Jackrel receives $300K from ALS Association

Meredith Jackrel, assistant professor of chemistry in Arts & Sciences, received a $300,000 grant from the ALS Association to support a project titled “Countering the aggregation of TDP-43, FUS, DPRS, and Matrin 3 with engineered protein disaggregases.” Read more.

Jackrel lab makes protein finding that could help fight disease

Researchers in the laboratory of Meredith Jackrel, assistant professor of chemistry in Arts & Sciences at Washington University in St. Louis, discovered that proteins implicated in Ewing’s sarcoma and liposarcoma can be dissolved by protein disaggregases, a finding that could be used to combat disease. The new research is published in the Journal of Biological […]

Engineering proteins to help counter devastating diseases

As human lifespans have gotten longer, certain proteins in our bodies are increasingly prone to take on alternative shapes. These misfolded proteins can ultimately trigger neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Lou Gehrig’s disease, formally known as amyotrophic lateral sclerosis (ALS). Meredith Jackrel, assistant professor of chemistry in Arts & Sciences at Washington University in St. […]

Engineering the right protein

Chemists in Arts & Sciences are working to engineer proteins that may help counter devastating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. The proteins in our bodies have evolved over many millions of years to reach their current diversity of functions, spurring on the necessary chemical reactions occurring within our cells, and protecting us […]