Treatment not always needed to prevent vision loss in patients with elevated eye pressure

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma. When the study was launched, it was universally accepted that all patients with elevated eye pressure should be given medication to […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 5, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Ruopeng An to associate professor at the Brown School; Arpita Bose to associate professor of biology in Arts & Sciences; Hong […]

Changing how we see the brain

His phone rang all day. Same unknown number. It had to be a telemarketer. Engrossed in an NIH workshop about the obstacles of research, Damien Fair, PhD ’08, ignored the call. At the end of the day, he answered to say, in his polite Minnesota-bred way, “Please take me off your list!” A weighted pause. […]

Consortium to investigate role of neurofilament light chain in neurodegenerative diseases

Clinical scientists at Washington University School of Medicine in St. Louis and University College London are collaborating with pharmaceutical companies AbbVie, Biogen, Bristol Myers Squibb and Roche to investigate the role of neurofilament light (NfL) chain in neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease and Alzheimer’s disease. NfL is a protein […]

WashU weekly Neuroscience publications

"TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro" (2021) Nature Communications TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro(2021) Nature Communications, 12 (1), art. no. 1924, .  Baek, M.a , Choe, Y.-J.a , Bannwarth, S.b , Kim, J.H.a , Maitra, S.a , Dorn, G.W., IIc , Taylor, J.P.d , Paquis-Flucklinger, V.b , Kim, N.C.a a Department of Pharmacy Practice and Pharmaceutical […]

Limbrick appointed to St. Louis Regional Health Commission

David D. Limbrick, MD, PhD, the T. S. Park, MD, Professor of Pediatric Neurosurgery at Washington University School of Medicine in St. Louis, has been appointed to the St. Louis Regional Health Commission as the representative from the School of Medicine. The commission is dedicated to ensuring the financial sustainability of the health-care safety net […]

Gordon receives Kober Medal

Jeffrey I. Gordon, MD, has been awarded the George M. Kober Medal from the Association of American Physicians in recognition of his outstanding contributions to the field of gut microbiome research. Gordon, director of the Edison Family Center for Genome Sciences & Systems Biology at Washington University School of Medicine in St. Louis, is considered to […]

For malnourished children, a new type of microbiome-directed food boosts growth

A new type of therapeutic food specifically designed to repair the gut microbiomes of malnourished children is superior to standard therapy in promoting growth, according to the results of a proof-of-concept clinical trial conducted in Bangladesh. The study, conducted by an interdisciplinary team of researchers from Washington University School of Medicine in St. Louis and […]

WashU weekly Neuroscience publications

“Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders” (2021) Journal of Neurodevelopmental Disorders Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders (2021) Journal of Neurodevelopmental Disorders, 13 (1), art. no. 10, .  Rahn, R.M.a b c , Weichselbaum, C.T.a b d , Gutmann, D.H.d e , Dougherty, J.D.a b d , Maloney, S.E.b d a Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO […]

Mice with hallucination-like behaviors reveal insight into psychotic illness

The humble lab mouse has provided invaluable clues to understanding diseases ranging from cancer to diabetes to COVID-19. But when it comes to psychiatric conditions, the lab mouse has been sidelined, its rodent mind considered too different from that of humans to provide much insight into mental illness. A new study, however, shows there are […]

Chemo for glioblastoma may work better in morning than evening

An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study from Washington University in St. Louis suggests that a minor adjustment […]

Brain Tumor Center established at Siteman Cancer Center

Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital have established the Brain Tumor Center, a multidisciplinary practice of physicians and scientists whose mission is to provide leading-edge, patient-centric care for brain tumor patients while also developing transformative basic, translational and clinical research to develop new therapies and improve patient outcomes. Neurosurgeon and scientist Albert H. Kim, […]

WashU weekly Neuroscience publications

“The transcriptional landscape of Shh medulloblastoma” (2021) Nature Communications The transcriptional landscape of Shh medulloblastoma (2021) Nature Communications, 12 (1), art. no. 1749, .  Skowron, P.a b c , Farooq, H.a b c , Cavalli, F.M.G.a c , Morrissy, A.S.d e f , Ly, M.a b c , Hendrikse, L.D.a c g , Wang, E.Y.a c g , Djambazian, H.h i , Zhu, H.g j , Mungall, K.L.k , Trinh, Q.M.j , Zheng, T.l , Dai, S.m , Stucklin, A.S.G.a c , Vladoiu, M.C.a b c , Fong, V.a c , Holgado, B.L.a c , Nor, C.a c , Wu, […]

Zika virus helps destroy deadly brain cancer in mice

The Zika virus that ravaged the Americas, leaving many babies with permanent brain damage, may have a silver lining. The virus can activate immune cells to destroy an aggressive brain cancer in mice, giving a powerful boost to an immunotherapy drug and sparking long-lasting immunological memory that can ward off tumor recurrence for at least […]

Widening political rift in U.S. may threaten science, medicine

The lightning speed with which scientists developed and tested the COVID-19 vaccine is a true scientific triumph — one that would not have been possible without the more than 70,000 volunteers who participated in clinical trials of the vaccine. Public participation is critical to the success of any medical research. Yet recruiting volunteers for trials […]

WashU weekly Neuroscience publications

“Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis” (2021) Acta Neuropathologica Communications Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis (2021) Acta Neuropathologica Communications, 9 (1), art. no. 40, .  Celorrio, M.a , Abellanas, M.A.a c d , Rhodes, J.a , Goodwin, V.a , Moritz, J.a , Vadivelu, S.a , Wang, L.b , Rodgers, R.b , Xiao, S.a , Anabayan, […]

Study: COVID-19 death risk higher for people with severe MS disability

Older adults with severe disability due to multiple sclerosis are 25 times more likely to die from COVID-19 than those with more mild forms of the neurological disorder, a study published Friday by JAMA Neurology found. These same patients with multiple sclerosis are up to four times as likely to develop severe COVID-19 symptoms and require hospital care after […]

Can changes in driving habits predict cognitive decline in older adults?

“Driving is an integral part of the American identity,” said Ganesh Babulal, assistant professor of neurology. Babulal is the principal investigator on two of the grants and a co-principal investigator on the third. “For the next three decades, there’s going to be massive growth of the aging population, and driving — not autonomous vehicles or ride-sharing, but […]

Researchers elected to American Society for Clinical Investigation

Five physician-scientists at Washington University School of Medicine in St. Louis have been elected members of the American Society for Clinical Investigation in recognition of original, creative and independent investigations in the clinical or allied sciences of medicine. The new members will be inducted April 8. Patricia Dickson, MD, is the Centennial Professor of Pediatrics, […]

Brain rewires itself after injury ‘on the edge of what’s compatible with life’

For 13 years, Daniel Carr had no idea he was missing part of his brain. One of the first clues occurred on the baseball field. The coach of his seventh-grade boys’ competitive team in suburban St. Louis noticed Daniel’s unusual, albeit effective, fielding tactic in the outfield. Daniel wore his glove on his right hand. […]

International Alzheimer’s clinical trial to test tau drugs

A worldwide clinical trial aimed at finding treatments for Alzheimer’s disease has expanded to include investigational drugs targeting a harmful form of the brain protein tau. The trial, known as the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and led by Washington University School of Medicine in St. Louis, launched in 2012 as the first […]

WashU weekly Neuroscience publications

"Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus" (2021) Communications Biology Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus(2021) Communications Biology, 4 (1), art. no. 260, .  Jansson, D.a b c , Dieriks, V.B.b d , Rustenhoven, J.e f , Smyth, L.C.D.g h , Scotter, E.a b , Aalderink, M.a b , Feng, S.a b , Johnson, R.a b , Schweder, P.i , Mee, E.i , Heppner, P.j , Turner, C.k , Curtis, M.b d , […]

Podcast: Loss of smell, heart problems common symptoms for long-haulers

In the year since COVID-19 infections first appeared in the United States, a few things have become clear. One is that many who get sick don’t recover quickly. Even those who don’t have to be hospitalized can experience symptoms that linger. Called long-haulers, these individuals suffer from a variety of issues such as shortness of […]

COVID Survivors Hope Experimental Therapy Will Help Them Learn To Smell Again

Elizabeth Tesson remembers the exact moment she lost her sense of smell, the day after she tested positive for COVID-19. “I got a very odd feeling in my nose, like a burning sensation in my sinuses and along my cheeks,” said Tesson, who lives in St. Louis County. “About an hour and a half later, […]

WashU weekly Neuroscience publications

“Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel” (2021) Nature Communications Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel (2021) Nature Communications, 12 (1), art. no. 926, .  Arnold, W.R.a , Carnevale, L.N.a , Xie, Z.b , Baylon, J.L.c , Tajkhorshid, E.c , Hu, H.b , Das, A.d e a Department of Biochemistry, University of Illinois Urbana-Champaign, […]

Finding a possible early treatment for COVID-19 in a 40-year-old antidepressant

The race to find vaccines for COVID-19 has dominated the headlines, but there’s been less news about how to keep people with COVID out of the hospital. Tonight, we’re going to tell you a story about one possible treatment. It’s called fluvoxamine. The generic drug was developed 40 years ago as an antidepressant and has […]

Opioid overdose reduced in patients taking buprenorphine

Even during the COVID-19 pandemic, opioid misuse has continued unabated in the United States, with an estimated 2.5 million or more Americans suffering from opioid use disorder. Most people treated for the disorder are given medications, such as buprenorphine, that activate opioid receptors. But there is disagreement about whether it’s safe to prescribe buprenorphine for […]

WashU weekly Neuroscience publications

“A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors” (2021) Scientific Reports A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors (2021) Scientific Reports, 11 (1), art. no. 3858, .  Mattar, P.a f g , Jolicoeur, C.a , Dang, T.f g , Shah, S.f g , Clark, B.S.b c , Cayouette, M.a d e a Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada b John […]

Electrical signaling in cells focus of $8.8 million grant

The squiggly shapes in the illustration represent proteins that make up different parts of an ion channel in a cell. Ion channels are involved in the conversion of chemical and mechanical messages into electrical signals in cells. Researchers at Washington University School of Medicine in St. Louis have received an eight-year, $8.8 million grant to study ion channels as potential targets for new drugs to treat disorders affecting the brain, heart and muscles. (Image: Chanda lab)

Researchers at Washington University School of Medicine in St. Louis have received an eight-year, $8.8 million grant to study cells’ ion channels as potential targets for new drugs to treat disorders affecting the brain, heart and muscles. Ion channels are found in a variety of cells, where they are involved in the conversion of chemical […]

Holtzman, Karch honored for research into neurodegenerative diseases

Alzheimer’s researchers David M. Holtzman, MD, and Celeste Karch, PhD, of Washington University School of Medicine in St. Louis, have been recognized by the Rainwater Charitable Foundation for scientific achievements that could lead to new, effective treatments for neurodegenerative diseases associated with the accumulation of tau protein in the brain. Alzheimer’s is the best known such disease. […]

Rainwater Charitable Foundation Announces Second-Annual Rainwater Prize Winners for Brain Research

The Rainwater Charitable Foundation, one of the largest independent funders of neurodegenerative disease research, today announced Dr. David M. Holtzman (the Andrew B. and Gretchen P. Jones Professor and Chair of Neurology, Washington University School of Medicine in St. Louis) and Dr. Celeste Karch (Associate Professor of Psychiatry, Washington University School of Medicine in St. Louis) as this year’s recipients of the Rainwater Annual Prize for […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: evidence from economic decision-making” (2021) Cognitive Research: Principles and Implications Domain-general cognitive motivation: evidence from economic decision-making (2021) Cognitive Research: Principles and Implications, 6 (1), art. no. 4, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, Box 1125, St. Louis, MO 63130, United […]

Protein linked to Alzheimer’s, strokes cleared from brain blood vessels

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise […]

WashU weekly Neuroscience publications

“Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury” (2021) Nature Communications Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury (2021) Nature Communications, 12 (1), art. no. 781, .  Brommer, B.a , He, M.a , Zhang, Z.a , Yang, Z.a , Page, J.C.a , Su, J.a , Zhang, Y.a , […]

Aggressive brain tumor mapped in genetic, molecular detail

Pictured are MRI scans of eight patients with glioblastoma, an aggressive brain tumor. A new study led by Washington University School of Medicine in St. Louis has mapped out detailed molecular and genetic schematics of these tumors, opening the door to potential improved therapies. (Image: Albert H. Kim)

Glioblastoma is among the most aggressive and devastating of cancers. While rare compared with other cancers, it’s the most common type of brain cancer. Even with intensive therapy, relatively few patients survive longer than two years after diagnosis, and fewer than 10% of patients survive beyond five years. Despite extensive studies focused on genomic features […]

Obituary: Lawrence Coben, emeritus associate professor of neurology, 94

Lawrence Coben, MD, who with his colleagues at Washington University School of Medicine in St. Louis developed a widely used scale that characterizes and tracks impairment in dementia patients, died of cancer Oct. 7, 2020, in Dedham, Mass. He was 94. Coben was an emeritus associate professor of neurology at the university. He retired in […]

WashU weekly Neuroscience publications

"A 2020 view of tension-based cortical morphogenesis" (2021) Proceedings of the National Academy of Sciences of the United States of America A 2020 view of tension-based cortical morphogenesis(2021) Proceedings of the National Academy of Sciences of the United States of America, 117 (52), pp. 32868-32879.  van Essen, D.C. Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, […]

WashU weekly Neuroscience publications

“‘It’s way more than just writing a prescription’: A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use disorder” (2021) Addiction Science and Clinical Practice “It’s way more than just writing a prescription”: A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use […]

Brain signals decoded to determine what a person sees

Some people are trapped within their own minds, able to think and feel but unable to express themselves because brain injury or disease has damaged their lines of communication with the outside world. As a step toward helping people in such situations communicate, scientists at Washington University School of Medicine in St. Louis have demonstrated […]

How does the immune system keep tabs on the brain?

Immune cells (yellow and purple) fill a sinus (teal) in the outer layer of the meninges, the tissue that surrounds the brain and spinal cord. Researchers at Washington University School of Medicine in St. Louis have found that immune cells stationed in such sinuses monitor the brain and initiate an immune response if they detect a problem.

Alzheimer’s disease, multiple sclerosis, autism, schizophrenia and many other neurological and psychiatric conditions have been linked to inflammation in the brain. There’s growing evidence that immune cells and molecules play a key role in normal brain development and function as well. But at the core of the burgeoning field of neuroimmunology lies a mystery: How […]

Acute itching in eczema patients linked to environmental allergens

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines — the standard treatment for itching and allergy — often don’t help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes […]

WashU weekly Neuroscience publications

“Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States” (2021) PLoS ONE Exercise routine change is associated with prenatal depression scores during the COVID-19 pandemic among pregnant women across the United States (2021) PLoS ONE, 15 (12 December), art. no. e0243188, .  Gildner, T.E.a b , Laugier, E.J.a c , Thayer, Z.M.a c a Department of […]

WashU weekly Neuroscience publications

“A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder” (2021) International Journal of Bipolar Disorders A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder (2021) International Journal of Bipolar Disorders Musket, C.W.a , […]

Doctors test popular anti-depressant to see if it fights off Covid-19

Doctors are running a clinical trial to see if a popular anti-depressant might keep someone from becoming severely ill with Covid-19. The researchers at Washington University of St. Louis are recruiting 1,100 people in the beginning stages of Covid-19 to test out the drug fluvoxamine, also known as Luvox. While an anti-depressant may seem like […]

WashU weekly Neuroscience publications

"Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns" (2021) Annals of Emergency Medicine Destigmatizing Naloxone: Associations of Perceived Availability on Opioid Use Patterns(2021) Annals of Emergency Medicine, 77 (1), pp. 134-135.  Ellis, M.S., Kasper, Z.A., Cicero, T.J. Washington University in St. Louis, Department of Psychiatry, School of Medicine, St. Louis, MO, United States Document Type: LetterPublication Stage: FinalSource: Scopus "Prevalence, […]

Podcast: Vaccines have arrived but COVID-19 treatments progressing much more slowly

A new episode of our podcast, “Show Me the Science,” has been posted. At present, these podcast episodes are highlighting research and patient care on the Washington University Medical Campus as our scientists and clinicians confront the COVID-19 pandemic. COVID-19 vaccine development has been rapid and successful. Two vaccines that report more than 90% efficacy […]

Common brain malformation traced to its genetic roots

About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms. In […]

WashU weekly Neuroscience publications

"Oral and maxillofacial surgeons’ assessment of the role of Pernkopf's atlas in surgical practice" (2021) Annals of Anatomy Oral and maxillofacial surgeons’ assessment of the role of Pernkopf’s atlas in surgical practice(2021) Annals of Anatomy, 234, art. no. 151614, .  Yee, A.a , Li, J.b , Lilly, J.b , Hildebrandt, S.c , Seidelman, W.E.d , Brown, D.e , Kopar, P.e , Coert, J.H.f , Mackinnon, S.E.a , Israel, H.A.b a Division of […]