Alzheimer’s disease and frontotemporal dementia are devastating disorders that emerge following the buildup of misfolded proteins in the brain. The newest generation of Alzheimer’s therapeutics targets accumulations of the protein amyloid beta with engineered antibodies, but the results have been underwhelming, with some adverse effects, not to mention using engineered antibodies can be prohibitively expensive. […]
A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies — stacks of peptides that include amyloid beta, most notably associated with Alzheimer’s disease. These cross-β fibril assemblies are also useful building blocks within designer biomaterials for medical applications, but their resemblance […]
Matthew Lew, PhD, an associate professor of electrical and systems engineering at the McKelvey School of Engineering at Washington University in St. Louis, has received a five-year $2 million Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health (NIH) to support his ongoing work to improve microscopic imaging techniques. Lew will use the […]