The ‘surprisingly simple’ arithmetic of smell

Smell a cup of coffee. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni — even at a pizza parlor with a scone! — coffee smells like coffee. Why don’t other smells or different environmental factors “get in the way,” so to speak, […]

WashU weekly Neuroscience publications

“Electroconvulsive therapy in treatment resistant depression” (2022) Journal of the Neurological Sciences Electroconvulsive therapy in treatment resistant depression(2022) Journal of the Neurological Sciences, 434, art. no. 120095, .  Subramanian, S.a b , Lopez, R.a b , Zorumski, C.F.a b , Cristancho, P.a b a Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, United Statesb Department of Psychiatry, University of Texas Rio Grande Valley […]

WashU weekly Neuroscience publications

“Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations” (2022) NeuroImage Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations(2022) NeuroImage, 247, art. no. 118838, .  Kaplan, S.a , Meyer, D.a , Miranda-Dominguez, O.g h , Perrone, A.f j , Earl, E.h j , Alexopoulos, D.a , Barch, D.M.b d e , Day, T.K.M.f , Dust, J.a , Eggebrecht, A.T.b , Feczko, E.g h , Kardan, O.k , […]

Understanding features that help cells stay organized

The labs of Tanja Mittag, PhD at St. Jude and Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor of biomedical engineering at the McKelvey School of Engineering, created a stickers-and-spacers model to discern the rules underlying the driving forces for phase separation. The “stickers” and “spacers” are different types of amino acids along the […]

International team finds new mechanism critical for formation of membrane vesicles

Researchers from the McKelvey School of Engineering at Washington University in St. Louis, Université de Montréal and McGill University have discovered a new mechanism by which membrane vesicles are made. The roles played by these self-contained nanoparticles are essential to the normal function of our cells. Their dysfunction is implicated in diseases ranging from cancers […]

WashU weekly Neuroscience publications

“Psychometric properties of the Peceived Benefits of Thinness Scale in college-aged women” (2022) Body Image Psychometric properties of the Peceived Benefits of Thinness Scale in college-aged women(2022) Body Image, 40, pp. 103-109.  Flatt, R.E.a , Karam, A.M.b , Fitzsimmons-Craft, E.E.b , Balantekin, K.N.c , Graham, A.K.d , Eichen, D.M.e , Monterubio, G.E.b , Goel, N.J.f , Fowler, L.A.b , Sadeh-Sharvit, S.g h i , Wilfley, D.b , Mazina, V.j k , Taylor, C.B.g h , Trockel, […]

WashU weekly Neuroscience publications

“Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning” (2022) Journal of Neuroscience Methods Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning(2022) Journal of Neuroscience Methods, 366, art. no. 109421, .  Zhang, X.a , Landsness, E.C.b , Chen, W.b , Miao, H.b , Tang, M.b , Brier, L.M.c , Culver, J.P.c d e f , Lee, […]

Paola Cepeda named Director of Postdoctoral Affairs

Dear Colleagues, I am pleased to announce that, after a nationwide search, Paola Cepeda, PhD, has been named Director of Postdoctoral Affairs in the Office of the Vice Chancellor for Research, effective January 4, 2022. Paola currently serves as the Program Manager for Graduate and Postdoctoral Professional Development at Stony Brook University. In the role […]

IpsiHand stroke-recovery device named product of year by science society

The IpsiHand, an innovative stroke-recovery device that helps stroke patients recover significant arm and hand function by retraining their brains, has received the 2021 Pantheon Product of the Year Award from California Life Sciences. The organization advocates for the state’s life sciences sector and its innovation pipeline by supporting companies of all sizes, from early-stage […]

Covey, Milbrandt, Moran named to National Academy of Inventors

The National Academy of Inventors has elected three faculty members from Washington University in St. Louis to its 2021 cohort of fellows: Psychiatry professor Douglas F. Covey, PhD, geneticist Jeffrey Milbrandt, MD, PhD, both at the School of Medicine; and bioengineer Daniel Moran, PhD, at the McKelvey School of Engineering. The NAI fellowship is the highest professional distinction reserved solely […]

WashU weekly Neuroscience publications

“Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury” (2022) Pediatric Neurology Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury (2022) Pediatric Neurology, 126, pp. 114-119.  Surtees, T.-L.a , Kumar, I.b , Garton, H.J.L.c , Rivas-Rodriguez, F.d , Parmar, H.d , McCaffery, H.b , Riebe-Rodgers, J.b , Shellhaas, R.A.b a Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United Statesb Departments […]

Minton appointed vice chancellor for technology and chief information officer

Jessie Minton, vice provost and chief information officer at the University of Oregon, has been appointed vice chancellor for technology and chief information officer at Washington University in St. Louis, effective April 15, according to Shantay Bolton, executive vice chancellor and chief administrative officer. Minton will succeed Stephanie L. Reel, who has served as interim chief […]

Less energy, better quality PAM images with machine learning

Photoacoustic microscopy (PAM) allows researchers to see the smallest vessels inside a body, but it can generate some unwanted signals or noise. A team of researchers at the McKelvey School of Engineering at Washington University in St. Louis found a way to significantly reduce the noise and maintain image quality while reducing the laser energy […]

WashU weekly Neuroscience publications

“Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes” (2022) Medical Image Analysis Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes(2022) Medical Image Analysis, 75, art. no. 102304, .  Wen, J.a , Varol, E.b , Sotiras, A.c , Yang, Z.a , Chand, G.B.d , Erus, G.a , Shou, H.a e , Abdulkadir, A.a , Hwang, G.a , Dwyer, D.B.f , Pigoni, A.g , Dazzan, P.h , Kahn, R.S.i , Schnack, H.G.j , Zanetti, M.V.k , […]

Inventive pathways

Moving innovations out of the so-called ivory tower and into the public domain holds enormous power to treat disease and improve quality of life. But while academic researchers and physicians may imagine promising clinical solutions, some are unprepared to navigate commercialization: pitching themselves, attracting investors, wrangling with intellectual property law, designing rigorous proof-of-concept studies, locating […]

WashU weekly Neuroscience publications

“Personalized networks of social anxiety disorder and depression and implications for treatment” (2022) Journal of Affective Disorders Personalized networks of social anxiety disorder and depression and implications for treatment(2022) Journal of Affective Disorders, 298, pp. 262-276.  Piccirillo, M.L., Rodebaugh, T.L. Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, United States AbstractIntroduction: Social […]

Lodge to depart Washington University

Jennifer K. Lodge, PhD, vice chancellor for research at Washington University in St. Louis and the David T. Blasingame Professor, will leave the university at the end of the year. Lodge will be joining Duke University as vice president for research and innovation in January. “Dr. Lodge has served Washington University during extraordinary times, providing […]

WashU weekly Neuroscience publications

“Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome” (2022) Pediatric Neurology Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome(2022) Pediatric Neurology, 126, pp. 65-73.  Steele, J.L.a , Morrow, M.M.b , Sarnat, H.B.c , Alkhunaizi, E.d , Brandt, T.b , Chitayat, D.A.d , DeFilippo, C.P.e , Douglas, G.V.b , Dubbs, H.A.f , Elloumi, H.Z.b , Glassford, M.R.g , Hannibal, M.C.g , Héron, B.h , Kim, […]

Noninvasive brain biopsy shows improved sensitivity in tumor detection

Glioblastomas are aggressive brain tumors that are commonly diagnosed through a risky and invasive surgical biopsy. A team of researchers led by Hong Chen, PhD at Washington University in St. Louis has developed a noninvasive diagnostic method that may one day replace the tissue biopsy with a simple blood test. Chen, associate professor of biomedical engineering at […]

Seáñez receives NIH-funded research career development award

Ismael Seáñez, PhD, assistant professor of biomedical engineering at the McKelvey School of Engineering and of neurosurgery at the School of Medicine at Washington University in St. Louis, has been selected as a K12 scholar by the Interdisciplinary Rehabilitation Engineering Research Career Development Program in Movement and Rehabilitation Sciences funded by the National Institutes of […]

WashU weekly Neuroscience publications

“Contribution of animal models toward understanding resting state functional connectivity” (2021) NeuroImage Contribution of animal models toward understanding resting state functional connectivity(2021) NeuroImage, 245, art. no. 118630, .  Pais-Roldán, P.a , Mateo, C.b , Pan, W.-J.c , Acland, B.d , Kleinfeld, D.b e , Snyder, L.H.d , Yu, X.f , Keilholz, S.c a Medical Imaging Physics, Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich52425, Germanyb Department of Physics, University of […]

WashU weekly Neuroscience publications

“The relationship between diffusion heterogeneity and microstructural changes in high-grade gliomas using Monte Carlo simulations” (2022) Magnetic Resonance Imaging The relationship between diffusion heterogeneity and microstructural changes in high-grade gliomas using Monte Carlo simulations(2022) Magnetic Resonance Imaging, 85, pp. 108-120.  Lee, C.-Y.a , Bennett, K.M.b , Debbins, J.P.c , Choi, I.-Y.a d e f , Lee, P.a e f a Hoglund Biomedical Imaging Center, University of Kansas Medical Center, […]

WashU weekly Neuroscience publications

“Equivalent learning, but unequal participation: Male bumble bees learn comparably to females, but participate in cognitive assessments at lower rates” (2021) Behavioural Processes Equivalent learning, but unequal participation: Male bumble bees learn comparably to females, but participate in cognitive assessments at lower rates (2021) Behavioural Processes, 193, art. no. 104528, . Manning, T.H.a b , Austin, M.W.a b c , MuseMorris, K.a , Dunlap, A.S.a b  a Department […]

WashU weekly Neuroscience publications

“Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids” (2021) Nature Communications Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids (2021) Nature Communications, 12 (1), art. no. 5763, .  Jones, J.R.a b , Chaturvedi, S.a , Granados-Fuentes, D.a , Herzog, E.D.a a Department of Biology, Washington University, St. Louis, St. Louis, MO, United States b Department of Biology, Texas […]

WashU weekly Neuroscience publications

“Spectral signature of attentional reorienting in the human brain” (2021) NeuroImage Spectral signature of attentional reorienting in the human brain (2021) NeuroImage, 244, art. no. 118616, .  Spadone, S.a , Betti, V.b c , Sestieri, C.a , Pizzella, V.a , Corbetta, M.d e f , Della Penna, S.a a Department of Neuroscience, Imaging and Clinical Sciences – and ITAB, Institute for Advanced Biomedical Technologies, G. d’Annunzio University of Chieti-Pescara, […]

WashU weekly Neuroscience publications

“A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging” (2021) Journal of Biomechanics A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging (2021) Journal of Biomechanics, 129, art. […]

WashU weekly Neuroscience publications

“A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging” (2021) Journal of Biomechanics A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging (2021) Journal of Biomechanics, 129, art. […]

WashU weekly Neuroscience publications

“Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease” (2021) Alzheimer’s Research and Therapy Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease (2021) Alzheimer’s Research and Therapy, 13 (1), art. no. 153, .  Hassenstab, J.a b , Nicosia, J.a , LaRose, M.a , Aschenbrenner, A.J.a , Gordon, B.A.b c , Benzinger, T.L.S.c , Xiong, C.a d , Morris, J.C.a a Charles F. and […]

WashU weekly Neuroscience publications

“Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases” (2022) Neural Regeneration Research Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases (2022) Neural Regeneration Research, 17 (4), pp. 867-874.  Li, H., Knight, W., Xu, J. Department of Radiology, Washington University School of Medicine, St. Louis, […]

‘First-in-class’ tool for potential treatment of brain disorders

New methods to treat human brain disorders is one of the top priorities of the National Institutes of Health’s ambitious BRAIN Initiative. To find noninvasive tools that are equally or more effective is a kind of Holy Grail for neuroscience, and a biomedical engineer at Washington University in St. Louis has it in her sights. […]

WashU weekly Neuroscience publications

“The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons” (2021) Cell and Bioscience The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons (2021) Cell and Bioscience, 11 (1), art. no. 167, .  Zhang, Y.a b f , Ma, S.a b , Ke, X.a b , Yi, Y.a b , Yu, H.a b , Yu, D.a b , Li, Q.c , Shang, Y.b d , Lu, […]

WashU weekly Neuroscience publications

"A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System" (2021) Scientific Reports A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System(2021) Scientific Reports, 11 (1), art. no. 16896, .  Camilleri, J.A.a b , Eickhoff, S.B.a b , Weis, S.a b , Chen, J.a b c , Amunts, J.a b , Sotiras, A.d , […]

‘Unprecedented opportunity’ to understand neurovascular recovery after stroke

Each year in the U.S., nearly 800,000 people have a stroke, which leads to more than $46 billion spent annually in health care and related costs. A powerhouse team of researchers at Washington University in St. Louis is collaborating to understand how the brain remodels after stroke with the goal of finding new therapeutic targets […]

WashU weekly Neuroscience publications

“Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia” (2021) Psychiatry Research – Neuroimaging Basal ganglia shape features differentiate schizoaffective disorder from schizophrenia (2021) Psychiatry Research – Neuroimaging, 317, art. no. 111352, .  Cobia, D.a e , Rich, C.b , Smith, M.J.c , Mamah, D.d , Csernansky, J.G.e , Wang, L.e f g a Department of Psychology and Neuroscience Center, Brigham Young University, 1036 KMBL, Provo, UT 84602, United […]

WashU weekly Neuroscience publications

“Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice” (2021) Communications Biology Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice (2021) Communications Biology, 4 (1), art. no. 955, .  Spencer, N.J.a , Travis, L.a , Wiklendt, L.b , Costa, M.a , Hibberd, T.J.a , Brookes, S.J.a , Dinning, P.b , Hu, H.c , Wattchow, […]

Variations in sodium channel molecular composition may drive drug efficacy

Precision medicine considers each person’s unique genetic makeup, lifestyle and environment when considering treatments for illness and disease. A team of Washington University in St. Louis researchers is taking steps toward developing precision medicine for patients with irregular heartbeats by studying how two anti-arrhythmic drugs affect different parts of the heart. Jeanne Nerbonne, PhD, professor […]

WashU weekly Neuroscience publications

"Chronic neuroleptic treatment combined with a high fat diet elevated (3H) flunitrazepam binding in the cerebellum (2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum(2022) Progress in Neuro-Psychopharmacology and Biological Psychiatry, 112, art. no. 110407, .  Richardson, B.a b , Swenson, S.a , Hamilton, J.a b , Leonard, K.c , Delis, F.d , […]

Connective issue: AI learns by doing more with less

Brains have evolved to do more with less. Take a tiny insect brain, which has less than a million neurons but shows a diversity of behaviors and is more energy efficient than current AI systems. These tiny brains serve as models for computing systems that are becoming more sophisticated as billions of silicon neurons can […]

WashU weekly Neuroscience publications

“Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons” (2021) Nature Communications Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons (2021) Nature Communications, 12 (1), art. no. 4251, .  Pearson, T.S.a b , Gupta, N.a , San Sebastian, W.a , Imamura-Ching, J.a , Viehoever, A.c , Grijalvo-Perez, A.c , […]

NIH funds Rudra, Jackrel to improve vaccines for elderly

The coronavirus pandemic has emphasized the importance of vaccines, particularly for the elderly, who have been disproportionately impacted by the virus. However, a decline in immune response as well as inflammation that accompanies aging require a booster to improve the immune response. Jai Rudra, PhD, assistant professor of biomedical engineering at the McKelvey School of […]

WashU weekly Neuroscience publications

“A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq” (2021) Developmental Biology A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq (2021) Developmental Biology, 478, pp. 41-58.  Shiau, F.a , Ruzycki, P.A.a , Clark, B.S.a b a John F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of […]

MRI’s magnetic field affects focused ultrasound technology

In a mouse model study of MRI-guided focused ultrasound-induced blood-brain barrier opening at MRI field strengths ranging from ­approximately 0 T (outside the magnetic field) to 4.7 T, the static magnetic field dampened the detected microbubble cavitation signal and decreased the BBB opening volume. (Image courtesy of Chen lab)

MRI-guided focused ultrasound combined with microbubbles can open the blood-brain barrier and allow therapeutic drugs to reach the diseased brain location under the guidance of MRI. It is a promising technique that has been shown safe in patients with various brain diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS) and glioblastoma. Chen While MRI […]

Nanoparticles create heat from light to manipulate electrical activity in neurons

Nanomaterials have been used in a variety of emerging applications, such as in targeted pharmaceuticals or to bolster other materials and products such as sensors and energy harvesting and storage devices. A team in the McKelvey School of Engineering at Washington University in St. Louis is using nanoparticles as heaters to manipulate the electrical activity […]

WashU weekly Neuroscience publications

"Comparing stress prediction models using smartwatch physiological signals and participant self-reports" (2021) Computer Methods and Programs in Biomedicine Comparing stress prediction models using smartwatch physiological signals and participant self-reports(2021) Computer Methods and Programs in Biomedicine, 208, art. no. 106207, .  Dai, R.a , Lu, C.a , Yun, L.b , Lenze, E.c , Avidan, M.b , Kannampallil, T.b d a Department of Computer Science, McKelvey School of Engineering, United […]

WashU weekly Neuroscience publications

“Critical tests of the continuous dual-process model of recognition” (2021) Cognition Critical tests of the continuous dual-process model of recognition (2021) Cognition, 215, art. no. 104827, .  Cha, J., Dobbins, I.G. Department of Psychological and Brain Sciences, Washington University in Saint Louis, United States Abstract Dual process recognition models assume recognition depends upon context recollection and/or item familiarity. While most […]

WashU weekly Neuroscience publications

“Advanced cognitive impairment among older nursing home residents” (2021) BMC Geriatrics Advanced cognitive impairment among older nursing home residents (2021) BMC Geriatrics, 21 (1), art. no. 382, .  Gracner, T.a , Stone, P.W.b , Agarwal, M.c , Sorbero, M.d , Mitchell, S.L.e f , Dick, A.W.g a RAND Corporation, 1776 Main Street, Santa Monica, CA 90401, United States b Center for Health Policy, Columbia University School of Nursing, 560 […]

McKelvey Engineering faculty lead MURI to study brain dynamics, reinforcement learning

Over the past half century, artificial intelligence has gone from a concept to everyday life, with electronic payments, facial recognition and social media becoming the norm. But the dynamic mechanisms in the brain on which artificial intelligence is based, which are more efficient, reliable and flexible, remain unclear to scientists, leading to a disconnect between […]

WashU weekly Neuroscience publications

“GPS driving: a digital biomarker for preclinical Alzheimer disease” (2021) Alzheimer’s Research and Therapy GPS driving: a digital biomarker for preclinical Alzheimer disease (2021) Alzheimer’s Research and Therapy, 13 (1), art. no. 115, .  Bayat, S.a b , Babulal, G.M.c d e , Schindler, S.E.c d , Fagan, A.M.c d f , Morris, J.C.c d f g h i , Mihailidis, A.a b j , Roe, C.M.c d a Institute of Biomedical Engineering, University of Toronto, 550 University Avenue, Toronto, ON M5G 1X5, […]

WashU weekly Neuroscience publications

“Epigenetic regulation in Huntington’s disease” (2021) Neurochemistry International Epigenetic regulation in Huntington’s disease (2021) Neurochemistry International, 148, art. no. 105074, .  Hyeon, J.W.a , Kim, A.H.a b c d e , Yano, H.a b c e a Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States b Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States c Department of Genetics, Washington University […]

WashU weekly Neuroscience publications

“In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community” (2021) BMC Medical Genomics In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community (2021) BMC Medical Genomics, 14 (1), art. no. 139, .  Bourdon, J.L.a , Dorsey, A.b , Zalik, M.b , Pietka, A.b , Salyer, P.b , Bray, […]