The series brings in WashU faculty and other experts across disciplines whose research has particular implications for interventions in Autism.
Each lecture lasts about 45 minutes, with the remaining time allotted to interactions and discussion with attendees. Appetizers and drinks are provided. Speaker information and reading materials for preparation of each series will be sent out in the weeks leading up to each session.
The Autism Seminar Series is brought to you by the Department of Neuroscience and the Intellectual and Developmental Disabilities Research Center (IDDRC).
Third Monday of the month
McDonnell Sciences Building, Room 928
4:00-5:30p unless noted
Note that individual events also are listed on the ONR Calendar.
For inquiries, please contact Daniel Gray (Program Manager, IDDRC).
WashU Psychiatry, Neurology and Radiology
“Neurophenotyping a rare monogenic disorder: Lessons from Wolfram Syndrome”
- “Neuroimaging evidence of deficient axon myelination in Wolfram syndrome” Lugar, et al. Scientific Reports 2016.
- “Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease” Rigoli et al. Pediatric Research 2018.
October 29 – NOTE 4:30p start
Milbrandt and Mitra Labs, WashU Genetics
“CRANIUM – A Cas9-based platform to discover common mechanisms of rare disease genes”
- “On the design of CRISPR-based single-cell molecular screens” Hill, et al. Nat Methods. 2018
- “Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes” Ho, et al. Stem Cell Reports. 2017
WashU Dept. of Neuroscience
“Phenotypic and mechanistic insights from variant analysis of UBE3A”
- “The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome” Yi, et al. J Biological Chemistry. 2017
- “An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A” Yi, et al. Cell. 2015
“Epilepsy Genetics: A Gateway to Mosaicism in Neurodevelopmental Disorders”
WashU Dept. of Neuroscience
“From genetics to mechanism: understanding epigenetic disruption in autism and related disorders”
- “Novel genes for autism implicate both excitatory and inhibitory cell lineages in risk” Satterstrom, et al. bioRxiv (2018)
- “The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants [version 1; referees: 3 approved]” Tatton-Brown, et al. Wellcome Open Research (2018)
Gurnett and Dobbs Lab, WashU Neurology and Orthopaedic Surgery
“High-throughput functional characterization of genetic variation in human disease”
- “Massively parallel single-nucleotide mutagenesis using reversibly terminated inosine” Haller, et al. Nature Methods (2016)
- “A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis” Haller, et al. Human Molecular Genetics (2016)
“Mechanistic Links Between Epilepsy and Autism in the mTORopathies”
- “Impaired maturation of cortical GABAA receptor expression in pediatric epilepsy” Jansen, et al. Epilepsia (2010)
- “PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia” Jansen, et al. Brain (2015)
Cynthia Ortinau (WashU Pediatrics): “Altered prenatal brain development in congenital heart disease”
Rafael Galindo (WashU Neurology): “Neuroprotective actions of gonadotropins in the injured developing brain”
Stephanie Morris (WashU Neurology): “Genotype-Phenotype Correlation in NF1-ASD”
Bhooma Aravamuthan (WashU Neurology): “Pathophysiology of dystonia after neonatal brain injury”
Zachary Vesoulis (WashU Pediatrics): “Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury”
Jessica Chubiz (WashU Prematurity Research Center): “Prematurity Research Center (PRC) and Women & Infants Health Specimen Consortium (WIHSC) Resources”