WashU weekly Neuroscience publications

“Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program” (2020) Nature Communications Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program (2020) Nature Communications, 11 (1), art. no. 2611, .  Karagiannis, T.T.a b , Cleary, J.P., Jr.b c , Gok, B.b d , Henderson, A.J.e , Martin, N.G.f , Yajima, M.g , Nelson, […]

$3.7 million aimed at studying effect of manganese exposure on cognitive skills

Researchers at Washington University School of Medicine in St. Louis have received a $3.7 million grant to investigate the link between manganese and cognitive problems. Understanding how the metal harms the brain could lead to better ways to prevent or treat some forms of cognitive impairment, including in Parkinson’s disease. The grant, from the National […]

4 Ways to Help if Your Kid Is Depressed

A couple of weeks ago, I noticed a worrying shift in my 9-year-old. His characteristic silliness — his goofy giggles and incessant bad jokes — had disappeared. He stopped wanting to go outside and said he was too tired to play. He crawled under his bed covers and lay quietly in his room, while the […]

WashU weekly Neuroscience publications

“Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia” (2020) Nature Communications Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia (2020) Nature Communications, 11 (1), art. no. 2552, .  Wang, P.L.a b , Yim, A.K.Y.b , Kim, K.-W.a , Avey, D.b , Czepielewski, R.S.a , Colonna, M.a , Milbrandt, J.b , Randolph, G.J.a a Division […]

On the front lines: Jessica Gold

Psychiatrist Jessica Gold, MD, assistant professor of psychiatry at Washington University School of Medicine in St. Louis, talks about the impact the COVID-19 crisis has been having on mental health. This video is part of a series of short videos focusing on how Washington University health-care workers, scientists and students have responded to the coronavirus pandemic. Read more and […]

$13.7 million to further adolescent brain development study

Washington University scientists will receive $13.7 million in additional funding for ongoing research into adolescent brain development. Their work is part of the largest long-term study of brain development ever conducted in the United States. Washington University is one of 21 study sites around the country participating in the project. Launched in 2015, the Adolescent Brain […]

WashU weekly Neuroscience publications

“The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity” (2020) Operative Neurosurgery (Hagerstown, Md.) The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity (2020) Operative Neurosurgery (Hagerstown, Md.), 18 (6), pp. 583-589. Segreto, F.A.a b , Passias, P.G.a b , Brown, A.E.a b , Horn, S.R.a b , Bortz, C.A.a b , Pierce, K.E.a b , Alas, H.a b , […]

On the front lines: Jay Piccirillo

Otolaryngologist Jay Piccirillo, MD, professor of otolaryngology at Washington University School of Medicine in St. Louis, discusses the loss of smell and/or taste that is sometimes associated with the virus that causes COVID-19. Read more and watch.

Podcast: Global study tests chloroquine to protect health workers from COVID-19

More than 10% of those with serious COVID-19 infections have been front-line health-care workers. Now, an international group led by researchers at Washington University School of Medicine in St. Louis is launching a trial to see whether the drug chloroquine might help those workers. The drug trial won’t treat doctors, nurses and others after they […]

Global study to test malaria drug to protect health workers from COVID-19

With $9 million in philanthropic support, an international group of physicians and scientists is establishing a research network to evaluate promising therapies for COVID-19. The group, called the COVID-19 Research Outcomes Worldwide Network (CROWN) Collaborative, is testing whether the antimalaria drug chloroquine can prevent COVID-19 infection or decrease its severity in front-line health-care workers. An […]

Obituary: Barbara Geller, professor emerita of child psychiatry, 81

Barbara Geller, MD, an emerita professor of child psychiatry in the Department of Psychiatry at Washington University School of Medicine in St Louis, died Friday, May 8, 2020, in hospice in St. Louis after a brief illness. She was 81. A leading researcher in manic and depressive disorders in children, Geller was the recipient of […]

WashU weekly Neuroscience publications

“Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model” (2020) Scientific Reports Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model (2020) Scientific Reports, 10 (1), art. no. 7449, .  Pacia, C.P.a , Zhu, L.a , Yang, Y.a , Yue, Y.a , Nazeri, A.b , Michael Gach, H.a b […]

Chen receives early career award for research in therapeutic ultrasound

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, has been selected to receive the 2020 Frederic Lizzi Early Career Award from the International Society of Therapeutic Ultrasound (ISTU). The award recognizes individuals early in their professional career who have contributed substantially […]

Could COVID-19 Finally Destigmatize Mental Illness?

There is a research model going around that suggests as many as 150,000 additional people could die from mental health-related outcomes of COVID-19. I could argue the merits of the mathematical model as many of my colleagues have. I could also make the case that discussing the depths of despair and predicting increasing suicide rates […]

Six teams selected for LEAP funding

The Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship at Washington University in St. Louis recently announced six teams were selected for funding to prepare their projects for commercialization through the spring 2020 LEAP Gap Fund cycle. The LEAP Gap Fund is open to any person or team with potential or existing university intellectual property. Through the program, […]

‘Thank you, #WashU20’ features Claire Weichselbaum, Kow Essuman

To the Class of 2020: Thank you. For your commitment to academic excellence. For your service to the St. Louis community. For your support of your fellow students. For your devotion to your labs, your teams, your campus organizations. You made Washington University in St. Louis better. We wish we could express our gratitude to […]

WashU weekly Neuroscience publications

“The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective registry” (2020) International Journal of Bipolar Disorders The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective […]

Flies sleep when need arises to adapt to new situations

Flies that cannot take to the air respond by sleeping more as they learn to adapt to their flightlessness, according to a study from Washington University School of Medicine in St. Louis. The findings, published May 8 in Science Advances, suggest that sleep may be an evolutionary tool that helps animals adapt to challenging new […]

Stroke evaluations drop by nearly 40% during COVID-19 pandemic

The number of people evaluated for signs of stroke at U.S. hospitals has dropped by nearly 40% during the COVID-19 pandemic, according to a study led by researchers from Washington University School of Medicine in St. Louis who analyzed stroke evaluations at more than 800 hospitals across 49 states and the District of Columbia. The […]

Nikhil Aggarwal wins 2020 Quatrano Prize

Nikhil Aggarwal, a senior majoring in the neuroscience track of biology in Arts & Sciences at Washington University in St. Louis, has been awarded the 2020 Ralph S. Quatrano Prize. Established through a generous donation by Katherine Day Reinleitner, the Quatrano Prize is awarded to the thesis showing greatest evidence of creativity in design, research […]

4 ways to take care of your mental health during the coronavirus pandemic

Millions in the U.S. and around the world are under stay-at-home orders as officials hope to slow the spread of the coronavirus. But how do those practices affect individuals’ mental health? What are the unique mental health challenges people are facing during the COVID-19 pandemic, and how do they affect health care workers, those living […]

Gutmann receives Advocate of Hope award

David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor and vice chair for research affairs in the Department of Neurology at Washington University School of Medicine in St. Louis, has received the Advocate of Hope Award from the national Neurofibromatosis (NF) Network. The NF Network is a nonprofit dedicated to helping people living […]

WashU weekly Neuroscience publications

“Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review” (2020) Radiology Case Reports Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review (2020) Radiology Case Reports, 15 (7), pp. 863-866.  Samara, A.a , Eldaya, R.W.b a Department of Psychiatry, Washington University School of Medicine, 4525 Scott Ave, St. Louis, MO 63110, […]

Baron Chanda, PhD, joins Department of Anesthesiology

The Department of Anesthesiology extends a warm welcome to Baron Chanda, PhD, who has joined Washington University School of Medicine as Professor of Anesthesiology with secondary appointments in the Departments of Biochemistry and Neuroscience. Dr. Chanda comes to the department with a rich research background focused on understanding ion channel function in a physiological context. […]

New targets for childhood brain tumors identified

Children with the genetic condition neurofibromatosis type 1 (NF1) can develop brain and nerve tumors. If a tumor develops within the optic nerve, which connects the eye and the brain, the child may lose his or her vision. New research at Washington University School of Medicine in St. Louis indicates that the growth of these […]

Manasvi Verma wins 2020 Spector Prize

Manasvi Verma, a senior majoring in biology in Arts & Sciences at Washington University in St. Louis, has been awarded the 2020 Spector Prize. Each year, the Department of Biology in Arts & Sciences at Washington University in St. Louis awards a prize to a graduating senior in memory of Marion Smith Spector, a 1938 […]

Potential biomarker for autism identified in infants

Researchers at Washington University School of Medicine in St. Louis and Stanford University have identified a biomarker in newborns that may signal autism spectrum disorder months or even years before troubling symptoms develop and such diagnoses typically are made. The researchers found that babies diagnosed with autism later in childhood had in their cerebrospinal fluid, […]

WashU weekly Neuroscience publications

“The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease” (2020) Current Opinion in Neurobiology The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease (2020) Current Opinion in Neurobiology, 63, pp. 59-66.  Figley, M.D.a , DiAntonio, A.a b a Department of Developmental Biology, Washington University […]

Maker Task Force works to protect front-line health-care workers

In the face of the COVID-19 pandemic, a diverse team of makers from across Washington University in St. Louis’ Danforth and Medical campuses, Barnes-Jewish Hospital and BJC HealthCare have come together to protect front-line health-care workers and employees on the ground. “With the surge of COVID-19 patients we’re expecting, we want to make sure doctors, […]

Diabetes reversed in mice with genetically edited stem cells derived from patients

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice […]

Podcast: Preserving mental, physical health while isolating at home

The St. Louis region and most of the United States are under stay-at-home orders, meaning that aside from reporting to “essential” jobs that require attendance, and trips to the grocery store, drug store or other necessary errands, most people are spending more time at home than ever before. This week’s podcast features experts in maintaining […]

WashU weekly Neuroscience publications

“cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons” (2020) Experimental Neurology cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons (2020) Experimental Neurology, 329, art. no. 113252, .  Sasaki, Y.a , Engber, T.M.b , Hughes, R.O.b , Figley, M.D.c , Wu, T.a , Bosanac, T.b , Devraj, […]

Longevity Gene May Protect against a Notorious Alzheimer’s Risk Gene

Consumer genetic tests can sometimes result in a terrible surprise appearing in the same report that divulges whether one has a cilantro aversion or wet or dry earwax. Test takers may receive the devastating news that they have a version of a gene—apolipoprotein E epsilon 4 (APOE e4)—that greatly increases their chances of getting Alzheimer’s disease. The […]

Research in most university labs moved from bench to internet

When Washington University Vice Chancellor for Research Jennifer K. Lodge first sounded the alarm about the disruptive impact COVID-19 likely would have on labs across the university, the research community heeded her warning, taking steps to shut down lab work and move as much as possible online. Those in position to do so began pivoting their research […]

Podcast: Clinical trials launch to evaluate antimalarial, antidepressant drugs to treat COVID-19

Although anecdotal reports have suggested certain therapies help some patients, there still are no proven treatments for the disorder. In this episode, we discuss repurposing existing drugs to treat COVID-19. One study involves treating hospitalized patients. Another involves providing infected patients with a drug to take at home as a way to prevent them from […]

Study to evaluate antidepressant as potential COVID-19 treatment

Researchers at Washington University School of Medicine in St. Louis are launching a clinical trial in patients who have tested positive for COVID-19 but who are not sick enough to be hospitalized. The trial is investigating whether the antidepressant medication fluvoxamine, which is currently used to treat patients with obsessive-compulsive disorder (OCD), can be repurposed […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 6, several faculty members were appointed, promoted or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure  Stephanie Li as professor of English in Arts & Sciences;  Alessandro Vindigni as professor of medicine, of pathology and immunology, and of biochemistry and molecular biophysics at […]

Pagliarini named BJC investigator

Dave Pagliarini, PhD, whose studies of the so-called “powerhouses of the cell” have shed light on a set of rare but devastating diseases, has been named a BJC Investigator and will join the Department of Cell Biology & Physiology at Washington University School of Medicine in St. Louis. He will have secondary appointments in the biochemistry and […]

Social distancing has graduate students defending theses online

Across campus, centrifuges have stopped spinning, incubators have been shut off, and lab benches sit empty as graduate students, postdoctoral researchers and technicians at Washington University School of Medicine in St. Louis obey state and local shelter-at-home orders. Only researchers investigating ways to stop COVID-19 or performing other essential duties are allowed in the usually […]

WashU weekly Neuroscience publications

“Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective” (2020) Neurobiology of Stress Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective (2020) Neurobiology of Stress, 12, art. no. 100215, .  Paul, S.M.a b c , Pinna, G.d , Guidotti, A.d e a Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States b The Taylor Family Institute for […]

Insight into Alzheimer’s early stages provides clues to treatment strategies

Alzheimer’s disease is the most common form of dementia, affecting more than 5 million people in the U.S., but doctors have limited advice on how to protect against it. The disease develops silently in the brain for two decades or more before people begin showing the characteristic signs of forgetfulness and confusion. Understanding that silent […]

McKelvey Engineering staff creating face shields for health care workers

To help meet the increasing need for personal protective equipment (PPE) for health care workers on the front lines of the coronavirus pandemic, staff at McKelvey School of Engineering at Washington University in St. Louis are making use of the state-of-the-art facilities in the Spartan Light Metals Makerspace to create face shields for those treating […]

Richards named head of neuroscience

Linda J. Richards, PhD, recognized internationally for her expertise in brain development and developmental disorders, has been named head of the Department of Neuroscience and the Edison Professor of Neurobiology at Washington University School of Medicine in St. Louis. She will take the helm Jan. 1. Richards is a professor of neuroscience and the deputy director of […]

Loss of smell and taste can be only signs of coronavirus

Doctors are learning the loss of smell and taste are affecting about half of the coronavirus cases and some people may have those only two symptoms and no fever or body aches.  Fox 2’s Mandy Murphey spoke with Dr. Jay Piccirillo a professor of otolaryngology at Washington University School of Medicine in St. Louis.  He […]

Al-Hasani Receives Young Investigator Grant

Ream Al-Hasani Ph.D., assistant professor of pharmaceutical science at St. Louis College of Pharmacy and assistant professor of anesthesiology at Washington University School of Medicine in St. Louis, recently received a $70,000 Young Investigator Grant from the Brain and Behavior Research Foundation in support of her groundbreaking work in the field of opioid research. Al-Hasani […]

Cancerous tumors, surrounding cells illuminated by new imaging agent

Scientists at Washington University School of Medicine in St. Louis have developed a new imaging agent that could let doctors identify not only multiple types of tumors but the surrounding normal cells that the cancer takes over and uses as a shield to protect itself from attempts to destroy it. The study appears March 9 […]

Medical students lead effort to collect masks, gowns, gloves, eye protection

With cases of the novel coronavirus on the rise in the St. Louis region, Washington University in St. Louis is anticipating shortages of personal protective equipment (PPE) — such as masks, gowns, gloves and eyewear — at university-affiliated hospitals and clinics. As work is reduced in university laboratories, medical students are asking researchers to collect […]