Medication that lowers risk of overdose underused

Less than half of Americans who received treatment for opioid use disorder over a five-year period were offered a potentially lifesaving medication, researchers at Washington University School of Medicine in St. Louis and Saint Louis University have found. And treatment with the medication was even more rare for those with what’s known as polysubstance use […]

Neural pathway key to sensation of pleasant touch identified

Studying mice, scientists at Washington University School of Medicine in St. Louis have identified a neural circuit and a neuropeptide — a chemical messenger that carries signals between nerve cells — that transmit the sensation known as pleasant touch from the skin to the brain. Such touch — delivered by hugs, holding hands or caressing, […]

WashU weekly Neuroscience publications

“VCP suppresses proteopathic seeding in neurons” (2022) Molecular Neurodegeneration VCP suppresses proteopathic seeding in neurons(2022) Molecular Neurodegeneration, 17 (1), art. no. 30, .  Zhu, J.a , Pittman, S.a , Dhavale, D.a , French, R.b , Patterson, J.N.a , Kaleelurrrahuman, M.S.a , Sun, Y.c , Vaquer-Alicea, J.d , Maggiore, G.d , Clemen, C.S.e f , Buscher, W.J.g , Bieschke, J.c , Kotzbauer, P.a , Ayala, Y.b , Diamond, M.I.d , Davis, A.A.a , Weihl, C.a a Department of Neurology, Hope Center for […]

Calming overexcited neurons may protect brain after stroke

A new study has prompted scientists to reconsider a once-popular yet controversial idea in stroke research. Neuroscientists believed that, in the aftermath of a stroke, calming overexcited neurons might prevent them from releasing a toxic molecule that can kill neurons already damaged by lack of oxygen. This idea was supported by studies in cells and […]

Race of people given Alzheimer’s blood tests may affect interpretation of results

Three experimental blood tests used to identify people in early stages of Alzheimer’s disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis. The study showed that a fourth blood test — the PrecivityAD test, which is commercially available in the […]

Where’s Waldo?

After a busy morning of sitting crisscross applesauce during story time, of standing still like a statue in line, and of remembering to raise a hand before speaking (even when you’re ready to burst with excitement), the Curious Caterpillars skipped and ran outside to the playground, eager to participate in one of the highlights of […]

Risky driving behaviors increase as common sleep disorder worsens

People with sleep apnea wake up tired in the morning, no matter how many hours they actually sleep. The condition causes them to briefly stop and restart breathing dozens or even hundreds of times a night. Even though such breathing interruptions often don’t awaken those with apnea, they prevent them from sinking into deep, refreshing […]

WashU weekly Neuroscience publications

“The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells” (2022) Journal of Neuroimmunology The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells(2022) Journal of Neuroimmunology, 367, art. no. 577860, .  Paley, M.A.a , Baker, B.J.b , Dunham, S.R.b , Linskey, N.a , Cantoni, C.b , Lee, K.b , Hassman, L.M.c , […]

Researchers honored as outstanding mentors

The Office of Postdoctoral Affairs at Washington University in St. Louis presented outstanding mentor awards to James Stroud, PhD, Alexxai Kravitz, PhD, and John Russell, PhD, at the 17th annual Postdoc Symposium on March 21 at the Eric P. Newman Education Center on the Medical Campus. Stroud, a postdoctoral research associate in biology, received the Outstanding […]

Gut bacterium supports growth in infants with severe acute malnutrition

About 18 million children under age 5 suffer from severe acute malnutrition, and over 3 million children die from it each year. Treatment with high-calorie supplemental foods and antibiotics can prevent deaths, but these interventions often have limited impact on the long-term effects of severe acute malnutrition, such as persistent stunted growth, disrupted immune function […]

Rutherford to study noise-induced hearing loss

Mark A. Rutherford, PhD, assistant professor of otolaryngology at Washington University School of Medicine in St. Louis, received a $3.5 million grant from the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health (NIH) for research on the pore-forming and auxiliary subunit molecular anatomy of AMPA-type glutamate receptors in the cochlea […]

Barch recognized for achievement, excellence

The Society for Research in Psychopathology has awarded its Joseph Zubin Lifetime Achievement Award to Deanna Barch, PhD, chair and professor of psychological and brain sciences in Arts & Sciences as well as the Gregory B. Couch Professor of Psychiatry and professor of radiology​ at the School of Medicine, all at Washington University in St. Louis. The award, […]

Poverty, crime linked to differences in newborns’ brains

Poverty and crime can have devastating effects on a child’s health. But a new study from researchers at Washington University School of Medicine in St. Louis suggests that some environmental factors influence the structure and function of young brains even before babies make their entrances into the world. A study published online April 12 in […]

WashU weekly Neuroscience publications

“A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures” (2022) Stem Cell Research and Therapy A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures(2022) Stem Cell Research and Therapy, 13 (1), art. no. 131, .  Pardieck, J.a b , Harb, M.a , Sakiyama-Elbert, S.E.a a Department of Biomedical Engineering, […]

Bayly-led team to study mechanical strains, stresses in traumatic brain injury

Naval warfighters may be exposed to explosions, impacts or high accelerations that increase their risk for traumatic brain injury. A team of researchers led by Philip Bayly, PhD, at Washington University in St. Louis plans a comprehensive study of skull-brain mechanics using imaging, computer and preclinical models to study the strains and stresses of the […]

NIH funds Barch research on neurodevelopment

In order to understand healthy neurodevelopment — and the threats to that health — researchers need a more comprehensive understanding of how the brain grows throughout childhood and young adulthood. To that end, the National Institutes of Health (NIH) has awarded a $753,181 grant to Deanna Barch, PhD, chair and professor of psychological and brain […]

Gordon receives scientific innovator award

Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has been named the 2022 Senior Scientist Winner of the Innovators in Science Award administered by the New York Academy of Sciences and sponsored by Takeda Pharmaceuticals. Gordon, the Dr. Robert J. Glaser Distinguished University Professor, was selected by a jury of […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 4, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Carlos A. Botero to associate professor of biology in Arts & Sciences; Caitlyn M. Collins to associate professor of sociology in Arts & […]

WashU weekly Neuroscience publications

“Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series” (2022) Epilepsy and Behavior Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series(2022) Epilepsy and Behavior, 130, art. no. 108659, .  Hedaya, A.A.a , Hewitt, K.C.b , Hu, R.c , Epstein, C.M.b , Gross, R.E.a b , […]

Culver named director of Biophotonics Research Center

Joseph P. Culver, PhD, the Sherwood Moore Professor of Radiology at the Mallinckrodt Institute of Radiology (MIR) at Washington University School of Medicine in St. Louis, has been named director of the Biophotonics Research Center (BRC) in the Division of Radiological Sciences. Culver’s work has been at the leading edge of functional and molecular biological imaging, particularly […]

Podcast: Long COVID-19 can affect every organ system in the body

The death toll isn’t the only staggering statistic from the first two years of the pandemic. What’s become increasing clear is that some COVID-19 patients don’t get well right away. Since the earliest days of the pandemic, we’ve heard of survivors who continue to experience shortness of breath, extreme fatigue, lingering difficulty with taste and […]

Surgeon-scientist Olson named head of surgery

John A. Olson Jr., MD, PhD, noted for his clinical and scientific expertise in endocrine surgical diseases, has been named head of the Department of Surgery at Washington University School of Medicine in St. Louis. He will take the helm July 1. The position is a homecoming of sorts for Olson, who also will become the William […]

New strategy reduces brain damage in Alzheimer’s and related disorders, in mice

Alzheimer’s disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study by researchers at Washington University School of Medicine in St. Louis has shown that targeting astrocytes — an inflammatory cell in the brain — reduces tau-related brain […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report” (2022) Cognitive Research: Principles and Implications Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report(2022) Cognitive Research: Principles and Implications, 7 (1), art. no. 23, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, […]

COVID-19 infection linked to higher risk of neuropathy

Adding to a growing body of evidence that, for many, problems related to COVID-19 linger longer than the initial infection, researchers at Washington University School of Medicine in St. Louis have found that some people infected during the pandemic’s early months experienced peripheral neuropathy — pain, tingling and numbness in the hands and feet — […]

Daylight saving time year-round would make our lives worse, Wash U expert says

The U.S. Senate passed a bill last week that would make daylight saving time permanent. If it gains full congressional approval, the change would take place in fall 2023 and would keep evenings lighter year-round, eliminating the seasonal adjustments of springing forward and falling back to move in and out of standard time. Many rejoiced. […]

Saligrama part of team that received Wellcome Leap grant

Naresha Saligrama, PhD, an assistant professor of neurology and of pathology and immunology at the School of Medicine, is part of a team led by Lisa Wagar, of the University of California, Irvine, that has received a multiyear, multi-million-dollar grant through Wellcome Leap to use human tonsil organoids to study immune responses. Originally published on […]

WashU weekly Neuroscience publications

“Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder” (2022) Drug and Alcohol Dependence Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder(2022) Drug and Alcohol Dependence, 234, art. no. 109400, .  Ellis, M.S.a , Buttram, M.E.b , Kasper, Z.A.a a Washington University in St. Louis, School of Medicine. Department of […]

For accuracy, brain studies of complex behavior require thousands of people

As brain scans have become more detailed and informative in recent decades, neuroimaging has seemed to promise a way for doctors and scientists to “see” what’s going wrong inside the brains of people with mental illnesses or neurological conditions. Such imaging has revealed correlations between brain anatomy or function and illness, suggesting potential new ways […]

In U.S., alcohol use disorder linked to 232 million missed workdays annually

Heavy alcohol use is associated with missing work, but the scope of that relationship has not been well understood. Now, based on survey data from more than 110,000 U.S. adults with full-time jobs, researchers at Washington University School of Medicine in St. Louis have quantified the extent of the problem. Among U.S. adults working full […]

DiAntonio, Bloom, Milbrandt win ALS grant

Aaron DiAntonio, MD, PhD, the Alan A. and Edith L. Wolff Professor of Developmental Biology;  Joseph Bloom, PhD, assistant professor of genetics; and Jeffrey Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics, all at the School of Medicine, received a two-year $300,000 grant from the ALS Finding a Cure and […]

Kim named inaugural Danforth WashU Physician-Scientist Scholar

Albert H. Kim, MD, PhD, a professor of neurological surgery at Washington University School of Medicine in St. Louis, has been named the inaugural William H. Danforth Washington University Physician Scholar. He is the first researcher named as part of the School of Medicine’s new Physician-Scientist Investigators Initiative, which aims to recruit and retain elite […]

Damage early in Alzheimer’s disease ID’d via novel MRI approach

Alzheimer’s disease usually is diagnosed based on symptoms, such as when a person shows signs of memory loss and difficulty thinking. Up until now, MRI brain scans haven’t proven useful for early diagnosis in clinical practice. Such scans can reveal signs of brain shrinkage due to Alzheimer’s, but the signs only become unmistakable late in […]

Postdoc Sengupta wins research excellence award

Mohini Sengupta, PhD received third place in the 2021 Mightex Research Excellence Awards. Sengupta, a postdoctoral fellow in the lab of Martha Bagnall, PhD, assistant professor of neuroscience at Washington University School of Medicine in St. Louis, studies the connectivity among spinal neurons in zebrafish. Read more on the Department of Neuroscience website.

WashU weekly Neuroscience publications

“Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults” (2022) Neurobiology of Aging Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults(2022) Neurobiology of Aging, 112, pp. 181-190.  McKay, N.S.a b , Dincer, A.a b , Mehrotra, V.e , Aschenbrenner, A.J.b c , Balota, D.b d , Hornbeck, R.C.a b , Hassenstab, J.b c d , Morris, J.C.b c , Benzinger, T.L.S.a b , Gordon, B.A.a b d […]

CDC director discusses COVID-19 pandemic during Medical Campus visit

Rochelle P. Walensky, MD, the director of the Centers for Disease Control and Prevention (CDC), visited Washington University School of Medicine last week to discuss lessons learned from the COVID-19 pandemic. As part of the Department of Medicine’s weekly Grand Rounds series, she sat down March 3 with William G. Powderly, MD, the J. William […]

Risk of schizophrenia assessed with new screening tool

Researchers at Washington University School of Medicine in St. Louis and colleagues in Nairobi, Kenya, have shown that a screening tool developed at Washington University can help predict in about 5 minutes whether young people are at high risk for schizophrenia and may go on to develop the illness. The findings are published in the […]

An to lead Biomedical MR Center

Hongyu  An, PhD, a professor of radiology at the Washington University School of Medicine, is the new chief of the Biomedical Magnetic Resonance Lab (BMRL) in the Division of Radiological Sciences. An is renowned for her expertise in magnetic resonance (MR) physics, pulse sequences and image reconstruction analysis. Read more on the Mallinckrodt Institute of Radiology website.

WashU weekly Neuroscience publications

"Are children with unilateral hearing loss more tired?" (2022) International Journal of Pediatric Otorhinolaryngology Are children with unilateral hearing loss more tired?(2022) International Journal of Pediatric Otorhinolaryngology, 155, art. no. 111075, .  Carpenter, D.a , Dougherty, W.b , Sindhar, S.c , Friesen, T.-N.c , Lieu, J.c , Kesser, B.W.a a Department of Otolaryngology-Head and Neck Surgery, University of Virginia School of Medicine, P.O. Box 800713, Charlottesville, […]

Obituary: Michael J. Noetzel, professor of neurology, 70

Michael J. Noetzel, MD, a leading pediatric stroke researcher at Washington University School of Medicine in St. Louis, died of heart failure on Sunday, Feb. 20, 2022, at Barnes-Jewish Hospital. He was 70. Noetzel, a professor of neurology and of pediatrics, was a respected clinician, researcher, teacher and administrator. He spent his entire 45-year career […]

Does improving sleep reduce signs of early Alzheimer’s disease?

The TV sitcom grandpa character who always seems to fall asleep at unfortunate moments is so common it’s almost a cliché. But daytime napping and disjointed sleep at night aren’t normal parts of aging. Sleep disturbances can be an early sign of a neurodegenerative condition, and they may be treatable. Researchers at Washington University School […]

CDC director to speak about pandemic March 3 on Medical Campus

The director of the Centers for Disease Control and Prevention, Rochelle P. Walensky, MD, will participate in a conversation about the pandemic Thursday, March 3, from 8 to 9 a.m. at Washington University School of Medicine in St. Louis. The virtual event, available via livestream, will be geared toward faculty, staff, students and trainees on the […]

Risk, resiliency in aging brain focus of $33 million grant

A large study that investigates just what keeps our brains sharp as we age and what contributes to cognitive decline has been launched by researchers from Washington University School of Medicine in St. Louis, Harvard University/Massachusetts General Hospital, the University of Minnesota Medical School and the University of California Los Angeles (UCLA). Known as the […]

Predicting the chaos in Tourette syndrome tics

During the pandemic, news reports surfaced of a surge of young adults showing up at doctors’ offices with unexplainable movement disorders that looked, perhaps to a nonspecialist, a little bit like Tourette syndrome. But when those patients were sent to see a specialist, “They’d say, ‘that doesn’t look at all like any of my first […]

Blood test for Alzheimer’s highly accurate in large, international study

A blood test developed at Washington University School of Medicine in St. Louis has proven highly accurate in detecting early signs of Alzheimer’s disease in a study involving nearly 500 patients from across three continents, providing further evidence that the test should be considered for routine screening and diagnosis. The study is available in the […]

Low-cost, 3D printed device may broaden focused ultrasound use

Researchers and clinicians have been working to use focused ultrasound combined with microbubbles to open the blood-brain barrier (BBB) for both noninvasive diagnostic use as well as to deliver treatments to the brain for tumors and neurodegenerative diseases. However, the few existing devices for preclinical research are expensive, bulky and lack the precision needed for […]

Diagnostic odyssey

When you seek medical care, you expect a diagnosis. You may need to answer a lot of questions and undergo tests, but usually doctors can figure out the root of the problem. This is not the case for a surprisingly large group of patients. According to the National Institutes of Health (NIH), 25 million to […]

WashU weekly Neuroscience publications

“Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain” (2022) NeuroImage Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain(2022) NeuroImage, 250, art. no. 118965, .  Ose, T.a b , Autio, J.A.a , Ohno, M.a , Frey, S.c , Uematsu, A.a , Kawasaki, A.a , Takeda, C.a , Hori, Y.a d , Nishigori, K.a e , Nakako, T.a e , Yokoyama, C.a f , Nagata, H.e , Yamamori, T.g , Van Essen, […]

Gift to help SLCH, WashU develop care model to improve kids’ behavioral health

St. Louis Children’s Hospital and Washington University School of Medicine in St. Louis are tackling the issue of behavioral health support that has emerged as a leading health concern in our country — for people of all ages. The challenges of the COVID-19 pandemic have revealed the number of children suffering and how few resources are […]

WashU weekly Neuroscience publications

“Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate” (2022) Nature Communications Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate(2022) Nature Communications, 13 (1), art. no. 633, .  Parichha, A.a , Suresh, V.a , Chatterjee, M.a g , Kshirsagar, A.b , Ben-Reuven, L.b , Olender, T.b , Taketo, M.M.c , Radosevic, V.d e , Bobic-Rasonja, M.d e , Trnski, S.d , Holtzman, M.J.f , Jovanov-Milosevic, N.d e , Reiner, O.b , Tole, S.a […]