Cancerous tumors, surrounding cells illuminated by new imaging agent

Scientists at Washington University School of Medicine in St. Louis have developed a new imaging agent that could let doctors identify not only multiple types of tumors but the surrounding normal cells that the cancer takes over and uses as a shield to protect itself from attempts to destroy it. The study appears March 9 […]

Medical students lead effort to collect masks, gowns, gloves, eye protection

With cases of the novel coronavirus on the rise in the St. Louis region, Washington University in St. Louis is anticipating shortages of personal protective equipment (PPE) — such as masks, gowns, gloves and eyewear — at university-affiliated hospitals and clinics. As work is reduced in university laboratories, medical students are asking researchers to collect […]

WashU weekly Neuroscience publications

“Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study” (2020) Journal of Stroke and Cerebrovascular Diseases Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study (2020) Journal of Stroke and Cerebrovascular Diseases, 29 (4), art. no. 104645, .  Cross, D.B.a , Tiu, J.c , Medicherla, C.a , Ishida, K.a , Lord, A.a , Czeisler, B.a , Wu, C.a , Golub, D.a […]

Washington University to break ground on major neuroscience research hub

Washington University in St. Louis will begin construction in March on what will be one of the largest neuroscience research buildings in the country. Located on the School of Medicine campus, the 11-story, state-of-the-art research facility will merge, cultivate and advance some of the world’s leading neuroscience research. The 609,000-square-foot facility and interconnected projects initially […]

WashU weekly Neuroscience publications

“Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology” (2020) Scientific Reports Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) Scientific Reports, 10 (1), art. no. 2975, .  Shen, X.a , Ma, S.a , Vemuri, P.b , Simon, G.a , Weiner, M.W.c , Aisen, P.d , Petersen, R.b , Jack, C.R.b , Saykin, A.J.e , […]

WashU weekly Neuroscience publications

“Genomic prediction of alcohol-related morbidity and mortality” (2020) Translational Psychiatry Genomic prediction of alcohol-related morbidity and mortality (2020) Translational Psychiatry, 10 (1), art. no. 23, .  Kiiskinen, T.a f , Mars, N.J.f , Palviainen, T.f , Koskela, J.f , Rämö, J.T.f , Ripatti, P.f , Ruotsalainen, S.f , Palotie, A.f g h , Madden, P.A.F.b , Rose, R.J.c , Kaprio, J.d […]

Diabetes in mice cured rapidly using human stem cell strategy

Researchers have converted human stem cells into insulin-producing cells and demonstrated in mice infused with such cells that blood sugar levels can be controlled and diabetes functionally cured for nine months. The findings, from researchers at Washington University School of Medicine in St. Louis, are published online Feb. 24 in the journal Nature Biotechnology. “These […]

WashU weekly Neuroscience publications

“Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex” (2020) Communications Biology Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex (2020) Communications Biology, 3 (1), art. no. 64, .  Zhang, M.a c , Kwon, S.E.b d , Ben-Johny, M.a e , O’Connor, D.H.b , Issa, J.B.a f a Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, […]

Bomb-sniffing grasshoppers: the next frontier for public security?

Bomb-sniffing cyborg grasshoppers have been created by scientists to detect explosives such as TNT. Academics at Washington University in Missouri tapped into the insects’ minds to monitor whether they were smelling explosives, and if so, what kind they were detecting. Or as the researchers put it, the “bio-hacked” grasshoppers play a similar role to a “canary […]

WashU weekly Neuroscience publications

“Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures” (2020) Scientific Reports Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures (2020) Scientific Reports, 10 (1), art. no. 1980, .  Iskandar, H.N.a , Linan, E.E.b , Patel, A.c , Moore, R.d , Lasanajak, Y.d , Gyawali, C.P.b , Sayuk, G.S.b e , Ciorba, […]

WashU weekly Neuroscience publications

“Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy” (2020) Nature Communications Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy (2020) Nature Communications, 11 (1), art. no. 595, .  Hengel, H.a b , Bosso-Lefèvre, C.c d , Grady, G.e , Szenker-Ravi, E.c , Li, H.f , Pierce, S.g , Lebigot, É.h , Tan, T.-T.i , Eio, M.Y.i , […]

Collaboration lets researchers ‘read’ proteins for new properties

Clumps of proteins inside cells are a common thread in many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease. These clumps, or solid aggregates of proteins, appear to be the result of an abnormality in the process known as liquid-liquid phase separation (LLPS), in which individual proteins come together to form a […]

WashU weekly Neuroscience publications

“FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease” (2020) Nature Communications FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2020) Nature Communications, 11 (1), art. no. 411, .  Yan, T.a , Liang, J.b , Gao, J.a , Wang, L.a , Fujioka, H.c , Weiner, M.W.d , Schuff, N.d , Rosen, H.J.d , Miller, B.L.d , […]

What a lifetime of playing football can do to the human brain

Football isn’t just a contact sport — it’s a dangerous game of massive bodies colliding into one another. And while it may seem obvious that this sport can do extraordinary damage to brains and bodies, it’s taken far too long for the NFL, the medical community, and football fans to fully reckon with this. Doctors […]

WashU weekly Neuroscience publications

“Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning” (2020) Information Fusion Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning (2020) Information Fusion, 58, pp. 153-167.  Castillo-Barnes, D.a , Su, L.b , Ramírez, J.a , Salas-Gonzalez, D.a , Martinez-Murcia, F.J.c , Illan, I.A.a , Segovia, F.a , Ortiz, A.c , Cruchaga, C.d […]

WashU weekly Neuroscience publications

“Structural basis for adhesion G protein-coupled receptor Gpr126 function” (2020) Nature Communications Structural basis for adhesion G protein-coupled receptor Gpr126 function (2020) Nature Communications, 11 (1), art. no. 194, .  Leon, K.a b , Cunningham, R.L.c , Riback, J.A.a d , Feldman, E.a , Li, J.a b , Sosnick, T.R.a e , Zhao, M.a , Monk, K.R.c f , Araç, D.a […]

Wendland appointed Washington University provost

Beverly Wendland, the James B. Knapp Dean of the Krieger School of Arts & Sciences at Johns Hopkins University, has been appointed provost of Washington University in St. Louis, effective July 1, according to Chancellor Andrew D. Martin. Wendland will succeed Marion Crain, who has served as interim provost since July 2019. A member of the Johns […]

Division of Computational and Data Sciences marries AI, social science

Every day, social service professionals tackle complex problems across varying domains, working to determine which interventions are likely to be effective, fair and within an agency’s capabilities. For a struggling parent in danger of losing their home, which alternative would prove more helpful in the long run, housing assistance or job training? Might a child […]

WashU weekly Neuroscience publications

“Diffusion basis spectrum imaging provides insights into MS pathology” (2020) Neurology(R) Neuroimmunology & Neuroinflammation Diffusion basis spectrum imaging provides insights into MS pathology (2020) Neurology(R) Neuroimmunology & Neuroinflammation, 7 (2), .  Sun, P., George, A., Perantie, D.C., Trinkaus, K., Ye, Z., Naismith, R.T., Song, S.-K., Cross, A.H. From the Radiology (P.S., A.G., Z.Y., S.-K.S.), Washington University in Saint Louis, […]

These St. Louis Scientists Are Shaking Human Brains To Study Head Trauma

Philip Bayly has spent years trying to figure out the best way to jiggle a brain. The mechanical engineer is part of a team of researchers at Washington University studying how a jolt to the head can shake the brain — the kind of injury a football player suffers when crashing into an opponent. Using […]

WashU weekly Neuroscience publications

“Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage” (2020) Clinical Neurology and Neurosurgery Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage (2020) Clinical Neurology and Neurosurgery, 190, art. no. 105657, .  Garton, A.L.a , Gupta, V.P.b , Pucci, J.U.c , Couch, C.K.d , Connolly, E.S., Jrc […]

WashU weekly Neuroscience publications

“Clinical instrument to retrospectively capture levels of EDSS” (2020) Multiple Sclerosis and Related Disorders Clinical instrument to retrospectively capture levels of EDSS (2020) Multiple Sclerosis and Related Disorders, 39, art. no. 101884, .  Ciotti, J.R.a , Sanders, N.b , Salter, A.c , Berger, J.R.d , Cross, A.H.a , Chahin, S.a a Department of Neurology, Washington University in St. Louis, St. Louis, […]

WashU weekly Neuroscience publications

“Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan” (2020) NeuroImage Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan (2020) NeuroImage, 208, art. no. 116450, .  Pomponio, R.a , Erus, G.a , Habes, M.a b , Doshi, J.a , Srinivasan, D.a , Mamourian, E.a , Bashyam, V.a […]

WashU weekly Neuroscience publications

“Structural correlates of commission errors in prospective memory” (2020) Cortex Structural correlates of commission errors in prospective memory (2020) Cortex, 124, pp. 44-53.  Scullin, M.K.a , Ball, B.H.b c , Bugg, J.M.b a Baylor University, United States b Washington University in St. Louis, United States c University of Texas, Arlington, United States Abstract Prospective memory refers to remembering to perform an intended […]

Restoring arm, hand function after spinal cord injury focus of clinical trial

Spinal cord injuries caused by accidents, violence and disease paralyze from the neck down more than 5,000 people every year. In the first few months after injury, some people regain some movement and sensation in their limbs. Those who do not show improvement in the first few months are unlikely to ever recover. Now, a […]

WashU weekly Neuroscience publications

“The impact of dopamine D2-like agonist/antagonist on (18F)VAT PET measurement of VAChT in the brain of nonhuman primates” (2020) European Journal of Pharmaceutical Sciences The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates (2020) European Journal of Pharmaceutical Sciences, 143, art. no. 105152, .  Liu, H.a , Luo, Z.a , Gu, […]

WashU weekly Neuroscience publications

“Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear” (2020) Hearing Research Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear (2020) Hearing Research, 385, art. no. 107839, .  Wan, L.a , Lovett, M.b , Warchol, M.E.c , Stone, J.S.a a Virginia Merrill Bloedel Hearing […]

WashU weekly Neuroscience publications

“A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease” (2020) Neurobiology of Disease A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease (2020) Neurobiology of Disease, 134, art. no. 104647, .  Aflaki, E.a , Stubblefield, B.K.a , McGlinchey, R.P.b , McMahon, B.a , Ory, D.S.c , Sidransky, E.a a Section of Molecular Neurogenetics, National Human Genome Research […]

WashU weekly Neuroscience publications

“Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems” (2020) Bone Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems (2020) Bone, 130, art. no. 115144, .  Maximova, N.a , Zennaro, F.b , Gregori, M.a , Boz, G.c , Zanon, […]

WUSTL ENDURE Neuroscience Pipeline Program

The WUSTL Neuroscience Pipeline program prepares undergraduates from diverse backgrounds for neuroscience PhD programs. With support from the NIH Blueprint ENDURE Program and WUSTL, accepted students are funded for up to two 10-week summers. The program combines independent research and a rigorous summer curriculum of courses and workshops that focus on building a foundation in […]

WashU weekly Neuroscience publications

“Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis” (2019) Journal of Anxiety Disorders Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis (2019) Journal of […]

WashU weekly Neuroscience publications

“Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction” (2020) Early Human Development Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction (2020) Early Human Development, 140, art. no. 104891, .  Whitehead, H.V.a , Vesoulis, Z.A.a , Maheshwari, A.b , Rambhia, A.a , Mathur, A.M.c a Department of Pediatrics, Division of […]

WashU weekly Neuroscience publications

“Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex” (2020) Neurobiology of Disease Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex (2020) Neurobiology of Disease, 134, art. no. 104615, .  Zhang, B.a , Guo, D.a , Han, L.a , […]

New student cohort welcomed to campus

The McKelvey School of Engineering at Washington University in St. Louis recently welcomed the first cohort of students funded by a prestigious new grant from the China Scholarship Council, the Chinese Ministry of Education’s branch that oversees international exchange and collaboration. The award establishes an “International Cooperative Program for Innovative Talents” (ICPIT) and makes possible […]

WashU weekly Neuroscience publications

“Identifying reproducible individual differences in childhood functional brain networks: An ABCD study” (2019) Developmental Cognitive Neuroscience Identifying reproducible individual differences in childhood functional brain networks: An ABCD study (2019) Developmental Cognitive Neuroscience, 40, art. no. 100706, .  Marek, S.a , Tervo-Clemmens, B.b , Nielsen, A.N.c , Wheelock, M.D.a , Miller, R.L.d , Laumann, T.O.a , Earl, E.f , Foran, W.W.e […]

Where’s my car? WashU researchers to study short-term working memory

When we drive to a place and park the car, most of us walk away without giving any thought about how to find the car when we want to leave. A team of researchers at Washington University in St. Louis plans to study how and where the brain stores this type of information so that […]

WashU weekly Neuroscience publications

“Alzheimer Disease: An Update on Pathobiology and Treatment Strategies” (2019) Cell Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) Cell, 179 (2), pp. 312-339.  Long, J.M., Holtzman, D.M. Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, United States Abstract Long […]

Chen awarded $310K from National Institute on Aging of the NIH

Hong Chen, assistant professor at the McKelvey School of Engineering and at the School of Medicine, received a $309,909 grant from the National Institute on Aging of the National Institutes of Health (NIH) to explore the application of a focused ultrasound-mediated drug delivery technique for treating Alzheimer’s disease. Read more.

WashU weekly Neuroscience publications

“Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers” (2019) Neurobiology of Aging Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers (2019) Neurobiology of Aging, 83, pp. 54-62.  Chen, Q.a b , Boeve, B.F.c , Schwarz, C.G.b , Reid, R.b , Tosakulwong, N.d , Lesnick, T.G.d , Bove, J.e , Brannelly, P.f , Brushaber, […]

Yang Shi and Tamara Markovic win 2019 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition. Congratulations to the 2019 Thach Award winners: Short Talks: Yang Shi, PhD (Holtzman lab, WashU Neurology) “Microglia drive neurodegeneration and mediate APOE’s effect on neurodegeneration in a tauopathy mouse […]

WashU weekly Neuroscience publications

“The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability” (2019) NeuroImage The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability (2019) NeuroImage, 202, art. no. 115990, .  Betzel, R.F.a b c , Bertolero, M.A.a , Gordon, E.M.d e , Gratton, C.f g , Dosenbach, N.U.F.f h i , […]

Imaging technology could better monitor tumor growth, drug effectiveness

More than 90% of drugs in development never make it to market after failing in the testing process, either in cells in the lab, in small animals or in humans. A biomedical engineer in the McKelvey School of Engineering at Washington University in St. Louis plans to improve on an existing imaging method that will […]

New Imaging “Blinks” So You Don’t Miss Proteins Causing Alzheimers & Other Age-Related Diseases

Tiny protein structures called amyloids are key to understanding certain devastating age-related diseases. Amyloids form plaques in the brain, and are the main culprits in the progression of Alzheimer’s and Huntington’s diseases. “In patients you see these huge plaques, but that’s the endpoint of the disease. It’s not the beginning,” said Matthew Lew, PhD, assistant […]

WashU weekly Neuroscience publications

“Pioglitazone improves working memory performance when administered in chronic TBI” (2019) Neurobiology of Disease Pioglitazone improves working memory performance when administered in chronic TBI (2019) Neurobiology of Disease, 132, art. no. 104611, .  McGuire, J.L.a , Correll, E.A.a , Lowery, A.C.b , Rhame, K.c , Anwar, F.N.d , McCullumsmith, R.E.e , Ngwenya, L.B.a f a Department of Neurosurgery, University of Cincinnati, […]

Multi-institutional team to study effects of age, gender on brain injury mechanics

Traumatic brain injury and chronic traumatic encephalopathy (CTE) have become common in athletes who suffer repeated blows to the head. Most recently, former New England Patriots tight end Rob Gronkowski revealed that he had sustained about 20 concussions during his nine-year career in the National Football League. Now, a team of researchers nationwide, led by Philip […]

NSF awards $380K to Chakrabartty

Shantanu Chakrabartty, the Clifford Murphy Professor in the McKelvey School of Engineering at Washington University in St. Louis, recently received a $380,000 grant from the National Science Foundation to address a persistent problem when it comes to recreating the brain’s neuronal networks in silicon: energy efficiency. This is known as the “neuron-to-network energy gap.” His research also […]

Finding first principles last: A new control methodology

If an aeronautical engineer wants to make sure a plane stays steady in the air, she might first build a computational model, feeding into it variables such as information about the plane’s weight or the thrust that can be achieved, together with the laws of aerodynamics, which account for how a plane moves through the […]

WashU weekly Neuroscience publications

“Large posttraumatic stress disorder improvement and antidepressant medication adherence” (2020) Journal of Affective Disorders Large posttraumatic stress disorder improvement and antidepressant medication adherence (2020) Journal of Affective Disorders, 260, pp. 119-123.  Salas, J.a b , Scherrer, J.F.a b , Tuerk, P.c , van den Berk-Clark, C.a , Chard, K.M.d , Schneider, F.D.e , Schnurr, P.P.f , Friedman, M.J.f , […]

Light-activated nanoheaters may control nerve cells, locust mind

The neurons in our brains are its basic computational units analogous to a computer transistor. They process information and send and receive messages to and from the rest of our bodies. Engineers at Washington University in St. Louis want to know if they can control certain neurons using nanotechnology to better understand behavior and disease. […]