Researchers at Washington University in St. Louis recently invented a technique for generating ultrasound waves that can self-bend, like the rainbow. Airy beams are a class of acoustic waves that move on a curved, arch-like trajectory and can auto-focus around obstacles that are directly in the beam’s path, which makes them well suited for ultrasound […]
People with spinal cord injuries often experience lifelong movement impairment or paralysis, for which there is no cure. When coupled with rehabilitative exercise, electrical spinal cord stimulation can help restore some movement, though the mechanisms of how the nerves in the spinal cord recover are unknown. Ismael Seáñez, PhD, assistant professor of biomedical engineering at […]
Scopus list of publications for September 4, 2022
Epilepsy is a neurological disorder that arises from abnormal electrical activity in the brain leading to seizures. These seizure events can have a variety of causes, including genetic variants in a family of proteins that regulate potassium ions in the brain. Researchers at Washington University in St. Louis have led an international team to take […]
Scopus list of publications for August 29, 2022
Scopus list of publications for August 22, 2022
Hospitals spend about one-third of their expenses on perioperative care – the high-stakes period just before and after a patient is in surgery — to prevent complications afterward. Washington University in St. Louis researchers have developed a machine learning approach that exploits the large amount of clinical data collected during perioperative care to predict potential […]
The factors that lead to preterm birth, which affects nearly 10% of pregnancies worldwide, are poorly understood. Its effects, however, are known. Among them: cerebral palsy, intellectual disability, and visual and hearing impairments. In order to better understand the cause of preterm birth, researchers need to better understand the uterine contractions patterns responsible for initiating […]
Precision medicine, which considers the unique characteristics of individuals to provide the most effective treatment, has been a goal of health care providers for decades. Now, it is a goal for those with critical neurological illnesses, such as stroke, traumatic brain injury and spine trauma, to track and predict secondary injury, such as seizures, and […]
Collaboration across disciplines is integral at WashU, often yielding life-changing discoveries. In 2002, when Eric Leuthardt, MD, and Dan Moran, PhD, were introduced to each other by their department chairs, no one could have predicted it would lead to a collaboration that is reshaping the future of neuroscience. Moran, professor of biomedical engineering at the […]
Scopus list of publications for August 8, 2022
The National Institutes of Health has awarded Daniel Moran, PhD, professor of biomedical engineering in the McKelvey School of Engineering, more than $1 million over five years to create the Translational Neuroscience and Neurotechnology Training Program. This interdisciplinary program will train students to use engineering tools to develop technology that address neurological issues such as […]
Scopus list of publications for August 3, 2022
Scopus list of publications for July 26, 2022
Scientists use photoacoustic microscopy to measure various biomarkers in the body, but some of these measurements can be inaccurate due to limitations of the light-focusing beam that produces out-of-focus images. Engineers in the McKelvey School of Engineering at Washington University in St. Louis have designed a new technique that combines hardware and software innovations as […]
Brain-computer interfaces connect activity in the brain to an external device by means of a computer. Research has shown it’s possible to use such interfaces to move robotic arms and perform other tasks. Almost 30 years ago, Washington University researcher Eric Leuthardt, MD, a professor of neurosurgery, demonstrated that he could hook electrodes to the brains […]
Scopus list of publications for July 18, 2022
A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to […]
Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor […]
Scopus list of publications for July 11, 2022
Scopus list of publications for July 5, 2022
Scopus list of publications for June 27, 2022
Gerald Early, PhD, the Merle King Professor of Modern Letters in Arts & Sciences, will serve as interim director of the Center for the Study of Race, Ethnicity & Equity (CRE2) at Washington University in St. Louis, effective July 1. The center provides programs and partnerships for Danforth and Medical campus faculty researching issues related to race […]
Scopus list of publications for June 20, 2022
At the Washington University in St. Louis Board of Trustees meeting May 6, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Appointment with tenure Andrew Clark as associate professor of electrical and systems engineering at the McKelvey School of Engineering; Xianglin Li as associate professor of mechanical […]
Scopus list of publications for June 8, 2022
Research from the lab of Matthew Lew, PhD at Washington University in St. Louis offers entirely new ways to see the very small. The research — two papers by PhD students at the McKelvey School of Engineering — was published in the journals Optica and Nano Letters. They have developed novel hardware and algorithms that allow them to visualize the […]
Scopus list of publications for May 22, 2022
Scopus list of publications for May 19, 2022
“Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study” (2022) Nature Communications Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study(2022) Nature Communications, 13 (1), art. no. 2217, . Chen, J.a b c d , Tam, A.a b c d , Kebets, V.a b c d , Orban, C.a b c d , Ooi, L.Q.R.a b c d e , Asplund, C.L.b c d f g h , Marek, S.i , Dosenbach, N.U.F.j k l m , […]
The Department of Biomedical Engineering at the McKelvey School of Engineering welcomed students, judges and guests back May 2 for the first in-person BME Day since 2019. The celebration rounds out a year of learning with senior design competitions, research awards, faculty presentation and the Frank C.P. and Grace C. Yin Distinguished Lecture. Student teams […]
Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]
"Naturalistic driving measures of route selection associate with resting state networks in older adults" (2022) Scientific Reports Naturalistic driving measures of route selection associate with resting state networks in older adults(2022) Scientific Reports, 12 (1), art. no. 6486, . Wisch, J.K.a , Roe, C.M.a , Babulal, G.M.a d e , Metcalf, N.a , Johnson, A.M.f , Murphy, S.a , Hicks, J.a , Doherty, J.M.a , Morris, J.C.a c , Ances, B.M.a b c a Department of Neurology, […]
“VCP suppresses proteopathic seeding in neurons” (2022) Molecular Neurodegeneration VCP suppresses proteopathic seeding in neurons(2022) Molecular Neurodegeneration, 17 (1), art. no. 30, . Zhu, J.a , Pittman, S.a , Dhavale, D.a , French, R.b , Patterson, J.N.a , Kaleelurrrahuman, M.S.a , Sun, Y.c , Vaquer-Alicea, J.d , Maggiore, G.d , Clemen, C.S.e f , Buscher, W.J.g , Bieschke, J.c , Kotzbauer, P.a , Ayala, Y.b , Diamond, M.I.d , Davis, A.A.a , Weihl, C.a a Department of Neurology, Hope Center for […]
“The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells” (2022) Journal of Neuroimmunology The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells(2022) Journal of Neuroimmunology, 367, art. no. 577860, . Paley, M.A.a , Baker, B.J.b , Dunham, S.R.b , Linskey, N.a , Cantoni, C.b , Lee, K.b , Hassman, L.M.c , […]
Irregular heartbeat, or arrhythmia, affects about 5 million people in the United States, and interestingly, some of the drugs used to treat the condition can also cause it. A biomedical engineer in the McKelvey School of Engineering at Washington University in St. Louis is going deep into the basic mechanisms that lead to arrhythmia to […]
“A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures” (2022) Stem Cell Research and Therapy A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures(2022) Stem Cell Research and Therapy, 13 (1), art. no. 131, . Pardieck, J.a b , Harb, M.a , Sakiyama-Elbert, S.E.a a Department of Biomedical Engineering, […]
Naval warfighters may be exposed to explosions, impacts or high accelerations that increase their risk for traumatic brain injury. A team of researchers led by Philip Bayly, PhD, at Washington University in St. Louis plans a comprehensive study of skull-brain mechanics using imaging, computer and preclinical models to study the strains and stresses of the […]
At the Washington University in St. Louis Board of Trustees meeting March 4, numerous faculty members were appointed or promoted with tenure or granted tenure, effective July 1 unless otherwise indicated. Promotion with tenure Carlos A. Botero to associate professor of biology in Arts & Sciences; Caitlyn M. Collins to associate professor of sociology in Arts & […]
“Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series” (2022) Epilepsy and Behavior Open surgery or laser interstitial thermal therapy for low-grade epilepsy-associated tumors of the temporal lobe: A single-institution consecutive series(2022) Epilepsy and Behavior, 130, art. no. 108659, . Hedaya, A.A.a , Hewitt, K.C.b , Hu, R.c , Epstein, C.M.b , Gross, R.E.a b , […]
“Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report” (2022) Cognitive Research: Principles and Implications Domain-general cognitive motivation: Evidence from economic decision-making – Final Registered Report(2022) Cognitive Research: Principles and Implications, 7 (1), art. no. 23, . Crawford, J.L.a , Eisenstein, S.A.b c , Peelle, J.E.d , Braver, T.S.a a Department of Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Dr, […]
“Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder” (2022) Drug and Alcohol Dependence Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder(2022) Drug and Alcohol Dependence, 234, art. no. 109400, . Ellis, M.S.a , Buttram, M.E.b , Kasper, Z.A.a a Washington University in St. Louis, School of Medicine. Department of […]
“Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults” (2022) Neurobiology of Aging Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults(2022) Neurobiology of Aging, 112, pp. 181-190. McKay, N.S.a b , Dincer, A.a b , Mehrotra, V.e , Aschenbrenner, A.J.b c , Balota, D.b d , Hornbeck, R.C.a b , Hassenstab, J.b c d , Morris, J.C.b c , Benzinger, T.L.S.a b , Gordon, B.A.a b d […]
"Are children with unilateral hearing loss more tired?" (2022) International Journal of Pediatric Otorhinolaryngology Are children with unilateral hearing loss more tired?(2022) International Journal of Pediatric Otorhinolaryngology, 155, art. no. 111075, . Carpenter, D.a , Dougherty, W.b , Sindhar, S.c , Friesen, T.-N.c , Lieu, J.c , Kesser, B.W.a a Department of Otolaryngology-Head and Neck Surgery, University of Virginia School of Medicine, P.O. Box 800713, Charlottesville, […]
During the pandemic, news reports surfaced of a surge of young adults showing up at doctors’ offices with unexplainable movement disorders that looked, perhaps to a nonspecialist, a little bit like Tourette syndrome. But when those patients were sent to see a specialist, “They’d say, ‘that doesn’t look at all like any of my first […]
Researchers and clinicians have been working to use focused ultrasound combined with microbubbles to open the blood-brain barrier (BBB) for both noninvasive diagnostic use as well as to deliver treatments to the brain for tumors and neurodegenerative diseases. However, the few existing devices for preclinical research are expensive, bulky and lack the precision needed for […]
“Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain” (2022) NeuroImage Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain(2022) NeuroImage, 250, art. no. 118965, . Ose, T.a b , Autio, J.A.a , Ohno, M.a , Frey, S.c , Uematsu, A.a , Kawasaki, A.a , Takeda, C.a , Hori, Y.a d , Nishigori, K.a e , Nakako, T.a e , Yokoyama, C.a f , Nagata, H.e , Yamamori, T.g , Van Essen, […]
“Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate” (2022) Nature Communications Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate(2022) Nature Communications, 13 (1), art. no. 633, . Parichha, A.a , Suresh, V.a , Chatterjee, M.a g , Kshirsagar, A.b , Ben-Reuven, L.b , Olender, T.b , Taketo, M.M.c , Radosevic, V.d e , Bobic-Rasonja, M.d e , Trnski, S.d , Holtzman, M.J.f , Jovanov-Milosevic, N.d e , Reiner, O.b , Tole, S.a […]
“Hierarchical and nonhierarchical features of the mouse visual cortical network” (2022) Nature Communications Hierarchical and nonhierarchical features of the mouse visual cortical network(2022) Nature Communications, 13 (1), art. no. 503, . D’Souza, R.D.a , Wang, Q.a b , Ji, W.a , Meier, A.M.a , Kennedy, H.c d , Knoblauch, K.c e , Burkhalter, A.a a Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United Statesb Allen Institute for […]
“Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains” (2022) Molecular Neurodegeneration Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains(2022) Molecular Neurodegeneration, 17 (1), art. no. 10, . Bigley, T.M.a , Xiong, M.b c d , Ali, M.f , Chen, Y.b c e , Wang, C.b , Serrano, J.R.b , Eteleeb, A.f g , Harari, O.b f g , […]
