WashU weekly Neuroscience publications

“Structural basis for adhesion G protein-coupled receptor Gpr126 function” (2020) Nature Communications Structural basis for adhesion G protein-coupled receptor Gpr126 function (2020) Nature Communications, 11 (1), art. no. 194, .  Leon, K.a b , Cunningham, R.L.c , Riback, J.A.a d , Feldman, E.a , Li, J.a b , Sosnick, T.R.a e , Zhao, M.a , Monk, K.R.c f , Araç, D.a […]

Wendland appointed Washington University provost

Beverly Wendland, the James B. Knapp Dean of the Krieger School of Arts & Sciences at Johns Hopkins University, has been appointed provost of Washington University in St. Louis, effective July 1, according to Chancellor Andrew D. Martin. Wendland will succeed Marion Crain, who has served as interim provost since July 2019. A member of the Johns […]

Division of Computational and Data Sciences marries AI, social science

Every day, social service professionals tackle complex problems across varying domains, working to determine which interventions are likely to be effective, fair and within an agency’s capabilities. For a struggling parent in danger of losing their home, which alternative would prove more helpful in the long run, housing assistance or job training? Might a child […]

WashU weekly Neuroscience publications

“Diffusion basis spectrum imaging provides insights into MS pathology” (2020) Neurology(R) Neuroimmunology & Neuroinflammation Diffusion basis spectrum imaging provides insights into MS pathology (2020) Neurology(R) Neuroimmunology & Neuroinflammation, 7 (2), .  Sun, P., George, A., Perantie, D.C., Trinkaus, K., Ye, Z., Naismith, R.T., Song, S.-K., Cross, A.H. From the Radiology (P.S., A.G., Z.Y., S.-K.S.), Washington University in Saint Louis, […]

These St. Louis Scientists Are Shaking Human Brains To Study Head Trauma

Philip Bayly has spent years trying to figure out the best way to jiggle a brain. The mechanical engineer is part of a team of researchers at Washington University studying how a jolt to the head can shake the brain — the kind of injury a football player suffers when crashing into an opponent. Using […]

WashU weekly Neuroscience publications

“Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage” (2020) Clinical Neurology and Neurosurgery Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage (2020) Clinical Neurology and Neurosurgery, 190, art. no. 105657, .  Garton, A.L.a , Gupta, V.P.b , Pucci, J.U.c , Couch, C.K.d , Connolly, E.S., Jrc […]

WashU weekly Neuroscience publications

“Clinical instrument to retrospectively capture levels of EDSS” (2020) Multiple Sclerosis and Related Disorders Clinical instrument to retrospectively capture levels of EDSS (2020) Multiple Sclerosis and Related Disorders, 39, art. no. 101884, .  Ciotti, J.R.a , Sanders, N.b , Salter, A.c , Berger, J.R.d , Cross, A.H.a , Chahin, S.a a Department of Neurology, Washington University in St. Louis, St. Louis, […]

WashU weekly Neuroscience publications

“Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan” (2020) NeuroImage Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan (2020) NeuroImage, 208, art. no. 116450, .  Pomponio, R.a , Erus, G.a , Habes, M.a b , Doshi, J.a , Srinivasan, D.a , Mamourian, E.a , Bashyam, V.a […]

WashU weekly Neuroscience publications

“Structural correlates of commission errors in prospective memory” (2020) Cortex Structural correlates of commission errors in prospective memory (2020) Cortex, 124, pp. 44-53.  Scullin, M.K.a , Ball, B.H.b c , Bugg, J.M.b a Baylor University, United States b Washington University in St. Louis, United States c University of Texas, Arlington, United States Abstract Prospective memory refers to remembering to perform an intended […]

Restoring arm, hand function after spinal cord injury focus of clinical trial

Spinal cord injuries caused by accidents, violence and disease paralyze from the neck down more than 5,000 people every year. In the first few months after injury, some people regain some movement and sensation in their limbs. Those who do not show improvement in the first few months are unlikely to ever recover. Now, a […]

WashU weekly Neuroscience publications

“The impact of dopamine D2-like agonist/antagonist on (18F)VAT PET measurement of VAChT in the brain of nonhuman primates” (2020) European Journal of Pharmaceutical Sciences The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates (2020) European Journal of Pharmaceutical Sciences, 143, art. no. 105152, .  Liu, H.a , Luo, Z.a , Gu, […]

WashU weekly Neuroscience publications

“Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear” (2020) Hearing Research Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear (2020) Hearing Research, 385, art. no. 107839, .  Wan, L.a , Lovett, M.b , Warchol, M.E.c , Stone, J.S.a a Virginia Merrill Bloedel Hearing […]

WashU weekly Neuroscience publications

“A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease” (2020) Neurobiology of Disease A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson’s disease (2020) Neurobiology of Disease, 134, art. no. 104647, .  Aflaki, E.a , Stubblefield, B.K.a , McGlinchey, R.P.b , McMahon, B.a , Ory, D.S.c , Sidransky, E.a a Section of Molecular Neurogenetics, National Human Genome Research […]

WashU weekly Neuroscience publications

“Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems” (2020) Bone Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems (2020) Bone, 130, art. no. 115144, .  Maximova, N.a , Zennaro, F.b , Gregori, M.a , Boz, G.c , Zanon, […]

WUSTL ENDURE Neuroscience Pipeline Program

The WUSTL Neuroscience Pipeline program prepares undergraduates from diverse backgrounds for neuroscience PhD programs. With support from the NIH Blueprint ENDURE Program and WUSTL, accepted students are funded for up to two 10-week summers. The program combines independent research and a rigorous summer curriculum of courses and workshops that focus on building a foundation in […]

WashU weekly Neuroscience publications

“Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis” (2019) Journal of Anxiety Disorders Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis (2019) Journal of […]

WashU weekly Neuroscience publications

“Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction” (2020) Early Human Development Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction (2020) Early Human Development, 140, art. no. 104891, .  Whitehead, H.V.a , Vesoulis, Z.A.a , Maheshwari, A.b , Rambhia, A.a , Mathur, A.M.c a Department of Pediatrics, Division of […]

WashU weekly Neuroscience publications

“Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex” (2020) Neurobiology of Disease Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex (2020) Neurobiology of Disease, 134, art. no. 104615, .  Zhang, B.a , Guo, D.a , Han, L.a , […]

New student cohort welcomed to campus

The McKelvey School of Engineering at Washington University in St. Louis recently welcomed the first cohort of students funded by a prestigious new grant from the China Scholarship Council, the Chinese Ministry of Education’s branch that oversees international exchange and collaboration. The award establishes an “International Cooperative Program for Innovative Talents” (ICPIT) and makes possible […]

WashU weekly Neuroscience publications

“Identifying reproducible individual differences in childhood functional brain networks: An ABCD study” (2019) Developmental Cognitive Neuroscience Identifying reproducible individual differences in childhood functional brain networks: An ABCD study (2019) Developmental Cognitive Neuroscience, 40, art. no. 100706, .  Marek, S.a , Tervo-Clemmens, B.b , Nielsen, A.N.c , Wheelock, M.D.a , Miller, R.L.d , Laumann, T.O.a , Earl, E.f , Foran, W.W.e […]

Where’s my car? WashU researchers to study short-term working memory

When we drive to a place and park the car, most of us walk away without giving any thought about how to find the car when we want to leave. A team of researchers at Washington University in St. Louis plans to study how and where the brain stores this type of information so that […]

WashU weekly Neuroscience publications

“Alzheimer Disease: An Update on Pathobiology and Treatment Strategies” (2019) Cell Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) Cell, 179 (2), pp. 312-339.  Long, J.M., Holtzman, D.M. Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, United States Abstract Long […]

Chen awarded $310K from National Institute on Aging of the NIH

Hong Chen, assistant professor at the McKelvey School of Engineering and at the School of Medicine, received a $309,909 grant from the National Institute on Aging of the National Institutes of Health (NIH) to explore the application of a focused ultrasound-mediated drug delivery technique for treating Alzheimer’s disease. Read more.

WashU weekly Neuroscience publications

“Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers” (2019) Neurobiology of Aging Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers (2019) Neurobiology of Aging, 83, pp. 54-62.  Chen, Q.a b , Boeve, B.F.c , Schwarz, C.G.b , Reid, R.b , Tosakulwong, N.d , Lesnick, T.G.d , Bove, J.e , Brannelly, P.f , Brushaber, […]

Yang Shi and Tamara Markovic win 2019 Thach Awards

Many thanks to all who participated in this year’s Neuroscience Retreat.  Graduate student and post doc presenters at the Retreat were eligible for the Thach Award competition. Congratulations to the 2019 Thach Award winners: Short Talks: Yang Shi, PhD (Holtzman lab, WashU Neurology) “Microglia drive neurodegeneration and mediate APOE’s effect on neurodegeneration in a tauopathy mouse […]

WashU weekly Neuroscience publications

“The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability” (2019) NeuroImage The community structure of functional brain networks exhibits scale-specific patterns of inter- and intra-subject variability (2019) NeuroImage, 202, art. no. 115990, .  Betzel, R.F.a b c , Bertolero, M.A.a , Gordon, E.M.d e , Gratton, C.f g , Dosenbach, N.U.F.f h i , […]

Imaging technology could better monitor tumor growth, drug effectiveness

More than 90% of drugs in development never make it to market after failing in the testing process, either in cells in the lab, in small animals or in humans. A biomedical engineer in the McKelvey School of Engineering at Washington University in St. Louis plans to improve on an existing imaging method that will […]

New Imaging “Blinks” So You Don’t Miss Proteins Causing Alzheimers & Other Age-Related Diseases

Tiny protein structures called amyloids are key to understanding certain devastating age-related diseases. Amyloids form plaques in the brain, and are the main culprits in the progression of Alzheimer’s and Huntington’s diseases. “In patients you see these huge plaques, but that’s the endpoint of the disease. It’s not the beginning,” said Matthew Lew, PhD, assistant […]

WashU weekly Neuroscience publications

“Pioglitazone improves working memory performance when administered in chronic TBI” (2019) Neurobiology of Disease Pioglitazone improves working memory performance when administered in chronic TBI (2019) Neurobiology of Disease, 132, art. no. 104611, .  McGuire, J.L.a , Correll, E.A.a , Lowery, A.C.b , Rhame, K.c , Anwar, F.N.d , McCullumsmith, R.E.e , Ngwenya, L.B.a f a Department of Neurosurgery, University of Cincinnati, […]

Multi-institutional team to study effects of age, gender on brain injury mechanics

Traumatic brain injury and chronic traumatic encephalopathy (CTE) have become common in athletes who suffer repeated blows to the head. Most recently, former New England Patriots tight end Rob Gronkowski revealed that he had sustained about 20 concussions during his nine-year career in the National Football League. Now, a team of researchers nationwide, led by Philip […]

NSF awards $380K to Chakrabartty

Shantanu Chakrabartty, the Clifford Murphy Professor in the McKelvey School of Engineering at Washington University in St. Louis, recently received a $380,000 grant from the National Science Foundation to address a persistent problem when it comes to recreating the brain’s neuronal networks in silicon: energy efficiency. This is known as the “neuron-to-network energy gap.” His research also […]

Finding first principles last: A new control methodology

If an aeronautical engineer wants to make sure a plane stays steady in the air, she might first build a computational model, feeding into it variables such as information about the plane’s weight or the thrust that can be achieved, together with the laws of aerodynamics, which account for how a plane moves through the […]

WashU weekly Neuroscience publications

“Large posttraumatic stress disorder improvement and antidepressant medication adherence” (2020) Journal of Affective Disorders Large posttraumatic stress disorder improvement and antidepressant medication adherence (2020) Journal of Affective Disorders, 260, pp. 119-123.  Salas, J.a b , Scherrer, J.F.a b , Tuerk, P.c , van den Berk-Clark, C.a , Chard, K.M.d , Schneider, F.D.e , Schnurr, P.P.f , Friedman, M.J.f , […]

Light-activated nanoheaters may control nerve cells, locust mind

The neurons in our brains are its basic computational units analogous to a computer transistor. They process information and send and receive messages to and from the rest of our bodies. Engineers at Washington University in St. Louis want to know if they can control certain neurons using nanotechnology to better understand behavior and disease. […]

WashU weekly Neuroscience publications

“Alternative ecological strategies lead to avian brain size bimodality in variable habitats” (2019) Nature Communications Alternative ecological strategies lead to avian brain size bimodality in variable habitats (2019) Nature Communications, 10 (1), art. no. 3818, .  Fristoe, T.S.a b , Botero, C.A.b a Department of Biology, University of Konstanz, Universitätsstraße 10, Konstanz, 78464, Germany b Department of Biology, Washington University in St. Louis, […]

New, fundamental limit to ‘seeing and believing’ in imaging

Answers to big questions increasingly require access to the realm of the very small. As researchers continue to push the limits of imaging, a scientist at Washington University in St. Louis has uncovered a fundamental barrier to accuracy when it comes to measuring the rotational motion of molecules. Lew Matthew Lew, assistant professor in the […]

Cindy Brantmeier named inaugural WashU Faculty Fellow in International Research

Dear Colleagues, I am pleased to announce that Dr. Cindy Brantmeier has been selected to serve as the first Faculty Fellow in International Research for the School of Medicine and Danforth Campus. The Faculty Fellow in International Research will advise faculty on conducting international research and achieving effective collaborations with international partners that are compliant […]

WashU weekly Neuroscience publications

“Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter” (2019) Scientific Reports Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter (2019) Scientific Reports, 9 (1), art. no. 12246, .  Fukutomi, H.a b , Glasser, M.F.c d , Murata, K.e , […]

New faculty join McKelvey School of Engineering

Ten new faculty are set to join the McKelvey School of Engineering, bringing the total number of full-time faculty to more than 140, including 98 tenured and tenure-track faculty. “With opening of Henry A. and Elvira H. Jubel Hall for Mechanical Engineering and Materials Science and with the ongoing construction of James M. McKelvey, Sr. […]

WashU weekly Neuroscience publications

"Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex" (2019) Scientific Reports Differential neural dynamics underling pragmatic and semantic affordance processing in macaque ventral premotor cortex(2019) Scientific Reports, 9 (1), art. no. 11700, .  Maranesi, M.a , Bruni, S.a b , Livi, A.a c , Donnarumma, F.d , Pezzulo, G.d , Bonini, L.a a Department of Medicine […]

WashU weekly Neuroscience publications

“Sleep disturbances in Wolfram syndrome” (2019) Orphanet Journal of Rare Diseases Sleep disturbances in Wolfram syndrome (2019) Orphanet Journal of Rare Diseases, 14 (1), art. no. 188, .  Licis, A.a , Davis, G.d e , Eisenstein, S.A.b c , Lugar, H.M.b , Hershey, T.a b c a Department of Neurology, Washington University, School of Medicine, Campus Box 8111, 660 South Euclid Ave, […]

WashU weekly Neuroscience publications

“Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia” (2019) Scientific Reports Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia (2019) Scientific Reports, 9 (1), art. no. 10854, .  Bonham, L.W.a b , Steele, N.Z.R.a , Karch, C.M.c […]

WashU weekly Neuroscience publications

“A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings” (2019) Journal of Substance Abuse Treatment A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings (2019) Journal of Substance Abuse Treatment, 104, pp. 135-143.  Presnall, N.J.a b , Wolf, D.A.P.S.a , Brown, D.S.a , Beeler-Stinn, S.a , Grucza, R.A.b a Brown School of […]

Culver named Sherwood Moore Professor of Radiology

Joseph P. Culver, PhD, a professor of radiology recognized for helping develop optical neuroimaging technologies to map brain function in humans and animals, has been named the inaugural Sherwood Moore Professor of Radiology. Based at the university’s Mallinckrodt Institute of Radiology (MIR), Culver’s lab is notable for advancing diffuse optical tomography (DOT), a technology that uses light […]

WashU weekly Neuroscience publications

“CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)” (2019) Scientific Reports CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease) (2019) Scientific Reports, 9 (1), art. no. 9891, .  Eaton, S.L.a , Proudfoot, C.a , Lillico, S.G.a , Skehel, P.b c , Kline, R.A.a , Hamer, K.e , Rzechorzek, N.M.d […]

BrainWorks: Theater production explores wonders of human brain

Two nationally renowned neurosurgeons at Washington University School of Medicine in St. Louis will present “BrainWorks,” a live theatrical performance that explores the wonders of the human brain by dramatizing real-life neurological cases. The performance, comprised of four one-act plays, will debut July 19-21 at the Loretto-Hilton Center for the Performing Arts at Webster University. Albert Kim, […]

WashU weekly Neuroscience publications

“A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation” (2019) Molecular Genetics and Metabolism Reports A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation (2019) Molecular Genetics and Metabolism Reports, 20, art. no. 100484, .  Ahmed, A.a , Ou, L.b , Rudser, K.c , […]

WashU weekly Neuroscience publications

“Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns” (2019) Nature Communications Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns (2019) Nature Communications, 10 (1), art. no. 2548, .  Czamara, D.a , Eraslan, G.b c , Page, C.M.d e , Lahti, J.f g , Lahti-Pulkkinen, M.f h , Hämäläinen, E.i […]

WashU weekly Neuroscience publications

“High-fidelity mapping of repetition-related changes in the parietal memory network” (2019) NeuroImage High-fidelity mapping of repetition-related changes in the parietal memory network (2019) NeuroImage, 199, pp. 427-439.  Gilmore, A.W.a , Nelson, S.M.h i j , Laumann, T.O.b c , Gordon, E.M.h i , Berg, J.J.a , Greene, D.J.c d , Gratton, C.b , Nguyen, A.L.b , Ortega, M.b , […]