WashU weekly Neuroscience publications

“Virtual navigation in healthy aging: Activation during learning and deactivation during retrieval predicts successful memory for spatial locations” (2022) Neuropsychologia Virtual navigation in healthy aging: Activation during learning and deactivation during retrieval predicts successful memory for spatial locations(2022) Neuropsychologia, 173, art. no. 108298, .  Richmond, L.L.a b , Sargent, J.Q.c , Zacks, J.M.a a Department of Psychological and Brain Sciences, Washington University in St […]

Early to serve as interim CRE2 director

Gerald Early, PhD, the Merle King Professor of Modern Letters in Arts & Sciences, will serve as interim director of the Center for the Study of Race, Ethnicity & Equity (CRE2) at Washington University in St. Louis, effective July 1. The center provides programs and partnerships for Danforth and Medical campus faculty researching issues related to race […]

WashU weekly Neuroscience publications

"Relationships between food-related behaviors, obesity, and medication use in individuals with Smith-Magenis syndrome" (2022) Research in Developmental Disabilities Relationships between food-related behaviors, obesity, and medication use in individuals with Smith-Magenis syndrome(2022) Research in Developmental Disabilities, 127, art. no. 104257, .  Gandhi, A.A.a , Wilson, T.A.a , Sisley, S.b c , Elsea, S.H.a , Foster, R.H.d e a Department of Molecular and Human Genetics, Baylor College of Medicine, […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting May 6, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure Andrew Clark as associate professor of electrical and systems engineering at the McKelvey School of Engineering; Xianglin Li as associate professor of mechanical […]

WashU weekly Neuroscience publications

"A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images" (2022) NeuroImage A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images(2022) NeuroImage, 257, art. no. 119304, .  Varadarajan, D.a b , Magnain, C.a b , Fogarty, M.c d , Boas, D.A.f , Fischl, B.a b e , Wang, H.a b a Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, […]

Lew lab sheds new light on cell membranes

Research from the lab of Matthew Lew, PhD at Washington University in St. Louis offers entirely new ways to see the very small. The research — two papers by PhD students at the McKelvey School of Engineering — was published in the journals Optica and Nano Letters. They have developed novel hardware and algorithms that allow them to visualize the […]

WashU weekly Neuroscience publications

“Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response” (2022) Genome Medicine Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response(2022) Genome Medicine, 14 (1), art. no. 49, .  Wang, A.Z.a b c d e , Bowman-Kirigin, J.A.a b c d , Desai, R.a d , Kang, L.-I.f , Patel, P.R.g , Patel, B.a d , Khan, S.M.a d , Bender, D.c , […]

WashU weekly Neuroscience publications

“Donor activation focused rehabilitation approach to hand closing nerve transfer surgery in individuals with cervical level spinal cord injury” (2022) Spinal Cord Series and Cases Donor activation focused rehabilitation approach to hand closing nerve transfer surgery in individuals with cervical level spinal cord injury(2022) Spinal Cord Series and Cases, 8 (1), art. no. 47, .  Kahn, L.C.a , Evans, A.G.b c , Hill, E.J.R.c , […]

WashU weekly Neuroscience publications

“Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study” (2022) Nature Communications Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study(2022) Nature Communications, 13 (1), art. no. 2217, .  Chen, J.a b c d , Tam, A.a b c d , Kebets, V.a b c d , Orban, C.a b c d , Ooi, L.Q.R.a b c d e , Asplund, C.L.b c d f g h , Marek, S.i , Dosenbach, N.U.F.j k l m , […]

BME Day 2022 showcases senior design projects and student innovation

The Department of Biomedical Engineering at the McKelvey School of Engineering welcomed students, judges and guests back May 2 for the first in-person BME Day since 2019. The celebration rounds out a year of learning with senior design competitions, research awards, faculty presentation and the Frank C.P. and Grace C. Yin Distinguished Lecture. Student teams […]

Pappu lab untangles more IDR secrets

Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]

WashU weekly Neuroscience publications

"Naturalistic driving measures of route selection associate with resting state networks in older adults" (2022) Scientific Reports Naturalistic driving measures of route selection associate with resting state networks in older adults(2022) Scientific Reports, 12 (1), art. no. 6486, .  Wisch, J.K.a , Roe, C.M.a , Babulal, G.M.a d e , Metcalf, N.a , Johnson, A.M.f , Murphy, S.a , Hicks, J.a , Doherty, J.M.a , Morris, J.C.a c , Ances, B.M.a b c a Department of Neurology, […]

WashU weekly Neuroscience publications

“VCP suppresses proteopathic seeding in neurons” (2022) Molecular Neurodegeneration VCP suppresses proteopathic seeding in neurons(2022) Molecular Neurodegeneration, 17 (1), art. no. 30, .  Zhu, J.a , Pittman, S.a , Dhavale, D.a , French, R.b , Patterson, J.N.a , Kaleelurrrahuman, M.S.a , Sun, Y.c , Vaquer-Alicea, J.d , Maggiore, G.d , Clemen, C.S.e f , Buscher, W.J.g , Bieschke, J.c , Kotzbauer, P.a , Ayala, Y.b , Diamond, M.I.d , Davis, A.A.a , Weihl, C.a a Department of Neurology, Hope Center for […]

WashU weekly Neuroscience publications

“The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells” (2022) Journal of Neuroimmunology The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells(2022) Journal of Neuroimmunology, 367, art. no. 577860, .  Paley, M.A.a , Baker, B.J.b , Dunham, S.R.b , Linskey, N.a , Cantoni, C.b , Lee, K.b , Hassman, L.M.c , […]

Cui to seek better drugs for irregular heartbeat

Irregular heartbeat, or arrhythmia, affects about 5 million people in the United States, and interestingly, some of the drugs used to treat the condition can also cause it. A biomedical engineer in the McKelvey School of Engineering at Washington University in St. Louis is going deep into the basic mechanisms that lead to arrhythmia to […]

WashU weekly Neuroscience publications

“A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures” (2022) Stem Cell Research and Therapy A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures(2022) Stem Cell Research and Therapy, 13 (1), art. no. 131, .  Pardieck, J.a b , Harb, M.a , Sakiyama-Elbert, S.E.a a Department of Biomedical Engineering, […]

Bayly-led team to study mechanical strains, stresses in traumatic brain injury

Naval warfighters may be exposed to explosions, impacts or high accelerations that increase their risk for traumatic brain injury. A team of researchers led by Philip Bayly, PhD, at Washington University in St. Louis plans a comprehensive study of skull-brain mechanics using imaging, computer and preclinical models to study the strains and stresses of the […]

Board grants faculty appointments, promotions, tenure

At the Washington University in St. Louis Board of Trustees meeting March 4, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Carlos A. Botero to associate professor of biology in Arts & Sciences; Caitlyn M. Collins to associate professor of sociology in Arts & […]

WashU weekly Neuroscience publications

“Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series” (2022) Epilepsy and Behavior Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series(2022) Epilepsy and Behavior, 130, art. no. 108659, .  Hedaya, A.A.a , Hewitt, K.C.b , Hu, R.c , Epstein, C.M.b , Gross, R.E.a b , […]

WashU weekly Neuroscience publications

“Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report” (2022) Cognitive Research: Principles and Implications Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report(2022) Cognitive Research: Principles and Implications, 7 (1), art. no. 23, .  Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, […]

WashU weekly Neuroscience publications

“Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder” (2022) Drug and Alcohol Dependence Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder(2022) Drug and Alcohol Dependence, 234, art. no. 109400, .  Ellis, M.S.a , Buttram, M.E.b , Kasper, Z.A.a a Washington University in St. Louis, School of Medicine. Department of […]

WashU weekly Neuroscience publications

“Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults” (2022) Neurobiology of Aging Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults(2022) Neurobiology of Aging, 112, pp. 181-190.  McKay, N.S.a b , Dincer, A.a b , Mehrotra, V.e , Aschenbrenner, A.J.b c , Balota, D.b d , Hornbeck, R.C.a b , Hassenstab, J.b c d , Morris, J.C.b c , Benzinger, T.L.S.a b , Gordon, B.A.a b d […]

WashU weekly Neuroscience publications

"Are children with unilateral hearing loss more tired?" (2022) International Journal of Pediatric Otorhinolaryngology Are children with unilateral hearing loss more tired?(2022) International Journal of Pediatric Otorhinolaryngology, 155, art. no. 111075, .  Carpenter, D.a , Dougherty, W.b , Sindhar, S.c , Friesen, T.-N.c , Lieu, J.c , Kesser, B.W.a a Department of Otolaryngology-Head and Neck Surgery, University of Virginia School of Medicine, P.O. Box 800713, Charlottesville, […]

Predicting the chaos in Tourette syndrome tics

During the pandemic, news reports surfaced of a surge of young adults showing up at doctors’ offices with unexplainable movement disorders that looked, perhaps to a nonspecialist, a little bit like Tourette syndrome. But when those patients were sent to see a specialist, “They’d say, ‘that doesn’t look at all like any of my first […]

Low-cost, 3D printed device may broaden focused ultrasound use

Researchers and clinicians have been working to use focused ultrasound combined with microbubbles to open the blood-brain barrier (BBB) for both noninvasive diagnostic use as well as to deliver treatments to the brain for tumors and neurodegenerative diseases. However, the few existing devices for preclinical research are expensive, bulky and lack the precision needed for […]

WashU weekly Neuroscience publications

“Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain” (2022) NeuroImage Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain(2022) NeuroImage, 250, art. no. 118965, .  Ose, T.a b , Autio, J.A.a , Ohno, M.a , Frey, S.c , Uematsu, A.a , Kawasaki, A.a , Takeda, C.a , Hori, Y.a d , Nishigori, K.a e , Nakako, T.a e , Yokoyama, C.a f , Nagata, H.e , Yamamori, T.g , Van Essen, […]

WashU weekly Neuroscience publications

“Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate” (2022) Nature Communications Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate(2022) Nature Communications, 13 (1), art. no. 633, .  Parichha, A.a , Suresh, V.a , Chatterjee, M.a g , Kshirsagar, A.b , Ben-Reuven, L.b , Olender, T.b , Taketo, M.M.c , Radosevic, V.d e , Bobic-Rasonja, M.d e , Trnski, S.d , Holtzman, M.J.f , Jovanov-Milosevic, N.d e , Reiner, O.b , Tole, S.a […]

WashU weekly Neuroscience publications

“Hierarchical and nonhierarchical features of the mouse visual cortical network” (2022) Nature Communications Hierarchical and nonhierarchical features of the mouse visual cortical network(2022) Nature Communications, 13 (1), art. no. 503, .  D’Souza, R.D.a , Wang, Q.a b , Ji, W.a , Meier, A.M.a , Kennedy, H.c d , Knoblauch, K.c e , Burkhalter, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United Statesb Allen Institute for […]

WashU weekly Neuroscience publications

“Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains” (2022) Molecular Neurodegeneration Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains(2022) Molecular Neurodegeneration, 17 (1), art. no. 10, .  Bigley, T.M.a , Xiong, M.b c d , Ali, M.f , Chen, Y.b c e , Wang, C.b , Serrano, J.R.b , Eteleeb, A.f g , Harari, O.b f g , […]

WashU weekly Neuroscience publications

“Plasma MCP-1 and changes on cognitive function in community-dwelling older adults” (2022) Alzheimer’s Research and Therapy Plasma MCP-1 and changes on cognitive function in community-dwelling older adults(2022) Alzheimer’s Research and Therapy, 14 (1), art. no. 5, .  Sanchez-Sanchez, J.L.a b , Giudici, K.V.a , Guyonnet, S.a c , Delrieu, J.a c , Li, Y.d e , Bateman, R.J.d e f g , Parini, A.h , Vellas, B.a c , de Souto Barreto, P.a c , Vellas, B.i , Guyonnet, S.i , Carrié, […]

WashU weekly Neuroscience publications

“Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients” (2022) Molecular Neurodegeneration Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients(2022) Molecular Neurodegeneration, 17 (1), art. no. 1, .  Bloom, A.J.a , Mao, X.a , Strickland, A.a , Sasaki, Y.a , Milbrandt, J.a , DiAntonio, A.b a Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School […]

The ‘surprisingly simple’ arithmetic of smell

Smell a cup of coffee. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni — even at a pizza parlor with a scone! — coffee smells like coffee. Why don’t other smells or different environmental factors “get in the way,” so to speak, […]

WashU weekly Neuroscience publications

“Electroconvulsive therapy in treatment resistant depression” (2022) Journal of the Neurological Sciences Electroconvulsive therapy in treatment resistant depression(2022) Journal of the Neurological Sciences, 434, art. no. 120095, .  Subramanian, S.a b , Lopez, R.a b , Zorumski, C.F.a b , Cristancho, P.a b a Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, United Statesb Department of Psychiatry, University of Texas Rio Grande Valley […]

WashU weekly Neuroscience publications

“Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations” (2022) NeuroImage Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations(2022) NeuroImage, 247, art. no. 118838, .  Kaplan, S.a , Meyer, D.a , Miranda-Dominguez, O.g h , Perrone, A.f j , Earl, E.h j , Alexopoulos, D.a , Barch, D.M.b d e , Day, T.K.M.f , Dust, J.a , Eggebrecht, A.T.b , Feczko, E.g h , Kardan, O.k , […]

Understanding features that help cells stay organized

The labs of Tanja Mittag, PhD at St. Jude and Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor of biomedical engineering at the McKelvey School of Engineering, created a stickers-and-spacers model to discern the rules underlying the driving forces for phase separation. The “stickers” and “spacers” are different types of amino acids along the […]

International team finds new mechanism critical for formation of membrane vesicles

Researchers from the McKelvey School of Engineering at Washington University in St. Louis, Université de Montréal and McGill University have discovered a new mechanism by which membrane vesicles are made. The roles played by these self-contained nanoparticles are essential to the normal function of our cells. Their dysfunction is implicated in diseases ranging from cancers […]

WashU weekly Neuroscience publications

“Psychometric properties of the Peceived Benefits of Thinness Scale in college-aged women” (2022) Body Image Psychometric properties of the Peceived Benefits of Thinness Scale in college-aged women(2022) Body Image, 40, pp. 103-109.  Flatt, R.E.a , Karam, A.M.b , Fitzsimmons-Craft, E.E.b , Balantekin, K.N.c , Graham, A.K.d , Eichen, D.M.e , Monterubio, G.E.b , Goel, N.J.f , Fowler, L.A.b , Sadeh-Sharvit, S.g h i , Wilfley, D.b , Mazina, V.j k , Taylor, C.B.g h , Trockel, […]

WashU weekly Neuroscience publications

“Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning” (2022) Journal of Neuroscience Methods Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning(2022) Journal of Neuroscience Methods, 366, art. no. 109421, .  Zhang, X.a , Landsness, E.C.b , Chen, W.b , Miao, H.b , Tang, M.b , Brier, L.M.c , Culver, J.P.c d e f , Lee, […]

Paola Cepeda named Director of Postdoctoral Affairs

Dear Colleagues, I am pleased to announce that, after a nationwide search, Paola Cepeda, PhD, has been named Director of Postdoctoral Affairs in the Office of the Vice Chancellor for Research, effective January 4, 2022. Paola currently serves as the Program Manager for Graduate and Postdoctoral Professional Development at Stony Brook University. In the role […]

IpsiHand stroke-recovery device named product of year by science society

The IpsiHand, an innovative stroke-recovery device that helps stroke patients recover significant arm and hand function by retraining their brains, has received the 2021 Pantheon Product of the Year Award from California Life Sciences. The organization advocates for the state’s life sciences sector and its innovation pipeline by supporting companies of all sizes, from early-stage […]

Covey, Milbrandt, Moran named to National Academy of Inventors

The National Academy of Inventors has elected three faculty members from Washington University in St. Louis to its 2021 cohort of fellows: Psychiatry professor Douglas F. Covey, PhD, geneticist Jeffrey Milbrandt, MD, PhD, both at the School of Medicine; and bioengineer Daniel Moran, PhD, at the McKelvey School of Engineering. The NAI fellowship is the highest professional distinction reserved solely […]

WashU weekly Neuroscience publications

“Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury” (2022) Pediatric Neurology Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury (2022) Pediatric Neurology, 126, pp. 114-119.  Surtees, T.-L.a , Kumar, I.b , Garton, H.J.L.c , Rivas-Rodriguez, F.d , Parmar, H.d , McCaffery, H.b , Riebe-Rodgers, J.b , Shellhaas, R.A.b a Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United Statesb Departments […]

Minton appointed vice chancellor for technology and chief information officer

Jessie Minton, vice provost and chief information officer at the University of Oregon, has been appointed vice chancellor for technology and chief information officer at Washington University in St. Louis, effective April 15, according to Shantay Bolton, executive vice chancellor and chief administrative officer. Minton will succeed Stephanie L. Reel, who has served as interim chief […]

Less energy, better quality PAM images with machine learning

Photoacoustic microscopy (PAM) allows researchers to see the smallest vessels inside a body, but it can generate some unwanted signals or noise. A team of researchers at the McKelvey School of Engineering at Washington University in St. Louis found a way to significantly reduce the noise and maintain image quality while reducing the laser energy […]

WashU weekly Neuroscience publications

“Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes” (2022) Medical Image Analysis Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes(2022) Medical Image Analysis, 75, art. no. 102304, .  Wen, J.a , Varol, E.b , Sotiras, A.c , Yang, Z.a , Chand, G.B.d , Erus, G.a , Shou, H.a e , Abdulkadir, A.a , Hwang, G.a , Dwyer, D.B.f , Pigoni, A.g , Dazzan, P.h , Kahn, R.S.i , Schnack, H.G.j , Zanetti, M.V.k , […]

Inventive pathways

Moving innovations out of the so-called ivory tower and into the public domain holds enormous power to treat disease and improve quality of life. But while academic researchers and physicians may imagine promising clinical solutions, some are unprepared to navigate commercialization: pitching themselves, attracting investors, wrangling with intellectual property law, designing rigorous proof-of-concept studies, locating […]

WashU weekly Neuroscience publications

“Personalized networks of social anxiety disorder and depression and implications for treatment” (2022) Journal of Affective Disorders Personalized networks of social anxiety disorder and depression and implications for treatment(2022) Journal of Affective Disorders, 298, pp. 262-276.  Piccirillo, M.L., Rodebaugh, T.L. Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, United States AbstractIntroduction: Social […]

Lodge to depart Washington University

Jennifer K. Lodge, PhD, vice chancellor for research at Washington University in St. Louis and the David T. Blasingame Professor, will leave the university at the end of the year. Lodge will be joining Duke University as vice president for research and innovation in January. “Dr. Lodge has served Washington University during extraordinary times, providing […]

WashU weekly Neuroscience publications

“Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome” (2022) Pediatric Neurology Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome(2022) Pediatric Neurology, 126, pp. 65-73.  Steele, J.L.a , Morrow, M.M.b , Sarnat, H.B.c , Alkhunaizi, E.d , Brandt, T.b , Chitayat, D.A.d , DeFilippo, C.P.e , Douglas, G.V.b , Dubbs, H.A.f , Elloumi, H.Z.b , Glassford, M.R.g , Hannibal, M.C.g , Héron, B.h , Kim, […]

Noninvasive brain biopsy shows improved sensitivity in tumor detection

Glioblastomas are aggressive brain tumors that are commonly diagnosed through a risky and invasive surgical biopsy. A team of researchers led by Hong Chen, PhD at Washington University in St. Louis has developed a noninvasive diagnostic method that may one day replace the tissue biopsy with a simple blood test. Chen, associate professor of biomedical engineering at […]