Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting Dec. 6, several faculty members were appointed or promoted with tenure, effective Jan. 1 unless otherwise indicated. Appointment with tenure Lisa Tabor Connor as professor of occupational therapy at the School of Medicine, effective Dec. 6; Richard J. Cote, MD, as professor of pathology and immunology […]

WashU weekly Neuroscience publications

“Structural basis for adhesion G protein-coupled receptor Gpr126 function” (2020) Nature Communications Structural basis for adhesion G protein-coupled receptor Gpr126 function (2020) Nature Communications, 11 (1), art. no. 194, .  Leon, K.a b , Cunningham, R.L.c , Riback, J.A.a d , Feldman, E.a , Li, J.a b , Sosnick, T.R.a e , Zhao, M.a , Monk, K.R.c f , Araç, D.a […]

The bullied brain

The TV show “Survivor,” now in its 39th season, has spawned hosts of spin-offs and adaptations. Most cater to reality-TV lovers worldwide, but one surprising variation has become part of the toolbox researchers use to understand the effects of bullying on adolescents. Bullying is known to be a risk factor for depression, especially among young […]

$29 million for new phase of international Alzheimer’s study

For more than a decade, Washington University School of Medicine in St. Louis has led an international effort to better understand Alzheimer’s disease by studying people with rare genetic mutations that cause the disease to develop in their 50s, 40s or even 30s. The researchers have shown that the disease begins developing two decades or […]

Nature vs. nurture

Compelled by the potential to improve the lives of vulnerable children, emeritus trustee Walter Metcalfe and his wife, Cynthia, have committed nearly $4 million through outright and estate gifts to support the work of Joan L. Luby, MD, a highly regarded child psychiatrist. Luby and her colleagues have linked adversity, including poverty and neglect in the […]

Mokalled receives $1.93M from the NINDS of the NIH

Mayssa Mokalled, assistant professor of developmental biology, has received a five-year, $1.93 million grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) for her project titled “Mechanisms of glial bridging and neurogenesis during spinal cord regeneration in zebrafish.” Read more.

Fighting MS

During his freshman year of college, Brian Phillips came home one day to find his parents unexpectedly already there. With tears in his eyes, his dad, a former Marine, put his hand on his son’s shoulder and asked him to sit down. “I’ll never forget it,” Phillips said. “I’d never seen my dad cry before.” […]

Wendland appointed Washington University provost

Beverly Wendland, the James B. Knapp Dean of the Krieger School of Arts & Sciences at Johns Hopkins University, has been appointed provost of Washington University in St. Louis, effective July 1, according to Chancellor Andrew D. Martin. Wendland will succeed Marion Crain, who has served as interim provost since July 2019. A member of the Johns […]

Victoria Church receives $165K postdoctoral fellowship award from Bumpus Foundation

Victoria Church, a postdoctoral research scholar in the lab of Andrew S. Yoo,  associate professor of developmental biology at the School of Medicine, received a three-year, $165,000 postdoctoral fellowship award from the William N. & Bernice E. Bumpus Foundation for her project titled “Modeling PD with patient-derived directly reprogrammed neurons.” Read more.

WashU weekly Neuroscience publications

“Diffusion basis spectrum imaging provides insights into MS pathology” (2020) Neurology(R) Neuroimmunology & Neuroinflammation Diffusion basis spectrum imaging provides insights into MS pathology (2020) Neurology(R) Neuroimmunology & Neuroinflammation, 7 (2), .  Sun, P., George, A., Perantie, D.C., Trinkaus, K., Ye, Z., Naismith, R.T., Song, S.-K., Cross, A.H. From the Radiology (P.S., A.G., Z.Y., S.-K.S.), Washington University in Saint Louis, […]

Fitzpatrick elected to microscopy society governing council

James Fitzpatrick, PhD, a professor of neuroscience and of cell biology and physiology at Washington University School of Medicine in St. Louis, has been elected biological sciences director of the Microscopy Society of America. He will serve a three-year term on the society’s governing council beginning in 2020. An expert in biological imaging, Fitzpatrick is […]

Depression, anxiety may hinder healing in young patients with hip pain

New research suggests that physicians evaluating young patients with hip pain should consider more than such patients’ physical health. They also should consider screening those patients for clinical depression and anxiety — impairments that researchers at Washington University School of Medicine in St. Louis have found can have a negative impact on outcomes following hip […]

Timothy Miller receives international innovation prize

Timothy Miller, MD, PhD, the David Clayson Professor of Neurology at Washington University School of Medicine in St. Louis, and a group of his colleagues have received the inaugural Healey Center International Prize for innovation in amyotrophic lateral sclerosis (ALS) research from the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital. […]

Cavalli receives $300K Stein Innovation Award

Valeria Cavalli, professor of neuroscience at the School of Medicine, received a $300,000 Stein Innovation Award from Research to Prevent Blindness to explore ways to support the survival or regeneration of cells in the eye in order to prevent blindness caused by glaucoma. Read more.

WashU weekly Neuroscience publications

“Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage” (2020) Clinical Neurology and Neurosurgery Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage (2020) Clinical Neurology and Neurosurgery, 190, art. no. 105657, .  Garton, A.L.a , Gupta, V.P.b , Pucci, J.U.c , Couch, C.K.d , Connolly, E.S., Jrc […]

Laura Ibanez awarded $281K grant from Alzheimer’s Drug Discovery Foundation

Laura Ibanez, a postdoctoral research associate in neurogenetics and informatics in the laboratory of Carlos Cruchaga at the School of Medicine, has received a $281,370 grant from the Alzheimer’s Drug Discovery Foundation to study gene products associated with Alzheimer’s disease that can be found in the blood. The project will use next-generation sequencing to measure […]

WashU weekly Neuroscience publications

“Clinical instrument to retrospectively capture levels of EDSS” (2020) Multiple Sclerosis and Related Disorders Clinical instrument to retrospectively capture levels of EDSS (2020) Multiple Sclerosis and Related Disorders, 39, art. no. 101884, .  Ciotti, J.R.a , Sanders, N.b , Salter, A.c , Berger, J.R.d , Cross, A.H.a , Chahin, S.a a Department of Neurology, Washington University in St. Louis, St. Louis, […]

WashU weekly Neuroscience publications

“Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan” (2020) NeuroImage Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan (2020) NeuroImage, 208, art. no. 116450, .  Pomponio, R.a , Erus, G.a , Habes, M.a b , Doshi, J.a , Srinivasan, D.a , Mamourian, E.a , Bashyam, V.a […]

Hogan elected officer of American Epilepsy Society

R. Edward Hogan, MD, a professor of neurology and head of the Adult Epilepsy Section at Washington University School of Medicine in St. Louis, has been elected second vice president of the American Epilepsy Society. In 2022, he will become the organization’s president. Hogan’s research interests include neuroimaging in epilepsy. Among other accomplishments, he has […]

Zipfel named Dacey Distinguished Professor of Neurological Surgery

Gregory J. Zipfel, MD, the recently named head of the Department of Neurosurgery at Washington University School of Medicine in St. Louis and neurosurgeon-in-chief at Barnes-Jewish Hospital (BJH), is also now the inaugural Ralph G. Dacey Distinguished Professor of Neurological Surgery. The professorship was funded by dozens of friends, colleagues and admirers of Dacey, the Henry G. & Edith R. […]

WashU weekly Neuroscience publications

“Structural correlates of commission errors in prospective memory” (2020) Cortex Structural correlates of commission errors in prospective memory (2020) Cortex, 124, pp. 44-53.  Scullin, M.K.a , Ball, B.H.b c , Bugg, J.M.b a Baylor University, United States b Washington University in St. Louis, United States c University of Texas, Arlington, United States Abstract Prospective memory refers to remembering to perform an intended […]

Restoring arm, hand function after spinal cord injury focus of clinical trial

Spinal cord injuries caused by accidents, violence and disease paralyze from the neck down more than 5,000 people every year. In the first few months after injury, some people regain some movement and sensation in their limbs. Those who do not show improvement in the first few months are unlikely to ever recover. Now, a […]

Washington People: James DuBois

James DuBois believes in second chances. DuBois, DSc, PhD, the Steven J. Bander Professor of Medical Ethics and Professionalism at Washington University School of Medicine in St. Louis, founded the first national training program for researchers who have had lapses in laboratory compliance or research ethics, providing strategies and resources to help them get back […]

Why doesn’t deep-brain stimulation work for everyone?

People with severe Parkinson’s disease or other neurological conditions that cause intractable symptoms such as uncontrollable shaking, muscle spasms, seizures, obsessive thoughts and compulsive behaviors are sometimes treated with electric stimulators placed inside the brain. Such stimulators are designed to interrupt aberrant signaling that causes the debilitating symptoms. The therapy, deep-brain stimulation, can provide relief […]

WashU weekly Neuroscience publications

“The impact of dopamine D2-like agonist/antagonist on (18F)VAT PET measurement of VAChT in the brain of nonhuman primates” (2020) European Journal of Pharmaceutical Sciences The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates (2020) European Journal of Pharmaceutical Sciences, 143, art. no. 105152, .  Liu, H.a , Luo, Z.a , Gu, […]

Halting opioid abuse aim of several grants from NIH, CDC

Tapped for their work aimed at stemming opioid abuse and halting what has become an epidemic in the United States, researchers at Washington University School of Medicine in St. Louis have received federal grants totaling more than $10 million from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC). […]

WashU weekly Neuroscience publications

“Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear” (2020) Hearing Research Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear (2020) Hearing Research, 385, art. no. 107839, .  Wan, L.a , Lovett, M.b , Warchol, M.E.c , Stone, J.S.a a Virginia Merrill Bloedel Hearing […]

WashU weekly Neuroscience publications

“A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease” (2020) Neurobiology of Disease A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease (2020) Neurobiology of Disease, 134, art. no. 104647, .  Aflaki, E.a , Stubblefield, B.K.a , McGlinchey, R.P.b , McMahon, B.a , Ory, D.S.c , Sidransky, E.a a Section of Molecular Neurogenetics, National Human Genome Research […]

Brain imaging of babies with Down syndrome focus of $11.5 million grant

Researchers at Washington University School of Medicine in St. Louis have received a five-year, $11.5 million grant to lead a multicenter effort to understand how brain development in babies with Down syndrome differs from that in other babies. The effort, which involves scanning the babies’ brains using MRI, will provide a foundation that may lead […]

AI helps identify gene, environment networks that shape personality

Using artificial intelligence techniques, researchers studying the role of genes and the environment in shaping our personalities have identified gene networks largely responsible for the development of and variation in personality. Those networks include 972 individual genes linked to aspects of personality, such as self-awareness, intentionality — which has to do with a person being […]

Major Alzheimer’s study to open 5 new Latin American sites

A major international Alzheimer’s disease research initiative will open five new sites in Latin America to help researchers understand the development of early-onset Alzheimer’s in Latino populations. For more than a decade, the Dominantly Inherited Alzheimer Network (DIAN) – funded in large part by the National Institutes of Health (NIH) and led by Washington University School of […]

WashU weekly Neuroscience publications

“Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems” (2020) Bone Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems (2020) Bone, 130, art. no. 115144, .  Maximova, N.a , Zennaro, F.b , Gregori, M.a , Boz, G.c , Zanon, […]

WUSTL ENDURE Neuroscience Pipeline Program

The WUSTL Neuroscience Pipeline program prepares undergraduates from diverse backgrounds for neuroscience PhD programs. With support from the NIH Blueprint ENDURE Program and WUSTL, accepted students are funded for up to two 10-week summers. The program combines independent research and a rigorous summer curriculum of courses and workshops that focus on building a foundation in […]

Kipnis named BJC Investigator

Jonathan Kipnis, PhD, an internationally recognized scientific leader in how the nervous and immune systems interact in neurodegenerative, neuroinflammatory and neurodevelopmental disorders, has been named a BJC Investigator at Washington University School of Medicine in St. Louis. He will join the Department of Pathology and Immunology, with secondary appointments in the neurology, neuroscience, and neurosurgery departements. Kipnis […]

WashU weekly Neuroscience publications

“Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis” (2019) Journal of Anxiety Disorders Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis (2019) Journal of […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting Oct. 4, more than a dozen faculty members were appointed or promoted with tenure or granted tenure, effective Oct. 4 unless otherwise indicated. Appointment with tenure Flora Cassen as associate professor of Jewish, Islamic and Middle Eastern studies and of history in Arts & Sciences; […]

López named BJC Investigator

Carolina López, PhD, recognized internationally for her research on viral infections, has been named a BJC Investigator and will join the faculty of the Department of Molecular Microbiology at Washington University School of Medicine in St. Louis. She also will become a member of the faculty at the school’s Center for Women’s Infectious Disease Research. The BJC Investigators Program recruits […]

Vogel-Hammen receives award for research in child, adolescent psychiatry

Alecia Vogel-Hammen, MD, PhD, an instructor in child psychiatry at Washington University School of Medicine in St. Louis, has received the American Academy of Child & Adolescent Psychiatry’s 2019 Pilot Research Award for Attention Disorders. The award, supported by the academy’s Elaine Schlosser Lewis Fund, provides up to $15,000 in funding to junior faculty and […]

Academy of Educators introduces inaugural class

The Academy of Educators at Washington University School of Medicine in St. Louis introduced its inaugural class Tuesday, Sept. 24, in a ceremony at the Eric P. Newman Education Center. Also that day, the academy celebrated the graduation of the first class selected to the Teaching Scholars Program. The Academy of Educators — led by Mary E. Klingensmith, […]

New antidepressants on horizon

More than 14 million Americans suffer from clinical depression, yet one in three doesn’t experience relief from approved antidepressant drugs. A new treatment approach involving drugs called neurosteroids is on the horizon, however. Neurosteroids occur naturally in the brain and help regulate and modulate the activity of brain cells, but similar molecules also can be […]

WashU weekly Neuroscience publications

“Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction” (2020) Early Human Development Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction (2020) Early Human Development, 140, art. no. 104891, .  Whitehead, H.V.a , Vesoulis, Z.A.a , Maheshwari, A.b , Rambhia, A.a , Mathur, A.M.c a Department of Pediatrics, Division of […]

7 Tales of Perplexing Perception

While Conversational Intelligence (C-IQ) is traditionally a methodology, its roots lie in mythology. The late Judith E. Glaser, anthropologist and founder of C-IQ (and long-time author of this blog), first introduced me to the topic of mythology through oral tradition. Her tales of Greek and Roman Philosophy would paint a picture of the themes of […]

Deep sleep may allow brain to rinse out toxins

The deep stages of sleep may give the brain a chance to wash itself free of potentially toxic substances, a new study suggests. Researchers found that during deep sleep, the “slow-wave” activity of nerve cells appears to make room for cerebral spinal fluid to rhythmically move in and out of the brain — a process […]

Velders Named HRPO Executive Director

Dear Colleagues, We are delighted to announce that Jeanne Velders has accepted the position of IRB Executive Director of the Human Research Protection Office (HRPO) at Washington University. Jeanne has been serving as the Interim Executive Director for HRPO following Martha Jones’ departure this past July. In her new role, Jeanne will be responsible for […]

WashU weekly Neuroscience publications

“Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex” (2020) Neurobiology of Disease Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex (2020) Neurobiology of Disease, 134, art. no. 104615, .  Zhang, B.a , Guo, D.a , Han, L.a , […]

WashU Neuroscience Program ranks 9th globally

Location: St. Louis, Missouri, U.S. Neuroscience Program Global rank: 9 Best Global Universities overall rank: 31 Fact: Washington University in St. Louis is home to a wide array of research centers related to neuroscience, including the Hope Center for Neurological Disorders, the Charles F. and Joanne Knight Alzheimer Disease Research Center and the McDonnell Center for Systems Neuroscience. Neuroscience […]

Grant to help train researchers on mental health disparities in U.S., abroad

Researchers at Washington University in St. Louis have been awarded a grant from the National Institute on Minority Health and Health Disparities of the National Institutes of Health (NIH) to train young scientists to recognize, investigate and work toward correcting disparities in access to mental health care in the United States and sub-Saharan Africa. Although […]

Dementia patients’ adult kids diagnosed earlier than their parents

A person’s chance of developing dementia is influenced by family history, variations in certain genes, and medical conditions such as cardiovascular disease and diabetes. But less is known about the factors that affect when the first symptoms of forgetfulness and confusion will arise. A new study from Washington University School of Medicine in St. Louis […]

Division of Biostatistics: Integration into Institute for Informatics

Dear Faculty, Staff and Students: With great enthusiasm, I am writing to you to announce that the Division of Biostatistics will be integrating into the Institute for Informatics (I2), effective Dec. 1. The Division of Biostatistics is a medical school-wide facility engaged in research, biostatistical consultation, teaching and training. Its academic mission is grounded in […]

Low Blood Sugar Levels May Keep Alzheimer’s At Bay

Brain scientists are offering a new reason to control blood sugar levels: It might help lower your risk of developing Alzheimer’s disease. “There’s many reasons to get [blood sugar] under control,” says David Holtzman, chairman of neurology at Washington University in St. Louis. “But this is certainly one.” Holtzman moderated a panel Sunday at the Society […]