Tapped for their work aimed at stemming opioid abuse and halting what has become an epidemic in the United States, researchers at Washington University School of Medicine in St. Louis have received federal grants totaling more than $10 million from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC). The grants are part of a nationwide push to fund research targeting the epidemic.
At the School of Medicine, much of the grant funding is directed toward improving treatments for chronic pain; curbing rates of opioid-use disorder and overdoses; gaining a better understanding of why, and among whom, overdoses and deaths are occurring; helping patients achieve long-term recovery from opioid addiction; and other efforts.
Among those receiving grants is Robert W. Gereau IV, PhD, the Dr. Seymour and Rose T. Brown Professor of Anesthesiology at Washington University, who is collaborating with John A. Rogers, PhD, a professor of biomedical and neurological engineering at Northwestern. They have a two-year, $4.2 million grant from NIH — as part of its HEAL (Helping to End Addiction Long-Term) Initiative — to develop an implantable device that would automatically deliver life-saving doses of the drug naloxone (Narcan) to people experiencing acute opioid overdoses. The device they are developing would deliver naloxone to a person experiencing respiratory distress, the primary cause of overdose deaths.
They envision the devices being implanted under the skin in people who have been treated for opioid-use disorder or who have been incarcerated after abusing opioids, resulting in long periods of abstinence from opioids.
“People in treatment for opioid addiction and those who have been incarcerated have a high risk of relapse,” said Gereau, who directs the Washington University Pain Center. “While Narcan can prevent deaths, it is not always readily available, and even if it is available, there is not always another person around to administer the medicine. This device could fill that void, helping to ensure that if a person relapses and gets into trouble, there would be a fail-safe way to deliver the drug that could save them.”…
…Impact on young brains
Another grant focuses on the impact of opioids on expectant mothers and their babies. Cynthia E. Rogers, MD, an associate professor of psychiatry and of pediatrics, and Christopher D. Smyser, MD, an associate professor of pediatric neurology, share the renewable, one-year $1 million planning grant with colleagues from Northwestern.
Using advanced neuroimaging and clinical measurements, the team will test the feasibility of assessing healthy brain development in infants compared to brain development in the babies of mothers who used opioids during pregnancy. The project involved in this grant will assess brain development only in babies who have been exposed to opioids.
The grant also will involve analysis of legal and ethical issues surrounding opioid use by pregnant women in the states of Missouri and Illinois, where the legal approaches regarding drug use by expectant mothers are very different.
“Washington University neuroscientists and experts on substance use, child welfare, and maternal and child mental health will collaborate with experts in neuroscience, bioethics, pediatric population health, addiction and other specialties at Northwestern,” Rogers said. “Together, we hope to get a better handle on the impact of the opioid epidemic and the risk it poses to the health and development of children and families.”…
…While not all NIH and CDC grants have been announced, other related grants to Washington University investigators include:
- A three-year, $447,000 grant for Sarah Hartz, MD, PhD, an assistant professor of psychiatry, to work with educational leaders to implement a medical school curriculum to ensure that graduating medical students have the training necessary to be certified in medication-assisted treatments for opioid-use disorder. The funding also would address such training for residents in psychiatry, emergency medicine and internal medicine. Other investigators involved in the training and curriculum development include Carrie Mintz, MD, an instructor in psychiatry, David Liss, MD, an assistant professor of medicine in the Division of Emergency Medicine, and Evan S. Schwarz, MD, an associate professor of emergency medicine. This grant is from the Substance Abuse and Mental Health Services Administration of the U.S. Department of Health and Human Services.
- Yu-Qing Cao, PhD, an associate professor of anesthesiology at the Washington University Pain Center, has received a two-year, $500,000 grant from the National Institute of Neurological Disorders and Stroke of the NIH to validate the potassium channel TRESK as a novel target for chronic pain medicine. The Cao lab is particularly interested in migraine headaches and developing ways to prevent pain from such headaches without use of opioid drugs.