Discussing WIPs and recent papers in aging biology and age-associated disease
Explore the archives below.
January 25, 2024
Virginia Hsu (Imai lab, WashU Developmental Biology)
“Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice” Cell Metabolism (2023)
February 22, 2024 – NOTE location: Couch 4001B
Prashant Kuntala (Wang lab, WashU Genetics)
Thesis Proposal brainstorming: “Epigenetic Determinants of Exceptional Longevity in Humans“
March 7, 2024
Logan Thrasher Collins (Curiel lab, WashU Radiation Oncology)
WiP: “Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy’s neutralizing antibody problem”
March 21, 2024
Thomas Mahan (Yoo lab, WashU Developmental Biology)
“Developing human cell based models of Alzheimer disease in Trisomy 21”
April 18, 2024
Pavla Bohacova (Artyomov lab, WashU Pathology & Immunology)
Talk practice: “Dissecting age-related cellular, compositional, and functional remodeling of naive T cells in humans”
May 2, 2024
Yudong Ren (Yoo lab, WashU Developmental Biology)
May 16, 2024
Ruiyi Tian (Vagelos DBBS Biomedical Informatics and Data Science Program)
Practice Talk: “Accelerated aging and early-onset GI cancer”
May 30, 2024
Changfeng Chen (Humphreys lab, WashU Medicine)
“Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity” Nature (2024)
June 13, 2024
Kyohei Tokizane (Imai lab, WashU Developmental Biology)
“IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline” Cell Metabolism (2024)
March 9, 2023
Brian Lananna (Imai lab, WashU Pathology & Immunology)
“Loss of epigenetic information as a cause of mammalian aging” Cell 2023
March 23, 2023
Christian Suarez (Weihl lab, WashU Neurology)
“Epigenetic regulation of proteasome activity” (QE practice)
April 6, 2023
Reed Trende (Boon lab, WashU Immunology)
“Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing” Nature Cell Biology 2023
April 20, 2023
Virginia Hsu (Imai lab, WashU Developmental Biology)
“Ageing-associated changes in transcriptional elongation influence longevity” (Science 2023)
May 4, 2023
Kyohei Tokizane (Imai lab, WashU Developmental Biology)
“Hypothalamic Menin regulates systemic aging and cognitive decline” PLoS Biology (2023)
May 18, 2023
Prashant Kuntala (Wang lab, WashU Genetics)
QE Practice
“Understanding the Role of DNA methylation of Transposable Elements in Exceptional Longevity”
June 1, 2023
Jason Colasanti (Apte lab, WashU Ophthalmology & Visual Sciences)
“The role of miR-34a in age-related macular degeneration”
June 29, 2023
Thomas Mahan (Yoo lab, WashU Developmental Biology)
“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain” Molecular Psychiatry (2021)
July 13, 2023
Kentaro Mori (Imai lab, WashU Developmental Biology)
WiP: “Anti-aging effects of novel myokine via inter-tissue communication”
July 27, 2023
Yudong Ren (Yoo lab, WashU Developmental Biology)
WiP (QE): “Elucidating the mechanism of neuroprotective role of Lamivudine (3TC) on late-onset Alzheimer’s reprogrammed cortical neuronsAnti-aging effects of novel myokine via inter-tissue communication”
September 21, 2023
Wangchao Xu (Kipnis lab, WashU Pathology & Immunology)
WiP: “A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan”
October 5, 2023
Prashant Kuntala (Wang lab, WashU Genetics)
“Profiling epigenetic age in single cells” Nature Aging (2021)
October 19, 2023
Brian Lananna (Imai lab, WashU Developmental Biology)
“Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease” Cell Metabolism (2023)
November 2, 2023
Ena Haseljic (Vagelos DBBS Molecular Genetics & Genomics Program)
QE practice: “Investigating neuronal activity-dependent DNA repair”
November 16, 2023
Cecilia Lei (Imai lab, WashU Developmental Biology)
“Taurine deficiency as a driver of aging” Science (2023)