019 Thach Award winners: Short Talks: Yang Shi, PhD (Holtzman lab, WashU Neurology) “Microglia drive neurodegeneration and mediate APOE’s effect on neurodegeneration in a tauopathy mouse […]

School of Medicine establishes Division of Physician-Scientists

Addressing a nationwide shortage of physician-scientists, Washington University School of Medicine in St. Louis has established a Division of Physician-Scientists to help nurture the career development of physicians who treat patients and also want to conduct scientific research. The division will provide resources, mentorships, and research and leadership programs to encourage and inspire physicians interested […]

Gutmann wins prestigious neuro-oncology prize

David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor and vice chair for research affairs in the Department of Neurology at Washington University School of Medicine in St. Louis, has received the Abhijit Guha Award from the Society for Neuro-Oncology and the Section on Tumors of the American Association of Neurological Surgeons/Congress of […]

WashU weekly Neuroscience publications

“The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability” (2019) NeuroImage The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability (2019) NeuroImage, 202, art. no. 115990, .  Betzel, R.F.a b c , Bertolero, M.A.a , Gordon, E.M.d e , Gratton, C.f g , Dosenbach, N.U.F.f h i , […]

Childhood obesity in low-income Missouri families aim of CDC grant

Obesity researchers from around Missouri, led by scientists at Washington University School of Medicine in St. Louis, have received a grant to help evaluate and put in place family-focused weight-management programs designed to reduce childhood obesity, particularly among children from low-income families. With a five-year, $3.7 million grant from the Centers for Disease Control and […]

For gut microbes, not all types of fiber are created equal

Certain human gut microbes with links to health thrive when fed specific types of ingredients in dietary fibers, according to a new study from Washington University School of Medicine in St. Louis. The work — conducted in mice colonized with human gut bacteria and using new technologies for measuring nutrient processing — is a step […]

Cause of rare, fatal disorder in young children pinpointed

Scientists at Washington University School of Medicine in St. Louis appear to have solved a decades-long mystery regarding the precise biochemical pathway leading to a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3. Studying a mouse model with the same human illness — called Krabbe disease […]

WashU weekly Neuroscience publications

“Pioglitazone improves working memory performance when administered in chronic TBI” (2019) Neurobiology of Disease Pioglitazone improves working memory performance when administered in chronic TBI (2019) Neurobiology of Disease, 132, art. no. 104611, .  McGuire, J.L.a , Correll, E.A.a , Lowery, A.C.b , Rhame, K.c , Anwar, F.N.d , McCullumsmith, R.E.e , Ngwenya, L.B.a f a Department of Neurosurgery, University of Cincinnati, […]

Barch receives $550K grant from NIH

Deanna Barch, chair of psychological and brain sciences in Arts & Sciences and the Gregory B. Couch Professor of Psychiatry at the School of Medicine, received a $554,195 grant from the National Institutes of Health (NIH) for computational psychiatry research. Read more.

WashU weekly Neuroscience publications

“Large posttraumatic stress disorder improvement and antidepressant medication adherence” (2020) Journal of Affective Disorders Large posttraumatic stress disorder improvement and antidepressant medication adherence (2020) Journal of Affective Disorders, 260, pp. 119-123.  Salas, J.a b , Scherrer, J.F.a b , Tuerk, P.c , van den Berk-Clark, C.a , Chard, K.M.d , Schneider, F.D.e , Schnurr, P.P.f , Friedman, M.J.f , […]

$1.04M CDI grant awarded to Theunissen, Kroll and Solnica-Krezel

Thorold Theunissen, assistant professor of developmental biology, Kristen Kroll, associate professor of developmental biology, and Lilianna Solnica-Krezel, the Alan A. and Edith L. Wolff Distinguished Professor and head of developmental biology, all at the School of Medicine, have received a three-year, $1.04 million grant from the Children’s Discovery Institute for their project titled “Establishing novel stem cell platforms to model developmental disorders […]

Zika diagnostic test granted market authorization by FDA

Zika virus can cause babies to be born with devastating brain damage. But the signs of Zika infection in adults – rash, fever, headache and body aches – are nonspecific, so a pregnant woman who develops such symptoms can’t be sure if she has contracted Zika or something less risky for her fetus. A diagnostic […]

WashU weekly Neuroscience publications

“Alternative ecological strategies lead to avian brain size bimodality in variable habitats” (2019) Nature Communications Alternative ecological strategies lead to avian brain size bimodality in variable habitats (2019) Nature Communications, 10 (1), art. no. 3818, .  Fristoe, T.S.a b , Botero, C.A.b a Department of Biology, University of Konstanz, Universitätsstraße 10, Konstanz, 78464, Germany b Department of Biology, Washington University in St. Louis, […]

Cindy Brantmeier named inaugural WashU Faculty Fellow in International Research

Dear Colleagues, I am pleased to announce that Dr. Cindy Brantmeier has been selected to serve as the first Faculty Fellow in International Research for the School of Medicine and Danforth Campus. The Faculty Fellow in International Research will advise faculty on conducting international research and achieving effective collaborations with international partners that are compliant […]

Brain Scans, Saliva Tests, and Baby Teeth: Inside the Massive, Government-Funded Effort to Understand How Kids’ Brains Develop

Researchers expect this massive endeavor, receiving $30 million in federal funding per year, will transform our understanding of brain development. Neuroscientists are positively giddy about ABCD, and for good reason: It is larger and more racially and socioeconomically diverse than any comparable study to date. “We’re going to be working with this dataset for decades,” […]

WashU weekly Neuroscience publications

“Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter” (2019) Scientific Reports Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter (2019) Scientific Reports, 9 (1), art. no. 12246, .  Fukutomi, H.a b , Glasser, M.F.c d , Murata, K.e , […]

Stable home lives improve prospects for preemies

As they grow and develop, children who were born at least 10 weeks before their due dates are at risk for attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder and anxiety disorders. They also have a higher risk than children who were full-term babies for other neurodevelopmental issues, including cognitive problems, language difficulties and motor delays. Researchers […]

WashU weekly Neuroscience publications

"Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex" (2019) Scientific Reports Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex(2019) Scientific Reports, 9 (1), art. no. 11700, .  Maranesi, M.a , Bruni, S.a b , Livi, A.a c , Donnarumma, F.d , Pezzulo, G.d , Bonini, L.a a Department of Medicine […]

Kroll receives $150K from Undiagnosed Diseases Network

Kristen Kroll, associate professor of developmental biology at the School of Medicine, has received a one-year, $150,000 grant from the Undiagnosed Diseases Network for her project titled “Using human pluripotent stem cell models to evaluate pathogenicity and define disease mechanisms for ZNF292 variant found in UDN373964.” Read more.

Wash U Researchers Find Blood Test Can Detect Early Alzheimer’s Symptoms

For years, doctors have used an expensive brain scan to detect symptoms of Alzheimer’s disease. But researchers at Washington University have found that a simple blood test could be similarly effective, according to a study published this month in the journal Neurology. A blood test to diagnose early symptoms could help make finding a cure […]

Genes linked to Alzheimer’s risk, resilience ID’d

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer’s disease. Most genes implicated thus far in Alzheimer’s affect neurons that transmit messages, allowing different regions of the brain to communicate with one […]

WashU weekly Neuroscience publications

“Sleep disturbances in Wolfram syndrome” (2019) Orphanet Journal of Rare Diseases Sleep disturbances in Wolfram syndrome (2019) Orphanet Journal of Rare Diseases, 14 (1), art. no. 188, .  Licis, A.a , Davis, G.d e , Eisenstein, S.A.b c , Lugar, H.M.b , Hershey, T.a b c a Department of Neurology, Washington University, School of Medicine, Campus Box 8111, 660 South Euclid Ave, […]

Antisense Drugs for Huntington’s, ALS and Prion Diseases Could Meet the Dire Need for Brain Treatments

Among the human body’s many maladies, few have stumped medical researchers like those that decimate the brain. After decades of effort, effectively treating—let alone curing—neurodegenerative disorders such as Huntington’s and Alzheimer’s disease has been a source of frustration for many, as old theories are questioned and clinical trials fail. Basic scientists have achieved some progress. […]

WashU weekly Neuroscience publications

“Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia” (2019) Scientific Reports Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia (2019) Scientific Reports, 9 (1), art. no. 10854, .  Bonham, L.W.a b , Steele, N.Z.R.a , Karch, C.M.c […]

Neuroscientists Discover the Brain Circuity for Persistence

Why do some people give up easily and others do not? A common leadership ability among extraordinary achievers—such as CEOs, inventors, astronauts, best-selling authors, successful artists and musicians, popular comedians, media stars, trail-blazing entrepreneurs, ace pilots, Nobel prize winning scientists, and professional athletes—is persistence and motivation—the ability to go the extra mile and not give up easily. Is […]

Blood test is highly accurate at identifying Alzheimer’s before symptoms arise

Up to two decades before people develop the characteristic memory loss and confusion of Alzheimer’s disease, damaging clumps of protein start to build up in their brains. Now, a blood test to detect such early brain changes has moved one step closer to clinical use. Researchers from Washington University School of Medicine in St. Louis […]

WashU weekly Neuroscience publications

“A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings” (2019) Journal of Substance Abuse Treatment A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings (2019) Journal of Substance Abuse Treatment, 104, pp. 135-143.  Presnall, N.J.a b , Wolf, D.A.P.S.a , Brown, D.S.a , Beeler-Stinn, S.a , Grucza, R.A.b a Brown School of […]

A Blood Test for Alzheimer’s? It’s Coming, Scientists Report

For decades, researchers have sought a blood test for beta amyloid, the protein that is a hallmark of Alzheimer’s disease. Several groups and companies have made progress, and on Thursday, scientists at Washington University in St. Louis reported that they had devised the most sensitive blood test yet. The test will not be available for […]

Culver named Sherwood Moore Professor of Radiology

Joseph P. Culver, PhD, a professor of radiology recognized for helping develop optical neuroimaging technologies to map brain function in humans and animals, has been named the inaugural Sherwood Moore Professor of Radiology. Based at the university’s Mallinckrodt Institute of Radiology (MIR), Culver’s lab is notable for advancing diffuse optical tomography (DOT), a technology that uses light […]

Covey named Taylor Distinguished Professor of Psychiatry

Douglas F. Covey, PhD, a leader in the development of a new class of drugs — neurosteroids — to treat mental illness, has been installed as the inaugural Andrew C. and Barbara B. Taylor Distinguished Professor of Psychiatry at Washington University School of Medicine in St. Louis. The professorship was established through a gift from […]

Children with rare genetic disorder gather for research clinic at Washington University

ST. LOUIS — Emily Bejerano, who has worn glasses since before she can remember, was diagnosed at age 5 with insulin-dependent diabetes. Two years later, a doctor linked her vision troubles and diabetes symptoms to diagnose her with Wolfram syndrome, a rare genetic disease that affects only one in every 500,000 people worldwide. “You see […]

Whelan named head of molecular microbiology

Noted virologist Sean Whelan, PhD, has been named head of the Department of Molecular Microbiology and the Marvin A. Brennecke Distinguished Professor of Microbiology at Washington University School of Medicine in St. Louis. He studies how deadly viruses such as Ebola and rabies enter cells and multiply, a key step to finding targets for new […]

“A fact of life – not a crime”

Fifty years ago today the Stonewall uprising began in the early morning hours of June 28, 1969, at the Stonewall Inn in Greenwich Village. In the 1960s, as in preceding decades, police commonly raided bars that catered to gay and lesbian clientele on the pretext of liquor license violations. This was the case at Stonewall when officers […]

WashU weekly Neuroscience publications

“CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)” (2019) Scientific Reports CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) (2019) Scientific Reports, 9 (1), art. no. 9891, .  Eaton, S.L.a , Proudfoot, C.a , Lillico, S.G.a , Skehel, P.b c , Kline, R.A.a , Hamer, K.e , Rzechorzek, N.M.d […]