WashU weekly Neuroscience publications

“Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases” (2022) Neural Regeneration Research Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases (2022) Neural Regeneration Research, 17 (4), pp. 867-874.  Li, H., Knight, W., Xu, J. Department of Radiology, Washington University School of Medicine, St. Louis, […]

‘First-in-class’ tool for potential treatment of brain disorders

New methods to treat human brain disorders is one of the top priorities of the National Institutes of Health’s ambitious BRAIN Initiative. To find noninvasive tools that are equally or more effective is a kind of Holy Grail for neuroscience, and a biomedical engineer at Washington University in St. Louis has it in her sights. […]

WashU weekly Neuroscience publications

“The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons” (2021) Cell and Bioscience The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons (2021) Cell and Bioscience, 11 (1), art. no. 167, .  Zhang, Y.a b f , Ma, S.a b , Ke, X.a b , Yi, Y.a b , Yu, H.a b , Yu, D.a b , Li, Q.c , Shang, Y.b d , Lu, […]

WashU weekly Neuroscience publications

"A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System" (2021) Scientific Reports A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System(2021) Scientific Reports, 11 (1), art. no. 16896, .  Camilleri, J.A.a b , Eickhoff, S.B.a b , Weis, S.a b , Chen, J.a b c , Amunts, J.a b , Sotiras, A.d , […]

‘Unprecedented opportunity’ to understand neurovascular recovery after stroke

Each year in the U.S., nearly 800,000 people have a stroke, which leads to more than $46 billion spent annually in health care and related costs. A powerhouse team of researchers at Washington University in St. Louis is collaborating to understand how the brain remodels after stroke with the goal of finding new therapeutic targets […]

WashU weekly Neuroscience publications

“Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia” (2021) Psychiatry Research – Neuroimaging Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia (2021) Psychiatry Research – Neuroimaging, 317, art. no. 111352, .  Cobia, D.a e , Rich, C.b , Smith, M.J.c , Mamah, D.d , Csernansky, J.G.e , Wang, L.e f g a Department of Psychology and Neuroscience Center, Brigham Young University, 1036 KMBL, Provo, UT 84602, United […]

WashU weekly Neuroscience publications

“Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice” (2021) Communications Biology Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice (2021) Communications Biology, 4 (1), art. no. 955, .  Spencer, N.J.a , Travis, L.a , Wiklendt, L.b , Costa, M.a , Hibberd, T.J.a , Brookes, S.J.a , Dinning, P.b , Hu, H.c , Wattchow, […]

Variations in sodium channel molecular composition may drive drug efficacy

Precision medicine considers each person’s unique genetic makeup, lifestyle and environment when considering treatments for illness and disease. A team of Washington University in St. Louis researchers is taking steps toward developing precision medicine for patients with irregular heartbeats by studying how two anti-arrhythmic drugs affect different parts of the heart. Jeanne Nerbonne, PhD, professor […]

WashU weekly Neuroscience publications

"Chronic neuroleptic treatment combined with a high fat diet elevated (3H) flunitrazepam binding in the cerebellum (2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum(2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry, 112, art. no. 110407, .  Richardson, B.a b , Swenson, S.a , Hamilton, J.a b , Leonard, K.c , Delis, F.d , […]

Connective issue: AI learns by doing more with less

Brains have evolved to do more with less. Take a tiny insect brain, which has less than a million neurons but shows a diversity of behaviors and is more energy efficient than current AI systems. These tiny brains serve as models for computing systems that are becoming more sophisticated as billions of silicon neurons can […]

WashU weekly Neuroscience publications

“Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons” (2021) Nature Communications Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons (2021) Nature Communications, 12 (1), art. no. 4251, .  Pearson, T.S.a b , Gupta, N.a , San Sebastian, W.a , Imamura-Ching, J.a , Viehoever, A.c , Grijalvo-Perez, A.c , […]

NIH funds Rudra, Jackrel to improve vaccines for elderly

The coronavirus pandemic has emphasized the importance of vaccines, particularly for the elderly, who have been disproportionately impacted by the virus. However, a decline in immune response as well as inflammation that accompanies aging require a booster to improve the immune response. Jai Rudra, PhD, assistant professor of biomedical engineering at the McKelvey School of […]

WashU weekly Neuroscience publications

“A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq” (2021) Developmental Biology A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq (2021) Developmental Biology, 478, pp. 41-58.  Shiau, F.a , Ruzycki, P.A.a , Clark, B.S.a b a John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of […]

MRI’s magnetic field affects focused ultrasound technology

In a mouse model study of MRI-guided focused ultrasound-induced blood-brain barrier opening at MRI field strengths ranging from ­approximately 0 T (outside the magnetic field) to 4.7 T, the static magnetic field dampened the detected microbubble cavitation signal and decreased the BBB opening volume. (Image courtesy of Chen lab)

MRI-guided focused ultrasound combined with microbubbles can open the blood-brain barrier and allow therapeutic drugs to reach the diseased brain location under the guidance of MRI. It is a promising technique that has been shown safe in patients with various brain diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS) and glioblastoma. Chen While MRI […]

Nanoparticles create heat from light to manipulate electrical activity in neurons

Nanomaterials have been used in a variety of emerging applications, such as in targeted pharmaceuticals or to bolster other materials and products such as sensors and energy harvesting and storage devices. A team in the McKelvey School of Engineering at Washington University in St. Louis is using nanoparticles as heaters to manipulate the electrical activity […]

WashU weekly Neuroscience publications

"Comparing stress prediction models using smartwatch physiological signals and participant self-reports" (2021) Computer Methods and Programs in Biomedicine Comparing stress prediction models using smartwatch physiological signals and participant self-reports(2021) Computer Methods and Programs in Biomedicine, 208, art. no. 106207, .  Dai, R.a , Lu, C.a , Yun, L.b , Lenze, E.c , Avidan, M.b , Kannampallil, T.b d a Department of Computer Science, McKelvey School of Engineering, United […]

WashU weekly Neuroscience publications

“Critical tests of the continuous dual-process model of recognition” (2021) Cognition Critical tests of the continuous dual-process model of recognition (2021) Cognition, 215, art. no. 104827, .  Cha, J., Dobbins, I.G. Department of Psychological and Brain Sciences, Washington University in Saint Louis, United States Abstract Dual process recognition models assume recognition depends upon context recollection and/or item familiarity. While most […]

WashU weekly Neuroscience publications

“Advanced cognitive impairment among older nursing home residents” (2021) BMC Geriatrics Advanced cognitive impairment among older nursing home residents (2021) BMC Geriatrics, 21 (1), art. no. 382, .  Gracner, T.a , Stone, P.W.b , Agarwal, M.c , Sorbero, M.d , Mitchell, S.L.e f , Dick, A.W.g a RAND Corporation, 1776 Main Street, Santa Monica, CA 90401, United States b Center for Health Policy, Columbia University School of Nursing, 560 […]

McKelvey Engineering faculty lead MURI to study brain dynamics, reinforcement learning

Over the past half century, artificial intelligence has gone from a concept to everyday life, with electronic payments, facial recognition and social media becoming the norm. But the dynamic mechanisms in the brain on which artificial intelligence is based, which are more efficient, reliable and flexible, remain unclear to scientists, leading to a disconnect between […]

WashU weekly Neuroscience publications

“GPS driving: a digital biomarker for preclinical Alzheimer disease” (2021) Alzheimer’s Research and Therapy GPS driving: a digital biomarker for preclinical Alzheimer disease (2021) Alzheimer’s Research and Therapy, 13 (1), art. no. 115, .  Bayat, S.a b , Babulal, G.M.c d e , Schindler, S.E.c d , Fagan, A.M.c d f , Morris, J.C.c d f g h i , Mihailidis, A.a b j , Roe, C.M.c d a Institute of Biomedical Engineering, University of Toronto, 550 University Avenue, Toronto, ON M5G 1X5, […]

WashU weekly Neuroscience publications

“Epigenetic regulation in Huntington’s disease” (2021) Neurochemistry International Epigenetic regulation in Huntington’s disease (2021) Neurochemistry International, 148, art. no. 105074, .  Hyeon, J.W.a , Kim, A.H.a b c d e , Yano, H.a b c e a Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States b Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States c Department of Genetics, Washington University […]

WashU weekly Neuroscience publications

“In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community” (2021) BMC Medical Genomics In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community (2021) BMC Medical Genomics, 14 (1), art. no. 139, .  Bourdon, J.L.a , Dorsey, A.b , Zalik, M.b , Pietka, A.b , Salyer, P.b , Bray, […]

WashU weekly Neuroscience publications

“Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis” (2021) Communications Biology Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis (2021) Communications Biology, 4 (1), art. no. 607, .  Karlow, J.A.a , Miao, B.a b , Xing, X.a , Wang, T.a c , Zhang, B.a b a The Edison Family Center for Genome Sciences and Systems […]

New tool activates deep brain neurons by combining ultrasound, genetics

Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on […]

WashU weekly Neuroscience publications

“Interhemispheric Parietal-Frontal Connectivity Predicts the Ability to Acquire a Nondominant Hand Skill” (2021) Brain Connectivity Interhemispheric Parietal-Frontal Connectivity Predicts the Ability to Acquire a Nondominant Hand Skill (2021) Brain Connectivity, 11 (4), pp. 308-318.  Philip, B.A.a b , McAvoy, M.P.c , Frey, S.H.b a Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, United States b Department of Psychological Sciences, University of […]

WashU weekly Neuroscience publications

“Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain” (2021) Scientific Reports Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain (2021) Scientific Reports, 11 (1), art. no. 9798, .  Jiang, J.a d , Giri, T.a , Raghuraman, N.b , Cahill, A.G.c , Palanisamy, A.a b a Department of Anesthesiology, Washington University School of Medicine, St. […]

Compound may prevent risk of form of arrhythmia from common medications

Dozens of commonly used drugs, including antibiotics, anti-nausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, […]

WashU weekly Neuroscience publications

“Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study” (2021) Epilepsy and Behavior Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, […]

Grant funds research pushing limits of cyborg insects

The Office of Naval Research has awarded Barani Raman, PhD, professor of biomedical engineering at the McKelvey School of Engineering at Washington University in St. Louis, an $851,320 grant for research to determine just how sensitive locusts’ noses are when it comes to explosives — and how well researchers can interpret what the insects are […]

WashU weekly Neuroscience publications

“New guidance to seekers of autism biomarkers: an update from studies of identical twins” (2021) Molecular Autism New guidance to seekers of autism biomarkers: an update from studies of identical twins (2021) Molecular Autism, 12 (1), art. no. 28, .  Constantino, J.N. Department of Psychiatry, Washington University in St. Louis, 660 S Euclid Ave, Campus Box 8504, St. Louis, MO 63110, […]

WashU weekly Neuroscience publications

“White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study” (2021) Journal of Neurodevelopmental Disorders White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study (2021) Journal of Neurodevelopmental Disorders, 13 (1), art. no. 17, .  Bazydlo, A.a , Zammit, M.a , Wu, M.b , Dean, D.a c , Johnson, S.a c d , Tudorascu, […]

Team developing tool to handle big data generated by advanced imaging tool

Light-sheet fluorescence microscopy, an imaging tool that can rapidly produce 3D images of complex cellular structures, gives scientists the power to visualize the myriad miniature dramas unfolding inside living cells and tissues. Scientists at Washington University School of Medicine in St. Louis are using the technique to watch, in astonishing detail, tiny organelles rearrange themselves […]

Stroke-recovery device using brain-computer interface receives FDA market authorization

A first-of-its kind device that helps people disabled by stroke regain significant control over their arm and hand function by using their minds has received market authorization from the Food and Drug Administration (FDA). The IpsiHand Upper Extremity Rehabilitation System, developed by Neurolutions Inc. – a Washington University in St. Louis startup company – leverages brain-computer interface […]

WashU weekly Neuroscience publications

“Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease” (2021) BMC Neurology Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease (2021) BMC Neurology, 21 (1), art. no. 154, .  Gregori-Pla, C.a , Mesquita, R.C.b , Favilla, C.G.c , Busch, D.R.d , Blanco, […]

Washington University researchers to design detectors of airborne SARS-CoV-2

As the COVID-19 pandemic surged last summer and contact tracers struggled to identify sources of infections, John Cirrito, PhD, an associate professor of neurology at Washington University School of Medicine in St. Louis, and Carla Yuede, PhD, an associate professor of psychiatry, began to kick around an idea. Could a biosensor they’d developed years ago for Alzheimer’s disease […]

WashU weekly Neuroscience publications

"Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma" (2021) Acta Neuropathologica Communications Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma(2021) Acta Neuropathologica Communications, 9 (1), art. no. 61, .  Schieffer, K.M.a , Feldman, A.Z.b , Kautto, E.A.a , […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 5, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Ruopeng An to associate professor at the Brown School; Arpita Bose to associate professor of biology in Arts & Sciences; Hong […]

WashU weekly Neuroscience publications

"TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro" (2021) Nature Communications TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro(2021) Nature Communications, 12 (1), art. no. 1924, .  Baek, M.a , Choe, Y.-J.a , Bannwarth, S.b , Kim, J.H.a , Maitra, S.a , Dorn, G.W., IIc , Taylor, J.P.d , Paquis-Flucklinger, V.b , Kim, N.C.a a Department of Pharmacy Practice and Pharmaceutical […]

WashU weekly Neuroscience publications

“Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders” (2021) Journal of Neurodevelopmental Disorders Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders (2021) Journal of Neurodevelopmental Disorders, 13 (1), art. no. 10, .  Rahn, R.M.a b c , Weichselbaum, C.T.a b d , Gutmann, D.H.d e , Dougherty, J.D.a b d , Maloney, S.E.b d a Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO […]

BME Doctoral student Bandres wins American Society of Neurorehabilitation Diversity Fellowship

Maria F. Bandres, a doctoral student in the Department of Biomedical Engineering, has received the 2021 American Society of Neurorehabilitation (ASNR) Diversity Fellowship. The fellowship, awarded annually to up to three individuals from groups underrepresented in the biomedical, clinical, behavioral and social sciences, provides travel funds and registration expenses for conferences for the three years. […]

Brain Tumor Center established at Siteman Cancer Center

Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital have established the Brain Tumor Center, a multidisciplinary practice of physicians and scientists whose mission is to provide leading-edge, patient-centric care for brain tumor patients while also developing transformative basic, translational and clinical research to develop new therapies and improve patient outcomes. Neurosurgeon and scientist Albert H. Kim, […]

WashU weekly Neuroscience publications

“The transcriptional landscape of Shh medulloblastoma” (2021) Nature Communications The transcriptional landscape of Shh medulloblastoma (2021) Nature Communications, 12 (1), art. no. 1749, .  Skowron, P.a b c , Farooq, H.a b c , Cavalli, F.M.G.a c , Morrissy, A.S.d e f , Ly, M.a b c , Hendrikse, L.D.a c g , Wang, E.Y.a c g , Djambazian, H.h i , Zhu, H.g j , Mungall, K.L.k , Trinh, Q.M.j , Zheng, T.l , Dai, S.m , Stucklin, A.S.G.a c , Vladoiu, M.C.a b c , Fong, V.a c , Holgado, B.L.a c , Nor, C.a c , Wu, […]

WashU weekly Neuroscience publications

“Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis” (2021) Acta Neuropathologica Communications Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis (2021) Acta Neuropathologica Communications, 9 (1), art. no. 40, .  Celorrio, M.a , Abellanas, M.A.a c d , Rhodes, J.a , Goodwin, V.a , Moritz, J.a , Vadivelu, S.a , Wang, L.b , Rodgers, R.b , Xiao, S.a , Anabayan, […]

FUSIN promising in therapeutic agent delivery to brain tumor

Brainstem glioma is often diagnosed in children and young adults and has a low survival rate. A multidisciplinary team at Washington University in St. Louis developed a technique that delivered a therapeutic agent to the gliomas using focused ultrasound with very promising results. Dezhuang Ye, a doctoral student in the lab of Hong Chen, PhD, […]

WashU weekly Neuroscience publications

"Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus" (2021) Communications Biology Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus(2021) Communications Biology, 4 (1), art. no. 260, .  Jansson, D.a b c , Dieriks, V.B.b d , Rustenhoven, J.e f , Smyth, L.C.D.g h , Scotter, E.a b , Aalderink, M.a b , Feng, S.a b , Johnson, R.a b , Schweder, P.i , Mee, E.i , Heppner, P.j , Turner, C.k , Curtis, M.b d , […]

WashU weekly Neuroscience publications

“Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel” (2021) Nature Communications Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel (2021) Nature Communications, 12 (1), art. no. 926, .  Arnold, W.R.a , Carnevale, L.N.a , Xie, Z.b , Baylon, J.L.c , Tajkhorshid, E.c , Hu, H.b , Das, A.d e a Department of Biochemistry, University of Illinois Urbana-Champaign, […]

NIH awards $3.1 million grant for WashU, St. Jude ALS research

Scientists from Washington University in St. Louis and St. Jude Children’s Research Hospital have been awarded a five-year $3.1 million grant from the National Institute of Neurological Disorders and Stroke, an affiliate of the National Institutes of Health (NIH). Rohit Pappu, PhD, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering […]

WashU weekly Neuroscience publications

“A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors” (2021) Scientific Reports A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors (2021) Scientific Reports, 11 (1), art. no. 3858, .  Mattar, P.a f g , Jolicoeur, C.a , Dang, T.f g , Shah, S.f g , Clark, B.S.b c , Cayouette, M.a d e a Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada b John […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: evidence from economic decision-making” (2021) Cognitive Research: Principles and Implications Domain-general cognitive motivation: evidence from economic decision-making (2021) Cognitive Research: Principles and Implications, 6 (1), art. no. 4, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, Box 1125, St. Louis, MO 63130, United […]

WashU weekly Neuroscience publications

“Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury” (2021) Nature Communications Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury (2021) Nature Communications, 12 (1), art. no. 781, .  Brommer, B.a , He, M.a , Zhang, Z.a , Yang, Z.a , Page, J.C.a , Su, J.a , Zhang, Y.a , […]