WashU weekly Neuroscience publications

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states
(2018) Scientific Reports, 8 (1), art. no. 4103, . 

Mahjoub, I.^{a b} , Mahjoub, M.A.^b , Rekik, I.^a , Weiner, M.^c , Aisen, P.^d , Petersen, R.^e , Jack, C.^f , Jagust, W.^g , Trojanowki, J.^h , Toga, A.ⁱ , Beckett, L.^j , Green, R.^k , Saykin, A.^l , Morris, J.^m , Shaw, L.^m , Kaye, J.ⁿ , Quinn, J.ⁿ , Silbert, L.ⁿ , Lind, B.ⁿ , Carter, R.ⁿ , Dolen, S.ⁿ , Schneider, L.ⁿ , Pawluczyk, S.ⁱ , Beccera, M.ⁱ , Teodoro, L.ⁱ , Spann, B.ⁱ , Brewer, J.^o , Vanderswag, H.^o , Fleisher, A.^{o bb} , Heidebrink, J.^p , Lord, J.^p , Mason, S.^f , Albers, C.^f , Knopman, D.^f , Johnson, K.^f , Doody, R.^q , Villanueva-Meyer, J.^q , Chowdhury, M.^q , Rountree, S.^q , Dang, M.^q , Stern, Y.^r , Honig, L.^r , Bell, K.^r , Ances, B.^m , Carroll, M.^m , Creech, M.^c , Franklin, E.^m , Mintun, M.^m , Schneider, S.^m , Oliver, A.^m , Marson, D.^s , Grifth, R.^s , Clark, D.^s , Geldmacher, D.^s , Brockington, J.^s , Roberson, E.^s , Natelson Love, M.^s , Grossman, H.^t , Mitsis, E.^t , Shah, R.^u , Detoledo-Morrell, L.^u , Duara, R.^v , Varon, D.^v , Greig, M.^v , Roberts, P.^v , Albert, M.^w , Onyike, C.^w , D’Agostino, D.^w , Kielb, S.^w , Galvin, J.^x , Cerbone, B.^x , Michel, C.^x , Pogorelec, D.^x , Rusinek, H.^x , De Leon, M.^x , Glodzik, L.^x , De Santi, S.^x , Doraiswamy, P.^y , Petrella, J.^y , Borges-Neto, S.^y , Wong, T.^y , Coleman, E.^y , Smith, C.^z , Jicha, G.^z , Hardy, P.^z , Sinha, P.^z , Oates, E.^z , Conrad, G.^z , Porsteinsson, A.^aa , Goldstein, B.^aa , Martin, K.^aa , Makino, K.^aa , Ismail, M.^aa , Brand, C.^aa , Mulnard, R.^ab , Thai, G.^ab , Mc-Adams-Ortiz, C.^ab , Womack, K.^ac , Mathews, D.^ac , Quiceno, M.^ac , Levey, A.^ad , Lah, J.^ad , Cellar, J.^ad , Burns, J.^ae , Swerdlow, R.^ae , Brooks, W.^ae , Apostolova, L.^af , Tingus, K.^af , Woo, E.^af , Silverman, D.^af , Lu, P.^af , Bartzokis, G.^af , Graf-Radford, N.^ag , Parftt, F.^ag , Kendall, T.^ag , Johnson, H.^ag , Farlow, M.^l , Hake, A.M.^l , Matthews, B.^l , Brosch, J.^l , Herring, S.^l , Hunt, C.^l , Dyck, C.^ah , Carson, R.^ah , MacAvoy, M.^ah , Varma, P.^ah , Chertkow, H.^ai , Bergman, H.^ai , Hosein, C.^ai , Black, S.^aj , Stefanovic, B.^aj , Caldwell, C.^aj , Robin Hsiung, G.-Y.^aj , Feldman, H.^ak , Mudge, B.^ak , Assaly, M.^ak , Finger, E.^al , Pasternack, S.^al , Rachisky, I.^al , Trost, D.^al , Kertesz, A.^al , Bernick, C.^am , Munic, D.^am , Mesulam, M.-M.^an , Lipowski, K.^an , Weintraub, S.^am , Bonakdarpour, B.^am , Kerwin, D.^am , Wu, C.-K.^am , Johnson, N.^an , Sadowsky, C.^ao , Villena, T.^ao , Turner, R.S.^ap , Johnson, K.^ap , Reynolds, B.^ap , Sperling, R.^aq , Johnson, K.^aq , Marshall, G.^aq , Yesavage, J.^ar , Taylor, J.^ar , Lane, B.^ar , Rosen, A.^ar , Tinklenberg, J.^ar , Sabbagh, M.^as , Belden, C.^as , Jacobson, S.^as , Sirrel, S.^as , Kowall, N.^at , Killiany, R.^at , Budson, A.^at , Norbash, A.^at , Johnson, P.L.^at , Obisesan, T.^au , Wolday, S.^au , Allard, J.^au , Lerner, A.^av , Ogrocki, P.^av , Tatsuoka, C.^av , Fatica, P.^av , Fletcher, E.^aw , Maillard, P.^aw , Olichney, J.^aw , Decarli, C.^aw , Carmichael, O.^aw , Kittur, S.^ax , Borrie, M.^ay , Lee, T.-Y.^ay , Bartha, R.^ay , Johnson, S.^az , Asthana, S.^az , Carlsson, C.^az , Potkin, S.^ba , Preda, A.^ba , Nguyen, D.^ba , Tariot, P.^bb , Burke, A.^bb , Trncic, N.^bb , Reeder, S.^bb , Bates, V.^bc , Capote, H.^bc , Rainka, M.^bc , Scharre, D.^bd , Kataki, M.^bd , Adeli, A.^bd , Zimmerman, E.^be , Celmins, D.^be , Brown, A.^be , Pearlson, G.^bf , Blank, K.^bf , Anderson, K.^bf , Flashman, L.^bg , Seltzer, M.^bg , Hynes, M.^bg , Santulli, R.^bg , Sink, K.^bh , Gordineer, L.^bh , Williamson, J.^bh , Garg, P.^bh , Watkins, F.^bh , Ott, B.^bi , Querfurth, H.^bi , Tremont, G.^bi , Salloway, S.^bj , Malloy, P.^bj , Correia, S.^bj , Rosen, H.^bk , Miller, B.^bk , Perry, D.^bk , Mintzer, J.^bl , Spicer, K.^bl , Bachman, D.^bl , Pomara, N.^bm , Hernando, R.^bn , Sarrael, A.^bm , Relkin, N.^bn , Chaing, G.^bn , Lin, M.^bn , Ravdin, L.^bn , Smith, A.^bo , Raj, B.A.^bo , Fargher, K.^bo

^a BASIRA Lab, CVIP Group, School of Science and Engineering, Computing, University of Dundee, Dundee, United Kingdom
^b LATIS Lab, ENISo – National Engineering School of Sousse, Sousse, Tunisia
^c Magnetic Resonance Unit at the VA Medical Center and Radiology, Medicine, Psychiatry and Neurology, University of California, San Francisco, United States
^d San Diego School of Medicine, University of California, California, United States
^e Mayo Clinic, Rochester, MN, United States
^f Mayo Clinic Rochester, United States
^g University of California, Berkeley, United States
^h University of Pennsylvania, Pennsylvania, United States
ⁱ University of Southern California, California, United States
^j University of California, Davis, CA, United States
^k MPH Brigham and Women’s Hospital/Harvard Medical School, Massachusetts, United States
^l Indiana University, Indiana, United States
^m Washington University St. Louis, St Louis, MO, United States
ⁿ Oregon Health and Science University, Oregon, United States
^o University of California-San Diego, California, United States
^p University of Michigan, Ann Arbor, MI, United States
^q Baylor College of Medicine, Houston, TX, United States
^r Columbia University Medical Center, New York, SC, United States
^s University of Alabama, Birmingham, AL, United States
^t Mount Sinai School of Medicine, New York, United States
^u Rush University Medical Center, Rush University, Chicago, IL, United States
^v Wien Center, Miami, FL, United States
^w Johns Hopkins University, Baltimore, MD, United States
^x New York University, New York, NY, United States
^y Duke University Medical Center, Durham, NC, United States
^z University of Kentucky, Lexington, KT, United States
^aa University of Rochester Medical Center, Rochester, NY, United States
^ab University of California, United States
^ac University of Texas Southwestern Medical School, Dallas, TX, United States
^ad Emory University, Atlanta, GA, United States
^ae University of Kansas, Medical Center, Kansas, United States
^af University of California, Los Angeles, CA, United States
^ag Mayo Clinic, Jacksonville, United States
^ah Yale University School of Medicine, New Haven, CT, United States
^ai McGill University, Montreal-Jewish General Hospital, Montreal, Canada
^aj Sunnybrook Health SciencesON, United States
^ak U.B.C. Clinic for AD and Related Disorders, Vancouver, BC, Canada
^al Cognitive Neurology – St. Joseph’s, Ontario, United States
^am Cleveland Clinic Lou Ruvo Center for Brain Health, Ohio, United States
^an Northwestern University, San Francisco, United States
^ao Premiere Research Inst (Palm Beach Neurology), west Palm Beach, United States
^ap Georgetown University Medical Center, Washington, DC, United States
^aq Brigham and Women’s Hospital, Massachusetts, United States
^ar Stanford University, California, United States
^as Banner Sun Health Research Institute, Sun City, AZ, United States
^at Boston University, Massachusetts, United States
^au Howard University, Washington, DC, United States
^av Case Western Reserve University, Ohio, United States
^aw University of California, Davis – SacramentoCA, United States
^ax Neurological Care of CNY, Liverpool, NY, United States
^ay Parkwood Hospital, Pennsylvania, United States
^az University of Wisconsin, Wisconsin, United States
^ba Univarsity of California, Irvine, United States
^bb Banner Alzheimer’s Institute, Phoenix, AZ, United States
^bc Dent Neurologic Institute, Amherst, NY, United States
^bd Ohio State University, Ohio, United States
^be Albany Medical College, Albany, NY, United States
^bf Hartford Hospital, Olin Neuropsychiatry Research Center, Hartford, CT, United States
^bg Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States
^bh Wake Forest University Health Sciences, Winston-Salem, NC, United States
^bi Rhode Island Hospital, State of Rhode Island, Providence, RI, United States
^bj Butler Hospital, Providence, RI, United States
^bk University of California, San Francisco, United States
^bl Medical University South Carolina, Charleston, SC, United States
^bm Nathan Kline Institute, Orangeburg, NY, United States
^bn Cornell University, Ithaca, NY, United States
^bo USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, FL, United States

Abstract
Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer’s disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, ‘shape connections’ between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus. © 2018 The Author(s).

Document Type: Article
Source: Scopus