“Pain And Opioid Systems, Implications In The Opioid Epidemic” (2019) Current Opinion in Behavioral Sciences Pain And Opioid Systems, Implications In The Opioid Epidemic (2019) Current Opinion in Behavioral Sciences, 26, pp. 69-74. Massaly, N.a b c , Morón, J.A.a b c d a Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, United States b Washington University […]
Category: School of Medicine
Does a dysfunctional biological clock increase Alzheimer’s risk?
From The San Diego Union-Tribune… Disruption of the sleep-wake cycle is a well-recognized symptom of Alzheimer’s disease, but recent research suggests that a disorganized biological clock may also be a key driver of neurodegenerative disease. An exploration of the circadian rhythm’s role in development of Alzheimer’s disease and other forms of dementia is among a […]
St. Louis researchers study non-opioid painkiller
From KMOV 4… Families continue to be devastated by the opioid epidemic. According to the Centers for Disease Control and Prevention (CDC), more than 63,000 Americans died because of a drug overdose in 2016. Nearly two-thirds of those deaths (66 percent) involved a prescription opioid or illegal opioid. Now, researchers at Washington University in St. Louis […]
Michael Bruchas Receives the Jacob P. Waletzky Award
From the Society for Neuroscience… The Society for Neuroscience (SfN) will present the Jacob P. Waletzky Award to Michael Bruchas, PhD, of the Washington University School of Medicine, at Neuroscience 2018, SfN’s annual meeting and the world’s largest source of emerging news about brain science and health. The award is given to a young scientist […]
$3 million to help expand Wolfram syndrome research
Grant to renew annual clinic, advance understanding of rare disorder From the WashU School of Medicine News… Researchers at Washington University School of Medicine in St. Louis have received a five-year, $3 million grant to study Wolfram syndrome, a rare genetic disorder that causes neurologic problems, insulin-dependent diabetes and other serious conditions. The new grant, […]
Tien-Phat Huynh, 2018 Poletsky Award recipient
Tien-Phat Huynh, MSTP Neuroscience program student in the David Holtzman Lab, has been honored with the 2018 Poletsky Award. The Poletsky Award is presented annually by the Knight Alzheimer’s Disease Research Center (Knight ADRC) at Washington University, and is intended to enhance the career development of a promising student or fellow working towards a research, […]
Grantham awarded $2.2 million training grant
Heather Grantham, associate professor in the Program in Audiology and Communication Sciences (PACS) at the School of Medicine, will be the principal investigator on a $2.2 million training grant awarded to PACS from the U.S. Department of Education. The two five-year awards will provide scholarship support and expanded training opportunities for students in the Master […]
WashU weekly Neuroscience publications
“Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study” (2019) Multiple Sclerosis and Related Disorders Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the […]
Following tragedy, St. Louis hospitals renew commitment to postpartum mental health
From the St. Louis Post-Dispatch… While pregnant with her fourth baby, Jerrika Massey felt depressed because her father died before he could meet his newest grandchild. He had always been there for her previous births. Massey didn’t tell anyone she was struggling because “I thought it was something I could handle by myself,” she said. […]
The Underestimated Cerebellum Gains New Respect From Brain Scientists
From NPR (heard on All Things Considered)… An ancient part of the brain long ignored by the scientific world appears to play a critical role in everything from language and emotions to daily planning. It’s the cerebellum, which is found in fish and lizards as well as people. But in the human brain, this structure […]
Mind’s quality control center found in long-ignored brain area
From the WashU Newsroom… The cerebellum can’t get no respect. Located inconveniently on the underside of the brain and initially thought to be limited to controlling movement, the cerebellum has long been treated like an afterthought by researchers studying higher brain functions. But researchers at Washington University School of Medicine in St. Louis say overlooking […]
WashU weekly Neuroscience publications
“Symptoms of social anxiety disorder and major depressive disorder: A network perspective” (2019) Journal of Affective Disorders Symptoms of social anxiety disorder and major depressive disorder: A network perspective (2019) Journal of Affective Disorders, 243, pp. 531-538. Langer, J.K.a , Tonge, N.A.a c , Piccirillo, M.a c , Rodebaugh, T.L.a c , Thompson, R.J.a c , Gotlib, I.H.b d […]
Cox named Wise Endowed Chair in Pediatric Anesthesiology
Noted for his talents as educator, collaborator, clinician From the WashU School of Medicine News… Thomas E. Cox, MD, an innovative educator and noted mentor and anesthesiologist at Washington University School of Medicine in St. Louis, has been named the inaugural Rudolph L. and Mary Frances Wise Endowed Chair in Pediatric Anesthesiology. Cox, a professor […]
Grad students Hailun Li and Weikang Shi win 2018 Thach Awards
Many thanks to all who participated in this year’s Neuroscience Retreat. Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition. The 2018 winners: Short Talks: Hailun Li (Neuroscience Program; DiAntonio lab) “A neuromodulatory circuit regulating the glial capacity to buffer K+” Posters: Weikang Shi (Neuroscience program; Padoa-Schioppa lab) “Establishing […]
New child maltreatment research center launched with $6.5 million NIH grant
Multidisciplinary center includes Constantino’s research on newborns From the WashU Newsroom… Melissa Jonson-Reid, the Ralph and Muriel Pumphrey Professor of Social Work Research at the Brown School, and her team, including faculty from several disciplines across Washington University in St. Louis and Saint Louis University, have received a five-year, $6,496,050 grant from the National Institutes of Health […]
Bonni, Diamond elected to National Academy of Medicine
Membership is one of highest U.S. honors in health and medicine From the WashU School of Medicine News… Neuroscientist Azad Bonni, MD, PhD, and virologist and immunologist Michael S. Diamond, MD, PhD, both of Washington University School of Medicine in St. Louis, have been elected to the National Academy of Medicine, a part of the National Academy […]
WashU weekly Neuroscience publications
“Associations between depression, anxious arousal and manifestations of psychological inflexibility” (2019) Journal of Behavior Therapy and Experimental Psychiatry Associations between depression, anxious arousal and manifestations of psychological inflexibility (2019) Journal of Behavior Therapy and Experimental Psychiatry, 62, pp. 88-96. Gilbert, K.E.a , Tonge, N.A.b , Thompson, R.J.b a Department of Psychiatry, Washington University School of Medicine, Washington University in St. […]
Implantable, biodegradable devices speed nerve regeneration in rats
Pulses of electrical stimulation help heal injured nerves From the WashU Newsroom… Car accidents, sports injuries, even too much typing and texting can injure the peripheral nerves, leaving people with numbness, tingling and weakness in their hands, arms or legs. Recovery can take months, and doctors have little to offer to speed it along. Now, […]
WashU weekly Neuroscience publications
“Examining the Role of Cone-expressed RPE65 in Mouse Cone Function” (2018) Scientific Reports Examining the Role of Cone-expressed RPE65 in Mouse Cone Function (2018) Scientific Reports, 8 (1), art. no. 14201, . Kolesnikov, A.V.a , Tang, P.H.b c , Kefalov, V.J.a a Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, United States b Department of Ophthalmology, […]
Both Sides of the Brain Are Active During One-Sided Arm Movement
From The Scientist… When you move only your right arm, there’s neural activity in both the left and right sides of the brain, researchers report today (October 8) in The Journal of Neuroscience. Recent animal and human studies have hinted that moving muscle on only one side of the body resulted in neural activity from the same side—or […]
Viruses in blood lead to digestive problems
Mouse study provides clues to sudden onset of digestive woes From the WashU Newsroom… While studying viruses best known for infecting the brain, researchers at Washington University School of Medicine in St. Louis stumbled upon clues to a conundrum involving a completely different part of the anatomy: the bowel, and why some people possibly develop […]
WashU weekly Neuroscience publications
“Distinct modes of functional connectivity induced by movie-watching” (2019) NeuroImage Distinct modes of functional connectivity induced by movie-watching (2019) NeuroImage, 184, pp. 335-348. Demirtaş, M.a b , Ponce-Alvarez, A.b , Gilson, M.b , Hagmann, P.d , Mantini, D.e f , Betti, V.g h , Romani, G.L.i , Friston, K.j , Corbetta, M.k l , Deco, G.b c m n […]
Mysteries explored: Pioneering neurologist Marcus Raichle, MD, opened up the human brain to scientific investigation
From the WashU School of Medicine’s Outlook Magazine… In a 1987 expedition, neurologist Marcus Raichle, MD, climbed 18,000 feet above sea level, scaling the icy Karakoram Mountains of Pakistan. There, amidst heavy snow and high winds, Raichle and 18 researchers injected themselves with radioactive xenon. A crude scanner measured the gas as it diffused through […]
Building independence: For 100 years, the occupational therapy program has helped people engage mind and body
From the WashU School of Medicine Outlook Magazine… In 1995, Washington University’s new chancellor, Mark S. Wrighton, paid his first visit to the Program in Occupational Therapy, which is part of the School of Medicine. Carolyn Baum, PhD, the program director, gave Wrighton a tour and asked her lean but energetic 12-member faculty to take […]
Roundtable on opioids brings HHS leaders to Medical Campus
Officials tour research lab focused on fighting opioid addiction From the WashU School of Medicine News… Leaders from the U.S. Department of Health and Human Services (HHS) visited the Washington University Medical Campus on Sept. 20 to learn about strategies to address the opioid crisis, which has claimed the lives of more than 200,000 people […]
Overlooked signal in MRI scans reflects amount, kind of brain cells
Data may aid diagnosis of brain conditions, shed light on brain development From the WashU School of Medicine News… An MRI scan often generates an ocean of data, most of which is never used. When overlooked data is analyzed using a new technique developed at Washington University School of Medicine in St. Louis, they surprisingly […]
WashU weekly Neuroscience publications
“Statistical learning and spelling: Evidence from Brazilian prephonological spellers” (2019) Cognition Statistical learning and spelling: Evidence from Brazilian prephonological spellers (2019) Cognition, 182, pp. 1-7. Treiman, R.a , Cardoso-Martins, C.b , Pollo, T.C.c , Kessler, B.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, United States b Departamento de Psicologia, Universidade Federal de Minas Gerais, Brazil c Departamento […]
WashU weekly Neuroscience publications
“Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation” (2018) World Neurosurgery Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation (2018) World Neurosurgery, 119, pp. 233-236. Baksh, B.S.a , Sinha, N.b , Salehi, A.a , Han, R.H.a , Miller, B.A.a d , Dahiya, S.b , Gauvain, K.M.c , Limbrick, D.D., Jr.a a Department of Neurological […]
‘The Curren(t)cy of Frankenstein’
Event to explore bioethics and medical practice Sept. 28-30 From the WashU Newsroom… Patient care. Informed consent. Genetics and transplantation. Mary Shelley’s “Frankenstein” is a thrilling adventure but also a prescient guidebook to the moral and ethical dilemmas of 20th and 21st century medicine. This month, Washington University in St. Louis’ School of Medicine and […]
Gordon receives Luminary Award
Precision medicine group honors father of the microbiome From the WashU Newsroom… Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has received a 2018 Luminary Award from the Precision Medicine World Conference. He is being honored for his pioneering work in founding the field of gut microbiome research and for fundamentally altering […]
Cordell Institute to take on issues of ethics, policy in data-driven health care and beyond
Institute will work at intersection of science, medicine, ethics and law From the WashU Newsroom… Precision medicine is an approach that allows doctors to more accurately treat and prevent disease by taking into consideration a patient’s data, such as his or her genetics, diet, environment and lifestyle. This approach provides a more individualized path of […]
WashU weekly Neuroscience publications
“Altered functional network connectivity relates to motor development in children born very preterm” (2018) NeuroImage Altered functional network connectivity relates to motor development in children born very preterm (2018) NeuroImage, 183, pp. 574-583. Wheelock, M.D.a , Austin, N.C.b , Bora, S.c , Eggebrecht, A.T.d , Melzer, T.R.e , Woodward, L.J.f , Smyser, C.D.d g h a Department of Psychiatry, Washington […]
Study seeks former opioid users who avoided addiction
Researchers want to understand how genetics affects opioid addiction From the WashU School of Medicine News… Individuals with a history of opioid misuse — but no history of opioid addiction — may help scientists identify genes that protect against opioid-use disorders. To that end, researchers at Washington University School of Medicine in St. Louis are […]
Gurnett named director of pediatric and developmental neurology
Physician-scientist specializes in epilepsy, neurodevelopmental disorders From the WashU School of Medicine News… Christina Gurnett, MD, PhD, a professor of neurology at Washington University School of Medicine in St. Louis, has been named director of the Division of Pediatric and Developmental Neurology at the School of Medicine and neurologist-in-chief at St. Louis Children’s Hospital. “Dr. […]
Focused delivery for brain cancers
Interdisciplinary research brings together imaging, aerosols and pediatric neuro oncology to fight tumors From the WashU Newsroom… A person’s brainstem controls some of the body’s most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating. Not only can such a growth […]
WashU weekly Neuroscience publications
“Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol” (2018) Contemporary Clinical Trials Training models for implementing evidence-based psychological treatment for college mental health: A cluster randomized trial study protocol (2018) Contemporary Clinical Trials, 72, pp. 117-125. Wilfley, D.E.a , Fitzsimmons-Craft, E.E.a , Eichen, D.M.b , Van Buren, D.J.a , Welch, […]
Experimental drug shows promise as multiple sclerosis treatment
Brain’s shrinking slows with drug From the WashU School of Medicine News… People with a progressive form of multiple sclerosis (MS) face a gradual decline of brain function that slowly strips away the ability to walk and may cause problems with speech and vision. Available treatments are only modestly effective at slowing the decline. Now, […]
Brain Initiative grants Chen $2.7 million for neuroscience study
An interdisciplinary team of WashU researchers will be developing a non-invasive neuromodulation tool From the WashU School of Engineering & Applied Science News… Hong Chen, assistant professor of biomedical engineering in the School of Engineering & Applied Science and radiation oncology in the School of Medicine, has received a $2.7 million grant from the National Institutes of […]
Washington People: Robyn Klein
Neuroimmunologist promotes diversity in science From the WashU School of Medicine News… In 2016, as Robyn Klein, MD, PhD, and Jessica Williams, PhD, then a postdoctoral fellow in Klein’s lab, looked over the program for an upcoming international neuroimmunology meeting they were planning to attend, one thing jumped out at them: Only 13 of the 85 […]
WashU weekly Neuroscience publications
“Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model” (2018) Translational Psychiatry Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model (2018) Translational Psychiatry, 8 (1), art. no. 158, . Duan, J.a b , Göring, H.H.H.c , Sanders, A.R.a b , Moy, W.a b , Freda, J.a , Drigalenko, E.I.d , Kos, M.c […]
Lasers help fight deadly brain tumors
Therapy increases survival in grim diagnosis From the WashU Newsroom… People diagnosed with the aggressive brain cancer glioblastoma face a grim prognosis. Half die within 14 months of diagnosis. Even if initial treatment with surgery, radiation and chemotherapy is successful, such brain tumors typically recur, leaving patients with few options. Now, a research team at […]
Alzheimer’s one day may be predicted during eye exam
Noninvasive test may screen for disease before symptoms appear From the WashU School of Medicine News… It may be possible in the future to screen patients for Alzheimer’s disease using an eye exam. Using technology similar to what is found in many eye doctors’ offices, researchers at Washington University School of Medicine in St. Louis […]
Depressed patients see quality of life improve with nerve stimulation
Study focuses on people not treated effectively with antidepressants From the WashU School of Medicine News… People with depression who are treated with nerve stimulation experience significant improvements in quality of life, even when their depression symptoms don’t completely subside, according to results of a national study led by researchers at Washington University School of […]
WashU weekly Neuroscience publications
“Dynamic contrast enhancement and flexible odor codes” (2018) Nature Communications Dynamic contrast enhancement and flexible odor codes (2018) Nature Communications, 9 (1), art. no. 3062, . Nizampatnam, S.a b , Saha, D.a , Chandak, R.a , Raman, B.a b a Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, United States b Department of Electrical and Systems Engineering, Washington University in […]
New approach to developing antidepressants
CRISPR technology helps target mood-boosting receptors in brain From the WashU School of Medicine News… An estimated 13 percent of Americans take antidepressant drugs for depression, anxiety, chronic pain or sleep problems. For the 14 million Americans who have clinical depression, roughly one third don’t find relief with antidepressants. But now, researchers at Washington University […]
Many Faces of Neurofibromatosis
Art installation at School of Medicine depicts humanity of NF patients From the WashU School of Medicine News… Large, glossy oil paintings of people enjoying the small pleasures of everyday life – reading, practicing martial arts, scooping ice cream – line the hallways in the Farrell Learning and Teaching Center at Washington University School of […]
Diagnosing Depression in Young Kids is Harder, Incredibly Important
Experts agree that preschoolers are entirely capable of suffering from clinical depression. And that this depression is not always the result of abuse or neglect. From Fatherly… Until he began doodling bloody pictures of bleeding necks, April Lisbon wasn’t worried about the mental health of her four-year-old student. As a psychologist working with young children […]
WashU weekly Neuroscience publications
“Matrine inhibits itching by lowering the activity of calcium channel” (2018) Scientific Reports Matrine inhibits itching by lowering the activity of calcium channel (2018) Scientific Reports, 8 (1), art. no. 11328, . Geng, X.a , Shi, H.a , Ye, F.a , Du, H.b , Qian, L.a , Gu, L.a , Wu, G.a , Zhu, C.a , Yang, Y.a , Wang, C.a […]
Scientists uncover new details in how sense of smell develops
Findings could help determine how dogs evolved such good noses From the WashU School of Medicine News… Dogs, known for their extraordinarily keen senses of smell, can be trained to use their sensitive sniffers to find drugs, bombs, bed bugs, missing hikers and even cancer. Among dogs and other animals that rely on smell, at […]
How bacteria can save children’s lives
A ground-breaking new project in Bangladesh could help reduce the life-long health problems that come from childhood malnourishment – by focusing on the gut. From BBC – Future… For decades, undernourished infants across the world have been treated with a course of high-calorie, high-protein rich foods. The foods may come in various forms – from […]