Acute itching in eczema patients linked to environmental allergens

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines — the standard treatment for itching and allergy — often don’t help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes […]

WashU weekly Neuroscience publications

“Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States” (2021) PLoS ONE Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States (2021) PLoS ONE, 15 (12 December), art. no. e0243188, .  Gildner, T.E.a b , Laugier, E.J.a c , Thayer, Z.M.a c a Department of […]

WashU weekly Neuroscience publications

“A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder” (2021) International Journal of Bipolar Disorders A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder (2021) International Journal of Bipolar Disorders Musket, C.W.a , […]

Doctors test popular anti-depressant to see if it fights off Covid-19

Doctors are running a clinical trial to see if a popular anti-depressant might keep someone from becoming severely ill with Covid-19. The researchers at Washington University of St. Louis are recruiting 1,100 people in the beginning stages of Covid-19 to test out the drug fluvoxamine, also known as Luvox. While an anti-depressant may seem like […]

WashU weekly Neuroscience publications

"Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns" (2021) Annals of Emergency Medicine Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns(2021) Annals of Emergency Medicine, 77 (1), pp. 134-135.  Ellis, M.S., Kasper, Z.A., Cicero, T.J. Washington University in St. Louis, Department of Psychiatry, School of Medicine, St. Louis, MO, United States Document Type: LetterPublication Stage: FinalSource: Scopus "Prevalence, […]

Podcast: Vaccines have arrived but COVID-19 treatments progressing much more slowly

A new episode of our podcast, “Show Me the Science,” has been posted. At present, these podcast episodes are highlighting research and patient care on the Washington University Medical Campus as our scientists and clinicians confront the COVID-19 pandemic. COVID-19 vaccine development has been rapid and successful. Two vaccines that report more than 90% efficacy […]

Common brain malformation traced to its genetic roots

About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms. In […]

WashU weekly Neuroscience publications

"Oral and maxillofacial surgeons’ assessment of the role of Pernkopf's atlas in surgical practice" (2021) Annals of Anatomy Oral and maxillofacial surgeons’ assessment of the role of Pernkopf’s atlas in surgical practice(2021) Annals of Anatomy, 234, art. no. 151614, .  Yee, A.a , Li, J.b , Lilly, J.b , Hildebrandt, S.c , Seidelman, W.E.d , Brown, D.e , Kopar, P.e , Coert, J.H.f , Mackinnon, S.E.a , Israel, H.A.b a Division of […]

WashU weekly Neuroscience publications

“Midfoot and ankle motion during heel rise and gait are related in people with diabetes and peripheral neuropathy” (2021) Gait and Posture Midfoot and ankle motion during heel rise and gait are related in people with diabetes and peripheral neuropathy (2021) Gait and Posture, 84, pp. 38-44.  Jeong, H.-J., Mueller, M.J., Zellers, J.A., Hastings, M.K. Program in Physical Therapy, […]

Garcia to head Department of Biochemistry and Molecular Biophysics

Benjamin A. Garcia, PhD, a noted leader in the field of biochemistry, especially for his work advancing mass spectrometry techniques, has been named head of the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine in St. Louis. Garcia, whose appointment tentatively is set to begin July 1, also will become the Raymond H. […]

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood. Researchers at Washington University School of Medicine in St. […]

WashU weekly Neuroscience publications

“Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability” (2021) Neurobiology of Aging Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability (2021) Neurobiology of Aging, 98, pp. 116-123.  Meeker, K.L.a b , Ances, B.M.b , Gordon, B.A.c , Rudolph, C.W.a , Luckett, P.b , Balota, D.A.d , Morris, J.C.b , Fagan, A.M.b , Benzinger, T.L.c , Waring, J.D.a […]

Bateman, Diamond, Hultgren named to National Academy of Inventors

Neurologist Randall J. Bateman, MD, virologist and immunologist Michael S. Diamond, MD, PhD, and microbiologist Scott Hultgren — all faculty members at Washington University School of Medicine in St. Louis — have been named fellows of the National Academy of Inventors, the highest professional distinction accorded solely to academic inventors. They are among 175 new fellows elected this year […]

WashU weekly Neuroscience publications

“Fronto-cerebellar connectivity mediating cognitive processing speed” (2021) NeuroImage Fronto-cerebellar connectivity mediating cognitive processing speed (2021) NeuroImage, 226, art. no. 117556, . Wong, C.H.Y.a b c , Liu, J.d e f l , Lee, T.M.C.b c j k , Tao, J.d e l , Wong, A.W.K.g h , Chau, B.K.H.a i , Chen, L.d e l , Chan, C.C.H.a i a Applied Cognitive Neuroscience Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong b Laboratory of Neuropsychology and Human Neuroscience, Department of […]

Novel form of Alzheimer’s protein found in spinal fluid indicates stage of the disease

A novel form of an Alzheimer’s protein found in the fluid that surrounds the brain and spinal cord indicates what stage of the disease a person is in, and tracks with tangles of tau protein in the brain, according to a study from researchers at Washington University School of Medicine in St. Louis. Tau tangles […]

Construction progresses on neuroscience research building

Washington University School of Medicine’s eastern border began noticeably changing in April and will look strikingly different in 2023, when the neuroscience research building — 11 stories tall and 609,000 square feet — is complete. The building project, the largest in the medical school’s history, will span almost a block in the 200-acre Cortex Innovation […]

Washington University to offer genetic counseling master’s program

Washington University School of Medicine in St. Louis is offering a new master’s program in genetic counseling, a field that has been growing in importance as genetic testing becomes more common. Patients are gaining access to more and more information about their genes and genetic risk of disease, and consequently, the demand for trained genetic counselors […]

Chan Zuckerberg Initiative names two WashU groups Frontiers of Imaging grantees

The Chan Zuckerberg Initiative (CZI) on Dec. 2 announced two research groups led by Washington University in St. Louis faculty were named Frontiers of Imaging grantees. Both groups will focus on the brain — where current imaging techniques can penetrate just about the depth of a couple of human hairs — with $1 million each […]

Fitzpatrick named a Chan Zuckerberg Initiative Imaging Scientist

James Fitzpatrick, PhD, a professor of neuroscience and of cell biology & physiology at Washington University School of Medicine in St. Louis and director of the Washington University Center for Cellular Imaging (WUCCI), is one of 22 researchers worldwide named a Chan Zuckerberg Imaging Scientist by the Chan Zuckerberg Initiative. Modern microscopy techniques can show how molecules fit together […]

WashU weekly Neuroscience publications

“Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants” (2020) Developmental Cognitive Neuroscience Prenatal stress exposure and multimodal assessment of amygdala–medial prefrontal cortex connectivity in infants (2020) Developmental Cognitive Neuroscience, 46, art. no. 100877, . Humphreys, K.L.a , Camacho, M.C.b , Roth, M.C.a , Estes, E.C.a a Vanderbilt University, Department of Psychology and Human Development, 230 Appleton Place, #552, Nashville, […]

AAAS names 7 Washington University faculty as 2020 fellows

Seven faculty members at Washington University in St. Louis are among 489 new fellows selected by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. And four of those seven are School of Medicine faculty. The newly selected fellows from the medical school are: Aaron DiAntonio, MD, PhD; David H. Gutmann, […]

WashU weekly Neuroscience publications

"Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial" (2020) The Lancet Neurology Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the […]

Young people with disabilities focus of COVID-19 testing grant

Researchers at Washington University School of Medicine in St. Louis have received a two-year $5 million grant to offer 50,000 saliva tests for the SARS-CoV-2 virus to students, teachers and staff in the six special education schools operated by the Special School District of St. Louis County (SSD). The pandemic has disproportionately impacted students with […]

Luby honored for advancing understanding of brain, behavior disorders

Joan L. Luby, MD, the Samuel and Mae S. Ludwig Professor of Psychiatry at Washington University School of Medicine in St. Louis, has received the Ruane Prize for Child & Adolescent Psychiatry from the Brain & Behavior Research Foundation. The prize honors important advances in the understanding and treatment of early-onset brain and behavior disorders. […]

Lethal brain infections in mice thwarted by decoy molecule

Researchers at Washington University School of Medicine in St. Louis have identified a molecule that protects mice from brain infections caused by Venezuelan equine encephalitis virus (VEEV), a mosquito-borne virus notorious for causing fast-spreading, deadly outbreaks in Mexico, Central America and northern South America. As the climate changes, the virus is likely to expand its […]

Obituary: Karen Seibert, executive director of pharmacology center, 61

Karen Seibert, a deeply respected leader in pharmacology at Washington University School of Medicine in St. Louis, died Monday, Nov. 9, 2020, at her home in Chesterfield, Mo., after a battle with a cancer. She was 61. Seibert wore many hats in her long, successful career. She was the founding executive director of the Center for […]

WashU weekly Neuroscience publications

“Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study” (2021) Neurobiology of Aging Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study (2021) Neurobiology of Aging, 97, pp. 65-72. Walker, K.A.a , Chawla, S.b , Nogueras-Ortiz, C.b , Coresh, J.c , Sharrett, A.R.c , Wong, D.F.d , Jack, C.R., Jr.e , Spychalla, […]

Scientists Discover A Link Between Lack Of Deep Sleep And Alzheimer’s Disease

There’s growing evidence that a lack of deep sleep increases the risk of Alzheimer’s disease. Scientists say that’s because during deep sleep, the brain removes toxins associated with Alzheimer’s. Transcript ARI SHAPIRO, HOST: We continue to learn about the connection between sleep and Alzheimer’s disease. NPR’s Jon Hamilton brings us this report done with the NPR […]

Fluvoxamine may prevent serious illness in COVID-19 patients

In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious complications of the illness and make hospitalization and the need for supplemental oxygen […]

WashU weekly Neuroscience publications

"Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage" (2021) Brain Research Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage(2021) Brain Research, 1750, art. no. 147169, .  Athiraman, U.a , Liu, M.a , Jayaraman, K.b , Yuan, J.a , […]

Gutmann receives Neuro-oncology Scientific Award

David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor and vice chair for research affairs in the Department of Neurology at Washington University School of Medicine in St. Louis, is a recipient of the 2020 Neuro-oncology Scientific Award from the American Academy of Neurology. The award recognizes singular scientific achievement that has advanced […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting Oct. 2, several faculty members were appointed or promoted with tenure or granted tenure, effective that day unless otherwise indicated… …Promotion with tenure Luis F.Z. Batista to associate professor of medicine and of developmental biology at the School of Medicine (tenure effective Jan. 1); Nico […]

Lewis receives national award for volunteerism

Collins E. Lewis, MD, an associate professor emeritus of psychiatry at Washington University School of Medicine in St. Louis, has received the 2020 National Citizen Scientist Cornerstone Award from the Global Alzheimer’s Platform Foundation. He was honored in recognition of his extraordinary efforts to support Alzheimer’s research by participating in and promoting diversity in clinical trials. Lewis […]

Improving emergency care for people with dementia is focus of new grant

Washington University School of Medicine in St. Louis is one of four institutions awarded a total of $7.5 million from the National Institutes of Health (NIH) to study and improve care in emergency departments for people with dementia. The school’s Division of Emergency Medicine, which will become the Department of Emergency Medicine in February, is one of […]

Cornea appears to resist infection from novel coronavirus

New findings from researchers at Washington University School of Medicine in St. Louis suggest the eye’s cornea can resist infection from the novel coronavirus. Although the herpes simplex virus can infect the cornea and spread to other parts of the body in patients with compromised immune systems, and Zika virus has been found in tears […]

WashU weekly Neuroscience publications

“N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury” (2021) Experimental Neurology N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury (2021) Experimental Neurology, 335, art. no. 113507, . Celorrio, M., Rhodes, J., Vadivelu, S., Davies, M., Friess, S.H. Division of Critical Care Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, One […]

New insight into how brain neurons influence choices

When you are faced with a choice — say, whether to have ice cream or chocolate cake for dessert — sets of brain cells just above your eyes fire as you weigh your options. Animal studies have shown that each option activates a distinct set of neurons in the brain. The more enticing the offer, […]

Fail Better: Celia McKee

(Video: Tom Malkowicz/Washington University) “My grant got rejected. I failed. So I’m saying it on Twitter. I don’t want sympathy. I just wish people would say stuff like this on Twitter.” Celia McKee, a doctoral student studying neuroscience at Washington University in St. Louis, had no idea those 140 characters would mean so much to […]

Sarafinovska honored for work to improve medical students’ mental health

Simona Sarafinovska, a Washington University Medical Scientist Training Program student, has been named the inaugural recipient of The brAvery Foundation Award. The foundation, dedicated to the prevention of youth suicide, created the award to recognize an exceptional medical student or resident who has demonstrated a commitment to a career in child and adolescent psychiatry. Sarafinovska […]

WashU weekly Neuroscience publications

“Relationships between accelerometry and general compensatory movements of the upper limb after stroke” (2020) Journal of NeuroEngineering and Rehabilitation Relationships between accelerometry and general compensatory movements of the upper limb after stroke (2020) Journal of NeuroEngineering and Rehabilitation, 17 (1), art. no. 138, . Barth, J.a , Klaesner, J.W.a d , Lang, C.E.a b c a Washington University School of Medicine, Program in Physical Therapy, St. Louis, […]

Alzheimer’s in adults with Down syndrome focus of multicenter NIH grant

Researchers from Washington University School of Medicine in St. Louis are taking part in a multisite study to investigate the biomarkers of Alzheimer’s disease in people with Down syndrome. By middle age, nearly all people with Down syndrome show signs of Alzheimer’s disease, and doctors have no way to prevent it or to stop the […]

The path to the National Academy of Medicine

In this Q&A, Deanna Barch, PhD discusses her path to a research career, the importance of interdisciplinary inquiry in health and medicine, and the big questions that drive her work. Barch was recently elected to the National Academy of Medicine. A few weeks ago, on a late Friday afternoon just as the work week was […]

Uncovering genetic roots of marijuana use disorder

A large study exploring possible genetic influences on cannabis use disorder has identified two regions in our DNA — one newly identified and a second that replicates a past finding — that appear to contribute to one’s risk of becoming dependent on marijuana. The findings — published Oct. 20 in Lancet Psychiatry — stem from […]

Barch, Bateman elected to National Academy of Medicine

Deanna M. Barch, PhD, an expert in cognitive and language deficits in psychological disorders, and Randall J. Bateman, MD, a leading Alzheimer’s disease researcher, have been elected to the National Academy of Medicine, a part of the National Academy of Sciences. Membership in the organization is extended to those who have demonstrated outstanding professional achievement and commitment […]

Startup company founded by Washington University scientists acquired by Eli Lilly

Pharmaceutical maker Eli Lilly and Company has purchased Disarm Therapeutics, a startup biotechnology firm founded by researchers at Washington University School of Medicine in St. Louis. Disarm Therapeutics was co-founded by Jeffrey Milbrandt, MD, PhD, and Aaron DiAntonio, MD, PhD, to speed the development of treatments for multiple neurodegenerative conditions. Based on research from the Milbrandt and […]

WashU weekly Neuroscience publications

“Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells” (2020) Brain Research Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells (2020) Brain Research, 1749, art. no. 147139, . Matsuhisa, K.a b , Cai, L.a , Saito, A.a b , Sakaue, F.b , Kamikawa, Y.b , Fujiwara, S.b , Asada, R.c , Kudo, Y.d , Imaizumi, K.a a Department of Biochemistry, […]

Neuroscientist Ponce named a 2020 Packard fellow

Carlos Ponce, MD, PhD, an assistant professor of neuroscience at Washington University School of Medicine in St. Louis, has received a 2020 Packard Fellowship for Science and Engineering. Each of the 20 Packard fellows — among the nation’s top early-career scientists — will receive a five-year, $875,000 grant to pursue research. Ponce studies how visual […]

Racial differences in Alzheimer’s research focus of $15 million grant

In efforts to identify who is at risk of developing Alzheimer’s dementia, researchers over the years have zeroed in on several signs — or biological markers — that indicate early stages of the disease. If individuals could be identified long before symptoms of dementia begin to appear, doctors could target those patients with future preventive […]

WashU weekly Neuroscience publications

“Depression and Buprenorphine Treatment in Patients with Non-cancer Pain and Prescription Opioid Dependence without Comorbid Substance Use Disorders” (2021) Journal of Affective Disorders Depression and Buprenorphine Treatment in Patients with Non-cancer Pain and Prescription Opioid Dependence without Comorbid Substance Use Disorders (2021) Journal of Affective Disorders, 278, pp. 563-569. Scherrer, J.F.a , Salas, J.a , Grucza, R.a , Sullivan, M.D.b , Lustman, P.J.c d , […]

Brain inflammation in Parkinson’s disease focus of $3.2 million grant

Parkinson’s disease usually is thought of as a movement disorder. People with Parkinson’s typically first develop a tremor in one hand, followed by slowed movement, stiffness and loss of balance. But within 10 years of diagnosis, more than three-quarters of Parkinson’s patients also develop cognitive problems such as difficulty with memory and with performing sequential […]