Leading the way for personalized medicine

Washington University is working with unparalleled research capabilities to make personalized medicine a reality. The medical school is pioneering individualized treatment approaches in obesity, diabetes, breast cancer and Alzheimer’s disease. Watch the video spotlight.

Genes linked to Alzheimer’s risk, resilience ID’d

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer’s disease. Most genes implicated thus far in Alzheimer’s affect neurons that transmit messages, allowing different regions of the brain to communicate with one […]

New genetic clues to early-onset form of dementia

Culprit is lone error in one gene, but researchers find many potential therapeutic targets From the School of Medicine News… Unlike the more common Alzheimer’s disease, frontotemporal dementia tends to afflict young people. It accounts for an estimated 20 percent of all cases of early-onset dementia. Patients with the illness typically begin to suffer memory […]

Cardiovascular disease, Alzheimer’s genetically linked

Managing cholesterol, triglycerides may reduce Alzheimer’s risk, study suggests From the WashU Newsroom… Studying DNA from more than 1.5 million people, an international team of researchers — led by Washington University School of Medicine in St. Louis and the University of California, San Francisco — has identified points of DNA that increase the risk of […]

ALS, rare dementia share genetic link

Findings point to potential treatment strategy for both disorders From the WashU Newsroom… Nearly half of all patients with amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder, develop cognitive problems that affect memory and thinking. Why a disease that primarily affects movement also disrupts thinking has been unclear. But now, an international team of researchers has […]

Link between 2 key Alzheimer’s proteins explained

Targeting tau production may lead to treatment From the WashU Newsroom… It’s a paradox of Alzheimer’s disease: Plaques of the sticky protein amyloid beta are the most characteristic sign in the brain of the deadly neurodegenerative disease. However, many older people have such plaques in their brains but do not have dementia. The memory loss […]