WashU weekly Neuroscience publications

“Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective” (2020) Neurobiology of Stress Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective (2020) Neurobiology of Stress, 12, art. no. 100215, .  Paul, S.M.a b c , Pinna, G.d , Guidotti, A.d e a Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States b The Taylor Family Institute for […]

WashU weekly Neuroscience publications

“Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study” (2020) Journal of Stroke and Cerebrovascular Diseases Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study (2020) Journal of Stroke and Cerebrovascular Diseases, 29 (4), art. no. 104645, .  Cross, D.B.a , Tiu, J.c , Medicherla, C.a , Ishida, K.a , Lord, A.a , Czeisler, B.a , Wu, C.a , Golub, D.a […]

WashU weekly Neuroscience publications

“Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology” (2020) Scientific Reports Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) Scientific Reports, 10 (1), art. no. 2975, .  Shen, X.a , Ma, S.a , Vemuri, P.b , Simon, G.a , Weiner, M.W.c , Aisen, P.d , Petersen, R.b , Jack, C.R.b , Saykin, A.J.e , […]

WashU weekly Neuroscience publications

“Genomic prediction of alcohol-related morbidity and mortality” (2020) Translational Psychiatry Genomic prediction of alcohol-related morbidity and mortality (2020) Translational Psychiatry, 10 (1), art. no. 23, .  Kiiskinen, T.a f , Mars, N.J.f , Palviainen, T.f , Koskela, J.f , Rämö, J.T.f , Ripatti, P.f , Ruotsalainen, S.f , Palotie, A.f g h , Madden, P.A.F.b , Rose, R.J.c , Kaprio, J.d […]

WashU weekly Neuroscience publications

“Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex” (2020) Communications Biology Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex (2020) Communications Biology, 3 (1), art. no. 64, .  Zhang, M.a c , Kwon, S.E.b d , Ben-Johny, M.a e , O’Connor, D.H.b , Issa, J.B.a f a Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, […]

Battling treatment resistant opioid use disorder

Similar to treatment resistant depression, there is a subpopulation of those addicted to opioids who do not respond to standard opioid use disorder (OUD) treatments. In a new paper, an addiction expert at the Brown School at Washington University in St. Louis suggests a new category for these types of patients: treatment resistant opioid use […]

WashU weekly Neuroscience publications

“Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures” (2020) Scientific Reports Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures (2020) Scientific Reports, 10 (1), art. no. 1980, .  Iskandar, H.N.a , Linan, E.E.b , Patel, A.c , Moore, R.d , Lasanajak, Y.d , Gyawali, C.P.b , Sayuk, G.S.b e , Ciorba, […]

WashU weekly Neuroscience publications

“Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy” (2020) Nature Communications Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy (2020) Nature Communications, 11 (1), art. no. 595, .  Hengel, H.a b , Bosso-Lefèvre, C.c d , Grady, G.e , Szenker-Ravi, E.c , Li, H.f , Pierce, S.g , Lebigot, É.h , Tan, T.-T.i , Eio, M.Y.i , […]

WashU weekly Neuroscience publications

“FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease” (2020) Nature Communications FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2020) Nature Communications, 11 (1), art. no. 411, .  Yan, T.a , Liang, J.b , Gao, J.a , Wang, L.a , Fujioka, H.c , Weiner, M.W.d , Schuff, N.d , Rosen, H.J.d , Miller, B.L.d , […]

WashU weekly Neuroscience publications

“Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning” (2020) Information Fusion Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning (2020) Information Fusion, 58, pp. 153-167.  Castillo-Barnes, D.a , Su, L.b , Ramírez, J.a , Salas-Gonzalez, D.a , Martinez-Murcia, F.J.c , Illan, I.A.a , Segovia, F.a , Ortiz, A.c , Cruchaga, C.d […]

WashU weekly Neuroscience publications

“Structural basis for adhesion G protein-coupled receptor Gpr126 function” (2020) Nature Communications Structural basis for adhesion G protein-coupled receptor Gpr126 function (2020) Nature Communications, 11 (1), art. no. 194, .  Leon, K.a b , Cunningham, R.L.c , Riback, J.A.a d , Feldman, E.a , Li, J.a b , Sosnick, T.R.a e , Zhao, M.a , Monk, K.R.c f , Araç, D.a […]

Wendland appointed Washington University provost

Beverly Wendland, the James B. Knapp Dean of the Krieger School of Arts & Sciences at Johns Hopkins University, has been appointed provost of Washington University in St. Louis, effective July 1, according to Chancellor Andrew D. Martin. Wendland will succeed Marion Crain, who has served as interim provost since July 2019. A member of the Johns […]

Division of Computational and Data Sciences marries AI, social science

Every day, social service professionals tackle complex problems across varying domains, working to determine which interventions are likely to be effective, fair and within an agency’s capabilities. For a struggling parent in danger of losing their home, which alternative would prove more helpful in the long run, housing assistance or job training? Might a child […]

WashU weekly Neuroscience publications

“Diffusion basis spectrum imaging provides insights into MS pathology” (2020) Neurology(R) Neuroimmunology & Neuroinflammation Diffusion basis spectrum imaging provides insights into MS pathology (2020) Neurology(R) Neuroimmunology & Neuroinflammation, 7 (2), .  Sun, P., George, A., Perantie, D.C., Trinkaus, K., Ye, Z., Naismith, R.T., Song, S.-K., Cross, A.H. From the Radiology (P.S., A.G., Z.Y., S.-K.S.), Washington University in Saint Louis, […]

WashU weekly Neuroscience publications

“Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage” (2020) Clinical Neurology and Neurosurgery Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage (2020) Clinical Neurology and Neurosurgery, 190, art. no. 105657, .  Garton, A.L.a , Gupta, V.P.b , Pucci, J.U.c , Couch, C.K.d , Connolly, E.S., Jrc […]

WashU weekly Neuroscience publications

“Clinical instrument to retrospectively capture levels of EDSS” (2020) Multiple Sclerosis and Related Disorders Clinical instrument to retrospectively capture levels of EDSS (2020) Multiple Sclerosis and Related Disorders, 39, art. no. 101884, .  Ciotti, J.R.a , Sanders, N.b , Salter, A.c , Berger, J.R.d , Cross, A.H.a , Chahin, S.a a Department of Neurology, Washington University in St. Louis, St. Louis, […]

WashU weekly Neuroscience publications

“Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan” (2020) NeuroImage Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan (2020) NeuroImage, 208, art. no. 116450, .  Pomponio, R.a , Erus, G.a , Habes, M.a b , Doshi, J.a , Srinivasan, D.a , Mamourian, E.a , Bashyam, V.a […]

WashU weekly Neuroscience publications

“Structural correlates of commission errors in prospective memory” (2020) Cortex Structural correlates of commission errors in prospective memory (2020) Cortex, 124, pp. 44-53.  Scullin, M.K.a , Ball, B.H.b c , Bugg, J.M.b a Baylor University, United States b Washington University in St. Louis, United States c University of Texas, Arlington, United States Abstract Prospective memory refers to remembering to perform an intended […]

WashU weekly Neuroscience publications

“The impact of dopamine D2-like agonist/antagonist on (18F)VAT PET measurement of VAChT in the brain of nonhuman primates” (2020) European Journal of Pharmaceutical Sciences The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates (2020) European Journal of Pharmaceutical Sciences, 143, art. no. 105152, .  Liu, H.a , Luo, Z.a , Gu, […]

WashU weekly Neuroscience publications

“Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear” (2020) Hearing Research Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear (2020) Hearing Research, 385, art. no. 107839, .  Wan, L.a , Lovett, M.b , Warchol, M.E.c , Stone, J.S.a a Virginia Merrill Bloedel Hearing […]

WashU weekly Neuroscience publications

“A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease” (2020) Neurobiology of Disease A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease (2020) Neurobiology of Disease, 134, art. no. 104647, .  Aflaki, E.a , Stubblefield, B.K.a , McGlinchey, R.P.b , McMahon, B.a , Ory, D.S.c , Sidransky, E.a a Section of Molecular Neurogenetics, National Human Genome Research […]

WashU weekly Neuroscience publications

“Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems” (2020) Bone Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems (2020) Bone, 130, art. no. 115144, .  Maximova, N.a , Zennaro, F.b , Gregori, M.a , Boz, G.c , Zanon, […]

WashU weekly Neuroscience publications

“Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis” (2019) Journal of Anxiety Disorders Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis (2019) Journal of […]

WashU weekly Neuroscience publications

“Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction” (2020) Early Human Development Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction (2020) Early Human Development, 140, art. no. 104891, .  Whitehead, H.V.a , Vesoulis, Z.A.a , Maheshwari, A.b , Rambhia, A.a , Mathur, A.M.c a Department of Pediatrics, Division of […]

WashU weekly Neuroscience publications

“Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex” (2020) Neurobiology of Disease Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex (2020) Neurobiology of Disease, 134, art. no. 104615, .  Zhang, B.a , Guo, D.a , Han, L.a , […]

Grant to help train researchers on mental health disparities in U.S., abroad

Researchers at Washington University in St. Louis have been awarded a grant from the National Institute on Minority Health and Health Disparities of the National Institutes of Health (NIH) to train young scientists to recognize, investigate and work toward correcting disparities in access to mental health care in the United States and sub-Saharan Africa. Although […]

WashU weekly Neuroscience publications

“Identifying reproducible individual differences in childhood functional brain networks: An ABCD study” (2019) Developmental Cognitive Neuroscience Identifying reproducible individual differences in childhood functional brain networks: An ABCD study (2019) Developmental Cognitive Neuroscience, 40, art. no. 100706, .  Marek, S.a , Tervo-Clemmens, B.b , Nielsen, A.N.c , Wheelock, M.D.a , Miller, R.L.d , Laumann, T.O.a , Earl, E.f , Foran, W.W.e […]

WashU weekly Neuroscience publications

“Alzheimer Disease: An Update on Pathobiology and Treatment Strategies” (2019) Cell Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) Cell, 179 (2), pp. 312-339.  Long, J.M., Holtzman, D.M. Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, United States Abstract Long […]

WashU weekly Neuroscience publications

“Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers” (2019) Neurobiology of Aging Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers (2019) Neurobiology of Aging, 83, pp. 54-62.  Chen, Q.a b , Boeve, B.F.c , Schwarz, C.G.b , Reid, R.b , Tosakulwong, N.d , Lesnick, T.G.d , Bove, J.e , Brannelly, P.f , Brushaber, […]

WashU weekly Neuroscience publications

“The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability” (2019) NeuroImage The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability (2019) NeuroImage, 202, art. no. 115990, .  Betzel, R.F.a b c , Bertolero, M.A.a , Gordon, E.M.d e , Gratton, C.f g , Dosenbach, N.U.F.f h i , […]

WashU weekly Neuroscience publications

“Pioglitazone improves working memory performance when administered in chronic TBI” (2019) Neurobiology of Disease Pioglitazone improves working memory performance when administered in chronic TBI (2019) Neurobiology of Disease, 132, art. no. 104611, .  McGuire, J.L.a , Correll, E.A.a , Lowery, A.C.b , Rhame, K.c , Anwar, F.N.d , McCullumsmith, R.E.e , Ngwenya, L.B.a f a Department of Neurosurgery, University of Cincinnati, […]

WashU weekly Neuroscience publications

“Large posttraumatic stress disorder improvement and antidepressant medication adherence” (2020) Journal of Affective Disorders Large posttraumatic stress disorder improvement and antidepressant medication adherence (2020) Journal of Affective Disorders, 260, pp. 119-123.  Salas, J.a b , Scherrer, J.F.a b , Tuerk, P.c , van den Berk-Clark, C.a , Chard, K.M.d , Schneider, F.D.e , Schnurr, P.P.f , Friedman, M.J.f , […]

CAPA Clinic shows promising results for addiction treatment patients in St. Louis

The Community Academic Partnership on Addiction (CAPA) Clinic, a partnership between the Brown School and Preferred Family Healthcare (PFH), was able to increase treatment completion rates by 11% over a six-month time period. “This is excellent work and very strong findings,” said Mary McKay, the Neidorff Family and Centene Corporation Dean of the Brown School at Washington University […]

WashU weekly Neuroscience publications

“Alternative ecological strategies lead to avian brain size bimodality in variable habitats” (2019) Nature Communications Alternative ecological strategies lead to avian brain size bimodality in variable habitats (2019) Nature Communications, 10 (1), art. no. 3818, .  Fristoe, T.S.a b , Botero, C.A.b a Department of Biology, University of Konstanz, Universitätsstraße 10, Konstanz, 78464, Germany b Department of Biology, Washington University in St. Louis, […]

Cindy Brantmeier named inaugural WashU Faculty Fellow in International Research

Dear Colleagues, I am pleased to announce that Dr. Cindy Brantmeier has been selected to serve as the first Faculty Fellow in International Research for the School of Medicine and Danforth Campus. The Faculty Fellow in International Research will advise faculty on conducting international research and achieving effective collaborations with international partners that are compliant […]

WashU weekly Neuroscience publications

“Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter” (2019) Scientific Reports Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter (2019) Scientific Reports, 9 (1), art. no. 12246, .  Fukutomi, H.a b , Glasser, M.F.c d , Murata, K.e , […]

$785K NIMH grant awarded to Brown School’s Mary McKay

Mary McKay, the Neidorff Family and Centene Corporation Dean of the Brown School, has received a five-year, $785,000 grant from the National Institutes of Health (NIH)’s National Institute of Mental Health for a project titled “Navigating Resource-Constrained Systems and Communities to Promote the Behavioral Health of Black Youth.” Sean Joe, the Benjamin E. Youngdahl Professor of Social Development […]

WashU weekly Neuroscience publications

"Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex" (2019) Scientific Reports Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex(2019) Scientific Reports, 9 (1), art. no. 11700, .  Maranesi, M.a , Bruni, S.a b , Livi, A.a c , Donnarumma, F.d , Pezzulo, G.d , Bonini, L.a a Department of Medicine […]

WashU weekly Neuroscience publications

“Sleep disturbances in Wolfram syndrome” (2019) Orphanet Journal of Rare Diseases Sleep disturbances in Wolfram syndrome (2019) Orphanet Journal of Rare Diseases, 14 (1), art. no. 188, .  Licis, A.a , Davis, G.d e , Eisenstein, S.A.b c , Lugar, H.M.b , Hershey, T.a b c a Department of Neurology, Washington University, School of Medicine, Campus Box 8111, 660 South Euclid Ave, […]

WashU weekly Neuroscience publications

“Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia” (2019) Scientific Reports Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia (2019) Scientific Reports, 9 (1), art. no. 10854, .  Bonham, L.W.a b , Steele, N.Z.R.a , Karch, C.M.c […]

WashU weekly Neuroscience publications

“A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings” (2019) Journal of Substance Abuse Treatment A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings (2019) Journal of Substance Abuse Treatment, 104, pp. 135-143.  Presnall, N.J.a b , Wolf, D.A.P.S.a , Brown, D.S.a , Beeler-Stinn, S.a , Grucza, R.A.b a Brown School of […]

WashU weekly Neuroscience publications

“CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)” (2019) Scientific Reports CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) (2019) Scientific Reports, 9 (1), art. no. 9891, .  Eaton, S.L.a , Proudfoot, C.a , Lillico, S.G.a , Skehel, P.b c , Kline, R.A.a , Hamer, K.e , Rzechorzek, N.M.d […]

WashU weekly Neuroscience publications

“A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation” (2019) Molecular Genetics and Metabolism Reports A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation (2019) Molecular Genetics and Metabolism Reports, 20, art. no. 100484, .  Ahmed, A.a , Ou, L.b , Rudser, K.c , […]

WashU weekly Neuroscience publications

“Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns” (2019) Nature Communications Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns (2019) Nature Communications, 10 (1), art. no. 2548, .  Czamara, D.a , Eraslan, G.b c , Page, C.M.d e , Lahti, J.f g , Lahti-Pulkkinen, M.f h , Hämäläinen, E.i […]

WashU weekly Neuroscience publications

“High-fidelity mapping of repetition-related changes in the parietal memory network” (2019) NeuroImage High-fidelity mapping of repetition-related changes in the parietal memory network (2019) NeuroImage, 199, pp. 427-439.  Gilmore, A.W.a , Nelson, S.M.h i j , Laumann, T.O.b c , Gordon, E.M.h i , Berg, J.J.a , Greene, D.J.c d , Gratton, C.b , Nguyen, A.L.b , Ortega, M.b , […]

WashU weekly Neuroscience publications

“A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ” (2019) Nature Communications A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ (2019) Nature Communications, 10 (1), art. no. 2448, .  Kim, W.S.a , Shalit, Z.A.a , Nguyen, S.M.b , Schoepke, E.c , Eastman, A.d , Burris, T.P.c , Gaur, A.B.b , Micalizio, G.C.a a Dartmouth College, Department of […]

Thorp to conclude term as Washington University provost

Holden Thorp, provost at Washington University in St. Louis, will leave his position effective July 15, according to Chancellor Andrew D. Martin. Thorp, who has served in his current role since 2013, plans to take a one-year sabbatical and then return to the university in a newly created leadership role in the drug discovery and […]

WashU weekly Neuroscience publications

“Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling” (2019) Current Opinion in Neurobiology Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling (2019) Current Opinion in Neurobiology, 59, pp. 59-68.  Goodman, J.V.a b , Bonni, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States b Medical Scientist Training Program, Washington […]

WashU weekly Neuroscience publications

“Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms” (2019) Nature Communications Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms (2019) Nature Communications, 10 (1), art. no. 2246, .  Li, P.a , Marshall, L.a , Oh, G.b , Jakubowski, J.L.a , Groot, D.b , He, Y.c , Wang, […]