WashU weekly Neuroscience publications

The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke
(2020) Human Brain Mapping, . 

Liew, S.-L.^{a b c d} , Zavaliangos-Petropulu, A.^{b d e} , Jahanshad, N.^{b e} , Lang, C.E.^f , Hayward, K.S.^{g h} , Lohse, K.R.^{i j} , Juliano, J.M.^d , Assogna, F.^k , Baugh, L.A.^{l m} , Bhattacharya, A.K.ⁿ , Bigjahan, B.^{b o} , Borich, M.R.^p , Boyd, L.A.^{q r} , Brodtmann, A.^s , Buetefisch, C.M.^{p t} , Byblow, W.D.^u , Cassidy, J.M.^v , Conforto, A.B.^{w x} , Craddock, R.C.^y , Dimyan, M.A.^{z aa} , Dula, A.N.^{y ab} , Ermer, E.^z , Etherton, M.R.^{ac ad} , Fercho, K.A.^{l ae} , Gregory, C.M.^af , Hadidchi, S.^{ag ah} , Holguin, J.A.^a , Hwang, D.H.^o , Jung, S.^ai , Kautz, S.A.^{af aj} , Khlif, M.S.^s , Khoshab, N.^ak , Kim, B.^{al am} , Kim, H.^b , Kuceyeski, A.^{an ao} , Lotze, M.^ap , MacIntosh, B.J.^{aq ar} , Margetis, J.L.^a , Mohamed, F.B.^as , Piras, F.^k , Ramos-Murguialday, A.^{at au} , Richard, G.^{av aw ax} , Roberts, P.^ay , Robertson, A.D.^{az ba} , Rondina, J.M.^bb , Rost, N.S.^bc , Sanossian, N.^bd , Schweighofer, N.^be , Seo, N.J.^{af aj bf} , Shiroishi, M.S.^bg , Soekadar, S.R.^{bh bi} , Spalletta, G.^{k bj} , Stinear, C.M.^bk , Suri, A.^bl , Tang, W.K.W.^bm , Thielman, G.T.^{bn bo} , Vecchio, D.^k , Villringer, A.^{bp bq br} , Ward, N.S.^bs , Werden, E.^s , Westlye, L.T.^{av aw} , Winstein, C.^{be bt} , Wittenberg, G.F.^{bu bv} , Wong, K.A.^bw , Yu, C.^{bx by} , Cramer, S.C.^bz , Thompson, P.M.^{b e}

^a Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, United States
^b Department of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
^c Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States
^d Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States
^e Imaging Genetics Center, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
^f Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States
^g Department of Physiotherapy, and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
^h NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, University of Melbourne, Parkville, VIC, Australia
ⁱ Department of Health, Kinesiology, and Recreation, University of Utah, Salt Lake City, UT, United States
^j Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, United States
^k Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
^l Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States
^m Sioux Falls VA Health Care System, Sioux Falls, SD, United States
ⁿ Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
^o Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
^p Department of Rehabilitation Medicine, Emory University, Atlanta, GA, United States
^q Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
^r Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada
^s Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia
^t Department of Neurology, Emory University, Atlanta, GA, United States
^u Department of Exercise Sciences, Centre for Brain Research, University of Auckland, Auckland, New Zealand
^v Division of Physical Therapy, Department Allied Health Sciences, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States
^w Neurology Clinical Division, Hospital das Clínicas/São Paulo University, São Paulo, Brazil
^x Hospital Israelita Albert Einstein, São Paulo, Brazil
^y Department of Diagnostic Medicine, The University of Texas at Austin Dell Medical School, Austin, TX, United States
^z Department of Neurology and Neurorehabilitation, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States
^aa VA Maryland Health Care System, Baltimore, MD, United States
^ab Department of Neurology, Dell Medical School at University of Texas at Austin, Austin, TX, United States
^ac Department of Neurology, Massachusetts General Hospital, Boston, MA, United States
^ad J. Philip Kistler Stroke Research Center, Harvard Medical School, Boston, MA, United States
^ae Federal Aviation Administration, Civil Aerospace Medical Institute, Oklahoma City, OK, United States
^af Department of Health Sciences and Research, Medical University of South Carolina, Charleston, SC, United States
^ag Department of Radiology, Wayne State University/Detroit Medical Center, Detroit, MI, United States
^ah Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, MI, United States
^ai Department of Neurology, University of Bern, Bern, Switzerland
^aj Ralph H Johnson VA Medical Center, Charleston, SC, United States
^ak Department of Anatomy and Neurobiology, University of California, Irvine, CA, United States
^al Department of Physical Therapy Education, State University of New York Upstate Medical University, Syracuse, NY, United States
^am Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States
^an Department of Radiology, Weill Cornell Medicine, New York, NY, United States
^ao Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States
^ap Functional Imaging Unit, Center for Diagnostic Radiology, School of Medicine, University of Greifswald, Greifswald, Germany
^aq Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
^ar Physical Sciences Platform, Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada
^as Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States
^at TECNALIA, Basque Research and Technology Alliance (BRTA), Neurotechnology Laboratory, Derio, Spain
^au Institute of Medical Psychology and Behavioural Neurobiology, University of Tubingen, Tübingen, Germany
^av Department of Psychology, University of Oslo, Oslo, Norway
^aw NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
^ax Institute of Clinical Medicine, University of Oslo, Oslo, Norway
^ay Department of Physical Medicine and Rehabilitation, Cedars-Sinai, Los Angeles, CA, United States
^az Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
^ba Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, ON, Canada
^bb Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
^bc Stroke Division, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
^bd Division of Neurocritical Care and Stroke, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
^be Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States
^bf Division of Occupational Therapy, Department of Health Professions, Medical University of South Carolina, Charleston, SC, United States
^bg Division of Neuroradiology, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
^bh Department of Psychiatry and Psychotherapy, Clinical Neurotechnology Laboratory, Charité – University Medicine Berlin, Berlin, Germany
^bi Applied Neurotechnology Laboratory, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
^bj Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States
^bk Department of Medicine, University of Auckland, Auckland, New Zealand
^bl Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, United States
^bm Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong
^bn Physical Therapy and Neuroscience, University of the Sciences, Philadelphia, PA, United States
^bo Samson College, Quezon City, Philippines
^bp Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
^bq Department of Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany
^br Center for Stroke Research, Charité-Universitätsmedizin Berlin, Berlin, Germany
^bs UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
^bt Department of Neurology, University of Southern California, Los Angeles, CA, United States
^bu Department of Neurology, University of Pittsburgh, Pittsburgh, PA, United States
^bv Department of Veterans Affairs, University Drive Campus, Pittsburgh, PA, United States
^bw Department of Physical Medicine and Rehabilitation, Dell Medical School, University of Texas Austin, Austin, TX, United States
^bx Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
^by Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
^bz Department of Neurology, UCLA and California Rehabilitation Institute, Los Angeles, CA, United States

Abstract
The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided. © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.

Author Keywords
big data;  lesions;  MRI;  neuroinformatics;  stroke

Document Type: Review
Publication Stage: Article in Press
Source: Scopus
Access Type: Open Access