WashU weekly Neuroscience publications

“A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine” (2020) Nature Communications A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine (2020) Nature Communications, 11 (1), art. no. 3368, . Guo, Y.a b c , Rist, P.M.a b c , Daghlas, I.a b , Giulianini, F.a , Gormley, P.e f g h , Anttila, V.f g i , Winsvold, B.S.j k l , Palta, P.m , Esko, T.f n o , Pers, T.H.f o p q , Farh, K.-H.f i r , Cuenca-Leon, E.e f g s , Muona, […]

Chen receives $500,000 grant to study new technique in pediatric brain cancer model

In Australia, brain cancer kills more children than any other disease. But it is difficult to treat without significant risks from surgical or drug treatment. Hong Chen, assistant professor of biomedical engineering in the Washington University in St. Louis McKelvey School of Engineering and of radiation oncology in the School of Medicine, will address the […]

An emerging understanding of smell

How does the brain detect smells? To find out, you could rely on biological sciences, using high tech imaging methods, or studying anatomical diagrams. You could even get philosophical and ask, “What is smell, anyway?” Or, you could turn to engineering. Ching That’s what ShiNung Ching, an associate professor in the McKelvey School of Engineering at […]

WashU weekly Neuroscience publications

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Praesent euismod, quam at feugiat commodo, turpis orci feugiat justo, nec porta nibh lectus vitae dui. Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9) (2020) Scientific Reports Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific […]

Artificial intelligence identifies, locates seizures in real-time

Researchers from Washington University in St. Louis’ McKelvey School of Engineering have combined artificial intelligence with systems theory to develop a more efficient way to detect and accurately identify an epileptic seizure in real-time. Their results were published May 26 in the journal Scientific Reports. The research comes from the lab of Jr-Shin Li, professor in the […]

WashU weekly Neuroscience publications

“Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples” (2020) Translational Psychiatry Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples (2020) Translational Psychiatry, 10 (1), art. no. 196, . Barr, P.B.a , Ksinan, A.b , Su, J.c , Johnson, E.C.d , […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting May 1, several faculty members were appointed or promoted with tenure, effective July 1 unless otherwise indicated. Appointment with tenure  …Jonathan Kipnis as professor of pathology and immunology at the School of Medicine; Carolina B. Lopez as professor of molecular microbiology at the School of Medicine […]

WashU weekly Neuroscience publications

“Entropy, mutual information, and systematic measures of structured spiking neural networks” (2020) Journal of Theoretical Biology Entropy, mutual information, and systematic measures of structured spiking neural networks (2020) Journal of Theoretical Biology, 501, art. no. 110310, . Li, W.a , Li, Y.b a Department of Mathematics and Statistics, Washington University, St. Louis, MO 63130, United States b Department […]

WashU weekly Neuroscience publications

“GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors” (2020) Scientific Reports GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors (2020) Scientific Reports, 10 (1), art. no. 9027, . Fu, Y.a b , Liu, C.J.a b , Kobayashi, D.K.a b , Johanns, T.M.b c , Bowman-Kirigin, J.A.a , Schaettler, M.O.a , Mao, D.D.a , Bender, D.b , Kelley, D.G.d , Uppaluri, R.e , Bi, W.L.f , Dunn, I.F.g , […]

WashU weekly Neuroscience publications

“Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program” (2020) Nature Communications Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program (2020) Nature Communications, 11 (1), art. no. 2611, .  Karagiannis, T.T.a b , Cleary, J.P., Jr.b c , Gok, B.b d , Henderson, A.J.e , Martin, N.G.f , Yajima, M.g , Nelson, […]

New microscopy method provides unprecedented look at amyloid protein structure

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are often accompanied by amyloid proteins in the brain that have become clumped or misfolded. At Washington University in St. Louis, a newly developed technique that measures the orientation of single molecules is enabling, for the first time, optical microscopy to reveal nanoscale details about the structures of […]

Silicon ‘neurons’ may add a new dimension to computer processors

When it fires, a neuron consumes significantly more energy than an equivalent computer operation. And yet, anetwork of coupled neurons can continuously learn, sense and perform complex tasks at energy levels that are currently unattainable for even state-of-the-art processors. What does a neuron do to save energy that a contemporary computer processing unit doesn’t? Computer […]

WashU weekly Neuroscience publications

“Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia” (2020) Nature Communications Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia (2020) Nature Communications, 11 (1), art. no. 2552, .  Wang, P.L.a b , Yim, A.K.Y.b , Kim, K.-W.a , Avey, D.b , Czepielewski, R.S.a , Colonna, M.a , Milbrandt, J.b , Randolph, G.J.a a Division […]

WashU weekly Neuroscience publications

“The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity” (2020) Operative Neurosurgery (Hagerstown, Md.) The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity (2020) Operative Neurosurgery (Hagerstown, Md.), 18 (6), pp. 583-589. Segreto, F.A.a b , Passias, P.G.a b , Brown, A.E.a b , Horn, S.R.a b , Bortz, C.A.a b , Pierce, K.E.a b , Alas, H.a b , […]

WashU weekly Neuroscience publications

“Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model” (2020) Scientific Reports Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model (2020) Scientific Reports, 10 (1), art. no. 7449, .  Pacia, C.P.a , Zhu, L.a , Yang, Y.a , Yue, Y.a , Nazeri, A.b , Michael Gach, H.a b […]

Chen receives early career award for research in therapeutic ultrasound

Hong Chen, assistant professor of biomedical engineering at the McKelvey School of Engineering and of radiation oncology at the School of Medicine, has been selected to receive the 2020 Frederic Lizzi Early Career Award from the International Society of Therapeutic Ultrasound (ISTU). The award recognizes individuals early in their professional career who have contributed substantially […]

Six teams selected for LEAP funding

The Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship at Washington University in St. Louis recently announced six teams were selected for funding to prepare their projects for commercialization through the spring 2020 LEAP Gap Fund cycle. The LEAP Gap Fund is open to any person or team with potential or existing university intellectual property. Through the program, […]

WashU weekly Neuroscience publications

“The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective registry” (2020) International Journal of Bipolar Disorders The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective […]

WashU weekly Neuroscience publications

“Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review” (2020) Radiology Case Reports Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review (2020) Radiology Case Reports, 15 (7), pp. 863-866.  Samara, A.a , Eldaya, R.W.b a Department of Psychiatry, Washington University School of Medicine, 4525 Scott Ave, St. Louis, MO 63110, […]

Biomedical engineering to add two new faculty

Alexandra L. Rutz and Ismael Seáñez are set to join the faculty of the Department of Biomedical Engineering at McKelvey School of Engineering in the 2020-21 academic year, bringing the department’s total number of faculty to 24. “We couldn’t be more pleased that with the hire of Professors Rutz and Seáñez, we brought not one, […]

WashU weekly Neuroscience publications

“The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease” (2020) Current Opinion in Neurobiology The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease (2020) Current Opinion in Neurobiology, 63, pp. 59-66.  Figley, M.D.a , DiAntonio, A.a b a Department of Developmental Biology, Washington University […]

Maker Task Force works to protect front-line health-care workers

In the face of the COVID-19 pandemic, a diverse team of makers from across Washington University in St. Louis’ Danforth and Medical campuses, Barnes-Jewish Hospital and BJC HealthCare have come together to protect front-line health-care workers and employees on the ground. “With the surge of COVID-19 patients we’re expecting, we want to make sure doctors, […]

WashU weekly Neuroscience publications

“cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons” (2020) Experimental Neurology cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons (2020) Experimental Neurology, 329, art. no. 113252, .  Sasaki, Y.a , Engber, T.M.b , Hughes, R.O.b , Figley, M.D.c , Wu, T.a , Bosanac, T.b , Devraj, […]

Juniors Eisner, Klapow awarded prestigious Truman Scholarship

Chancellor Andrew D. Martin (lower image) surprises Truman Scholars  Max Klapow (left) and Zach Eisner. (Video: Tom Malkowicz/Washington University) Roommates and best friends Zach Eisner and Max Klapow, juniors at Washington University in St. Louis, have both won a Truman Scholarship, the premier graduate fellowship in the United States for those pursuing careers as public service leaders. […]

Research in most university labs moved from bench to internet

When Washington University Vice Chancellor for Research Jennifer K. Lodge first sounded the alarm about the disruptive impact COVID-19 likely would have on labs across the university, the research community heeded her warning, taking steps to shut down lab work and move as much as possible online. Those in position to do so began pivoting their research […]

Board of Trustees grants faculty appointments, promotions

At the Washington University in St. Louis Board of Trustees meeting March 6, several faculty members were appointed, promoted or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure  Stephanie Li as professor of English in Arts & Sciences;  Alessandro Vindigni as professor of medicine, of pathology and immunology, and of biochemistry and molecular biophysics at […]

WashU weekly Neuroscience publications

“Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective” (2020) Neurobiology of Stress Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective (2020) Neurobiology of Stress, 12, art. no. 100215, .  Paul, S.M.a b c , Pinna, G.d , Guidotti, A.d e a Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States b The Taylor Family Institute for […]

McKelvey Engineering staff creating face shields for health care workers

To help meet the increasing need for personal protective equipment (PPE) for health care workers on the front lines of the coronavirus pandemic, staff at McKelvey School of Engineering at Washington University in St. Louis are making use of the state-of-the-art facilities in the Spartan Light Metals Makerspace to create face shields for those treating […]

WashU BME graduate program named No. 12 nationwide

The graduate program within the Department of Biomedical Engineering at the McKelvey School of Engineering at Washington University in St. Louis was ranked No. 12 in the nation, up from No. 14, by U.S. News & World Report. U.S. News ranks programs based on reputation among peer institutions, quality of the program’s students and faculty […]

New technology offers faster, broader 3D imaging of retinas, feasibility study shows

Each year, more than 30 million people have their eyes scanned using optical coherence tomography (OCT) to detect for diseases of the retina, such as age-related macular degeneration and diabetic retinopathy. While OCT takes excellent images, it is very sensitive to any movement — even breathing — by the patient, and is limited to a […]

Cancerous tumors, surrounding cells illuminated by new imaging agent

Scientists at Washington University School of Medicine in St. Louis have developed a new imaging agent that could let doctors identify not only multiple types of tumors but the surrounding normal cells that the cancer takes over and uses as a shield to protect itself from attempts to destroy it. The study appears March 9 […]

Medical students lead effort to collect masks, gowns, gloves, eye protection

With cases of the novel coronavirus on the rise in the St. Louis region, Washington University in St. Louis is anticipating shortages of personal protective equipment (PPE) — such as masks, gowns, gloves and eyewear — at university-affiliated hospitals and clinics. As work is reduced in university laboratories, medical students are asking researchers to collect […]

WashU weekly Neuroscience publications

“Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study” (2020) Journal of Stroke and Cerebrovascular Diseases Modafinil in Recovery after Stroke (MIRAS): A Retrospective Study (2020) Journal of Stroke and Cerebrovascular Diseases, 29 (4), art. no. 104645, .  Cross, D.B.a , Tiu, J.c , Medicherla, C.a , Ishida, K.a , Lord, A.a , Czeisler, B.a , Wu, C.a , Golub, D.a […]

Four McKelvey Engineering faculty receive LEAP awards

Four McKelvey School of Engineering faculty members received awards from the Skandalaris Center’s Leadership and Entrepreneurial Acceleration Program (LEAP). The LEAP Awards support Washington University faculty developing a product or innovation and provide industry connections and gap funding to stimulate Washington University technology commercialization, illuminate investment risk and rapidly accelerate development of validated projects. Out […]

Washington University to break ground on major neuroscience research hub

Washington University in St. Louis will begin construction in March on what will be one of the largest neuroscience research buildings in the country. Located on the School of Medicine campus, the 11-story, state-of-the-art research facility will merge, cultivate and advance some of the world’s leading neuroscience research. The 609,000-square-foot facility and interconnected projects initially […]

WashU weekly Neuroscience publications

“Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology” (2020) Scientific Reports Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) Scientific Reports, 10 (1), art. no. 2975, .  Shen, X.a , Ma, S.a , Vemuri, P.b , Simon, G.a , Weiner, M.W.c , Aisen, P.d , Petersen, R.b , Jack, C.R.b , Saykin, A.J.e , […]

WashU weekly Neuroscience publications

“Genomic prediction of alcohol-related morbidity and mortality” (2020) Translational Psychiatry Genomic prediction of alcohol-related morbidity and mortality (2020) Translational Psychiatry, 10 (1), art. no. 23, .  Kiiskinen, T.a f , Mars, N.J.f , Palviainen, T.f , Koskela, J.f , Rämö, J.T.f , Ripatti, P.f , Ruotsalainen, S.f , Palotie, A.f g h , Madden, P.A.F.b , Rose, R.J.c , Kaprio, J.d […]

Diabetes in mice cured rapidly using human stem cell strategy

Researchers have converted human stem cells into insulin-producing cells and demonstrated in mice infused with such cells that blood sugar levels can be controlled and diabetes functionally cured for nine months. The findings, from researchers at Washington University School of Medicine in St. Louis, are published online Feb. 24 in the journal Nature Biotechnology. “These […]

WashU weekly Neuroscience publications

“Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex” (2020) Communications Biology Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex (2020) Communications Biology, 3 (1), art. no. 64, .  Zhang, M.a c , Kwon, S.E.b d , Ben-Johny, M.a e , O’Connor, D.H.b , Issa, J.B.a f a Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, […]

Bomb-sniffing grasshoppers: the next frontier for public security?

Bomb-sniffing cyborg grasshoppers have been created by scientists to detect explosives such as TNT. Academics at Washington University in Missouri tapped into the insects’ minds to monitor whether they were smelling explosives, and if so, what kind they were detecting. Or as the researchers put it, the “bio-hacked” grasshoppers play a similar role to a “canary […]

Three McKelvey faculty members win research equipment awards

Three faculty members in the McKelvey School of Engineering will be able to purchase important equipment needed for their research through grants awarded by the Department of Defense. The faculty are Tae Seok Moon, associate professor of energy, environmental & chemical engineering; Barani Raman, associate professor of biomedical engineering; and Vijay Ramani, the Roma B. […]

WashU weekly Neuroscience publications

“Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures” (2020) Scientific Reports Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures (2020) Scientific Reports, 10 (1), art. no. 1980, .  Iskandar, H.N.a , Linan, E.E.b , Patel, A.c , Moore, R.d , Lasanajak, Y.d , Gyawali, C.P.b , Sayuk, G.S.b e , Ciorba, […]

WashU weekly Neuroscience publications

“Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy” (2020) Nature Communications Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy (2020) Nature Communications, 11 (1), art. no. 595, .  Hengel, H.a b , Bosso-Lefèvre, C.c d , Grady, G.e , Szenker-Ravi, E.c , Li, H.f , Pierce, S.g , Lebigot, É.h , Tan, T.-T.i , Eio, M.Y.i , […]

Collaboration lets researchers ‘read’ proteins for new properties

Clumps of proteins inside cells are a common thread in many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease. These clumps, or solid aggregates of proteins, appear to be the result of an abnormality in the process known as liquid-liquid phase separation (LLPS), in which individual proteins come together to form a […]

WashU weekly Neuroscience publications

“FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease” (2020) Nature Communications FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2020) Nature Communications, 11 (1), art. no. 411, .  Yan, T.a , Liang, J.b , Gao, J.a , Wang, L.a , Fujioka, H.c , Weiner, M.W.d , Schuff, N.d , Rosen, H.J.d , Miller, B.L.d , […]

What a lifetime of playing football can do to the human brain

Football isn’t just a contact sport — it’s a dangerous game of massive bodies colliding into one another. And while it may seem obvious that this sport can do extraordinary damage to brains and bodies, it’s taken far too long for the NFL, the medical community, and football fans to fully reckon with this. Doctors […]

WashU weekly Neuroscience publications

“Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning” (2020) Information Fusion Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning (2020) Information Fusion, 58, pp. 153-167.  Castillo-Barnes, D.a , Su, L.b , Ramírez, J.a , Salas-Gonzalez, D.a , Martinez-Murcia, F.J.c , Illan, I.A.a , Segovia, F.a , Ortiz, A.c , Cruchaga, C.d […]

WashU weekly Neuroscience publications

“Structural basis for adhesion G protein-coupled receptor Gpr126 function” (2020) Nature Communications Structural basis for adhesion G protein-coupled receptor Gpr126 function (2020) Nature Communications, 11 (1), art. no. 194, .  Leon, K.a b , Cunningham, R.L.c , Riback, J.A.a d , Feldman, E.a , Li, J.a b , Sosnick, T.R.a e , Zhao, M.a , Monk, K.R.c f , Araç, D.a […]

Wendland appointed Washington University provost

Beverly Wendland, the James B. Knapp Dean of the Krieger School of Arts & Sciences at Johns Hopkins University, has been appointed provost of Washington University in St. Louis, effective July 1, according to Chancellor Andrew D. Martin. Wendland will succeed Marion Crain, who has served as interim provost since July 2019. A member of the Johns […]